Microscope parameter processing method and apparatus

Abstract

This application relates to a method, apparatus, computer device, readable storage medium, and computer program product for processing microscope parameters. The method includes: acquiring input microscope parameters in response to a microscope parameter input operation triggered in a displayed microscope parameter input interface; and displaying a report result display interface in response to a microscope parameter calculation operation triggered in the microscope parameter input interface. The report result display interface includes report results for the number of target fields of view corresponding to multiple different types of tumors. The number of target fields of view is the number of nuclear divisions required to observe each type of tumor within the field of view of a target microscope, based on diagnostic criteria for each type of tumor. The target microscope is the microscope corresponding to the microscope parameters. This method can improve the conversion efficiency between microscope field of view and multiple tumor diagnostic criteria.

Description

Technical Field

[0001] This application relates to the field of medical information and computer-aided diagnostic technology, and in particular to a microscope parameter processing method, apparatus, computer equipment, readable storage medium, and computer program product. Background Technology

[0002] In tumor pathology diagnosis, mitotic count is a key quantitative indicator for assessing tumor malignancy and classifying pathological grading. The World Health Organization (WHO) and various pathological diagnostic standards have set clear threshold requirements for mitotic counts of different tumors, but these requirements are usually expressed in area units (such as mm²) or fixed field of view (such as 10 HPF).

[0003] In traditional techniques, pathologists manually calculate the required number of fields of view (FN) under a microscope using calculators or lookup tables. However, different hospitals and microscope models have different eyepiece field of view (FN) and objective magnification, resulting in significant differences in the actual area of ​​a single high-power field of view (HPF). Furthermore, the diagnostic criteria for different tumors vary, and the conversion relationships and rules corresponding to multiple diagnostic criteria are complex, which leads to low efficiency and a high risk of errors in the conversion process.

[0004] Therefore, traditional techniques suffer from low computational efficiency in converting between microscopic views and various tumor diagnostic criteria for nuclear division counting in tumor diagnosis. Summary of the Invention

[0005] Therefore, it is necessary to provide a microscope parameter processing method, device, computer equipment, readable storage medium, and computer program product that can improve the conversion calculation efficiency between microscope field of view and various tumor diagnostic criteria, in order to address the above-mentioned technical problems.

[0006] In a first aspect, this application provides a method for processing microscope parameters, the method comprising the following steps:

[0007] In response to a microscope parameter input operation triggered in the displayed microscope parameter input interface, the input microscope parameters are obtained;

[0008] In response to the microscope parameter calculation operation triggered in the microscope parameter input interface, a report result display interface is displayed. The report result display interface contains report results for the number of target fields of view corresponding to multiple different types of tumors. The number of target fields of view is the number of nuclear divisions required to observe each type of tumor within the field of view of the target microscope, based on the diagnostic criteria for each type of tumor. The target microscope is the microscope corresponding to the microscope parameters.

[0009] In one embodiment, the step of displaying a report result display interface in response to a microscope parameter calculation operation triggered in the microscope parameter input interface includes:

[0010] In response to the microscope parameter calculation operation, the actual field of view area corresponding to the target microscope is obtained according to the microscope parameters; the actual field of view area is used to characterize a high-power field of view of the target microscope;

[0011] The target number of fields of view is determined based on the ratio between the field of view area threshold corresponding to each type of tumor and the actual field of view area; the field of view area threshold is the field of view area required for observing and counting nuclear division numbers under a microscope in the diagnostic criteria for the tumor.

[0012] Based on the target number of fields of view, the report results are generated, and a report results display interface containing the report results is displayed.

[0013] In one embodiment, the microscope parameters include the eyepiece field of view number and objective lens magnification of the target microscope; obtaining the actual field of view area corresponding to the target microscope based on the microscope parameters includes:

[0014] The actual field diameter is obtained by the ratio between the eyepiece field of view number and the objective lens magnification.

[0015] The actual field of view area corresponding to the target microscope is obtained based on the actual field of view diameter.

