Tomato seed oil-based cream and preparation method and application thereof

Abstract

This invention belongs to the field of skincare technology and discloses a tomato seed oil-based cream, its preparation method, and its application. The cream is made with a specific ratio of water, tomato seed oil, a composite emulsifier, and low, medium, and high molecular weight hyaluronic acid. The composite emulsifier consists of Tween 60, Tween 80, and glycerol, with glycerol possessing both emulsifying and moisturizing functions. The hyaluronic acid is compounded in a mass ratio of 2-5:2-4:3-6, with the molecular weight increasing progressively. The resulting cream exhibits good physical stability, forming a water-locking protective film on the skin surface after application, providing long-lasting moisturizing effects, and significantly inhibiting the oxidative degradation of unsaturated fatty acids in tomato seed oil. This invention is applicable to leave-on skincare products such as creams, lotions, and serums.

Description

Technical Field

[0001] This invention belongs to the field of skin care technology, specifically a tomato seed oil-based cream, its preparation method, and its application. Background Technology

[0002] Tomato seed oil is rich in unsaturated fatty acids such as linoleic acid and oleic acid, and contains natural polyphenols and carotenoid derivatives, giving it the potential to have antioxidant and skin barrier-improving effects in skincare products. However, the high degree of unsaturation in tomato seed oil makes it prone to oxidative rancidity in aqueous systems and under the influence of heat, oxygen, and light, leading to the loss of active ingredients and the production of unpleasant odors. These shortcomings limit its direct application in leave-on skincare products.

[0003] While some products use synthetic antioxidants such as BHT and BHA to slow down the oxidation of tomato seed oil, these substances can cause skin irritation at higher concentrations and may trigger allergic reactions in certain individuals.

[0004] Furthermore, theoretically, tomato seed oil, when formulated as an oil-in-water microemulsion, can form a thicker water film on the surface of oil droplets through the continuous aqueous phase, thus slowing down oxidation. However, existing microemulsion technology still has the following prominent drawbacks in stabilizing tomato seed oil: First, conventional microemulsion formulations rely on volatile alcohols to regulate the hydrophilic-lipophilic balance. These additives easily damage the lipid structure of the stratum corneum, causing skin irritation and barrier damage, making them unsuitable for leave-on skincare products for sensitive skin. Second, the problem of post-application antioxidant protection remains unresolved. After the microemulsion matrix is ​​applied to the skin, the continuous aqueous phase rapidly thins or even disappears due to water evaporation and body temperature. If the aqueous phase is only pure water or low-viscosity polyols, it cannot form a continuous barrier film after drying. The exposed tomato seed oil nanodroplets will be directly exposed to air, causing the antioxidant protection established inside the bottle to fail instantly after application, resulting in the phenomenon of "accelerated oxidation after application." Third, the natural polyphenols in tomato seed oil have an amphiphilic tendency, making them more prone to migrating from the oil core to the oil-water interface for precipitation or degradation in unsuitable compound microemulsion systems, resulting in even worse stability. Summary of the Invention

[0005] The purpose of this invention is to provide a tomato seed oil-based cream, its preparation method, and its application. By using a specific ratio of composite emulsifier and three types of hyaluronic acid with varying molecular weights in a stepwise dilution process, a structurally stable tomato seed oil-based cream is obtained, thus solving the problem of insufficient stability and antioxidant capacity of tomato seed oil when used in leave-on skincare products.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0007] In a first aspect, the present invention provides a tomato seed oil-based cream, wherein the raw materials for making its effective ingredients include water, tomato seed oil, a compound emulsifier and hyaluronic acid;

[0008] The mass ratio of tomato seed oil to compound emulsifier is 1:5~8;

[0009] The composite emulsifier is composed of a surfactant and a co-surfactant in a mass ratio of 5 to 8:1; the surfactant is composed of Tween 60 and Tween 80; and the co-surfactant is a short-chain alcohol.

[0010] The hyaluronic acid contains low molecular weight hyaluronic acid, medium molecular weight hyaluronic acid and high molecular weight hyaluronic acid in a mass ratio of 2~5:2~4:3~6, with increasing molecular weight.

