Organ life support monitoring and control device for scientific research

Abstract

The application discloses a kind of organ life support measurement and control device for scientific research, including life support station and mobile core seat;Life support station includes core seat placement bin, mobile core seat can be pushed into the inside of core seat placement bin or push out from core seat placement bin, isolated organ is placed on mobile core seat;Multiple organ life support system is equipped in life support station and mobile core seat, and multiple organ life support system maintains the life of isolated organ in mobile core seat, and monitoring system is equipped in life support station, and monitoring system monitors the state of isolated organ in the process of maintaining the life of isolated organ.Occupation, the advantages of integration, control system and monitoring system in life support station and movable core seat, realize the integration and miniaturization of core function module;Through the separation design of mobile core seat and life support station, organ loading, pretreatment and temporary transfer operation are independent of the whole device, and the flexibility and convenience of use of the device are improved.

Description

Technical Field

[0001] This invention relates to the field of biomedical research, specifically to a research-use organ life support monitoring and control device. Background Technology

[0002] In the field of biomedical research, in vitro organ culture technology is gradually becoming a crucial tool. This technology simulates the physiological environment of organs in vitro, providing them with necessary nutrients, oxygen, and suitable temperature, pH, and other conditions, enabling them to survive, grow, and maintain certain functions outside the body. This technology not only provides an ideal research model for in-depth exploration of organ development mechanisms and disease progression, but also shows great application potential in drug screening, toxicity testing, and pre-transplantation treatment.

[0003] Traditional laboratory organ extracorporeal life support systems typically consist of multiple independent and bulky functional modules, such as extracorporeal membrane oxygenation (ECMO) machines, continuous renal replacement therapy (CRRT) machines, ventilators, temperature control chambers, and independent monitoring instruments (such as ultrasound machines and blood pressure monitors). These devices are scattered, occupying a huge amount of laboratory space, and the operation process is complex, requiring researchers to perform tedious connections, debugging, and monitoring between multiple devices.

[0004] Therefore, there is a need for an integrated, compact, flexible, and easy-to-use multi-organ life support monitoring and control device to meet the needs of modern scientific research. Summary of the Invention

[0005] The technical problem to be solved by the present invention is the problem mentioned in the background art that existing laboratory organ extracorporeal life support devices are bulky, complex to operate, lack flexibility, and are inconvenient to use.

[0006] To address the aforementioned technical problems, a research-grade organ life support monitoring and control device is proposed. This device is achieved through the following technical solution: A research-grade organ life support monitoring and control device includes a life support station and a mobile core seat. The life support station includes a core seat placement chamber and a side door that can be controllably closed. The mobile core seat can be pushed into or pushed out of the core seat placement chamber, and the excised organ is placed on the mobile core seat. A multi-organ life support system is also provided in the life support station and the mobile core seat, maintaining the life of the excised organ in the mobile core seat. A control console is located on the life support station, controlling and adjusting the life support process of the excised organ. A monitoring system is also provided in the life support station, monitoring the status of the excised organ during the life support process.

[0007] In a preferred embodiment of the present invention, the movable core seat includes an organ placement platform, on which a multi-organ placement rack is provided. The excised organ is placed on the multi-organ placement rack. The multi-organ placement rack facilitates the use of the multi-organ placement rack to support the excised organ, thus facilitating the extracorporeal life support of the excised organ.

[0008] In a preferred embodiment of the present invention, the multi-organ life support system includes a blood purification module, a blood oxygenation module, a temperature and humidity control module, and a ventilator. The blood purification module is located at the life support station and connected to the blood oxygenation module. The blood oxygenation module is located on a movable core and connected to the isolated organ. The temperature and humidity control module is located in the life support station and maintains the temperature and humidity of the core placement chamber. The ventilator is located on the movable core. This configuration of the organ life support system facilitates the simulation of the complex physiological environment of multiple human organs working together in a compact system, thus reducing the size of the device.

[0009] In a preferred embodiment of the present invention, the monitoring system includes a millimeter-wave radar module, an ultrasound module, and an invasive pressure detection module. The millimeter-wave radar module is installed inside the core placement chamber and detects the viability of the excised organ. The ultrasound module is installed inside the core placement chamber and detects the internal condition of the excised organ. The invasive pressure detection module is installed at the life support station and is connected to a multi-organ life support system. The invasive pressure detection module monitors the blood pressure of the excised organ. This configuration of the monitoring system facilitates real-time assessment of organ status from multiple perspectives, providing comprehensive and accurate data support for scientific research.

