A traditional Chinese medicine composition for treating varicose veins of lower limbs

Abstract

The application relates to a traditional Chinese medicine composition for treating varicose veins of lower limbs and application thereof, and belongs to the technical field of traditional Chinese medicines. The application provides a traditional Chinese medicine composition for treating varicose veins of lower limbs, which is composed of 30-60 parts of radix paeoniae alba, 6-40 parts of prepared licorice, 3-12 parts of prepared aconite, 15-30 parts of chuanxiong rhizome and 20-30 parts of eucommia ulmoides, and has the effects of strengthening suction, promoting reflux, balancing suction and pushing, activating blood and resolving stasis, fixing pulse and repairing, relaxing varicose veins and preventing thrombus, so that the application can treat both symptoms and root causes and can be prepared into a pharmaceutically acceptable oral dosage form.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating varicose veins of the lower extremities and its application. Background Technology

[0002] Varicose veins of the lower extremities are clinically characterized by tortuous and dilated veins in the calves, worm-like bulges, and a feeling of heaviness and distension. In severe cases, pigmentation, ulceration, and the risk of thrombosis may occur. Current Western medicine treatments primarily involve invasive methods such as surgical stripping, laser therapy, radiofrequency ablation, and sclerotherapy. These methods only address the dilated blood vessels without improving blood return dynamics, resulting in significant trauma and a high recurrence rate. Traditional Chinese medicine treatments often focus on promoting blood circulation, removing blood stasis, clearing dampness and unblocking the meridians, and softening and dispersing nodules. These methods only address local symptoms of stagnation without addressing the root cause, leading to limited efficacy and difficulty in achieving a comprehensive cure. Clinically, there is a widespread problem of "unclear understanding of the etiology and incorrect treatment direction," resulting in the disease being chronic, difficult to cure, and having a high recurrence rate. Summary of the Invention

[0003] I. Core Theories and Pathogenesis Innovation This invention, based on cardiac physiological function, the principle of physical balance, and the laws of fluid mechanics, combined with the structure of traditional Chinese medicine formulas, proposes the fundamental pathogenesis of varicose veins in the lower extremities: From the perspective of cardiac physiology and physics, the heart's work involves two alternating processes: contraction and relaxation, forming two dynamic forces: pumping and suction. During contraction, a forward thrust is generated, pumping blood to the extremities; during relaxation, the expansion of the heart chambers creates negative pressure, generating a suction force for blood to return to the heart. These two forces must maintain a balance to ensure smooth blood circulation. Once the suction force weakens and the pumping and suction become unbalanced, distal blood return is obstructed. From a fluid mechanics perspective, venous blood return is highly dependent on the negative pressure suction effect of the heart during relaxation. The lower extremities are low in position, and the weight of the blood column is high, resulting in significant resistance to blood return. If the heart's suction force is insufficient, the venous blood return speed decreases, blood flow stagnates, and the intravascular pressure continuously increases. Over time, this leads to passive dilation and tortuosity of the venous lumen, decreased elasticity of the vessel walls, relaxation, and deformation, resulting in varicose veins in the lower extremities. Due to insufficient venous return, stagnant blood in the lower limbs fails to be expelled, hindering the delivery of fresh, warm arterial blood to the feet, leading to coldness in the feet. Coldness causes blood to congeal, and stagnant blood easily forms thrombi. Once formed, these thrombi can travel upwards along the veins, affecting the heart. Therefore, the core biomechanical characteristics of this disease are insufficient venous return and stagnant blood flow, accompanied by damage to the venous wall structure, decreased elasticity, lumen dilation, and a tendency to thrombosis. From the fundamental mechanism of Traditional Chinese Medicine, varicose veins of the lower limbs are essentially an imbalance of Yin and Yang in the heart. Yang governs pushing, Yin governs suction; insufficient Yin weakens suction, and obstructed Yang makes blood prone to congealing due to cold, ultimately leading to this disease. Traditional treatments often focus on promoting blood circulation, clearing the vessels, and eliminating dampness, neglecting the core pathogenesis of "insufficient suction and imbalance between pushing and suction," and failing to emphasize venous wall repair, elasticity restoration, and thrombosis prevention. Therefore, they fail to address the root cause of the problem.