[0011] The hyaluronic acid has a weight-average molecular weight of 250-1000 kDa and accounts for 0.1-2% of the mass fraction of the raw material.

[0012] As a limitation of the present invention, the weight-average molecular weight of the low molecular weight hyaluronic acid is 250~350kDa.

[0013] The weight-average molecular weight of the medium molecular weight hyaluronic acid is 700~750kDa;

[0014] The weight-average molecular weight of the high molecular weight hyaluronic acid is 900~1000kDa.

[0015] As another limitation of the present invention, the surfactant is composed of Tween 60 and Tween 80 in a mass ratio of 3:2 to 3; the co-surfactant is glycerol.

[0016] As a further limitation of the present invention, water accounts for no less than 50% of the mass fraction of the raw material.

[0017] That is, the raw water added during the preparation process must be at least 1 times the mass of the tomato seed oil containing the compound emulsifier.

[0018] Secondly, the present invention also provides a method for preparing a clarified tomato seed oil-based cream, comprising the following steps performed sequentially:

[0019] S1. Preparation of oil base: Weigh tomato seed oil and compound emulsifier according to the mass ratio, and mix to obtain oil base;

[0020] S2. Stepwise dilution: Weigh the hyaluronic acid according to the mass ratio, mix it with water to obtain a water-based solution;

[0021] The water-based liquid is slowly added to the oil-based liquid, and the mixture is sheared and mixed. The water-based liquid is then continuously added until a homogeneous emulsion is obtained, which yields the tomato seed oil-based cream.

[0022] As a limitation of the present invention, the gradual dilution is carried out at room temperature.

[0023] Furthermore, the room temperature is 20~30℃.

[0024] When the temperature is too low, Tween 60 or Tween 80 will become turbid, which is not conducive to the formation of a stable and homogeneous product.

[0025] As another limitation of the present invention, in step S1, the preparation method of the composite emulsifier is as follows: take the Tween 60 and Tween 80, cut and mix them evenly, then add the co-surfactant, mix evenly, and the composite emulsifier is obtained.

[0026] As a further limitation of the present invention, the shearing is performed by magnetic stirring.

[0027] Preferably, a magnetic stirrer is used for stirring.

[0028] During the gradual dilution process, it is preferable to first perform preliminary shear mixing on the oil base to form a uniform continuous oil phase, and then slowly add the aqueous phase to the oil phase under continuous magnetic stirring until a uniform emulsion system is formed.

[0029] Thirdly, the present invention also provides the application of the above-mentioned method for preparing tomato seed oil-based cream in the preparation of skin care products.

[0030] Furthermore, the skincare product is a lotion.

[0031] By adopting the above technical solution, the technical progress achieved by this invention compared with the prior art is as follows:

[0032] The tomato seed oil-based cream of the present invention is prepared by synergistic compounding of a specific ratio of composite emulsifier with low, medium and high molecular weight hyaluronic acid, and by a step-dilution process at room temperature, resulting in a tomato seed oil-based cream for skin care with outstanding stability, antioxidant properties and moisturizing performance.

[0033] This invention introduces low, medium, and high molecular weight hyaluronic acid in a specific mass ratio with increasing weight-average molecular weight into an aqueous phase, forming a multi-level network structure in the aqueous phase. This improves the suspension stability of the cream and forms a water-locking protective film on the skin surface after application. This film works synergistically with glycerol to slow down water evaporation and prolong the moisturizing effect. At the same time, this film continuously coats tomato seed oil droplets, blocking oxygen and inhibiting the oxidation of unsaturated fatty acids. The glycerol in this film can both help emulsify and moisturize.

[0034] The method of this invention is simple and reproducible, and is suitable for the industrial production of leave-on skin care products such as creams, lotions, and essential oils. Attached Figure Description

[0035] Figure 1 This is a graph showing the sample compatibility results of the mixed systems obtained in Comparative Examples 1-5 of this invention;

[0036] Figure 2This is a graph showing the sample compatibility results of the mixed systems obtained in Comparative Examples 6-8 of this invention;

[0037] Figure 3 The graph shows the antioxidant effects of different concentrations of low molecular weight hyaluronic acid with a weight-average molecular weight of 300 kDa in Experiment Example 2 of the present invention.