[0016] In one embodiment, the field of view area threshold includes a grading area threshold, which is the field of view area required for the number of nuclear divisions used in tumor diagnostic criteria for grading and diagnosing tumors.

[0017] The determination of the target field of view number based on the ratio between the visual field area threshold corresponding to each type of tumor and the actual visual field area includes:

[0018] Obtain the required grading area thresholds for each grade of each type of tumor;

[0019] Based on the actual field of view area and the grading area threshold, the number of target fields of view required for each of the multiple grades of the tumor is obtained.

[0020] In one embodiment, the microscope parameters further include the area under the microscope, and the method further includes:

[0021] In response to a microscope parameter input operation triggered in the displayed microscope parameter input interface, the microscopic area is obtained;

[0022] In response to a microscope parameter calculation operation triggered in the microscope parameter input interface, the general field of view number is obtained based on the ratio between the under-microscope area and the actual field of view area; the general field of view number is the number of nuclear divisions required within the field of view range of the under-microscope area.

[0023] Generate a report containing the general field of view count, and display the report results interface containing the report results.

[0024] In one embodiment, the microscope parameter input interface displays microscope parameter input controls and microscope parameter calculation button controls; there are at least two microscope parameter input controls; the step of obtaining the input microscope parameters in response to a microscope parameter input operation triggered in the displayed microscope parameter input interface includes:

[0025] In response to a trigger operation on each of the microscope parameter input controls in the microscope parameter input interface, a selection list of microscope parameters corresponding to the microscope parameter input control is displayed; the selection list displays at least two parameter values ​​corresponding to the microscope parameter.

[0026] In response to the selection of the parameter value in the parameter selection list, the input microscope parameters are obtained;

[0027] The response to the microscope parameter calculation operation triggered in the microscope parameter input interface, displaying the report results interface, includes:

[0028] In response to the triggering operation of the microscope parameter calculation button control in the microscope parameter input interface, the report result display interface is displayed.

[0029] In one embodiment, the method further includes:

[0030] When the target control is triggered, a preset animation is played at the display position of the target control; the target control is either a microscope parameter input control or a microscope parameter calculation button control.

[0031] In one embodiment, the method further includes:

[0032] When the microscope parameter input interface is displayed on a mobile terminal, the adjusted style size for the microscope parameter input interface is obtained; the adjusted style size is matched with the mobile terminal.

[0033] The microscope parameter input interface is displayed according to the adjusted style size.

[0034] Secondly, this application provides a microscope parameter processing device, the device comprising:

[0035] The microscope parameter input module is used to obtain the input microscope parameters in response to the microscope parameter input operation triggered in the displayed microscope parameter input interface.

[0036] The report results display module is used to respond to the microscope parameter calculation operation triggered in the microscope parameter input interface and display the report results display interface. The report results display interface contains report results for the number of target fields of view corresponding to multiple different types of tumors. The number of target fields of view is the number of nuclear divisions required to observe each type of tumor within the field of view of the target microscope, based on the diagnostic criteria for each type of tumor. The target microscope is the microscope corresponding to the microscope parameters.

[0037] Thirdly, this application also provides a computer device, including a memory and a processor, wherein the memory stores a computer program, and the processor executes the computer program to implement the steps of the microscope parameter processing method described above.

[0038] Fourthly, this application also provides a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the steps of the above-described method.

[0039] Fifthly, this application also provides a computer program product, including a computer program that, when executed by a processor, implements the steps of the above-described method.

[0040] The aforementioned microscope parameter processing method, apparatus, computer equipment, readable storage medium, and computer program product acquire input microscope parameters in response to a microscope parameter input operation triggered in the displayed microscope parameter input interface; and display a report result display interface containing the target field of view number corresponding to multiple different types of tumors in response to a microscope parameter calculation operation triggered in the microscope parameter input interface. This solution provides users with a visual microscope parameter calculator that can perform standardized and automated calculations on the input microscope parameters. Based on the diagnostic criteria for each type of tumor and the field of view of the target microscope corresponding to the microscope parameters, it automatically calculates the target field of view number required to observe each type of tumor, significantly reducing the error rate of pathologists in calculating the required number of mitotic fields of view under the microscope based on different types of tumor diagnostic criteria. This reduces tumor diagnostic discrepancies caused by equipment differences and human calculation errors, effectively improving the efficiency of conversion calculation between microscope field of view and multiple tumor diagnostic criteria. Attached Figure Description