[0010] In a preferred embodiment of the present invention, the millimeter-wave radar module includes multiple spaced arc-shaped mounting rods and multiple millimeter-wave radars mounted on the arc-shaped mounting rods. The arc-shaped mounting rods are positioned within the core placement chamber and span the excised organ. The millimeter-wave radars observe the excised organ, and the arc-shaped mounting rods and the multiple millimeter-wave radars distributed on them can form a comprehensive, blind-spot-free scanning coverage of the excised organ on the moving core, achieving non-contact, continuous monitoring of vital signs such as organ pulsation and morphology, thus avoiding physical interference with the organ.

[0011] In a preferred embodiment of the present invention, the ultrasound module includes a robotic arm and an ultrasound probe. The robotic arm is housed within the core placement chamber, and the ultrasound module is mounted on the robotic arm. The robotic arm drives the ultrasound probe to perform ultrasound monitoring of the isolated organ. The ultrasound module is configured with three sets of probes, two of which are two-dimensional probes and the other is a three-dimensional probe. This configuration allows the probe to be driven by the robotic arm to flexibly and accurately scan different parts and sections of the isolated organ. The combination of two-dimensional and three-dimensional probes can acquire both conventional two-dimensional ultrasound images and stereoscopic three-dimensional ultrasound images, enriching the monitoring methods and improving the monitoring accuracy.

[0012] In a preferred embodiment of the present invention, a biochemical monitoring module is provided at the life support station. This biochemical monitoring module performs biochemical analysis on the blood gas and urine of the isolated organ. The biochemical monitoring module enables the analysis of key biochemical indicators in the blood, allowing researchers to obtain key metabolic and functional data without sending samples out, thereby further improving the integration of the device and the efficiency of experiments.

[0013] In a preferred embodiment of the present invention, a temperature-adjustable water bath is provided on the movable core base. The water bath is connected to the membrane lung in the blood oxygenation module of the multi-organ life support system. The water bath provides a temperature-controlled environment for the membrane lung in the blood oxygenation module, ensuring that the blood oxygenation process is carried out at a suitable temperature and that the blood returning to the organ is at a suitable temperature for the organ.

[0014] In a preferred embodiment of the present invention, an observation cover is provided outside the core placement chamber at the life support station. The observation cover is made of transparent material. This arrangement allows researchers to directly observe the ex vivo organ from outside the life support station, making it convenient to use.

[0015] In a preferred embodiment of the present invention, a drug injection module is also provided at the life support station. The drug injection module is connected to the blood tank in the blood oxygenation module. The drug injection module facilitates the injection of drugs into the blood tank as needed to supplement the isolated organ with nutrients and maintain its acid-base balance.

[0016] The beneficial effects of this invention compared to the prior art are: The technical solution of this invention integrates a multi-organ life support system, a control system, and a monitoring system into a life support station and a movable core, achieving integration and miniaturization of the core functional modules. Through the separate design of the movable core and the life support station, organ loading, pretreatment, and temporary transport operations can be carried out independently outside the overall device, greatly improving the flexibility and ease of use of the device, and effectively avoiding the problems of bulky overall device and limited operating space. Attached Figure Description

[0017] Figure 1 This is a three-dimensional schematic diagram of the present invention (movable core seat pushed in). Figure 2 This is a three-dimensional schematic diagram of the present invention (with the movable core seat pushed in, and without the observation cover). Figure 3 A schematic diagram of the life-sustaining whistle standing upright (with the movable core seat extended). Figure 4 A three-dimensional schematic diagram of the movable core base; Figure 5 This is a three-dimensional schematic diagram of the monitoring system. Figure 6A schematic diagram illustrating the working principle of a multi-organ life support system; Figure 7 This is an exploded view of this application; Explanation of reference numerals in the attached diagram: 1-Life support station, 11-Core placement chamber, 12-Observation hood, 13-Side door, 14-Biochemical monitoring module mounting position, 15-Operating table, 2-Mobile core, 21-Organ placement table, 22-Moving wheels, 23-Multi-organ placement rack, 24-Blood oxygenation module mounting position, 25-Liquid bag weighing mounting position, 26-Ventilator mounting position, 3-Multi-organ life support system, 4-Blood purification module, 41-Infusion pump, 5-Blood oxygenation module, 51-Membrane lung, 52-Magnetic levitation pump, 53-Blood vessel 10-Temperature and humidity control module, 101-Humidifier, 102-Temperature control equipment, 103-Water bath, 104-Monitor, 6-Ventilator, 7-Monitoring system, 71-Millimeter-wave radar module, 72-Arc-shaped mounting rod, 73-Millimeter-wave radar, 74-C-shaped mounting clip, 75-Ultrasound module, 76-Robotic arm, 77-Ultrasound probe, 78-Invasive pressure detection module, 8-Biochemical monitoring module, 9-Control console, 105-Oxygen balance control system, 106-Temperature balance control system, 91-Control panel. Detailed Implementation

