Multi-target synergistic complex essential oil composition, nose suction stick and preparation method thereof

Abstract

The application discloses a multi-target synergistic composite essential oil composition, a nose inhalation stick and a preparation method thereof, relates to the technical field of aromatherapy and neuropharmacology, and the multi-target synergistic composite essential oil composition is composed of the following natural plant essential oils in percentage by weight, and the sum of the content of each component is 100%: 25-35% of true lavender essential oil; 15-25% of sweet orange essential oil; 10-18% of Roman chamomile essential oil; 8-15% of lemon verbena essential oil; 6-12% of bergamot essential oil; 5-10% of lemon essential oil; 3-8% of ylang ylang essential oil; 2-6% of clary sage essential oil; 1-3% of black pepper essential oil; 1-3% of sandalwood essential oil; and 0.5-2% of patchouli essential oil. The application is based on a clear neuropharmacological mechanism, and eleven kinds of essential oils are scientifically matched without dilution of base oil; a significant emotional relaxation effect is generated within 5-10 minutes of active sniffing; and the application has the auxiliary function of improving sleep difficulty.

Description

Technical Field

[0001] This invention relates to the fields of aromatherapy and neuropharmacology, and particularly to multi-target synergistic compound essential oil compositions, nasal inhalers, and their preparation methods. Background Technology

[0002] Currently available nasal inhalers suffer from three major drawbacks: limited functionality, crude formulations, and mismatched carriers. They primarily use stimulating essential oils such as peppermint and eucalyptus, lacking professional solutions targeting the continuous emotional spectrum of "anxiety-sedation-sleep promotion." Some products use only one or two essential oils, resulting in limited efficacy, while others blindly pile on multiple essential oils, leading to aroma conflicts, volatilization imbalances, and a lack of neuropharmacological basis. Some products contain a large amount of base oil, which can clog the fiber core of the nasal inhaler and reduce the efficiency of inhaling active ingredients.

[0003] Recent studies in neuroaromatherapy have shown that different essential oils can regulate mood through different pathways: true lavender and clary sage can enhance GABA inhibitory transmission; bergamot and sweet orange can regulate 5-HT levels; lemon verbena and Roman chamomile can reduce cortisol; β-caryophyllene in black pepper can activate CB2 receptors; and sandalwood and ylang-ylang have profound calming and balancing effects. However, existing research mostly explores single essential oils or single mechanisms. How to systematically integrate multiple pathway mechanisms and design a simplified formula that is harmonious in aroma, orderly in volatility, synergistically efficient, and suitable for the characteristics of nasal inhalers remains an unsolved technical challenge. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a multi-target synergistic compound essential oil composition, nasal inhaler and its preparation method. Based on a clear neuropharmacological mechanism, it uses eleven essential oils in a scientific blend, without the need for base oil dilution, and produces a significant mood-soothing effect within 5-10 minutes of active inhalation, while also having an auxiliary function to improve difficulty falling asleep.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: This multi-target synergistic complex essential oil composition consists of the following natural plant essential oils by weight percentage, and the sum of the contents of each component is 100%: 25-35% genuine lavender essential oil; Sweet orange essential oil 15-25%; Roman chamomile essential oil 10-18%; Lemon verbena essential oil 8-15%; Bergamot essential oil 6-12%; Lemon essential oil 5-10%; Ylang-ylang essential oil 3-8%; Clary sage essential oil 2-6%; Black pepper essential oil 1-3%; Sandalwood essential oil 1-3%; Patchouli essential oil 0.5-2%.

[0006] A nasal inhaler loaded with the aforementioned multi-target synergistic complex essential oil composition, the nasal inhaler comprising a tubular outer shell and a central porous fiber core.

[0007] As a further improvement of the present invention, the tubular outer shell is a beech wood tube with a specification of Φ10×110mm, and the central porous fiber core is a cotton fiber core with a specification of Φ9.5×105mm.

[0008] A method for preparing a multi-target synergistic compound essential oil composition includes the following steps: S1, Weigh each essential oil component by weight percentage; S2, First, mix the sandalwood essential oil and patchouli essential oil evenly in a glass beaker; S3, add real lavender essential oil, Roman chamomile essential oil, lemon verbena essential oil, bergamot essential oil, ylang-ylang essential oil, clary sage essential oil, and black pepper essential oil in sequence. Stir slowly for 5 minutes until evenly mixed after each addition in the dark. S4, finally add sweet orange essential oil and lemon essential oil, and stir slowly until well mixed; S5. Transfer the mixed essential oils into a brown sealed glass bottle and let it mature in a cool place for 24 hours.

[0009] The beneficial effects of this invention are: 1. Rapid onset of action: Preliminary human trials (n=30, randomized, single-blind, self-controlled) showed that in a simulated acute anxiety scenario during a public speech, STAI-State anxiety scores decreased by an average of 28.5% after 5 minutes of use (p<0.01).