[0041] To more clearly illustrate the technical solutions in the embodiments of this application or related technologies, the drawings used in the description of the embodiments of this application or related technologies will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0042] Figure 1 This is an application environment diagram of a microscope parameter processing method in one embodiment;

[0043] Figure 2 This is a schematic diagram of a microscope parameter processing procedure in one embodiment;

[0044] Figure 3 This is a schematic diagram of a microscope parameter calculation system in one embodiment;

[0045] Figure 4 This is a schematic diagram of the microscope parameter input interface in one embodiment;

[0046] Figure 5 This is a schematic diagram of the report result display interface in one embodiment;

[0047] Figure 6 This is a structural block diagram of a microscope parameter processing device in one embodiment;

[0048] Figure 7 This is an internal structural diagram of a computer device in one embodiment. Detailed Implementation

[0049] To make the objectives, technical solutions, and advantages of this application clearer, the following detailed description is provided in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application.

[0050] In tumor pathology diagnosis, mitotic count is a key quantitative indicator for assessing tumor malignancy and classifying pathological grading. The World Health Organization (WHO) and various pathological diagnostic standards have set clear threshold requirements for mitotic counts of different tumors, but these requirements are usually expressed in area units (such as mm²) or fixed field of view (such as 10 HPF, 10x high-power field).

[0051] However, traditional techniques face the following technical challenges in practical application: a) Significant differences in microscope parameters: Different hospitals and microscope models have varying field numbers (FN) and objective magnifications, leading to significant differences in the actual area of ​​a single high-power field (HPF). b) Complex and error-prone parameter conversion process: Pathologists need to manually calculate the actual field number corresponding to a specific area (e.g., 5 mm² for gastrointestinal stromal tumors (GIST)) under the current microscope. This calculation involves formulas for the area of ​​a circle, unit conversions, etc., making it prone to errors. c) Inconsistent diagnostic criteria: Diagnostic criteria for different tumors (e.g., breast cancer, neuroendocrine tumors, soft tissue tumors) vary, resulting in complex conversion relationships. Doctors need to memorize numerous conversion rules. d) Lack of integrated tools: Currently, only scattered calculation formulas or tables exist; there are no automated tools that integrate microscope parameter calculations, conversion of multiple disease diagnostic criteria, and result visualization.

[0052] Based on this, this application aims to provide a microscope parameter processing method that can automatically, accurately, and in a standardized manner convert microscope field of view into tumor diagnostic standards, in order to reduce diagnostic discrepancies caused by equipment differences and human calculation errors and improve diagnostic consistency through standardized calculation of microscope parameters.

[0053] The microscope parameter processing method provided in this application embodiment can be applied to, for example... Figure 1 In the application environment shown, terminal 102 communicates with server 104 via a network. A data storage system can store the data that server 104 needs to process. The data storage system can be integrated onto server 104 or placed on a cloud or other network server. Terminal 102 can respond to a microscope parameter input operation triggered in the displayed microscope parameter input interface to obtain the input microscope parameters; terminal 102 can respond to a microscope parameter calculation operation triggered in the microscope parameter input interface to display a report result display interface, which includes report results for the number of target fields of view corresponding to multiple different types of tumors; the number of target fields of view is the number of nuclear divisions required to observe each type of tumor within the field of view of the target microscope, based on the diagnostic criteria for each type of tumor; the target microscope is the microscope corresponding to the microscope parameters. Terminal 102 can be, but is not limited to, various personal computers, laptops, smartphones, and tablets. The computer device can be a standalone physical server, a server cluster or distributed system composed of multiple physical servers, or a cloud server providing cloud computing services.