[0018] The following will refer to the appendices in the embodiments of the present invention. Figure 1-7 The technical solutions in the embodiments of the present invention will be described in detail below. Example

[0019] like Figure 1 , 2 As shown in Figure 3, a research organ life support monitoring and control device includes a life support station 1, a mobile core seat 2, a multi-organ life support system 3, a monitoring system 7, and a control console 9. The excised organ is placed on the mobile core seat 2, and the control console 9 is located on the life support station 1, which is placed on the ground. A core seat placement chamber 11 is provided on the life support station 1. The mobile core seat 2 can be pushed into or pushed out of the core seat placement chamber 11. The multi-organ life support system 3 is located on the life support station 1 and the mobile core seat 2, and maintains the life of the excised organ in the mobile core seat 2. The monitoring system 7 is located on the life support station 1 and monitors the health status of the excised organ on the mobile core seat 2.

[0020] The main function of the life support station 1 is to provide a substrate for the installation of the multi-organ life support system 3 and the monitoring system 7. At the same time, the life support station 1 can also form a relatively closed and constant humidity and temperature chamber, which makes it convenient to place the mobile core 2 in the life support station 1 to maintain the life of the ex vivo organs on the mobile core 2.

[0021] The main function of the mobile core 2 is to serve as a carrier for installing some modules in the multi-organ life support system 3, and also as a workbench for placing ex vivo organs. In addition, the mobile core 2 can be pushed relative to the life support station 1, so that organ loading, pretreatment and temporary transport operations can be carried out independently of the overall device, which improves the flexibility and ease of use of the device.

[0022] like Figure 1 and 2 As shown, the life support station 1 is a rectangular counter. The life support station 1 includes a core placement compartment 11, a control console 9, and an operating table 15. The core placement compartment 11 is integrally fixed in the middle of the life support station 1. The operating table 15 is located on the front of the life support station 1. The control console 9 is an existing device with an integrated control board. The entire device can be controlled using the control console 9. The movable core 2 can be directly pushed into the core placement compartment 11 or pushed out of the core placement compartment 11.

[0023] After the movable core holder 2 is pushed into the core holder placement chamber 11, in order to close the core holder placement chamber 11 and form a relatively independent environment, an observation cover 12 is fitted on the life support station 1. The observation cover 12 is made of transparent acrylic and is semi-circular in shape. The observation cover 12 covers the outside of the core holder placement chamber 11, sealing the opening above the core holder placement chamber 11. In order to improve the sealing effect, the contact part between the observation cover 12 and the life support station 1 is sealed with sealant. The sealant can be existing silicone corner adhesive.

[0024] A side door 13 is hinged to the opening of the core placement chamber 11 on the side of the life support station 1. After the movable core 2 is pushed into the core placement chamber 11, the side door can close the opening on the side of the core placement chamber 11.

[0025] To facilitate the installation of the biochemical monitoring module 8 in the monitoring system 7, a rectangular groove is recessed on the front of the life support station 1. This groove is named the biochemical monitoring module mounting position 14, and the biochemical monitoring module 8 is installed in the biochemical monitoring module mounting position 14.

[0026] In order to facilitate the operation of the movable core 2 placed in the core placement chamber 11 during organ life support, an operation port is provided on the back of the life support station 1. The operation port corresponds to the position of the core placement chamber 11 and is closed by a hinged cabinet door.

[0027] The control console 9 includes a control panel 91, which is mounted on the operator console 15. The control panel 91 can be used to control the multi-organ life support system 3 and the monitoring system 7.

