A traditional Chinese medicine composition and preparation for external use on pet skin, and a preparation method and application thereof

Abstract

The present application belongs to the technical field of pet medicine, and particularly relates to a traditional Chinese medicine composition and traditional Chinese medicine preparation for external use on pet skin, and a preparation method and application thereof. The traditional Chinese medicine raw materials contained in the traditional Chinese medicine composition of the present application include: Sophora flavescens, Stachys, Cnidium, Dictamnus dasycarpus, Taraxacum mongolicum, Phellodendron, Portulaca oleracea, Semen Haloxylon, and Melia azedarach. On the basis of years of clinical work experience and professional knowledge, the present application successfully obtains a traditional Chinese medicine composition and traditional Chinese medicine preparation for treating pet skin diseases. The traditional Chinese medicine composition of the present application is simple in prescription, reasonable in compatibility, safe and environmentally friendly, natural and hormone-free, and safe and reliable in use.

Description

Technical Field

[0001] This invention belongs to the field of pet medicine technology, and in particular relates to a traditional Chinese medicine composition and preparation for external use on pet skin, as well as its preparation method and application. Background Technology

[0002] In recent years, the number of pet owners has been steadily increasing, with pets becoming family members, children, and even emotional companions. In today's fast-paced life, pets provide emotional support, filling emotional voids and gaining an increasingly important place in the family. Pet health has naturally become a major concern for pet owners. Among these issues, pet skin diseases, while common, are prone to recurrence and have complex and diverse causes: they can be caused by bacterial, fungal, and parasitic infections (such as mites, fleas, and ticks). Genetics, environment, nutrition, and weakened immunity can also play a role. Symptoms include: red, swollen, hot, and painful skin, itching, scaling, mastitis, eczema, boils, carbuncles, hair loss, etc. These problems not only affect the pet's appearance but can also lead to depression due to intense itching, severely impacting the pet's quality of life and health, and may even cause cross-infection between pets and humans.

[0003] Currently, most common topical skin medications for pets with skin conditions are chemically synthesized products, such as clotrimazole, ketoconazole, terbinafine hydrochloride solution, metronidazole, antifungal cream, sulfur ointment, erythromycin, ivermectin, zinc oxide, griseofulvin, and amitraz. Although these medications can relieve symptoms in the short term, they have problems such as easy development of drug resistance and significant side effects. Long-term use may damage important organs such as the pet's liver and kidneys, leading to secondary health crises.

[0004] Traditional Chinese veterinary medicine has a long history and unique advantages in treating skin diseases. Its mechanism of action is through the synergistic effect of various Chinese herbs, which regulates the body's yin-yang balance, qi and blood circulation, and organ function as a whole. It can treat both the symptoms and the root cause, is less likely to cause drug resistance, and has fewer side effects. While treating pet skin diseases, it can also enhance the pet's immunity and improve its overall physical condition. This meets the current pet owners' demands for safe, efficient, and green pet medical care. This provides a strong theoretical basis and practical foundation for the research and development of traditional Chinese veterinary medicine for pet skin, and opens up a new direction for solving pet skin disease problems. The market prospects are extremely broad, and it is expected to become an important innovation and growth point in the pet medicine field. It is also the most likely class of drugs to obtain independent intellectual property rights, which can promote the entire industry to develop in a healthier and more sustainable direction.

[0005] In view of this, the present invention is proposed. Summary of the Invention

[0006] To address the aforementioned technical problems, this invention provides a traditional Chinese medicine composition and preparation for treating pet skin diseases, which has a wide range of applications, simple formulation, and definite curative effect.

[0007] The first aspect of this invention provides a traditional Chinese medicine composition for external use on pet skin, the traditional Chinese medicine composition containing the following raw materials: Sophora flavescens, Stemona japonica, Cnidium monnieri, Dictamnus dasycarpus, Taraxacum mongolicum, Portulaca oleracea, Melia toosendan, Kochia scoparia, and Phellodendron chinense.

[0008] Optionally, the traditional Chinese medicine composition contains the following raw materials: 100-120 parts by weight of Sophora flavescens, 80-100 parts by weight of Stemona japonica, 80-90 parts by weight of Cnidium monnieri, 60-80 parts by weight of Dictamnus dasycarpus, 50-60 parts by weight of Taraxacum mongolicum, 30-50 parts by weight of Melia azedarach, 30-50 parts by weight of Portulaca oleracea, 30-50 parts by weight of Kochia scoparia, and 30-50 parts by weight of Phellodendron chinense.