[0054] In one exemplary embodiment, such as Figure 2 As shown, a microscope parameter processing method is provided. This embodiment applies this method to... Figure 1The method is illustrated using terminal 102 as an example. In this embodiment, the method includes the following steps S202 to S204. Wherein:

[0055] Step S202: In response to the microscope parameter input operation triggered in the displayed microscope parameter input interface, the input microscope parameters are obtained.

[0056] In practical applications, when users (such as pathologists) need to observe and judge tumor tissue sections under a microscope, they need to determine the nuclear division count of the tissue section under their microscope field of view. Therefore, it is necessary to convert and calculate the microscope field of view with various tumor diagnostic standards. After the user successfully accesses the microscope parameter calculator (microscope parameter calculation system), the terminal 102 can display a microscope parameter input interface. The user enters the microscope parameters that need to be converted and calculated in this interface, including the objective magnification, eyepiece magnification, and eyepiece field of view. The terminal 102 can respond to the microscope parameter input operation triggered in the displayed microscope parameter input interface and obtain the input microscope parameters.

[0057] Step S204: In response to the microscope parameter calculation operation triggered in the microscope parameter input interface, the report result display interface is displayed.

[0058] The report results display interface can include report results for the number of target fields of view corresponding to multiple different types of tumors.

[0059] The target field of view (RFD) is the number of nuclear divisions (or nuclear count) required to observe each type of tumor within the field of view of the target microscope, based on the diagnostic criteria for each type of tumor. The target microscope is the microscope whose parameters correspond to the target microscope's parameters.

[0060] In a specific implementation, after the user completes the input of microscope parameters and triggers the microscope parameter calculation operation, the terminal 102 can respond to the microscope parameter calculation operation triggered in the microscope parameter input interface, perform calculations on the input microscope parameters, obtain the number of target fields of view under the field of view of the target microscope corresponding to the microscope parameters input by the user, and generate a report result containing the number of target fields of view corresponding to multiple different types of tumors, and then display the report result display interface.

[0061] The aforementioned microscope parameter processing method acquires the input microscope parameters in response to a microscope parameter input operation triggered in the displayed microscope parameter input interface; and displays a report result display interface containing the target field of view (Field of View) corresponding to multiple different types of tumors in response to a microscope parameter calculation operation triggered in the microscope parameter input interface. This solution provides users with a visual microscope parameter calculator that can perform standardized and automated calculations on the input microscope parameters. Based on the diagnostic criteria for each type of tumor and the target microscope's Field of View corresponding to the microscope parameters, it automatically calculates the target Field of View (Field of View) required to observe each type of tumor, significantly reducing the error rate in pathologists' calculations of the required Field of View (Field of View) under the microscope based on different tumor diagnostic criteria. This reduces discrepancies in tumor diagnosis caused by equipment differences and human calculation errors, effectively improving the efficiency of conversion calculations between microscope Field of View and multiple tumor diagnostic criteria.

[0062] In an exemplary embodiment, in response to a microscope parameter calculation operation triggered in the microscope parameter input interface, a report result display interface is displayed, including: in response to the microscope parameter calculation operation, obtaining the actual field of view area corresponding to the target microscope based on the microscope parameters; determining the target field of view number based on the ratio between the field of view area threshold corresponding to each type of tumor and the actual field of view area; generating a report result based on the target field of view number, and displaying a report result display interface containing the report result.

[0063] The actual field of view area can be used to characterize a high-power field of view (HPF) of the target microscope.

[0064] The field of view threshold is the area of ​​the field required for observing and counting nuclear mitotic figures under a microscope in the diagnostic criteria for tumors. For example, the WHO's pathological diagnostic criteria for gastrointestinal stromal tumors (GIST) require a count of 5 mm. 2 The number of nuclear fissions within the cell.

[0065] In practical applications, terminal 102 can respond to microscope parameter calculation operations and obtain the actual field of view area corresponding to the target microscope based on the microscope parameters. Based on the visual field area thresholds corresponding to each type of tumor. and actual field of view area The ratio between them determines the number of target fields of view. Based on the number of target fields of view Generate report results and display the report results interface containing the report results.