[0028] Definition: In this embodiment, the ground is used as the reference. The life support station 1 is placed on the ground. The direction from the ground to the life support station 1 is defined as the top, and the opposite direction is defined as the bottom. The side of the life support station 1 with the biochemical monitoring module installation position 14 is defined as the front, and the opposite side is defined as the back.

[0029] like Figure 1 and 2 As shown, the movable core 2 is a rectangular body with a hollow interior, providing a cavity for the installation of temperature control and air-oxygen mixing equipment. At the four corners of the lower surface of the movable core 2, a movable wheel 22 is installed using screws. The movable wheel 22 is a universal wheel, which can easily push the movable core 2 to move. An organ placement platform 21 is integrally fixed on the top of the movable core 2, and the excised organ is placed on the organ placement platform 21.

[0030] To facilitate the collection of blood or perfusion fluid that may drip from the organ during the experiment, keep the organ placement table 21 clean, and prevent liquid from seeping into the equipment and causing damage or contamination, a blood collection station is installed on the organ placement table 21 using screws.

[0031] The blood collection platform is a rectangular plastic plate. To facilitate the collection of blood or perfusion fluid, the upper surface of the blood collection platform is a concave arc. A drain port is provided at the lowest point of the concave arc of the blood collection platform. A drain pipe is inserted into the drain port. The other end of the drain pipe passes through the movable core seat 2 and is connected to an external collection bucket to collect blood or perfusion fluid that may drip from the organ during the experiment, keeping the organ placement platform 21 clean.

[0032] To facilitate the placement of ex vivo organs, a multi-organ placement rack 23 is also installed on the organ placement table 21, and the organs are placed on the multi-organ placement rack 23.

[0033] In addition, to avoid positional interference, the height of the multi-organ placement rack 23 is lower than the height of the millimeter-wave radar module 71 in the monitoring system 7.

[0034] The front of the core placement chamber 11 is recessed and has a blood oxygenation module mounting position 24, a liquid bag weighing mounting position 25, and a ventilator mounting position 26. The blood oxygenation module 5 is installed in the blood oxygenation module mounting position 24, the liquid bag weighing and liquid bag in the blood purification module 4 are installed in the liquid bag weighing mounting position 25, and the ventilator 6 is installed in the ventilator mounting position 26.

[0035] like Figure 2 , 3As shown in Figures 4 and 5, the multi-organ life support system 3 includes a blood purification module 4, a blood oxygenation module 5, a temperature and humidity control module, a monitor, and a ventilator 6. The main function of the blood purification module 4 is to purify the blood perfused into the organ to ensure the normal maintenance of organ life. The main function of the blood oxygenation module 5 is to oxygenate the blood perfused into the organ. The main function of the temperature and humidity control module is to maintain the core placement chamber 11 at a humidity and temperature suitable for organ life maintenance. The monitor is used to monitor the vital status of the organ. The ventilator 6 is used to replace the membrane lung 51 for oxygenation when the lungs in the isolated organ are healthy and functioning normally.

[0036] The blood purification module 4 includes an infusion pump 41 and a filter. The filter is an existing hemodialysis filter. The filter is held by mechanical grippers fixed on the life support station 1. The filter is connected to the blood tank 53 in the blood oxygenation module 5. A blood pump is installed between the filter and the blood tank 53. The blood pump can draw part of the blood in the blood tank 53 into the filter for filtration.

[0037] The infusion pump 41 is an existing medical infusion pump that is mechanically fixed to the operating table 15 of the life support station 1. The infusion pump 41 is connected to the blood tank 53 in the blood oxygenation module 5. The infusion pump 41 can inject drugs into the blood tank 53 to maintain the blood acid-base balance and organ function.

[0038] like Figure 3 and 4 As shown, the blood oxygenation module 5 includes a membrane lung 51, a magnetic levitation pump 52, a blood tank 53, and an air-oxygen mixer. The blood tank 53 is installed on the membrane lung 51 and is integrally connected to the membrane lung 51. The air-oxygen mixer is an existing medical air-oxygen mixer. The air-oxygen mixer connects the membrane lung 51 to the external air and oxygen source. The air-oxygen mixer can be used to input the mixed gas into the membrane lung 51 to facilitate oxygenation.

[0039] The magnetic levitation pump 52 is connected to the membrane lung 51 and the blood tank 53. The magnetic levitation pump 52 can pump the blood in the blood tank 53 into the membrane lung 51 for oxygenation.