[0010] 2. Improve sleep: Using it for 15 minutes before bedtime resulted in 85% of participants reporting a shorter time to fall asleep and a significant improvement in the PSQI sleep quality index.

[0011] 3. High acceptance and safety: 96% of users find the aroma "warm, reassuring and not pungent", with a much higher acceptance rate than single essential oil products.

[0012] 4. Formula stability and carrier compatibility: The base oil-free formula is stable and will not clog the nasal cannula core, ensuring the effectiveness and user experience throughout the product's entire life cycle. Detailed Implementation

[0013] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Example 1

[0014] Multi-target synergistic compound essential oil composition formulation (weight unit: g): 30g of genuine lavender essential oil; 20g sweet orange essential oil; 15g Roman chamomile essential oil; 12g lemon verbena essential oil; 10g of bergamot essential oil; 8g lemon essential oil; 5g of ylang-ylang essential oil; Clary sage essential oil 4g; 2g of black pepper essential oil; 2g of sandalwood essential oil; Patchouli essential oil 1g.

[0015] A method for preparing a multi-target synergistic compound essential oil composition includes the following steps: S1, Weigh each essential oil component by weight percentage; S2, First, mix the sandalwood essential oil and patchouli essential oil evenly in a glass beaker; S3, add real lavender essential oil, Roman chamomile essential oil, lemon verbena essential oil, bergamot essential oil, ylang-ylang essential oil, clary sage essential oil, and black pepper essential oil in sequence. Stir slowly for 5 minutes until evenly mixed after each addition in the dark. S4, finally add sweet orange essential oil and lemon essential oil, and stir slowly until well mixed; S5. Transfer the mixed essential oils into a brown sealed glass bottle and let it mature in a cool place for 24 hours.

[0016] Preparation of nasal aspirator: Take a Φ10×110mm beech wood tube and drill a hole inside; insert a Φ9.5×105mm cotton fiber core; inject 1.0mL of the above multi-target synergistic compound essential oil composition; seal the bottom and attach a screw cap to obtain the product.

[0017] This multi-target synergistic essential oil composition features a base oil-free design that ensures 100% high volatility of active ingredients and is compatible with nasal inhaler carriers. It constructs a multi-target synergistic network covering four core mood regulation pathways, achieving synergistic effects of calming, rapid and long-lasting effects, and inter-system synergy. The proportions are designed according to the volatility gradient to ensure consistent aroma and long-lasting efficacy.

[0018] A pioneering multi-pathway synergistic formulation system: For the first time, 11 essential oils with clear and complementary neuropharmacological mechanisms are scientifically combined to form a closed-loop regulatory system targeting the multi-pathway causes of anxiety.

[0019] Synergistic innovation of carrier and formulation: The "base oil-free" design enables high-concentration active ingredients to be efficiently inhaled through the nasal inhaler, solving the industry problem of incompatibility between traditional aromatherapy formulations and new carriers.

[0020] Achieving a sequential effect of "immediate relief + long-lasting soothing": Through precise volatile gradient design and efficacy combination, it can address acute anxiety and also be used for relaxation before bedtime, covering a wide range of application scenarios. Example 2

[0021] Multi-target synergistic compound essential oil composition formulation (weight unit: g): 25g of genuine lavender essential oil; 25g of sweet orange essential oil; 10g Roman chamomile essential oil; 15g lemon verbena essential oil; Bergamot essential oil 6g; 6g lemon essential oil; 3g of ylang-ylang essential oil; Clary sage essential oil 6g; 3g of black pepper essential oil; 1g of sandalwood essential oil; Patchouli essential oil 0.5g.

[0022] A method for preparing a multi-target synergistic compound essential oil composition includes the following steps: S1, Weigh each essential oil component by weight percentage; S2, First, mix the sandalwood essential oil and patchouli essential oil evenly in a glass beaker; S3, add real lavender essential oil, Roman chamomile essential oil, lemon verbena essential oil, bergamot essential oil, ylang-ylang essential oil, clary sage essential oil, and black pepper essential oil in sequence. Stir slowly for 5 minutes until evenly mixed after each addition in the dark. S4, finally add sweet orange essential oil and lemon essential oil, and stir slowly until well mixed; S5. Transfer the mixed essential oils into a brown sealed glass bottle and let it mature in a cool place for 24 hours.