[0004] II. Formulation Principles The formulation philosophy originates from the classic structure of Guizhi Tang (Cinnamon Twig Decoction) – "yin and yang in balance, pushing and suction in equilibrium": cinnamon twig warms yang and assists in pumping, while peony root astringes yin and assists in suction; together, they maintain the balance of qi and blood flow. The pathogenesis of varicose veins in the lower extremities lies in insufficient suction, weak venous return, and an imbalance between pushing and suction, rather than a lack of pumping force. Continuing to use warming and dispersing herbs like cinnamon twig would only enhance outward pumping without improving blood return, potentially worsening lower extremity blood stasis and hindering venous return. Therefore, this formula follows the principle of balancing pushing and suction in Guizhi Tang, without using its specific ingredients. Based on the classical formula's approach, it reconstructs the medicinal components, optimizes dosage, and expands the targeted efficacy, focusing on "strengthening suction, promoting venous return, balancing pushing and suction, repairing venous wall structure, restoring vascular elasticity, and preventing thrombosis from stagnant blood," forming a novel treatment plan targeting the fundamental pathogenesis of varicose veins in the lower extremities. The prepared aconite root in this formula is only used to warm and unblock the lower limbs to prevent cold stagnation and thrombosis, thus eliminating the impact of thrombosis on the heart; therefore, the dosage is relatively light. Most patients with varicose veins do not have a constitution that is extremely cold, so it is not necessary to use a large dose of warming yang. If the cold is severe, it usually falls under the category of cardiovascular and cerebrovascular diseases, and the treatment methods are different.

[0005] III. Technical Solution A traditional Chinese medicine composition for treating varicose veins of the lower extremities, comprising the following raw materials in parts by weight: - 30-60 parts of white peony root - Prepared licorice root 6-40 parts - Prepared aconite root 3-12 parts - 15-30 parts of Ligusticum chuanxiong - 20-30 parts of Eucommia ulmoides Preferred embodiment: White peony root 40 parts, prepared licorice root 30 parts, prepared aconite root 6 parts, chuanxiong rhizome 25 parts, and eucommia bark 30 parts.

[0006] IV. Solution White peony root (in large dose): Sour in taste and entering the Yin, it primarily astringes and consolidates, aids in blood return, and enhances the heart's diastolic pumping power; it is the principal herb. Prepared licorice root: Used in slightly smaller doses than white peony root, it invigorates Qi and restores the pulse, nourishes the heart and spirit, and moderates the strong astringent effect of white peony root. A strong dose of white peony root has a strong astringent effect; excessive blood return can easily impact the heart and increase its burden. Therefore, prepared licorice root is used to stabilize the heart and prevent palpitations, protecting the heart and ensuring a gentle and sustained return. Prepared aconite root: Due to insufficient venous return, old blood stagnates in the lower limbs, making it difficult for fresh, warm arterial blood to reach the feet, thus making the feet prone to coldness. Coldness causes blood clotting, easily leading to thrombosis, which may travel up the blood vessels and disturb the heart. This formula uses a small amount of prepared aconite root to warm and unblock the cold stagnation in the lower limbs, preventing the formation of thrombi from stagnant venous blood and eliminating the potential impact of thrombosis on the heart. Most patients with this condition do not have a generally cold constitution; therefore, a small dose is sufficient, and a large dose is unnecessary. Chuanxiong (Ligusticum striatum): Utilizing an effective repair dose, it protects and repairs damage to the venous intima, creating a structural basis for venous return. Eucommia ulmoides (Eucommia ulmoides): Utilizing an effective repair dose, it enhances the elasticity and tension of the venous wall, repairs relaxed and dilated blood vessels, and gradually shrinks and straightens dilated and tortuous veins. The combined effect of the formula: Strengthens aspiration, promotes return, balances aspiration, invigorates blood circulation, removes blood stasis, strengthens and repairs blood vessels, smooths varicose veins, and prevents thrombosis, achieving both symptomatic and root-cause treatment.