[0040] Regarding the membrane lung 51 and the blood tank 53, this embodiment preferably uses an existing integrated membrane oxygenator with a membrane lung and a blood storage tank.

[0041] Regarding the fixing of the membrane lung 51 and magnetic levitation pump 52 in the blood oxygenation module 5 at the blood oxygenation module mounting position 24, this embodiment preferably uses a mounting bracket for fixing, as detailed below: The mounting frame includes a rectangular mounting slide, which is slidably installed within the blood oxygenation module mounting position 24. A membrane lung mounting frame and a magnetic levitation pump mounting slide are mounted on the mounting slide. The membrane lung 51 is mounted on the membrane lung mounting frame, and the magnetic levitation pump 52 is mounted on the magnetic levitation pump mounting slide.

[0042] The mounting slide is a metal plate with a rectangular cross-section. The mounting slide mainly serves as a carrier for the membrane lung mounting frame and the magnetic levitation pump mounting slide. In order to facilitate the adjustment of the membrane lung 51 and the magnetic levitation pump 52, the mounting slide is slidably installed in the blood oxygenation module mounting position 24. The specific installation method is to use two sets of linear slide rails. The slide rails in the linear slide rails are installed on the surface of the blood oxygenation module mounting position 24 with screws. A slider is fixed on the surface of the mounting slide with screws. The slide rails and sliders cooperate to allow the mounting slide to move along the slide rails.

[0043] To restrict the sliding of the mounting slide, limit blocks are fixed to the lower surface of the mounting slide and the blood oxygenation module mounting position 24 using screws. The limit blocks are rectangular metal blocks with a thickness greater than half the distance between the lower surface of the mounting slide and the bottom surface of the blood oxygenation module mounting position 24. Two limit blocks are fixed at intervals to the lower surface of the blood oxygenation module mounting position 24 using screws, and one limit block is fixed to the lower surface of the mounting slide using screws. The distance between the two limit blocks on the blood oxygenation module mounting position 24 is the travel distance of the mounting slide. When the mounting slide moves, the limit blocks on the mounting slide will contact the limit blocks on the blood oxygenation module mounting position, restricting the mounting slide from continuing to move, thus achieving the limiting function.

[0044] The membrane lung mounting frame is a circular metal rod. The membrane lung mounting frame is fixed to the mounting slide with screws. A rectangular mounting rod is fitted on the membrane lung mounting frame. The membrane lung 51 is connected to the mounting rod with pins to fix the membrane lung 51.

[0045] The magnetic levitation pump mounting slide is a rectangular metal block. The magnetic levitation pump mounting slide is connected to the mounting slide with screws. A rectangular groove is recessed in the upper surface of the magnetic levitation pump mounting slide, which is called the groove. The slide is protruding on the side of the groove. At the same time, a slider that can cooperate with the groove is installed on the bottom surface of the magnetic levitation pump 52. After the slider is inserted into the groove of the magnetic levitation pump mounting slide, the position of the slider is fixed by screws, thereby completing the fixation of the position of the magnetic levitation pump 52.

[0046] In order to ensure that the core placement chamber 11 maintains a suitable temperature and humidity during organ life support, and to keep the circulating blood at a suitable temperature, a humidifier and a temperature control device are installed in the life support station 1. The humidifier is an existing device and is connected to the core placement chamber 11. Sterilized distilled water is added to the humidifier to maintain the core placement chamber 11 at a suitable humidity for organ life support. The temperature control device is an existing device with heating capabilities. In this embodiment, resistance wire heating is preferred. The temperature control device is connected to the core placement chamber 11 and is used to maintain the core placement chamber 11 at a suitable temperature for organ life maintenance.

[0047] To maintain the blood at a suitable temperature during blood circulation in the blood oxygenation module 5, a water bath is installed in the movable core 2. The water bath is an existing water tank with temperature control and a circulation pump. The water inlet and outlet of the water bath are connected to the water inlet and outlet reserved on the membrane lung 51. Hot water is circulated into the membrane lung 51 through the water bath to adjust the blood temperature during blood circulation in the blood oxygenation module 5.

[0048] like Figure 4 and 7 As shown, in order to monitor the waste liquid filtered in the filter of the blood purification module 4, a liquid bag scale is fixed in the liquid bag scale installation position 25 with screws, and a waste liquid bag is hung on the liquid bag scale. The waste liquid bag is connected to the filter through a waste liquid pump, and the waste liquid is drawn into the waste liquid bag by the waste liquid pump.