[0038] Figure 4 The graph shows the antioxidant effects of different concentrations of low molecular weight hyaluronic acid with a weight-average molecular weight of 730 kDa in Experimental Example 2 of the present invention.

[0039] Figure 5 The graph shows the antioxidant effects of low molecular weight hyaluronic acid with different concentrations and a weight-average molecular weight of 100 kDa in Experiment Example 2 of the present invention. Detailed Implementation

[0040] The present invention will be further described in detail below through specific embodiments. It should be understood that the described embodiments are only for explaining the present invention and do not limit the present invention.

[0041] Unless otherwise specified, the experimental methods used in the following examples are conventional methods in the art. Unless otherwise specified, the materials and reagents used in the following examples are commercially available.

[0042] Example 1

[0043] This embodiment describes a tomato seed oil-based cream and its preparation method. The tomato seed oil-based cream is a transparent, clear microemulsion, and its preparation method includes the following steps performed sequentially:

[0044] S1. Preparation of oil-based

[0045] Preparation of composite emulsifier: Weigh 45g of Tween 60 and 30g of Tween 80 at a mass ratio of 3:2, stir with a magnetic stirrer until homogeneous, and obtain the surfactant; weigh 60g of the surfactant, stir continuously, and add 10g of the co-surfactant glycerol, i.e., the mass ratio of surfactant to co-surfactant is 6:1, mix well, and obtain the composite emulsifier.

[0046] Preparation of oil base: Weigh 10g of tomato seed oil and 60g of compound emulsifier at a mass ratio of 1:6, mix them, and obtain the oil base.

[0047] The oil-based system is a tomato seed oil-compound emulsifier system.

[0048] S2. Gradual dilution

[0049] Take low molecular weight hyaluronic acid with a weight average molecular weight of 300kDa, medium molecular weight hyaluronic acid with a weight average molecular weight of 730kDa, and high molecular weight hyaluronic acid with a weight average molecular weight of 1000kDa in a mass ratio of 2:3:4.5, mix them to obtain hyaluronic acid, and set aside. The total weight of the three types of hyaluronic acid accounts for 2% of the total weight of the raw materials.

[0050] Add water to the obtained hyaluronic acid until the hyaluronic acid is fully dissolved to obtain a water-based solution.

[0051] At room temperature (25°C), the oil base was stirred using a magnetic stirrer. This initial shear mixing resulted in a homogeneous, continuous oil phase, forming a clear and transparent system. Subsequently, under continuous magnetic stirring and shear mixing conditions, the water base was slowly added to the oil base. Water was continuously added until a homogeneous cream was formed, thus obtaining the tomato seed oil-based cream. The final water content accounted for 60% of the total weight of the raw materials.

[0052] Comparative Examples 1-8

[0053] Comparative Examples 1-8 were prepared by mixing equal amounts of tomato seed oil with either a single surfactant or a co-surfactant as an adjuvant to compare the compatibility of different adjuvants with tomato seed oil. The compatibility results of the mixed system samples for each comparative example were photographed, and the results are shown below. Figure 1 and Figure 2 .

[0054] Comparative Example 1 was prepared by mixing equal amounts of Tween 20 and tomato seed oil. Figure 1 Samples of "Tween 20" were found in the middle.

[0055] Comparative Example 2 was prepared by mixing equal amounts of Tween 60 and tomato seed oil. Figure 1 The sample contains "Tween 60";

[0056] Comparative Example 3 was prepared by mixing equal amounts of Tween 80 and tomato seed oil. Figure 1 The sample contains "Tween 80";

[0057] Comparative Example 4 was prepared by mixing equal amounts of Span 20 and tomato seed oil. Figure 1 Sample "Sipan 20" from China;

[0058] Comparative Example 5 was prepared by mixing equal amounts of Span 80 and tomato seed oil. Figure 1 Sample "Sipan 80" from China;

[0059] Comparative Example 6 was prepared by mixing anhydrous ethanol and tomato seed oil. Figure 2 The sample contained "anhydrous ethanol";

[0060] Comparative Example 7 was prepared by mixing equal amounts of n-butanol and tomato seed oil. Figure 2 The sample contains n-butanol;

[0061] Comparative Example 8 was prepared by mixing equal amounts of glycerol and tomato seed oil. Figure 2 The sample of "glycerol" in the middle.

