A mouth liquid for treating oral ulcer and a preparation method thereof

Abstract

This invention relates to a mouthwash for treating oral ulcers and its preparation method. The mouthwash comprises the following components in the indicated weight ratios: 100 parts deionized water, containing 5-35 parts sodium chloride, 1-10 parts sodium bicarbonate, 0.1-1 parts borneol, 0.1-1 parts peppermint oil, 1-5 parts vitamin E, and 1-5 parts vitamin B12. First, all the above materials (excluding deionized water) are mixed in the indicated weight ratio and ground into a fine powder finer than 400 mesh. Then, peppermint oil is sprayed onto the powder mixture and stirred evenly to obtain the prepared mouthwash powder. The powder is then packaged and sealed. To use, the mouthwash powder is poured into a bottle containing the corresponding weight of deionized water and shaken until fully dissolved before use. This mouthwash has significant effects in treating oral ulcers, providing timely pain relief, accelerating ulcer healing, and shortening the course of the disease.

Description

Technical Field

[0001] This invention relates to the field of pharmaceuticals, and more specifically to a mouthwash for treating oral ulcers. Background Technology

[0002] Oral ulcers, commonly known as canker sores, are medically termed recurrent aphthous ulcers. They are superficial ulcers that occur on the oral mucosa. The ulcer lesions are round or oval and concave, with surrounding congestion. When ulcers occur, the tongue coating turns white or yellow, and they cause abnormal pain when stimulated. The size ranges from the size of a sesame seed in the early stage to the size of a soybean in the later stage. They can occur in different parts of the oral cavity, such as the tongue, gums, upper and lower jaws, and even lips.

[0003] Oral ulcers are the most common oral disease, and their etiology and mechanism are not yet fully understood. Modern medicine believes that the pathogenesis is related to local trauma, stress, food and drugs, endocrine disorders, vitamin and trace element deficiencies, and bacterial infections. Traditional Chinese medicine believes that it is caused by internal injury from the seven emotions and external pathogenic factors, leading to liver qi stagnation, which transforms into fire, and the deficiency fire rises to the mouth, causing the disease. This can explain why some people develop oral ulcers after injury, and also why some people develop oral ulcers after eating spicy food. However, it cannot explain why some people experience recurrent ulcers throughout their lives, and why it is related to genetics. This latter group accounts for a significant proportion of oral ulcer patients. Therefore, oral ulcers are actually a multifactorial disease characterized primarily by symptomatic manifestations, with oral ulcers caused by various reasons exhibiting similar symptoms.

[0004] At the same time, oral ulcers are also a self-limiting disease. Even without any treatment, they will heal on their own after a certain period of time, which is generally 7 to 15 days. However, during this process, they will cause great pain and inconvenience to patients, especially for those who suffer from long-term and recurrent ulcers. When oral ulcers occur, eating and speaking are very painful, and patients are seriously affected in their lives and social interactions.

[0005] Based on the characteristics of oral ulcers described above, current treatments for oral ulcers aim to improve symptoms, alleviate pain, and shorten the course of the disease. Methods include oral Chinese medicine, topical sprays, mouthwashes, adhesive patches, gels, etc. While these methods have some effect, they also have limitations. This invention provides a mouthwash that is effective, fast-acting, easy to use, and low-cost, along with its preparation method. Summary of the Invention

[0006] To solve the above-mentioned technical problems, the present invention provides a mouthwash for treating oral ulcers. The mouthwash contains a solution made of sodium chloride, sodium bicarbonate, borneol, peppermint oil, vitamin E, vitamin B12 and other materials and deionized water. By weight, every 100 parts of deionized water contains 5-35 parts of sodium chloride, 1-10 parts of sodium bicarbonate, 0.1-1 part of borneol, 0.1-1 part of peppermint oil, 1-5 parts of vitamin E and 1-5 parts of vitamin B12.

[0007] The required sodium chloride in the oral solution is pharmaceutical grade with a purity of 99.5% or higher, the required sodium bicarbonate is food grade with a purity of 99.0% or higher, the required borneol is natural borneol with a purity of 90% or higher, the required peppermint oil is pharmaceutical grade, and the required vitamin E and vitamin B12 are ordinary tablets.

[0008] The method for preparing oral liquid is as follows:

[0009] (1) Mix sodium chloride, sodium bicarbonate, borneol, vitamin E, vitamin B12, etc. in the weight ratio;

[0010] (2) Grind the mixture into a dry powder finer than 400 mesh using a grinding mill;

[0011] (3) Spray peppermint oil onto the fine powder of the mixture and stir evenly to make oral liquid dry powder. Then divide and seal it according to the weight required for 10 ml of water.