[0009] A second aspect of the present invention provides a traditional Chinese medicine preparation containing the above-mentioned traditional Chinese medicine composition, wherein the traditional Chinese medicine preparation contains a concentrated solution of aqueous extract of traditional Chinese medicine raw materials; the dosage form of the traditional Chinese medicine preparation is an external preparation, preferably a liquid preparation, an external ointment, or an external powder.

[0010] The third aspect of the present invention provides the use of the above-mentioned traditional Chinese medicine composition or the above-mentioned traditional Chinese medicine preparation in the preparation of a medicine for antibacterial, anti-swelling or antipruritic purposes for pet skin.

[0011] The fourth aspect of the present invention provides the use of the above-mentioned traditional Chinese medicine composition or traditional Chinese medicine preparation as described above in the preparation of a medicine for treating pet pruritus, eczema, scabies, mange, or insect bites, wherein eczema includes fungal eczema.

[0012] The technical solution provided by the embodiments of the present invention has the following advantages compared with the prior art: Based on years of clinical experience and professional knowledge, this invention successfully yields a traditional Chinese medicine composition and preparation for treating pet skin diseases. The traditional Chinese medicine composition of this invention has a simple formulation, reasonable compatibility, is safe and environmentally friendly, natural and hormone-free, and is safe and reliable to use.

[0013] The traditional Chinese medicine composition and preparation of the present invention have significant antibacterial, anti-inflammatory, and antipruritic effects, and are mild and non-irritating. They have significant curative effects on a variety of pet skin diseases, such as pruritus, eczema, mange, scabies, insect bites, and other pet skin symptoms. They have the technical advantages of wide applicability and definite curative effect. Detailed Implementation

[0014] To better understand the above-mentioned objectives, features, and advantages of the present invention, the solutions of the present invention will be further described below. It should be noted that, unless otherwise specified, the embodiments of the present invention and the features thereof can be combined with each other.

[0015] Many specific details are set forth in the following description in order to provide a full understanding of the invention, but the invention may also be practiced in other ways different from those described herein; obviously, the embodiments in the specification are only some embodiments of the invention, and not all embodiments.

[0016] In this article, prurigo is described as an inflammatory skin disease characterized by intensely itchy papules.

[0017] In this article, eczema is defined as an inflammatory skin reaction induced by various factors such as allergies, dampness, trauma, and parasites; fungal eczema: when eczema is directly caused by fungal infection, it is called fungal eczema, which is an inflammatory disease caused by fungi (such as Microsporum and Trichophyton) invading the epidermis and appendages of the skin.

[0018] In this article, scabies is described as a contagious skin disease caused by the parasitic scabies mite.

[0019] The formulation principle of the traditional Chinese medicine composition of this invention includes: Sophora flavescens: bitter and cold, it has the effects of clearing heat and drying dampness, killing parasites and removing accumulations, and promoting diuresis. Sophora flavescens contains a large amount of alkaloids, among which the highest content are matrine and oxymatrine. Oxymatrine has anti-allergic and anti-inflammatory effects, and can regulate immunity and increase white blood cells. Matrine has antibacterial effects both in vivo and in vitro.

[0020] Stemona japonica: It is sweet and bitter in nature, contains alkaloids, and can be used externally to kill insects, relieve itching, and kill lice. It also has an inhibitory effect on most pathogenic bacteria and skin fungi.

[0021] Melia bark: bitter and cold in nature, it has the effects of clearing heat, drying dampness and killing insects. It is used externally to treat scabies and itching.

[0022] Dandelion: It tastes bitter and sweet, and is cold in nature. It has the effects of clearing heat and detoxifying, reducing swelling and dissipating nodules, and promoting diuresis. It can be used to treat boils, carbuncles, mastitis, scrofula, etc.

[0023] Purslane: The whole plant is sour and cold in nature. It has the effects of cooling blood and detoxifying, removing dampness and promoting urination, and stopping dysentery. Externally, it can be used to treat sores, boils, tinea, eczema, etc.

[0024] Cnidium monnieri: pungent, bitter, and warm; it has the effects of drying dampness and dispelling wind, killing parasites and relieving itching; the osthol contained in Cnidium monnieri has the effects of enhancing immune function and broad-spectrum antibacterial activity.