[0007] V. Dosage and Pharmacological Basis 1. 15-30 parts of Ligusticum chuanxiong Modern pharmacology has confirmed that Ligusticum chuanxiong exhibits significant vascular endothelial repair, antioxidant, and venous wall protection effects only at medium to high doses; low doses primarily promote blood circulation and are insufficient for structural repair. The optimized dose in this formula is sufficient to achieve venous endothelial repair, laying the structural foundation for venous recovery. 2. Eucommia ulmoides, 20-30 parts Modern pharmacology has confirmed that Eucommia ulmoides needs to be taken at medium to high doses to significantly enhance the synthesis of elastic fibers and collagen in the blood vessel walls, increase venous wall tension, and tighten dilated blood vessels. The optimized dosage of this formula can effectively achieve vascular elasticity remodeling and varicose vein relief. 3. Prepared aconite root, 3-12 parts Insufficient venous return leads to the retention of old blood in the lower limbs and difficulty in the arrival of new blood, making the feet prone to coldness. This coldness can congeal and easily form blood clots, which may then affect the heart. Prepared aconite root can warm and unblock the lower limbs, break up blood clotting tendencies, prevent thrombus formation, and protect the heart from the effects of thrombosis. Patients with varicose veins do not typically experience systemic coldness, so small to medium doses are sufficient; high doses are unnecessary. 4. White peony root and prepared licorice root in combination White peony root is used in large quantities to astringe and replenish blood, while prepared licorice root is used in smaller quantities. The purpose is to protect the heart and gently astringe the blood, avoiding excessive astringency and strong blood replenishment that could impact the heart, thus ensuring a stable and coordinated pumping force.

[0008] VI. Beneficial Effects 1. Accurate diagnosis of pathogenesis: It reveals the fundamental pathogenesis from the perspective of cardiac pump-suction balance and fluid dynamics, breaking through the limitations of traditional treatment that only focuses on local blood circulation. 2. Innovative formulation approach: It follows the Yin-Yang opening and closing structure of Guizhi Tang, but abandons Guizhi according to the pathogenesis to avoid aggravating stagnation, which is a creative highlight. 3. Precise targeting: Primarily enhances aspiration and promotes reflux, while also considering vascular repair and thrombosis prevention, closely matching the pathophysiological characteristics of this disease. 4. Treating both the symptoms and the root cause: It can quickly improve the symptoms of blood stasis, repair the structure of the vein wall, restore the elasticity of blood vessels, and promote the retraction of dilated blood vessels, significantly reducing the recurrence rate. 5. Scientific and safe dosage: The medicine is simple in composition, mild in combination, and has no obvious toxic side effects, making it suitable for long-term conditioning. 6. High practicality: It is easy to prepare and can be made into a variety of oral dosage forms, making it easy to promote and apply. Detailed Implementation

[0009] The optimal formula is as follows: 40g of white peony root, 30g of prepared licorice root, 6g of prepared aconite root, 25g of chuanxiong rhizome, and 30g of eucommia bark. Preparation and decoction method: First, add water to the prepared aconite root and bring to a boil over high heat, then simmer over low heat for one hour. Then add the remaining medicinal materials and continue to decoct according to the conventional Chinese medicine decoction process. One dose per day, taken twice warm. It can also be made into pharmaceutically acceptable oral dosage forms such as decoction, granules, pills, capsules, tablets, and powders.

Claims

1. A traditional Chinese medicine composition for treating varicose veins of the lower extremities, characterized in that, It comprises the following active pharmaceutical ingredient in parts by weight: White peony root 30-60 parts, prepared licorice root 6-40 parts, prepared aconite root 3-12 parts, chuanxiong rhizome 15-30 parts, eucommia bark 20-30 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, It contains the following components by weight: 40 parts white peony root, 30 parts prepared licorice root, 6 parts prepared aconite root, 25 parts chuanxiong rhizome, and 30 parts eucommia bark.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, This composition is used to enhance cardiac pumping power, promote venous blood return, and improve blood circulation pumping imbalance.

4. The traditional Chinese medicine composition according to claim 1, characterized in that, This composition is used to repair vascular endothelium, enhance the elasticity of venous walls, and promote the recovery of dilated veins.

5. The traditional Chinese medicine composition according to claim 1, characterized in that, Processed aconite is used to warm and unblock the lower limbs to prevent venous blood stasis in the lower limbs from forming thrombi, and to protect the heart from the effects of thrombosis.

6. The traditional Chinese medicine composition according to claim 1, characterized in that, This composition is used to treat varicose veins of the lower extremities caused by insufficient venous return, blood stasis, decreased elasticity of the venous wall, and structural damage.

7. The traditional Chinese medicine composition according to any one of claims 1 to 6, characterized in that, The traditional Chinese medicine composition can be prepared into pharmaceutically acceptable oral preparations, including but not limited to decoctions, granules, pills, capsules, tablets, and powders.

8. The use of the traditional Chinese medicine composition according to any one of claims 1 to 7 in the preparation of a drug for treating varicose veins of the lower extremities.