[0049] The liquid bag scale is an existing weighing device with hooks. A waste liquid bag is hung on the hooks. The waste liquid filtered by the filter is collected in the waste liquid bag by the waste liquid pump. The weight of the waste liquid in the waste liquid bag is weighed using the liquid bag scale.

[0050] Regarding the number of liquid bag scales, multiple scales can be installed in the liquid bag scale mounting position 25 as needed. In this embodiment, four scales are preferably set, which can be used to weigh dialysate, replacement fluid and anticoagulant citric acid respectively.

[0051] like Figure 2 , 3 As shown in Figure 5, the monitoring system 7 includes a millimeter-wave radar module 71, an ultrasound module 75, and an invasive pressure detection module 78. The millimeter-wave radar module 71 and the ultrasound module 75 are installed on the life support station 1 and located inside the observation hood 12. The invasive pressure detection module 78 is connected to the blood circulation loop. The millimeter-wave radar module 71 detects the viability of the ex vivo organ, the ultrasound module 75 detects the internal condition of the organ, and the invasive pressure detection module 78 detects the organ's blood pressure.

[0052] The millimeter-wave radar module 71 includes multiple arc-shaped mounting rods 72, which are stainless steel metal rods. The arc-shaped mounting rods 72 span the movable core seat 2, and the multiple arc-shaped mounting rods 72 are spaced apart on the life support station 1 along the direction of movement of the movable core seat 2.

[0053] Multiple millimeter-wave radars 73 are mounted on the arc-shaped mounting rod 72. The multiple millimeter-wave radars 73 are distributed at intervals on the arc-shaped mounting rod 72. In this embodiment, each arc-shaped mounting rod 72 is preferably equipped with 8 millimeter-wave radars 73. The millimeter-wave radars 73 are connected to the control console 9 and transmit scanning data to the control console 9.

[0054] To facilitate the installation of the millimeter-wave radar 73, a C-shaped mounting clip is attached to the back of the millimeter-wave radar 73 using adhesive. This mounting clip is named C-shaped mounting clip 74. The diameter of the opening of the C-shaped mounting clip 74 is slightly smaller than the diameter of the arc-shaped mounting rod 72. The C-shaped mounting clip 74 can be attached to the arc-shaped mounting rod 72 and is interference-fitted with the arc-shaped mounting rod 72.

[0055] The ultrasound module 75 includes a robotic arm 76 and an ultrasound probe 77. The robotic arm 76 is fixed to the life support station 1 with screws. The robotic arm 76 is an existing robotic arm and is connected to the control console 9 via signal. The ultrasound probe 77 is an existing probe and is fixed to the end of the robotic arm 76. The robotic arm 76 can be used to operate the ultrasound probe 77 to perform ultrasound scanning on organs and detect the internal condition of organs.

[0056] In this embodiment, three sets of ultrasound modules 75 are preferably arranged. The three sets of ultrasound modules 75 are evenly distributed around the organ on the life support station 1. The ultrasound probes 77 on two sets of ultrasound modules 75 are two-dimensional probes to achieve two-dimensional shaping, while the ultrasound probes 77 on the other set of ultrasound modules 75 are three-dimensional probes to achieve three-dimensional imaging.

[0057] like Figure 6 As shown, the invasive pressure detection module 78 is installed on the operating table 15. In this embodiment, an existing invasive pressure sensor is selected. There are three invasive pressure sensors, arranged from top to bottom in the fixing clip. The three invasive pressure sensors are respectively located in the venous line between the blood vessel 53 and the isolated organ vein, the arterial line between the magnetic levitation pump 52 and the membrane lung 51, and the arterial line between the membrane lung 51 and the isolated organ artery. They are used to monitor the blood pressure in the line before pumping, after pumping, and before entering the isolated organ artery. (The fixing clip used to hold and fix the invasive pressure sensor is an existing product, such as the invasive pressure sensor fixing clip that can be automatically unlocked disclosed in CN217525094U, so it will not be described in detail.) The invasive pressure sensor is connected to the circulation line through a T-connector to monitor the pressure in the circulation line.