[0062] Figure 1 and Figure 2 The results showed that a single adjuvant could not form a stable and homogeneous transparent or semi-transparent system. Among the surfactants, Span 80 showed the best compatibility with tomato seed oil, followed by Tween 60 and Tween 80. Among the co-surfactants, n-butanol showed the best compatibility with tomato seed oil. Further analysis revealed that Span 80, with an HLB value of 4.3, tends to form a water-in-oil system, while Tween 60 and Tween 80, with HLB values ​​between 14 and 18, tend to form an oil-in-water system. Therefore, Tween 60 and Tween 80, which readily form oil-in-water microemulsions, were chosen to avoid a thick and greasy product texture caused by a continuous oil phase.

[0063] Comparative Example 9

[0064] This comparative example is basically the same as Example 1, except that the oil base is made from Span 80, n-butanol and tomato seed oil in a mass ratio of 1:9:10.

[0065] Comparative Examples 10-12

[0066] Comparative Example 10 is basically the same as Example 1, except that the oil base is made of Tween 60, n-butanol and tomato seed oil in a mass ratio of 1:19:20.

[0067] Comparative Example 11 is basically the same as Example 1, except that the oil base is made of Tween 60, n-butanol and tomato seed oil in a mass ratio of 1:9:10.

[0068] Comparative Example 12 is basically the same as Example 1, except that the oil base is made of Tween 60, n-butanol and tomato seed oil in a mass ratio of 2:8:10.

[0069] The oil bases of Comparative Examples 9-12 remained cloudy or had solid precipitation after preliminary shearing and mixing, rather than the clear and transparent state shown in Example 1. In particular, the product of Comparative Example 9 had the worst stability and the most solid precipitation. The results indicate that although Span 80 and n-butanol are compatible with tomato seed oil, their stability after being compounded in the manner of comparative examples is far worse than before compounding.

[0070] Effect Experiment Example 1

[0071] This experimental example aims to verify the applicability of commonly used additives in seven skin care products (A-G) to the tomato seed oil-complex emulsifier system in Example 1. Spreadability, skin penetration, and bioactivity were used as comprehensive evaluation indicators. A factorial experimental model was set up and ANOVA was performed using Type III partial sum of squares.

[0072] The common additives in skincare products A through G are numbered and abbreviated as follows: Niacinamide (A), Vitamin E (B), Panthenol (C), Low molecular weight hyaluronic acid with a weight average molecular weight of 300kDa (D-30W), Medium molecular weight hyaluronic acid with a weight average molecular weight of 730kDa (E-73W), High molecular weight hyaluronic acid with a weight average molecular weight of 1000kDa (F-100W), and Sodium heparin (G).

[0073] Using Design-Expert, the seven factors (A-G) and their upper and lower limits of addition were input. The software automatically generated an experimental sample formulation matrix as shown in Table 1. The experimental samples were mixed according to the proportions in Table 1, with the remainder being the oil base from Example 1. The corresponding experimental samples were prepared using the stepwise dilution method described in Example 1. The preparation methods for groups A-G are as follows:

[0074] Table 1 Experimental Sample Formulation Matrix

[0075]

[0076] The correlation between the spreadability, skin permeability, and comprehensive evaluation index of bioactivity of the experimental samples and the seven factors A to G was analyzed by variance. The results are shown in Table 2.

[0077] Table 2. Results of the suitability analysis of different additives on the tomato seed oil-compound emulsifier system

[0078]

[0079] Experimental results showed that the overall regression analysis of the model was statistically significant. The univariate effect test results indicated that D-30W and F-100W were the core key factors significantly improving the overall applicability of the system. D-30W had a p-value of 0.0041 and a mean square value of 716.03, making the most significant contribution to improving the system's spreading uniformity, skin penetration efficiency, and bioavailability. F-100W had a p-value of 0.0082 and a mean square value of 486.39, also significantly optimizing the system's emulsification stability and active release efficiency. However, the p-values ​​of nicotinamide (p=0.3686), vitamin E (p=0.2679), panthenol (p=0.5964), E-75W (p=0.1567), and heparin sodium (p=0.5392) were all greater than 0.05, indicating that the effects of these components on the overall performance of the system under the experimental conditions did not reach a statistically significant level and were not the dominant factors regulating the system's applicability.