[0066] The technical solution of this embodiment, by responding to microscope parameter calculation operations, obtains the actual field of view area corresponding to the target microscope based on the microscope parameters. This unifies the microscope field of view area benchmarks of different devices and laboratories, providing a standardized quantitative basis for accurately calculating the number of fields of view. Furthermore, based on the ratio between the field of view area threshold corresponding to each type of tumor and the actual field of view area, the target number of fields of view is determined. This achieves automated, multi-standard conversion between microscope field of view and tumor diagnostic standards. It can provide users with a visual display interface showing the report results containing the target number of fields of view, thereby reducing diagnostic discrepancies caused by equipment differences and human calculation errors.

[0067] In an exemplary embodiment, the microscope parameters include the number of eyepiece fields of view and the objective lens magnification of the target microscope; based on the microscope parameters, the actual field of view area corresponding to the target microscope is obtained, including: obtaining the actual field of view diameter based on the ratio between the number of eyepiece fields of view and the objective lens magnification; and obtaining the actual field of view area corresponding to the target microscope based on the actual field of view diameter.

[0068] In practice, the field of view area of ​​microscopes used in different laboratories may vary (e.g., 0.16 mm², 0.25 mm²), affecting the comparability of results. Therefore, it is necessary to standardize the calculation of the field of view diameter corresponding to the microscope. Terminal 102 can obtain the eyepiece field of view number (or eyepiece field of view diameter) from the input microscope parameters. objective lens magnification According to the number of eyepiece fields and objective lens magnification The ratio between them yields the actual field of view diameter. ,Right now Furthermore, based on the actual field of view diameter This allows us to obtain the actual field of view area corresponding to the target microscope. ,Right now .

[0069] Taking gastrointestinal stromal tumors (GIST) as an example, assuming the microscope parameters input by the user are: eyepiece field of view diameter (mm): 22, objective magnification (×): 40, eyepiece magnification (×): 10, then the actual field of view diameter... Actual field of view area Furthermore, based on the diagnostic criteria for gastrointestinal stromal tumors (GIST), the visual field threshold for GIST is... Then the number of target fields of view in GIST This means that gastrointestinal stromal tumors (GISTs) require counting 5mm diameter particles under a target microscope with a 22mm eyepiece field of view, 40× objective magnification, and 10× eyepiece magnification. 2The number of nuclear divisions within the field of view of a microscope; that is, in actual work, if a pathologist observes and counts the number of nuclear divisions in a tissue section of a gastrointestinal stromal tumor patient in 21 fields of view under a target microscope with a 22mm eyepiece field of view and a 400x magnification, and assesses the risk level of the gastrointestinal stromal tumor patient based on the nuclear division counts observed in the 21 fields of view.

[0070] The technical solution of this embodiment obtains the actual field diameter based on the ratio between the eyepiece field of view number and the objective lens magnification, and then obtains the actual field of view area corresponding to the target microscope. This clarifies the calculation method of the actual field diameter, reduces the discrepancies in conversion results caused by differences in different microscope equipment, and enables standardized and unified calculation of different microscope parameters, thereby achieving comparability between microscopes of various specifications.

[0071] The field of view area threshold includes a grading area threshold. In an exemplary embodiment, the target number of fields of view is determined based on the ratio between the field of view area threshold corresponding to each type of tumor and the actual field of view area. This includes: obtaining the grading area threshold required for each grade of each type of tumor; and obtaining the target number of fields of view required for multiple grades of each tumor based on the actual field of view area and the grading area threshold.

[0072] Among them, the grading area threshold is the field of view area required for the number of nuclear divisions used in tumor diagnostic criteria for grading and diagnosing tumors.

[0073] In practical applications, some tumors need to be graded. Therefore, terminal 102 can obtain the required grading area thresholds for each grade of each type of tumor. Based on the actual field area and the grading area thresholds, the number of target fields of view required for each tumor at multiple grades can be obtained.