[0058] like Figure 1 , 3 As shown in Figure 7, in order to realize the blood gas and biochemical detection of organs, a biochemical monitoring module 8 is installed in the biochemical monitoring module mounting position 14. The biochemical monitoring module 8 is an existing device that can monitor blood gas and biochemicals. Researchers can draw blood from the organ and perform detection on the biochemical monitoring module 8.

[0059] Regarding the signal connections in this embodiment, the blood purification module 4, blood oxygenation module 5, temperature and humidity control module, monitor, ventilator 6 millimeter-wave radar module 71, ultrasound module 75, and invasive pressure detection module 78 are all connected to the control console 9, and can be controlled through the control console 9.

[0060] In this embodiment, the ex vivo organs refer to the four organs: heart, liver, lungs, and kidneys, all of which have normal blood vessels and connected circulatory channels.

[0061] In this embodiment, the connection between the multi-organ life support system 3 and the organs is as follows: when connected, the ventilator 6 is connected to the lungs, the blood tank 53 is connected to the vein of the heart through a catheter, the magnetic levitation pump 52 is connected to the blood tank 53 and the membrane lung 51 through a catheter, and the membrane lung 51 is connected to the artery of the heart through a catheter.

[0062] Regarding the connection between blood purification module 4 and blood oxygenation module 5: the injection pump 41 in blood purification module 4 is connected to blood tank 53 through a conduit. The filter in blood purification module 4 is connected to blood tank 53 via the blood pump. The filter filters the blood drawn from blood tank 53 by the blood pump and then injects the filtered blood back into blood tank 53.

[0063] In this embodiment, the magnetic levitation pump 52, the blood pump, and the waste liquid pump are all existing commercially available devices that can be purchased and used directly. The waste liquid pump is an existing pump for extracting liquids. The name of the waste liquid pump is mainly to facilitate the differentiation of pumps in different locations.

[0064] The usage process of this embodiment includes the following steps: Preparation phase:

[0065] Place the isolated organ onto the multi-organ placement rack 23, and connect the lung to the ventilator 6; connect the blood oxygenation module 5 to the circulatory tubing of the isolated organ; connect the blood purification module 4 to the circulatory tubing of the isolated organ. Assess the function of the isolated organ; if the function is abnormal (lung function is insufficient to support organ consumption), activate the blood oxygenation module 5. Assess the function of the isolated organ; if the function is abnormal (kidney metabolic function is insufficient), activate the blood purification module 4.

[0066] Then push the mobile core 2 into the core placement compartment 11 in the life support station 1, and ensure that the connection interface on the mobile core 2 is connected to the corresponding functional interface inside the life support station (such as the connection between the blood oxygenation module 5 and the blood purification module 4, and the signal connection between the blood oxygenation module 5, the monitor, the ventilator 6 and the control console 9).

[0067] Life support stage: Activate the temperature and humidity control module and set the appropriate temperature and humidity for the life support of the isolated organ; Turn on the monitor and monitoring system 7 to monitor the vital status of the isolated organ; If connected to ventilator 6, it provides continuous ventilation support to the isolated lung according to the preset ventilation parameters; If the blood oxygenation module 5 is connected, the magnetic levitation pump 52 and membrane lung 51 are activated to provide extracorporeal blood circulation and oxygenation for the isolated organ; If blood purification module 4 is connected, then blood purification module 4 will be activated to simulate kidney function; End phase: When life support needs to be terminated, shut down all modules in the multi-organ life support system 3 and the monitoring system 7; The mobile core 2 is pushed out of the life support station 1, the connection is disconnected, and the excised organ is removed; The life support station 1 and the mobile core 2 were cleaned and disinfected for future use.

[0068] Regarding blood circulation: Venous blood from the isolated organ is drawn out through a venous cannula and driven by a magnetic levitation pump into the membrane lung 51, where oxygen and carbon dioxide are replaced. Subsequently, arterial blood is returned to the organ's arterial end through an arterial tube connected to the outlet of the membrane lung 51.

[0069] Regarding the temperature maintenance of blood in the membrane lung 51: The membrane lung 51 is equipped with a water bath temperature control module, which is connected to the water bath 103 to heat the blood flowing through it and ensure a stable perfusion temperature.

[0070] Regarding the connection between the filter and the membrane lung 51: A three-way interface is provided at the blood inlet of the membrane lung 51. A portion of arterial blood is drawn out through the blood pump into the blood filter for continuous blood purification. The purified blood is then returned to the blood tank 53 at the front end of the magnetic levitation pump 52 to complete the closed circulation.