[0025] Dictamnus dasycarpus root bark: bitter and cold in nature; it has the effects of clearing heat and detoxifying, dispelling wind and drying dampness, and is mainly used for damp-heat sores, eczema, urticaria, and scabies. Modern medical research and clinical applications have proven that Dictamnus dasycarpus root bark contains dictamnusine, dictamnus lactone, sitosterol, choline, quercetin, etc., which have varying degrees of inhibitory effects on a variety of pathogenic fungi.

[0026] Phellodendron bark: It tastes bitter and is cold in nature. It contains a variety of alkaloids, flavonoids, and steroidal components. It has the effects of clearing heat and drying dampness, purging fire and eliminating steaming, and detoxifying and healing sores. It is used externally to treat sores, eczema, impetigo, and burns.

[0027] Kochia scoparia fruit: It has a pungent and bitter taste and is cold in nature. It has the effects of clearing heat and dampness, dispelling wind and relieving itching. Kochia scoparia seeds contain triterpenoid saponins, which have an inhibitory effect on skin fungi. It can be used externally to treat urticaria, eczema and itchy skin.

[0028] The inventors have discovered that a topical Chinese medicine extract for pet skin, prepared by combining Sophora flavescens, Stemona japonica, Cnidium monnieri, Dictamnus dasycarpus, Taraxacum mongolicum, Phellodendron chinense, Portulaca oleracea, Kochia scoparia, and Melia azedarach, exhibits significant efficacy against various pet skin diseases. The effectiveness in treating pet skin diseases lies in the combined use of these nine herbs, along with the addition of Kochia scoparia and Phellodendron chinense. The synergistic effect of these nine herbs significantly treats various pet skin diseases, such as prurigo, eczema, mange, and insect bites.

[0029] In one embodiment, the traditional Chinese medicine composition of the present invention contains the following traditional Chinese medicine raw materials: 100-120 parts by weight of Sophora flavescens, 80-100 parts by weight of Stemona japonica, 80-90 parts by weight of Cnidium monnieri, 60-80 parts by weight of Dictamnus dasycarpus, 50-60 parts by weight of Taraxacum mongolicum, 30-50 parts by weight of Melia azedarach, 30-50 parts by weight of Portulaca oleracea, 30-50 parts by weight of Kochia scoparia, and 30-50 parts by weight of Phellodendron chinense.

[0030] In one embodiment, the traditional Chinese medicine composition of the present invention is composed of the following traditional Chinese medicine raw materials: 100 parts by weight of Sophora flavescens, 80 parts by weight of Stemona japonica, 80 parts by weight of Cnidium monnieri, 60 parts by weight of Dictamnus dasycarpus, 50 parts by weight of Taraxacum mongolicum, 30 parts by weight of Portulaca oleracea, 30 parts by weight of Melia azedarach, 30 parts by weight of Kochia scoparia, and 30 parts by weight of Phellodendron chinense. In one embodiment, the traditional Chinese medicine composition of the present invention is composed of the following traditional Chinese medicine raw materials: 100 parts by weight of Sophora flavescens, 100 parts by weight of Stemona japonica, 90 parts by weight of Cnidium monnieri, 80 parts by weight of Dictamnus dasycarpus, 60 parts by weight of Taraxacum mongolicum, 50 parts by weight of Portulaca oleracea, 50 parts by weight of Melia azedarach, 50 parts by weight of Kochia scoparia, and 50 parts by weight of Phellodendron chinense. In one embodiment, the traditional Chinese medicine composition of the present invention is composed of the following traditional Chinese medicine raw materials: 120 parts by weight of Sophora flavescens, 90 parts by weight of Stemona japonica, 80 parts by weight of Cnidium monnieri, 70 parts by weight of Dictamnus dasycarpus, 60 parts by weight of Taraxacum mongolicum, 50 parts by weight of Portulaca oleracea, 50 parts by weight of Melia azedarach, 50 parts by weight of Kochia scoparia, and 50 parts by weight of Phellodendron chinense.

[0031] A second aspect of this invention also provides a traditional Chinese medicine preparation based on the traditional Chinese medicine composition. The preparation contains a concentrated aqueous extract of the traditional Chinese medicine raw materials and may also contain other pharmaceutically acceptable excipients.