[0012] (4) Seal 10 ml of deionized water in a 15 ml glass bottle or medical plastic bottle, and prepare 1 portion of the required oral liquid powder in a box. When using, pour the oral liquid powder into the deionized water bottle, shake well until fully dissolved, and then use.

[0013] The beneficial effects of this invention are: the oral liquid of this invention acts directly on the ulcer site, which can quickly produce analgesic and anti-inflammatory effects, accelerate wound healing, restore normal oral mucosa, and has a significant effect on oral ulcers caused by various reasons.

[0014] The raw materials and proportions used in the oral liquid of this invention were precisely selected and determined. The prepared oral liquid powder contains no harmful additives or toxic substances. Besides its significant therapeutic effect on oral ulcers, this oral liquid is very safe for the human body. Furthermore, the method of storing the oral liquid powder and deionized water separately in sealed containers, and then mixing and dissolving them before use, extends the shelf life of the oral liquid after production and makes it more convenient to use. The uses and effects resulting from different proportions of the raw materials will be illustrated in the examples.

[0015] The roles of each ingredient in the oral liquid powder of this invention in treating oral ulcers are described below:

[0016] High-purity sodium chloride

[0017] Sodium chloride is a common food and chemical raw material. Ordinary sodium chloride is also known as table salt. In this invention, it is used as the main raw material of the oral liquid. The strong osmotic pressure of sodium chloride was discovered and utilized in experiments to treat oral ulcers and its antibacterial and anti-inflammatory functions. The lesion of oral ulcers is completely different from the mucous membrane of normal oral cavity. Its surface is porous and has decomposed necrotic tissue. Because a large number of bacteria and necrotic mucous tissue form ulcers in these lesions and continue to erode the surrounding area, the ulcers will continue to develop and expand after they are formed. Only after reaching a certain extent will the body's immune function be stimulated to produce resistance, kill bacteria, eliminate necrotic tissue, and regenerate new normal mucous membrane. This is the formation and healing process of oral ulcers. Therefore, relying on the body's own immune function to achieve self-healing often takes a long time. This invention uses a high-concentration sodium chloride solution. When the oral liquid comes into contact with the ulcer surface, the high concentration of the solution, due to osmotic pressure, causes severe dehydration and drying of the necrotic tissue at the ulcer site, preventing it from continuing to grow and expand. Bacterial proliferation is also effectively controlled. Furthermore, because the high-concentration sodium chloride solution has anti-inflammatory and analgesic effects, the pain caused by oral ulcers is rapidly reduced. Experiments have shown that the high-concentration sodium chloride solution does not damage normal oral mucosa, only causing slight changes in taste. These taste discomforts quickly disappear after the treatment. Once the ulcer's ability to spread is effectively controlled, the body's own repair capabilities kick in, generating new normal mucosa, thus accelerating the healing of the ulcer and achieving the therapeutic goal and expected effect.

[0018] Sodium bicarbonate

[0019] Sodium bicarbonate, commonly known as baking soda, is a beneficial food additive. It is highly alkaline and its main function in oral saliva is to neutralize acidic substances that are easily produced during treatment, maintain the alkaline state of the oral solution, inhibit bacterial growth, and has a significant synergistic effect on promoting the pain relief and healing of ulcers. The specific content varies depending on the specific condition of the ulcer.

[0020] Borneol

[0021] Borneol is a traditional Chinese medicine made from plant resins and volatile oils, commonly known as camphor. In this invention, it is added in small doses to the oral liquid powder. After dissolving, it gives the solution a cooling taste, reducing discomfort during treatment. At the same time, it also exerts its unique effects as a traditional Chinese medicine, such as clearing heat and detoxifying, reducing inflammation and relieving pain, and eliminating putrefaction and dissipating nodules. It is an auxiliary therapeutic ingredient in the oral liquid.

[0022] peppermint

[0023] Peppermint oil is a natural essential oil extracted from plants. It has a strong peppermint aroma. When used as a medicine in mouthwash, its main functions are to reduce inflammation and relieve pain, while also improving the taste of the mouthwash and increasing the duration of use.

[0024] Vitamin E and Vitamin B12

[0025] The addition of these two vitamins to the oral liquid utilizes their antioxidant and nerve-nourishing properties, which have significant effects on repairing ulcers and promoting the growth of normal mucous membranes.