[0074] Because nuclear division is unevenly distributed, to accurately reflect tumor activity, more fields of view are usually needed to observe the number of nuclear divisions in tumor tissue sections at different field ranges. Generally, it is required to count the number of nuclear divisions in 10 high-power fields (10HPF), that is, to observe 10 different locations of the tumor tissue section under the target microscope's field of view. Therefore, this method can also be used to calculate the number of target fields required for 10HPF, i.e. .

[0075] For example, consider a neuroendocrine tumor (NET). Using a microscope with an eyepiece magnification of 10×, an eyepiece field of view of 22mm, and an objective lens magnification of 40× as an example, the actual field of view diameter of this microscope would be... Actual field of view area .

[0076] According to the diagnostic criteria for neuroendocrine tumors (NETs), the threshold for the area of ​​view for mitotic counts in a NET G1 neuroendocrine tumor is ≤2 mitotic figures / 2 mm², for a NET G2 neuroendocrine tumor it is 2 to 20 mitotic figures / 2 mm², and for a NET G3 neuroendocrine tumor it is ≥20 mitotic figures / 2 mm². Therefore, under the aforementioned target microscope, the target field of view for a NET G1 neuroendocrine tumor is... That is, ≤2 / 8.42HPF; or can be achieved through The calculated mitotic count for a neuroendocrine tumor (NET) at 10 HPF is 2.38 / 10 HPF. This means that if fewer than 2 mitotic counts are observed in 10 high-power fields, the neuroendocrine tumor grade corresponds to NET G1. The upper limit for the target field number at 10 HPF for a grade 2 neuroendocrine tumor (NET G2) is... The target field of view for grade II neuroendocrine tumors (NET G2) is 2 / 8.42 HPF to 20 / 8.42 HPF (or 2.38 / 10 HPF to 23.76 / 10 HPF). This means that if ≥2 and ≤23 mitotic figures are observed in 10 high-power fields, the neuroendocrine tumor grade corresponds to NET G2. The target field of view for grade III neuroendocrine tumors (NET G3) is ≥20 / 8.42 HPF (23.76 / 10 HPF). This means that if ≥24 mitotic figures are observed in 10 high-power fields, the neuroendocrine tumor grade corresponds to NET G1.

[0077] For example, consider breast cancer. According to the diagnostic criteria for breast cancer, the visual field threshold... Taking a microscope with an eyepiece magnification of 10×, an eyepiece field of view of 20mm, and an objective lens magnification of 40× as an example, the actual field of view diameter of this microscope is... Actual field of view area Then, under this target microscope, the number of target fields of view for breast cancer .

[0078] However, in general, breast cancer needs to be assessed using the Nottingham Breast Cancer Score (Nottingham Histological Grading System) to evaluate the degree of malignancy and prognosis. According to the diagnostic criteria, the area threshold for a score of 1 is ≤6.9 nuclear divisions / mm², the area threshold for a score of 2 is 6.9~14.75 nuclear divisions / mm², and the area threshold for a score of 3 is ≥14.75 nuclear divisions / mm².

[0079] Therefore, the number of nuclear divisions in breast cancer is 1 point: A score of 1 for breast cancer requires 7 target fields of view. This means that under this target microscope, a score of 1 for breast cancer can have <7 / 10 HPF, i.e., if fewer than 7 nuclear mitotic figures are observed in 10 high-power fields, the breast cancer grade corresponds to 1. A score of 2 for breast cancer nuclear mitotic figures is also acceptable. <Number of target fields required for a score of 2 in breast cancer < A score of 8 / 10 HPF to 14 / 10 HPF means that if 8 or more but less than 14 mitotic figures are observed in 10 high-power fields, the breast cancer grade corresponds to a score of 2. A score of 3 for breast cancer mitotic figures is ≥ 14 / 10HPF means that if 14 or more nuclear divisions are observed in 10 high-power fields, the breast cancer grade corresponds to a breast cancer score of 3.