[0032] In one implementation scheme, the dosage form of the traditional Chinese medicine preparation is a topical preparation, specifically a liquid preparation, a topical ointment, or a topical powder. Water or other solvents may be added to the preparation to further adjust the concentration of the liquid preparation. Excipients such as preservatives, transdermal absorption modifiers, and flavoring agents may also be added to further optimize the performance of the liquid preparation.

[0033] In one implementation scheme, when the dosage form of the traditional Chinese medicine preparation is an external powder, some excipients need to be added to the preparation as a carrier, and water-soluble carriers are preferred. The water-soluble carrier can be one or more of pregelatinized starch, dextrin, and cyclodextrin.

[0034] In one implementation scheme, when the dosage form of the traditional Chinese medicine preparation is a topical ointment, some excipients need to be added to the preparation as a matrix. The matrix can be selected from oily matrix, emulsion matrix, and water-soluble matrix. Oily matrix includes animal oil, vegetable oil, silicone and hydrocarbon, wherein animal oil can be lanolin, vegetable oil can be sesame oil, peanut oil, tea oil, hydrocarbon can be petrolatum, and silicone can be dimethyl silicone oil.

[0035] When the dosage form of traditional Chinese medicine preparations is solid dosage form, one or more of the following can be added to the preparation: penetration enhancer, moisturizer, antioxidant, preservative, and transdermal absorption regulator, to further optimize the performance of the solid dosage form.

[0036] In the traditional Chinese medicine preparation of this invention, the raw materials of the above-mentioned traditional Chinese medicine composition need to be prepared into a concentrated liquid first. Each 1000 g of concentrated liquid contains the following water extracts of traditional Chinese medicine raw materials: Sophora flavescens 100-120 g, Stemona japonica 80-100 g, Cnidium monnieri 80-90 g, Dictamnus dasycarpus 60-80 g, Taraxacum mongolicum 50-60 g, Melia toosendan 30-50 g, Portulaca oleracea 30-50 g, Kochia scoparia 30-50 g, and Phellodendron chinense 30-50 g.

[0037] A third aspect of this invention also provides a method for preparing a traditional Chinese medicine preparation, comprising at least the following steps: S1. Preparation of concentrated solution: Take the Chinese herbal raw materials, soak them in 4 to 8 times the amount of water for 1 to 2 hours, decoct them 1 to 3 times, each time for 2 to 3 hours, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.05 to 1.1 at 50℃ to obtain a concentrated solution of the water extract of the Chinese herbal raw materials. S2. Preparation of Traditional Chinese Medicine Preparations: Pharmaceutically acceptable excipients are added to the concentrated liquid to prepare traditional Chinese medicine preparations.

[0038] In one embodiment, the pressure during decocting is 0.2 to 0.4 MPa, and the pressure during concentration is 0.2 to 0.4 MPa.

[0039] In one embodiment, a concentrated aqueous extract of a traditional Chinese medicine raw material for external use is added with pharmaceutically acceptable excipients, and then dried and pulverized to obtain an external powder of the traditional Chinese medicine extract; optionally, drying is performed using an oven; optionally, the oven drying temperature is 75~85℃.

[0040] In a fourth aspect of the present invention, the application of the above-mentioned traditional Chinese medicine composition and traditional Chinese medicine preparation is also proposed.

[0041] First, this invention proposes the application of the above-mentioned traditional Chinese medicine composition or preparation in the preparation of drugs for antibacterial, anti-swelling, or antipruritic purposes for pet skin. Specifically, the traditional Chinese medicine preparation of this invention can be evenly sprayed or applied to the affected area 2-3 times daily for 2-4 weeks.

[0042] Secondly, this invention provides the application of the above-mentioned traditional Chinese medicine composition or preparation in the preparation of a medicine for treating pet skin pruritus, eczema, scabies, mange, or insect bites; eczema includes fungal eczema. Specifically, the traditional Chinese medicine preparation of this invention can be evenly sprayed or applied to the affected area 2-3 times daily for 2-4 weeks.

[0043] Example 1 This embodiment provides a formula and preparation method for a topical traditional Chinese medicine liquid preparation for pets, as detailed below: 1. Weigh out the raw materials of Chinese medicine: 100 g of Sophora flavescens, 80 g of Stemona japonica, 80 g of Cnidium monnieri, 60 g of Dictamnus dasycarpus, 50 g of Taraxacum mongolicum, 30 g of Melia azedarach, 30 g of Portulaca oleracea, 30 g of Kochia scoparia, and 30 g of Phellodendron chinense; 2. Mix the above raw materials and clean them thoroughly; 3. Soak in 6 times the amount of water for 2 hours, then decoct twice, 2 hours each time, at a pressure of 0.3 MPa. 4. Combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.05–1.1 at 50°C. The concentration pressure is 0.3 MPa to obtain the concentrated solution. 5. Adjust the concentrate to 1000 g to obtain the traditional Chinese medicine liquid preparation.