[0026] The main effects of this oral liquid are as follows: Because the main raw materials of this oral liquid are not chemical drugs, but are basically made from edible materials, it has no toxic side effects and is very safe. Its effects are very significant: First, it can provide immediate pain relief; after each sufficiently long oral treatment, pain can be significantly reduced, with a decrease of 50% to 80%. Second, it can significantly inhibit the development of ulcers; in experiments, at the initial stage of an ulcer, even just two or three applications can control the ulcer's development and allow it to fully recover within one or two days. Third, it can comprehensively shorten the course of ulcers; in experiments, the course of the disease, which normally takes about ten days without treatment, is shortened to three to five days for complete recovery after improving the patient's pain and discomfort.

[0027] The clinical treatment criteria for oral ulcers using this invention are as follows:

[0028] Before use, pour one packet of the accompanying oral liquid powder into 10 ml of deionized water, shake well until all the powder dissolves, then hold it in your mouth. Adjust the angle and position of the mouthpiece according to the location of the ulcer, ensuring the ulcer surface is fully immersed in the oral liquid, and maintain this position for at least half an hour. Then spit out the oral liquid; do not rinse your mouth. For ulcers on the lips, palate, or near the throat, where oral treatment is not possible, use a cotton swab dipped in the oral liquid to repeatedly moisten the ulcer, also for at least half an hour. Depending on the situation, treat two to four times daily, with each course of treatment lasting seven days.

[0029] The criteria for effectiveness are: significant reduction in pain, feeling well, reduction in ulcer size, cessation of redness and swelling around the ulcer, and no impact on normal life after about one course of treatment; the criteria for cure are: complete healing of the ulcer in less than one course of treatment; the criteria for ineffectiveness are: no improvement in symptoms after more than one course of treatment, indicating that the treatment is ineffective.

[0030] From 2022 to 2024, 86 people, including Zhou Moumou, were clinically diagnosed with oral ulcers. After treatment with the oral liquid of this invention, 82 people were effective, with an overall effective rate of 95.3%, and 62 people were cured, with a cure rate of 72%. 4 people were ineffective, with an ineffective rate of 4.6%.

[0031] Typical case:

[0032] Mr. Zhou, male, 70 years old, from Jiangbei District, Chongqing, recalled suffering from recurrent oral ulcers since around age 20. In his youth, he had ulcers in his mouth for at least one-third of the year, often lasting for half a month at a time, healing for a few days, then flaring up again for another half month, causing great pain and severely impacting his quality of life. As he aged, he still experienced ulcers for about one to two months each year. He tried various treatments, including traditional Chinese medicine, Western medicine, dietary therapy, and folk remedies, all without significant effect. Eventually, he stopped treatment altogether, letting the pain develop and heal on its own each time. Since 2022, he has been using the oral liquid of this invention, with remarkable results. Each time an ulcer forms, the oral liquid significantly reduces the pain, allowing him to maintain a pain-free normal life. Furthermore, the duration of each ulcer has been shortened to three to five days. After nearly two years of intermittent treatment, the frequency of ulcers has gradually decreased from about five times a year to about two times.

[0033] Ms. Li, 35 years old, from Fuling District, Chongqing, developed oral ulcers due to internal heat from eating hot pot. She recovered after three days of treatment with this oral liquid.

[0034] Mr. Zhang, male, 59 years old, from Chenghua District, Chengdu, has suffered from recurrent oral ulcers for many years. Each time he is treated with this oral liquid, he usually recovers in about five days. On several occasions, when the ulcers first appeared, he only used the oral liquid three or four times and the development of the ulcers was inhibited within two days, and he was able to return to normal life.

[0035] Mr. Chen, male, 68 years old, from Qingyang District, Chengdu, had almost never had oral ulcers in his life. However, he developed oral ulcers due to unknown accidental reasons. The pain was extremely severe. After using this oral liquid, the symptoms were significantly relieved within two days and he recovered completely after six days.