[0080] In summary, this experiment, through quantitative statistical analysis, clarified that only D-30W and F-100W are the key compatible components for optimizing the comprehensive application performance of the tomato seed oil-compound emulsifier system.

[0081] Effect Experiment Example 2

[0082] This experimental example further analyzes the effect of concentration changes of hyaluronic acid with different molecular weights on the scavenging rate of antioxidant free radicals by conducting a single-factor concentration gradient experiment.

[0083] Low molecular weight hyaluronic acid with a weight average molecular weight of 300 kDa is designated as 30W hyaluronic acid, medium molecular weight hyaluronic acid with a weight average molecular weight of 730 kDa is designated as 73W hyaluronic acid, and high molecular weight hyaluronic acid with a weight average molecular weight of 1000 kDa is designated as 100W hyaluronic acid.

[0084] The specific formulations for each group of samples are shown in Table 3, and the preparation methods are as described in Example 1.

[0085]

[0086] Experimental results are as follows Figures 3-5The results showed that the concentration changes of hyaluronic acid with different molecular weights had significant effects on the antioxidant properties of the system: among them, the scavenging rate of 30W hyaluronic acid in the concentration range of 0~1% generally increased with increasing concentration, reaching a peak at 0.8% concentration and then slightly decreasing; the scavenging rate of 73W hyaluronic acid in the concentration range of 0~0.5% showed a fluctuating trend of first decreasing and then increasing, reaching a trough at 0.2% concentration and reaching a relatively high level at 0.5% concentration; the scavenging rate of 100W hyaluronic acid in the concentration range of 0~0.5% showed a trend of first decreasing and then significantly increasing, reaching a trough at 0.2% concentration and reaching the highest value at 0.5% concentration.

[0087] Effect Experiment Example 3

[0088] This effect experiment is based on the single-factor experiment results of Effect Experiment 1. The addition amount of hyaluronic acid with three molecular weights of 30W, 73W, and 100W is used as the factor to be investigated, and the comprehensive applicability of the tomato seed oil-compound emulsifier system is used as the response value. A quadratic polynomial response surface model is constructed and optimization analysis is carried out.

[0089] The analysis of variance (ANOVA) results for the response surface methodology showed that the overall p-value was 0.0267 (p < 0.05), indicating that the model was statistically significant; the p-value for the lack-of-fit term was 0.7944 (p > 0.05), indicating that the model had no significant lack of fit, good fit, and could effectively reflect the true relationship between each factor and the response value. The model's coefficient of determination R0 was [not specified]. 2 The value is 0.8581, indicating that the model can explain 85.81% of the response value variation, and the prediction accuracy is reliable. The results are shown in Table 4.

[0090] Table 4. Analysis results of the quadratic polynomial response surface model

[0091]

[0092] Further significance analysis of the factors and interaction terms showed that the interaction (BC) between 73W and 100W hyaluronic acid was highly significant (p=0.0072), and the quadratic term (C²) of 100W hyaluronic acid was also highly significant (p=0.0046), fully demonstrating the significant synergistic effect of hyaluronic acid with different molecular weights when combined, and that the ratio of these components has a key regulatory effect on the overall performance of the system. Through model optimization, it was determined that the overall response value of the system reached its peak when the addition amounts of 30W hyaluronic acid were approximately 0.16%, 73W hyaluronic acid approximately 0.24%, and 100W hyaluronic acid approximately 0.36%. At this point, the mass ratio of the three hyaluronic acids was approximately 2:3:4.5, which is completely consistent with the formulation ratio in Example 1 of this invention.