[0044] Example 2 This embodiment provides a formula and preparation method for a topical traditional Chinese medicine liquid preparation for pets, as detailed below: 1. Weigh out the raw materials of Chinese medicine: 100 g of Sophora flavescens, 100 g of Stemona japonica, 90 g of Cnidium monnieri, 80 g of Dictamnus dasycarpus, 60 g of Taraxacum mongolicum, 50 g of Portulaca oleracea, 50 g of Kochia scoparia, 50 g of Melia azedarach, and 50 g of Phellodendron chinense; 2. Mix the above raw materials and clean them thoroughly; 3. Soak in 4 times the amount of water for 2 hours, then decoct twice, 2 hours each time, at a pressure of 0.2 MPa. 4. Combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.05-1.1 at 50℃, with a pressure of 0.2 MPa during concentration, to obtain the concentrated solution; 5. Adjust the concentrate to 1000 g to obtain the traditional Chinese medicine liquid preparation.

[0045] Example 3 This embodiment provides a formula and preparation method for a topical traditional Chinese medicine powder for pet skin, as detailed below: 1. Weigh out the raw materials of Chinese medicine: 120 g of Sophora flavescens, 90 g of Stemona japonica, 80 g of Cnidium monnieri, 70 g of Dictamnus dasycarpus, 60 g of Taraxacum mongolicum, 50 g of Portulaca oleracea, 50 g of Kochia scoparia, 50 g of Melia azedarach, and 50 g of Phellodendron chinense; 2. Mix the above raw materials and clean them thoroughly; 3. Soak in 8 times the amount of water for 1 hour, then decoct twice, 2 hours each time, at a pressure of 0.4 MPa. 4. Combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.05-1.1 at 50℃. The concentration pressure is 0.4 MPa to obtain the concentrated solution.

[0046] 5. Adjust the concentrated liquid to 1000 g, add pregelatinized starch, dry in an oven at 80℃, and pulverize to make a traditional Chinese medicine external powder.

[0047] Experimental Example 1 This experimental example uses the traditional Chinese medicine preparation from Example 1 to treat canine fungal skin disease: Twenty pet dogs with skin diseases were selected, exhibiting symptoms such as itching, scratching, skin lesions, redness, swelling, and oozing. Laboratory diagnosis revealed a fungal dermatitis.

[0048] The treatment method is as follows: trim the hair, clean and dry the affected area, and evenly spray or apply the traditional Chinese medicine preparation prepared in Example 1 to the affected area 2 to 3 times a day for 3 consecutive weeks, and observe the clinical treatment effect. The criteria for judging the efficacy of clinical medication are as follows: Healing: The broken skin scabs over, and the shed hair gradually grows back; Effective: After application, skin exudate can be quickly reduced, and skin itching, damage, redness and swelling basically disappear, with no adverse reactions; Ineffective: No significant improvement in skin damage or hair loss.

[0049] The specific treatment results after three weeks are shown in Table 1.

[0050] Experiments have shown that after application, the medication quickly forms a protective film on the affected area, rapidly stopping skin exudation. After 2-3 days of use, skin itching, breakage, and redness largely disappear. After three weeks of use, the cure rate reaches 95%. No adverse reactions were observed during the treatment, demonstrating its safety and reliability.

[0051] Experimental Example 2 This experimental example uses the traditional Chinese medicine preparation from Example 1 to treat scabies in mink, and a control drug is used for efficacy comparison: Preparation of the control drug: Weigh the following Chinese herbal raw materials: 200g of Sophora flavescens, 160g of Cnidium monnieri, 120g of Dictamnus dasycarpus, 60g of Phellodendron chinense, and 60g of Portulaca oleracea; prepare them into a topical liquid preparation according to the preparation method in Example 1.

[0052] Thirty diseased mink were selected and randomly divided into three groups of 10 each. Symptoms included emaciation, dandruff-like growths on the head and face, scratching, and hemorrhagic scratches in the areas of hair loss. The laboratory diagnosis was mink scabies.