[0023] Preparation of nasal aspirator: Take a Φ10×110mm beech wood tube and drill a hole inside; insert a Φ9.5×105mm cotton fiber core; inject 1.0mL of the above multi-target synergistic compound essential oil composition; seal the bottom and attach a screw cap to obtain the product. Example 3

[0024] Multi-target synergistic compound essential oil composition formulation (weight unit: g): 35g of genuine lavender essential oil; 15g of sweet orange essential oil; Roman chamomile essential oil 18g; Lemon verbena essential oil 8g; Bergamot essential oil 12g; 5g lemon essential oil; Ylang-ylang essential oil 8g; Clary sage essential oil 2g; 1g of black pepper essential oil; 3g of sandalwood essential oil; Patchouli essential oil 2g.

[0025] A method for preparing a multi-target synergistic compound essential oil composition includes the following steps: S1, Weigh each essential oil component by weight percentage; S2, First, mix the sandalwood essential oil and patchouli essential oil evenly in a glass beaker; S3, add real lavender essential oil, Roman chamomile essential oil, lemon verbena essential oil, bergamot essential oil, ylang-ylang essential oil, clary sage essential oil, and black pepper essential oil in sequence. Stir slowly for 5 minutes until evenly mixed after each addition in the dark. S4, finally add sweet orange essential oil and lemon essential oil, and stir slowly until well mixed; S5. Transfer the mixed essential oils into a brown sealed glass bottle and let it mature in a cool place for 24 hours.

[0026] Preparation of nasal aspirator: Take a Φ10×110mm beech wood tube and drill a hole inside; insert a Φ9.5×105mm cotton fiber core; inject 1.0mL of the above multi-target synergistic compound essential oil composition; seal the bottom and attach a screw cap to obtain the product. Example 4

[0027] Multi-target synergistic compound essential oil composition formulation (weight unit: g): 28g of genuine lavender essential oil; 22g of sweet orange essential oil; Roman chamomile essential oil 14g; 10g lemon verbena essential oil; Bergamot essential oil 8g; 7g lemon essential oil; Ylang-ylang essential oil 6g; Clary sage essential oil 3g; 2g of black pepper essential oil; 2g of sandalwood essential oil; Patchouli essential oil 1g.

[0028] A method for preparing a multi-target synergistic compound essential oil composition includes the following steps: S1, Weigh each essential oil component by weight percentage; S2, First, mix the sandalwood essential oil and patchouli essential oil evenly in a glass beaker; S3, add real lavender essential oil, Roman chamomile essential oil, lemon verbena essential oil, bergamot essential oil, ylang-ylang essential oil, clary sage essential oil, and black pepper essential oil in sequence. Stir slowly for 5 minutes until evenly mixed after each addition in the dark. S4, finally add sweet orange essential oil and lemon essential oil, and stir slowly until well mixed; S5. Transfer the mixed essential oils into a brown sealed glass bottle and let it mature in a cool place for 24 hours.

[0029] Preparation of nasal aspirator: Take a Φ10×110mm beech wood tube and drill a hole inside; insert a Φ9.5×105mm cotton fiber core; inject 1.0mL of the above multi-target synergistic compound essential oil composition; seal the bottom and attach a screw cap to obtain the product. Example 5

[0030] Multi-target synergistic compound essential oil composition formulation (weight unit: g): 32g of genuine lavender essential oil; 18g of sweet orange essential oil; Roman chamomile essential oil 12g; 11g of lemon verbena essential oil; Bergamot essential oil 9g; 6g lemon essential oil; 4g of ylang-ylang essential oil; Clary sage essential oil 5g; 1.5g of black pepper essential oil; 1.5g of sandalwood essential oil; Patchouli essential oil 1g.

[0031] A method for preparing a multi-target synergistic compound essential oil composition includes the following steps: S1, Weigh each essential oil component by weight percentage; S2, First, mix the sandalwood essential oil and patchouli essential oil evenly in a glass beaker; S3, add real lavender essential oil, Roman chamomile essential oil, lemon verbena essential oil, bergamot essential oil, ylang-ylang essential oil, clary sage essential oil, and black pepper essential oil in sequence. Stir slowly for 5 minutes until evenly mixed after each addition in the dark. S4, finally add sweet orange essential oil and lemon essential oil, and stir slowly until well mixed; S5. Transfer the mixed essential oils into a brown sealed glass bottle and let it mature in a cool place for 24 hours.

[0032] Preparation of nasal aspirator: Take a Φ10×110mm beech wood tube and drill a hole inside; insert a Φ9.5×105mm cotton fiber core; inject 1.0mL of the above multi-target synergistic compound essential oil composition; seal the bottom and attach a screw cap to obtain the product.

[0033] Nasal inhaler usage: Unscrew the top cap, place it under one nostril, and inhale deeply and slowly 3-5 times. Repeat on the other side. Suitable for: Instant relief from sudden stress and anxiety during daytime work or study; Use 15 minutes before bed to help you relax and fall asleep.

[0034] To verify the non-obviousness and synergistic effect of the compound essential oil composition of the present invention, we designed the following comparative experiment: The testing method is as follows: Test design: A randomized, single-blind, self-controlled trial was conducted.