[0036] The above treatment examples demonstrate that the present invention has a significant therapeutic effect on oral ulcers, has no toxic side effects, and is inexpensive and easy to prepare. Detailed Implementation

[0037] Example 1: A mouthwash for treating oral ulcers and its preparation method. The formula uses the raw materials described in this invention, specifically in the following weight ratios: 15 parts sodium chloride, 5 parts sodium bicarbonate, 0.3 parts borneol, 0.8 parts vitamin E, and 0.8 parts vitamin B12. The solid raw materials prepared in the above ratio are ground into a dry powder finer than 400 mesh using a grinder. Then, 1 part peppermint oil is sprayed onto the dry powder, stirred evenly, and then sealed in 2.3-gram packets. These packets are then sealed in 15-ml glass or medical plastic bottles containing 10 ml of deionized water. Each packet is packaged with one packet of the mouthwash powder prepared according to the above formula. When using, the mouthwash powder is poured into the deionized water bottle, shaken until fully dissolved, and then used according to the clinical treatment standards described above. This example formula is mainly suitable for the treatment of oral ulcers caused by local trauma and other causes in their initial stages.

[0038] Example 2: A mouthwash for treating oral ulcers and its preparation method. The formula uses the raw materials described in this invention, specifically in the following weight ratios: 32 parts sodium chloride, 2 parts sodium bicarbonate, 1 part borneol, 0.5 parts vitamin E, and 0.5 parts vitamin B12. The solid raw materials prepared in the above ratio are ground into a dry powder finer than 400 mesh using a grinder. Then, 1 part peppermint oil is sprayed onto the dry powder, stirred evenly, and then sealed in 3.7-gram packets. Each packet is then sealed in a 15-ml glass bottle or medical plastic bottle containing 10 ml of deionized water. This is packaged together with one packet of the mouthwash powder prepared according to the above formula. When using, the mouthwash powder is poured into the deionized water bottle, shaken until fully dissolved, and then used according to the clinical treatment standards described above. This example formula is mainly suitable for patients with obvious symptoms, large ulcer lesions, and severe pain, and can be used throughout the entire treatment process.

[0039] Example 3: A mouthwash for treating oral ulcers and its preparation method. The formula uses the raw materials described in this invention, specifically in the following weight ratios: 18 parts sodium chloride, 8 parts sodium bicarbonate, 0.5 parts borneol, 3 parts vitamin E, and 3 parts vitamin B12. The solid raw materials prepared in the above ratio are ground into a dry powder finer than 400 mesh using a grinder. Then, 0.5 parts peppermint oil are sprayed onto the dry powder, stirred evenly, and packaged in 3.3-gram packets. Each packet is then sealed with 10 ml of deionized water in a 15 ml glass bottle or medical plastic bottle. This is packaged together with one packet of the mouthwash powder prepared according to the above formula. When using, pour the mouthwash powder into the deionized water bottle, shake until fully dissolved, and then use according to the clinical treatment standards described above. This formula is mainly suitable for treating patients in the recovery period of oral ulcers or those with mild symptoms and low pain.

[0040] Although specific embodiments of the present invention have been described, those skilled in the art will recognize that various changes and modifications can be made to the invention without departing from its scope or spirit. Therefore, the present invention is intended to cover all changes and modifications falling within the scope of the claims.

Claims

1. A mouthwash for treating oral ulcers, characterized in that, The oral solution comprises a solution made of sodium chloride, sodium bicarbonate, borneol, peppermint oil, vitamin E, vitamin B12, etc., and deionized water. By weight, every 100 parts of deionized water contains 5-35 parts of sodium chloride, 1-10 parts of sodium bicarbonate, 0.1-1 part of borneol, 0.1-1 part of peppermint oil, 1-5 parts of vitamin E, and 1-5 parts of vitamin B12.

2. The oral liquid according to claim 1, characterized in that, The oral liquid contains pharmaceutical-grade sodium chloride with a purity of 99.5% or higher, food-grade sodium bicarbonate with a purity of 99.0% or higher, natural borneol with a purity of 90% or higher, pharmaceutical-grade peppermint oil, and ordinary tablets of vitamin E and vitamin B12.

3. The oral liquid according to claims 1-2, its preparation method is as follows: (1) Mix sodium chloride, sodium bicarbonate, borneol, vitamin E, vitamin B12, etc. in the weight ratio; (2) Grind the mixture into a dry powder finer than 400 mesh using a grinding mill; (3) Spray peppermint oil onto the mixed dry powder and stir evenly to make oral liquid dry powder. Then divide and seal it according to the weight required for 10 ml of water. (4) Seal 10 ml of deionized water in a 15 ml glass bottle or medical plastic bottle and prepare one portion of the required oral liquid powder. When using, pour the oral liquid powder into the deionized water bottle, shake until fully dissolved, and then use.

4. The use of the oral liquid according to claims 1-3 in the preparation and treatment of oral ulcers.