[0053] After grouping, perform the following operations: The cage was thoroughly disinfected, the fur around the affected area of ​​the mink was trimmed, dirt was removed, and the area was washed with soapy water and dried.

[0054] Group 1: No treatment was given except for normal feeding and drinking water; this group served as the control group.

[0055] Group 2: In Example 1, the medicine was poured into a bath tub, the mink was placed in the tub, and after a 10-minute bath, it was taken out, dried, and the bath was repeated twice a day for 3 consecutive weeks.

[0056] Group 3: The control drug solution was poured into the bath tub, the mink were placed in the bath tub, and after a 10-minute bath, they were taken out, dried, and the treatment was repeated twice a day for 3 consecutive weeks.

[0057] The criteria for judging the efficacy of clinical medication are as follows: Healed: The patient is in good spirits, has resumed eating and drinking, the broken skin has scabbed over, and the lost hair is gradually growing back; Effective: Skin exudate can be quickly astringed, and skin itching, damage, redness and swelling basically disappear; Ineffective: No significant improvement in skin damage and hair loss, continued weight loss, or death.

[0058] The specific treatment results after three weeks are shown in Table 2.

[0059] Table 2: Effects of the mink treatment trial (n=30) After three weeks of treatment, the mink in the second group showed improved diet and mental state, healing of skin lesions, and shedding of dandruff, with a cure rate as high as 90% and an effective rate of 100%. The mink in the third group had a cure rate of 40% and an effective rate of 80%, which were lower than those of the group using the herbal composition of this invention.

[0060] The above experiments show that the herbal extract of the present invention has antibacterial and antipruritic effects, can effectively promote skin and hair regeneration, and is safe and non-irritating.

[0061] Experimental Example 3 This experimental example uses the traditional Chinese medicine preparation from Example 1 to conduct an irritation test on cat skin: Six healthy cats were selected, and a left-right self-control method was used. The day before application, the cats' fur was shaved on both sides, with a shaving area diameter of 4 cm on each side. The left side served as a control, applying sterile water, while the right side was treated with the formulation from Example 1 in a circular pattern, with an application diameter of 3 cm. After application, sterile dressings were applied. Four hours later, the dressings were removed, and the right-side application area was gently wiped with sterile water. Skin reactions were recorded at 1h, 4h, 18h, 24h, and 48h after the experiment, according to the skin irritation response evaluation criteria (Tables 3 and 4). Mental state, appetite, and body temperature were also observed and recorded.

[0062] The experimental results are shown in Table 5: Based on the above experimental results, it can be seen that after applying the concentrated solution of Example 1, no irritation reaction was observed on the cat's skin, the irritation score was 0, and the irritation evaluation was non-irritating.

[0063] The above description is merely a specific embodiment of the present invention, enabling those skilled in the art to understand or implement the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention is not to be limited to the embodiments described herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A traditional Chinese medicine composition for external use on pet skin, characterized in that, The traditional Chinese medicine composition contains the following raw materials: Sophora flavescens, Stemona japonica, Cnidium monnieri, Dictamnus dasycarpus, Taraxacum mongolicum, Portulaca oleracea, Melia toosendan, Kochia scoparia, and Phellodendron chinense.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition contains the following raw materials: 100-120 parts by weight of Sophora flavescens, 80-100 parts by weight of Stemona japonica, 80-90 parts by weight of Cnidium monnieri, 60-80 parts by weight of Dictamnus dasycarpus, 50-60 parts by weight of Taraxacum mongolicum, 30-50 parts by weight of Melia azedarach, 30-50 parts by weight of Portulaca oleracea, 30-50 parts by weight of Kochia scoparia, and 30-50 parts by weight of Phellodendron chinense. Optionally, the traditional Chinese medicine composition contains the following raw materials: 100 parts by weight of Sophora flavescens, 80 parts by weight of Stemona japonica, 80 parts by weight of Cnidium monnieri, 60 parts by weight of Dictamnus dasycarpus, 50 parts by weight of Taraxacum mongolicum, 30 parts by weight of Portulaca oleracea, 30 parts by weight of Melia azedarach, 30 parts by weight of Kochia scoparia, and 30 parts by weight of Phellodendron chinense. Optionally, the traditional Chinese medicine composition contains the following raw materials: 100 parts by weight of Sophora flavescens, 100 parts by weight of Stemona japonica, 90 parts by weight of Cnidium monnieri, 80 parts by weight of Dictamnus dasycarpus, 60 parts by weight of Taraxacum mongolicum, 50 parts by weight of Portulaca oleracea, 50 parts by weight of Melia azedarach, 50 parts by weight of Kochia scoparia, and 50 parts by weight of Phellodendron chinense. Optionally, the traditional Chinese medicine composition contains the following raw materials: 120 parts by weight of Sophora flavescens, 90 parts by weight of Stemona japonica, 80 parts by weight of Cnidium monnieri, 70 parts by weight of Dictamnus dasycarpus, 60 parts by weight of Taraxacum mongolicum, 50 parts by weight of Portulaca oleracea, 50 parts by weight of Melia azedarach, 50 parts by weight of Kochia scoparia, and 50 parts by weight of Phellodendron chinense.

