A method, system, terminal, and storage medium for evaluating the efficacy of intestinal microbiota transplantation.

By sequencing and bioinformatics analysis of fecal samples from children with autism spectrum disorder, combined with mathematical models to evaluate the efficacy of gut microbiota transplantation, the problem of inaccurate evaluation results was solved, and objective efficacy evaluation of young children was achieved.

CN122090940APending Publication Date: 2026-05-26SHENZHEN CHILDRENS HOSPITAL +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENZHEN CHILDRENS HOSPITAL
Filing Date
2025-12-31
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

In existing technologies, the assessment of the efficacy of enterobiota transplantation is easily affected by the assessor's subjective perception and the child's immediate condition. This is especially true for young children or children with autism spectrum disorder who have low cooperation levels, resulting in inaccurate assessment results and making the procedure difficult to implement.

Method used

By obtaining fecal samples from affected children, sequencing and preprocessing were performed to determine the relative abundance changes of gut microbiota markers. Random forest regression or support vector regression models were used to assess the efficacy and generate objective efficacy evaluation results.

Benefits of technology

It enables objective and quantitative assessment of the efficacy of intestinal microbiota transplantation, reduces subjective bias, improves the comparability and reproducibility of assessment results, and expands the coverage of the applicable population, especially young children.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention relates to the field of data processing technology and discloses a method, system, terminal, and storage medium for evaluating the efficacy of enterobiota transplantation (IVT). The method includes: obtaining fecal samples from the target child before and after IVT treatment; sequencing the fecal samples to generate raw sequencing data; preprocessing the raw sequencing data to obtain the target microbial sequence; determining the relative abundance of at least one intestinal flora marker in the target microbial sequence; calculating the change in relative abundance of at least one intestinal flora marker after treatment compared to before treatment based on the relative abundance; inputting the change in relative abundance into a preset efficacy evaluation model to obtain a predicted efficacy value; and generating an efficacy evaluation result based on the predicted efficacy value. In the process of evaluating the efficacy of IVT, this invention significantly reduces the bias caused by the assessor's subjective judgment and fundamentally overcomes the limitations of traditional evaluation methods in terms of applicable populations.
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