[0093] Further verification analysis showed that when the mass ratio of 30W, 73W, and 100W hyaluronic acid was controlled within the range of (2~5):(2~4):(3~6), the overall response value of the system remained at a significantly high level. This indicates that this ratio range is the optimal blending range for the three types of hyaluronic acid, which can ensure the optimal synergistic effect of the system's bioactivity, spreadability, and skin penetration performance, while also taking into account the stability of the formulation and the user experience of the product.

[0094] Example 2

[0095] This embodiment describes a tomato seed oil-based cream and its preparation method. The tomato seed oil-based cream is a transparent, clear microemulsion, and its preparation method includes the following steps performed sequentially:

[0096] S1. Preparation of oil-based

[0097] Preparation of composite emulsifier: Weigh 20.85g of Tween 60 and 20.85g of Tween 80 at a mass ratio of 1:1, stir with a magnetic stirrer until well mixed, and obtain a total of 41.7g of surfactant; continue stirring and add 8.3g of co-surfactant glycerol, that is, the mass ratio of surfactant to co-surfactant is 5:1, mix well, and obtain 50g of composite emulsifier.

[0098] Preparation of oil base: Weigh 10g of tomato seed oil and 50g of the above-mentioned compound emulsifier at a mass ratio of 1:5, mix them, and obtain the oil base.

[0099] S2. Gradual dilution

[0100] Take low molecular weight hyaluronic acid with a weight average molecular weight of 350 kDa, medium molecular weight hyaluronic acid with a weight average molecular weight of 700 kDa, and high molecular weight hyaluronic acid with a weight average molecular weight of 950 kDa in a mass ratio of 2.5:2:3, mix them to obtain hyaluronic acid, and set aside. The total weight of the three types of hyaluronic acid accounts for 0.1% of the total weight of the raw materials.

[0101] Add water to the obtained hyaluronic acid until the hyaluronic acid is fully dissolved to obtain a water-based solution.

[0102] At room temperature (18°C), the oil-based mixture was stirred using a magnetic stirrer. This initial shear mixing resulted in a homogeneous, continuous oil phase, forming a clear and transparent system. Subsequently, under continuous magnetic stirring and shear mixing conditions, the water-based mixture was slowly added to the oil-based mixture until a homogeneous cream was formed, thus obtaining the tomato seed oil-based cream. The final water content was 65% of the total weight of the raw materials.

[0103] Example 3

[0104] This embodiment describes a tomato seed oil-based cream and its preparation method. The tomato seed oil-based cream is a transparent, clear microemulsion, and its preparation method includes the following steps performed sequentially:

[0105] S1. Preparation of oil-based

[0106] Preparation of composite emulsifier: Weigh 23.7g of Tween 60 and 15.8g of Tween 80 at a mass ratio of 3:2, stir with a magnetic stirrer until well mixed, and obtain a total of 39.5g of surfactant; continue stirring and add 4.9g of co-surfactant glycerol, that is, the mass ratio of surfactant to co-surfactant is 8:1, mix well, and obtain 44.4g of composite emulsifier.

[0107] Preparation of oil base: Weigh 5g of tomato seed oil and 40g of the above-mentioned compound emulsifier at a mass ratio of 1:8, mix them, and obtain the oil base.

[0108] S2. Gradual dilution

[0109] Hyaluronic acid is prepared by mixing three types of hyaluronic acid in a mass ratio of 5:4:6: low molecular weight hyaluronic acid with a weight average molecular weight of 250 kDa, medium molecular weight hyaluronic acid with a weight average molecular weight of 750 kDa, and high molecular weight hyaluronic acid with a weight average molecular weight of 900 kDa. The total weight of the three types of hyaluronic acid accounts for 1.2% of the total weight of the raw materials.

[0110] Add water to the obtained hyaluronic acid until the hyaluronic acid is fully dissolved to obtain a water-based solution.

[0111] At room temperature (27°C), the oil-based mixture was stirred using a magnetic stirrer. This initial shear mixing resulted in a homogeneous, continuous oil phase, forming a clear and transparent system. Subsequently, under continuous magnetic stirring and shear mixing conditions, the water-based mixture was slowly added to the oil-based mixture until a homogeneous cream was formed, thus obtaining the tomato seed oil-based cream. The final water content was 60% of the total weight of the raw materials.