3. A traditional Chinese medicine preparation containing the traditional Chinese medicine composition as described in claim 1 or 2, characterized in that, The traditional Chinese medicine preparation contains a concentrated solution of the aqueous extract of the traditional Chinese medicine raw material; Optionally, the dosage form of the traditional Chinese medicine preparation is a topical preparation, preferably a liquid preparation, a topical ointment, or a topical powder.

4. The traditional Chinese medicine preparation according to claim 3, characterized in that, The traditional Chinese medicine preparation also contains pharmaceutically acceptable excipients; When the dosage form of the traditional Chinese medicine preparation is an external powder, the pharmaceutically acceptable excipients include a carrier, and also include one or more of the following: penetration enhancers, lubricants, flavoring agents, and preservatives; the carrier is selected from water-soluble carriers. Optionally, the water-soluble carrier is selected from one or more of pregelatinized starch, dextrin, and cyclodextrin; When the dosage form of the traditional Chinese medicine preparation is a topical ointment, the pharmaceutically acceptable excipients include a matrix, and also include one or more of the following: penetration enhancers, moisturizers, antioxidants, preservatives, and transdermal absorption modifiers; the matrix is ​​selected from oily matrix, emulsion matrix, and water-soluble matrix.

5. The traditional Chinese medicine preparation according to claim 3, characterized in that, Each 1000 g of the concentrate contains water extracts of the following Chinese medicinal materials: Sophora flavescens 100-120 g, Stemona japonica 80-100 g, Cnidium monnieri 80-90 g, Dictamnus dasycarpus 60-80 g, Taraxacum mongolicum 50-60 g, Melia toosendan 30-50 g, Portulaca oleracea 30-50 g, Kochia scoparia 30-50 g, and Phellodendron chinense 30-50 g.

6. A method for preparing a traditional Chinese medicine preparation as described in any one of claims 3 to 5, characterized in that, At least the following steps are included: S1. Preparation of concentrated solution: Take the Chinese herbal raw materials, soak them in 4 to 8 times the amount of water for 1 to 2 hours, decoct them 1 to 3 times, each time for 2 to 3 hours, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.05 to 1.1 at 50°C to obtain a concentrated solution of the water extract of the Chinese herbal raw materials; S2. Preparation of traditional Chinese medicine preparation: The concentrated liquid is mixed with pharmaceutically acceptable excipients to prepare the traditional Chinese medicine preparation.

7. The preparation method according to claim 6, characterized in that, The pressure during the decocting process is 0.2 to 0.4 MPa. Optionally, the pressure during the concentration process is 0.2 to 0.4 MPa.

8. The preparation method according to claim 6, characterized in that, The concentrated extract of the Chinese herbal raw material in the external powder is mixed with pharmaceutically acceptable excipients, dried and pulverized to obtain the external powder of the Chinese herbal extract. Optionally, the drying is performed using an oven. Optionally, the drying temperature in the oven is 75~85℃.

9. The use of the traditional Chinese medicine composition as described in claim 1 or 2, or the traditional Chinese medicine preparation as described in any one of claims 3 to 5, in the preparation of a medicine for inhibiting bacteria, reducing swelling, or relieving itching of pet skin.

10. The use of the traditional Chinese medicine composition as described in claim 1 or 2, or the traditional Chinese medicine preparation as described in any one of claims 3 to 5, in the preparation of a medicament for treating pet pruritus, eczema, scabies, mange, or insect bites; The eczema includes fungal eczema.

Images