[0080] The technical solution of this embodiment obtains the number of target fields of view required for each tumor at multiple levels by using the actual field of view area and the required grading area thresholds for each level of each type of tumor. Thus, for various types of tumors, based on the grading thresholds corresponding to the diagnostic criteria, the number of target fields of view required for each tumor at multiple levels can be accurately calculated, thereby providing a reliable basis for tumor pathological grading diagnosis.

[0081] In an exemplary embodiment, the microscope parameters also include the under-microscope area, and the method further includes: obtaining the under-microscope area in response to a microscope parameter input operation triggered in the displayed microscope parameter input interface; obtaining a general field of view number based on the ratio between the under-microscope area and the actual field of view area in response to a microscope parameter calculation operation triggered in the microscope parameter input interface; generating a report result containing the general field of view number, and displaying a report result display interface containing the report result.

[0082] The general field of view number can be the number of nuclear fissions required within the field of view of the microscope area.

[0083] In a specific implementation, the terminal 102 can obtain the microscopic area in response to a microscope parameter input operation triggered in the displayed microscope parameter input interface. ; In response to microscope parameter calculation operations triggered in the microscope parameter input interface, based on the area under the microscope Compared with the actual field of view area The ratio between them yields the general field of view number. Generate a report containing the general field of view count and display the report results interface containing the report results.

[0084] For example, taking a microscope with a user-inputted eyepiece magnification of 10×, eyepiece field of view of 22mm, and objective lens magnification of 40× as an example, the actual field of view diameter of this microscope is... Actual field of view area If the user also entered the area under the microscope: Area under the microscope (mm) 2 ) Then the general field of view number , indicating that in 1 mm 2 At high magnification, this is equivalent to 4.21 fields of view.

[0085] The technical solution of this embodiment obtains the microscopic area by responding to the microscope parameter input operation triggered in the displayed microscope parameter input interface; and obtains the general field of view number based on the ratio between the microscopic area and the actual field of view area by responding to the microscope parameter calculation operation triggered in the microscope parameter input interface, so as to generate a report result display interface containing the general field of view number. This can unify the benchmark of field of view area, thereby providing pathologists with a general nuclear division count as a reference that is not specific to any tumor.

[0086] In an exemplary embodiment, the microscope parameter input interface displays microscope parameter input controls and microscope parameter calculation button controls; there are at least two microscope parameter input controls; in response to a microscope parameter input operation triggered in the displayed microscope parameter input interface, the input microscope parameters are obtained, including: in response to a trigger operation for each microscope parameter input control in the microscope parameter input interface, displaying a selection list of microscope parameters corresponding to the microscope parameter input controls; and in response to a selection operation of parameter values ​​in the parameter selection list, obtaining the input microscope parameters.

[0087] In response to a microscope parameter calculation operation triggered in the microscope parameter input interface, a report result display interface is displayed, including: in response to a trigger operation of the microscope parameter calculation button control in the microscope parameter input interface, a report result display interface is displayed.

[0088] The selection list can display at least two parameter values ​​corresponding to the microscope parameters.

[0089] In its implementation, the microscope parameter calculator (microscope parameter calculation system) displays microscope parameter calculation button controls and at least two microscope parameter input controls on its microscope parameter input interface. After a user successfully accesses the microscope parameter input interface, the terminal 102 can respond to the trigger operation of each microscope parameter input control on the microscope parameter input interface, displaying a selection list of microscope parameters corresponding to the microscope parameter input controls. The user can select the microscope parameter to be converted from the selection list; in response to the selection operation of the parameter value in the parameter selection list, the input microscope parameter is obtained.

[0090] After the user completes the selection of parameter values ​​in the parameter selection list, the terminal 102 can respond to the trigger operation of the microscope parameter calculation button control in the microscope parameter input interface and display the report result display interface.

[0091] The technical solution of this embodiment, through the microscope parameter input control and microscope parameter calculation button control displayed in the microscope parameter input interface, can display a selection list of microscope parameters corresponding to the microscope parameter input control, thereby providing users with microscope parameters that can be directly selected, thus reducing errors caused by human input and improving the efficiency of parameter input.