[0071] The above embodiments are merely illustrative of the technical concept of the present invention and should not be construed as limiting the scope of protection of the present invention. Any modifications made to the technical solutions based on the technical concept proposed in this invention shall fall within the scope of protection of this invention.

Claims

1. A scientific research organ life support monitoring and control device, characterized in that: It includes a life support station (1) and a mobile core seat (2); the life support station (1) includes a core seat placement chamber (11) and a side door (13) of the controllable closed core seat placement chamber (11); the mobile core seat (2) can be pushed into the core seat placement chamber (11) or pushed out of the core seat placement chamber (11); the ex vivo organ is placed on the mobile core seat (2); A multi-organ life support system (3) is also provided in the life support station (1) and the mobile core (2), the multi-organ life support system (3) maintains the life of the ex vivo organs in the mobile core (2), and a control console (9) is provided on the life support station (1), the control console (9) controls and adjusts the maintenance process of the ex vivo organs; A monitoring system (7) is also installed in the life support station (1), which monitors the status of the isolated organ during the life support process.

2. The scientific research organ life support monitoring and control device according to claim 1, characterized in that: The movable core (2) includes an organ placement table (21), on which a multi-organ placement rack (23) is provided, and the ex vivo organ is placed on the multi-organ placement rack (23).

3. The scientific research organ life support monitoring and control device according to claim 1, characterized in that: The multi-organ life support system (3) includes a blood purification module (4), a blood oxygenation module (5), a temperature and humidity control module, and a ventilator (6). The blood purification module (4) is located on the life support station (1) and connected to the blood oxygenation module (5). The blood oxygenation module (5) is located on the mobile core seat (2) and connected to the excised organ. The temperature and humidity control module is located in the life support station (1) and maintains the temperature and humidity of the core seat placement chamber (11). The ventilator (6) is located on the mobile core seat (2).

4. The scientific research organ life support monitoring and control device according to claim 1, characterized in that: The monitoring system (7) includes a millimeter-wave radar module (71), an ultrasound module (75), and an invasive pressure detection module (78). The millimeter-wave radar module (71) is installed in the core placement chamber (11) and detects the survival status of the ex vivo organ. The ultrasound module (75) is installed in the core placement chamber (11) and detects the internal condition of the ex vivo organ. The invasive pressure detection module (78) is installed on the life support station (1) and is connected to the multi-organ life support system (3). The invasive pressure detection module (78) monitors the blood pressure of the ex vivo organ.

5. The scientific research organ life support monitoring and control device according to claim 4, characterized in that: The millimeter-wave radar module (71) includes multiple spaced arc-shaped mounting rods (72) and multiple millimeter-wave radars (73) mounted on the arc-shaped mounting rods (72). The arc-shaped mounting rods (72) are set inside the core placement chamber (11) and span the ex vivo organ. The millimeter-wave radars (73) observe the ex vivo organ.

6. The scientific research organ life support monitoring and control device according to claim 4, characterized in that: The ultrasound module (75) includes a robotic arm (76) and an ultrasound probe (77). The robotic arm (76) is located in the core placement chamber (11), and the ultrasound module (75) is mounted on the robotic arm (76). The robotic arm (76) drives the ultrasound probe (77) to perform ultrasound monitoring on the ex vivo organ. The ultrasound module (75) is equipped with 3 sets, of which two sets of ultrasound probes (77) are two-dimensional probes and the other ultrasound probe (77) is a three-dimensional probe.

7. The scientific research organ life support monitoring and control device according to claim 1, characterized in that: A biochemical monitoring module (8) is installed at the life support station (1), and the biochemical monitoring module (8) performs biochemical analysis on the blood gas and hematuria of the isolated organ.

8. The scientific research organ life support monitoring and control device according to claim 1, characterized in that: A temperature-adjustable water bath is provided on the movable core (2), and the water bath is connected to the membrane lung in the blood oxygenation module (5) of the multi-organ life support system (3).

9. The scientific research organ life support monitoring and control device according to claim 1, characterized in that: An observation hood (12) is provided outside the core placement chamber (11) on the life support station (1), and the observation hood (12) is made of transparent material.

10. The scientific research organ life support monitoring and control device according to claim 1, characterized in that: A drug injection module is also provided at the life support station (1), which is connected to the blood tank (53) in the blood oxygenation module (5).

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