[0035] Subjects: 40 healthy adults (half male and half female) were recruited, all of whom reported mild to moderate anxiety or stress problems.

[0036] Test sample: 1. Sample of the present invention: The compound essential oil prepared according to the formula and process of Example 1 is loaded into a standard nasal inhaler.

[0037] 2. Comparative Formula D (Core Component Missing): A formula containing 9 essential oils without Roman chamomile and black pepper essential oils was prepared, with the total weight supplemented by lavender and sweet orange in proportion.

[0038] 3. Comparative Example E (competitive product on the market): A nasal inhaler of single lavender essential oil from a well-known commercial brand.

[0039] Assessment Procedure: Subjects used three different samples on different days. The State-Trait Anxiety Scale (STAI-State) was completed before use and 5 minutes after using the nasal inhaler. Subjects' ratings of aroma acceptance (1-5, 5 being very comfortable) were also recorded.

[0040] Test Results and Data Analysis Test sample Composition Description STAI-State score decline rate (5 minutes, Mean ± SD) Aroma Acceptability (Mean ± SD) Synergistic effect assessment Sample of the present invention Complete formula of 11 essential oils 28.5%±3.1% 4.7±0.4 benchmark Comparative Example D Missing Roman chamomile and black pepper 17.2%±4.5% 4.0±0.6 The effect was significantly reduced (p<0.01). Comparative Example E Commercially available single-ingredient lavender 11.5%±5.2% 3.5±0.8 The effect is far inferior to that of the present invention (p<0.01). Results Analysis and Conclusions 1. Demonstrates synergistic effects, rather than simple additives: The anti-anxiety effect of this invention (a 28.5% decrease in STAI score) is far superior to commercially available single-ingredient lavender products (which only decrease by 11.5%). This clearly indicates that the effect of this invention does not stem from the calming effect of lavender alone, but rather from the synergistic effect of multiple essential oils.

[0041] 2. This demonstrates the crucial role of formulation integrity: the anti-anxiety effect of Comparative Formulation D (lacking Roman chamomile and black pepper) (a 17.2% decrease) was significantly lower than that of the complete formulation of this invention. This proves that: The "anti-irritant and soothing effects of Roman chamomile" and the GABA regulation of lavender create a deep calming synergy, and neither can be dispensed with.

[0042] Black pepper provides a crucial "soil" for other essential oil components to exert their effects by activating CB2 receptors to "stabilize the neural microenvironment," and its contribution cannot be easily replaced.

[0043] This result strongly refutes the potential argument that "the invention is a simple combination of known functions," proving that the complete combination of these 11 essential oils produces unexpected technical effects.

[0044] 3. Demonstrates the high acceptability and practicality of the formula: This invention achieves both optimal efficacy and the highest aroma acceptability. This indicates that the formula successfully solves the "odor conflict" problem often encountered in multifunctional compound essential oils, achieving a balance between efficacy and pleasantness, and possesses outstanding commercial potential.

[0045] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A multi-target synergistic compound essential oil composition, characterized in that, It is composed of the following natural plant essential oils by weight percentage, and the sum of the contents of each component is 100%: 25-35% genuine lavender essential oil; Sweet orange essential oil 15-25%; Roman chamomile essential oil 10-18%; Lemon verbena essential oil 8-15%; Bergamot essential oil 6-12%; Lemon essential oil 5-10%; Ylang-ylang essential oil 3-8%; Clary sage essential oil 2-6%; Black pepper essential oil 1-3%; Sandalwood essential oil 1-3%; Patchouli essential oil 0.5-2%.

2. A nasal suction stick, characterized in that, The nasal aspirator is loaded with the multi-target synergistic compound essential oil composition of claim 1, and the nasal aspirator comprises a tubular outer shell and a central porous fiber core.

3. A nasal suction stick according to claim 2, characterized in that, The tubular outer shell is made of beech wood and has a specification of Φ10×110mm. The central porous fiber core is made of cotton fiber and has a specification of Φ9.5×105mm.

4. The method for preparing the multi-target synergistic compound essential oil composition according to claim 1, characterized in that, Includes the following steps: S1, Weigh each essential oil component by weight percentage; S2, First, mix the sandalwood essential oil and patchouli essential oil evenly in a glass beaker; S3, add real lavender essential oil, Roman chamomile essential oil, lemon verbena essential oil, bergamot essential oil, ylang-ylang essential oil, clary sage essential oil, and black pepper essential oil in sequence. Stir slowly for 5 minutes until evenly mixed after each addition in the dark. S4, finally add sweet orange essential oil and lemon essential oil, and stir slowly until well mixed; S5. Transfer the mixed essential oils into a brown sealed glass bottle and let it mature in a cool place for 24 hours.