[0112] In other embodiments, the final water content accounts for 50% of the total weight of the raw materials (water, tomato seed oil, and compound emulsifier).

[0113] Example 4

[0114] This embodiment illustrates the application of the prepared tomato seed oil-based cream in the preparation of skincare products, as detailed below:

[0115] Tomato seed oil-based creams prepared in Examples 1, 2, and 3 were placed in three clean beakers and labeled as Sample A, B, and C, respectively. Pre-cooled sterile water at 4°C was added to each sample in batches, with the amounts being 5%, 15%, and 30% of the cream's mass, respectively. After each addition of water, a homogenizer was used to stir at 2000 rpm for 30 seconds, then increased to 6000 rpm for 1 minute to ensure uniform water dispersion and the formation of a fine, homogeneous semi-fluid or fluid emulsion.

[0116] By increasing the total water content by 5% to 10% from the original water content of the cream, the system achieves a higher consistency, maintaining a paste-like texture, suitable for canned products. In other embodiments, the total water content of the tomato seed oil-based cream is increased by 20% to 30%, resulting in a flowable, milky white or translucent texture that is easy to apply and absorb, suitable for pump bottle packaging.

[0117] It should be noted that the above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions described in the above embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the claims of the present invention.

Claims

1. A tomato seed oil-based cream, characterized in that, The raw materials used to make its active ingredients include water, tomato seed oil, compound emulsifiers, and hyaluronic acid; The mass ratio of tomato seed oil to compound emulsifier is 1:5~8; The composite emulsifier is composed of a surfactant and a co-surfactant in a mass ratio of 5 to 8:1; the surfactant is composed of Tween 60 and Tween 80; and the co-surfactant is a short-chain alcohol. The hyaluronic acid contains low molecular weight hyaluronic acid, medium molecular weight hyaluronic acid and high molecular weight hyaluronic acid in a mass ratio of 2~5:2~4:3~6, with increasing molecular weight. The hyaluronic acid has a weight-average molecular weight of 250-1000 kDa and accounts for 0.1-2% of the mass fraction of the raw material.

2. The tomato seed oil-based cream according to claim 1, characterized in that, The weight-average molecular weight of the low molecular weight hyaluronic acid is 250~350kDa; The weight-average molecular weight of the medium molecular weight hyaluronic acid is 700~750kDa; The weight-average molecular weight of the high molecular weight hyaluronic acid is 900~1000kDa.

3. A tomato seed oil-based cream according to claim 1 or 2, characterized in that, The surfactant is composed of Tween 60 and Tween 80 in a mass ratio of 3:2~3; the co-surfactant is glycerol.

4. The tomato seed oil-based cream according to claim 3, characterized in that, Water constitutes no less than 50% of the mass fraction of the raw material.

5. A method for preparing a tomato seed oil-based cream according to any one of claims 1 to 4, characterized in that, This includes the following steps performed sequentially: S1. Preparation of oil base: Weigh tomato seed oil and compound emulsifier according to the mass ratio, and mix to obtain oil base; S2. Stepwise dilution: Weigh the hyaluronic acid according to the mass ratio, mix it with water to obtain a water-based solution; The water-based liquid is slowly added to the oil-based liquid, and the mixture is sheared and mixed. The water-based liquid is then continuously added until a homogeneous emulsion is obtained, which yields the tomato seed oil-based cream.

6. The method for preparing a tomato seed oil-based cream according to claim 5, characterized in that, Gradual dilution was carried out at room temperature.

7. The method for preparing a tomato seed oil-based cream according to claim 6, characterized in that, In step S1, the composite emulsifier is prepared by: taking Tween 60 and Tween 80, shearing and mixing them, then adding the co-surfactant and mixing them to obtain the composite emulsifier.

8. A method for preparing a tomato seed oil-based cream according to any one of claims 5 to 7, characterized in that, The shearing process utilizes magnetic stirring.

9. The application of the method for preparing the tomato seed oil-based cream according to any one of claims 5 to 8 in the preparation of skin care products.

10. The application of the tomato seed oil-based cream according to claim 9, characterized in that, Adjust the water content to produce a lotion for skin care.

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