[0092] In one exemplary embodiment, the method further includes: playing a preset animation at the display position of the target control when the target control is triggered.

[0093] The target control can be either the microscope parameter input control or the microscope parameter calculation button control.

[0094] In practical applications, when either the microscope parameter input control or the microscope parameter calculation button control is triggered, the terminal 102 can play a preset animation, such as a focusing pulse halo, at the display position of the target control.

[0095] Meanwhile, the terminal 102 can also respond to microscope parameter calculation operations, display the report results display interface according to a preset background color, such as a dynamic pink-blue gradient background, and play preset animations, such as floating cloud decoration animations, in the report results display interface.

[0096] The technical solution of this embodiment plays a preset animation at the display position of the target control when the target control is triggered, which enables the target control to be highlighted when triggered, thereby enhancing the interactive experience and visual effect.

[0097] In one exemplary embodiment, the method further includes: when the microscope parameter input interface is displayed on a mobile terminal, obtaining the adjusted style size for the microscope parameter input interface; and displaying the microscope parameter input interface according to the adjusted style size.

[0098] The adjusted style size is matched to the mobile terminal.

[0099] In a specific implementation, when the microscope parameter input interface is displayed on a mobile terminal, the terminal (mobile terminal) 102 can adapt the controls (including form elements and button elements) in the microscope input interface to the size of the mobile terminal device to obtain the style and size adjusted for the microscope parameter input interface; and display the microscope parameter input interface according to the adjusted style and size.

[0100] For example, a responsive design for mobile adaptation rules is as follows:

[0101] @media (max-width: 768px) {

[0102] form { padding: 1.8rem;}

[0103] input[type="button"] { width: 100%;}

[0104] }

[0105] The technical solution of this embodiment, when the microscope parameter input interface is displayed on a mobile terminal, can achieve responsive design for different terminals by adjusting the style and size of the microscope parameter input interface to fit the mobile terminal, so that the interactive page can have a good display effect on different terminal devices.

[0106] In one exemplary embodiment, this application provides a microscope parameter processing method, which can be applied to a microscope parameter calculation system (or microscope calculator). This system can adopt a B / S (browser / server) architecture, be implemented using pure front-end technologies such as HTML5, CSS3, and JavaScript, and support mainstream browsers (Chrome, Firefox, Safari, Edge). The core modules included in this system are as follows: Figure 3 As shown.

[0107] This system can be implemented using a standalone HTML file, and deployment methods include: local operation: opening the HTML file directly in a browser; server deployment: placing it on a web server and accessing it via a URL; and integrated deployment: embedding it into a Hospital Information System (HIS) or Pathology Information System (PIS). Medical institutions can use it in pathology departments and laboratories at all levels of hospitals; medical education institutions can use it as a teaching aid for pathology teaching in medical schools; medical device companies can use it as supplementary software for microscopes; and medical information technology companies can integrate it into pathology information systems.

[0108] The system implements the flow of the microscope parameter processing method provided in this application, including:

[0109] Automated parameter conversion: through methods such as Figure 4 The microscope parameter input interface shown responds to the microscope parameter input operation on the microscope parameter input interface of the microscope parameter calculator, and obtains the input microscope parameters (microscope optical parameters); based on the input microscope optical parameters, the field of view diameter, single field of view area, and total magnification can be automatically calculated by the basic calculation unit.

[0110] Multi-standard intelligent conversion: Integrates WHO diagnostic criteria for at least 8 common types of tumors, including gastrointestinal stromal tumors (GIST), breast cancer, neuroendocrine tumors, thyroid tumors, and phyllodes tumors. Through the diagnostic criteria conversion unit, based on the diagnostic criteria for each type of tumor, it can automatically convert the area threshold into the specific number of fields of view under the current microscope (target microscope) corresponding to the input microscope parameters. That is, the target number of fields of view required to observe the number of nuclear divisions of each type of tumor within the field of view of the target microscope.

[0111] Real-time visualization: Based on the target number of views, a report is generated, and a report results display interface containing the report results is displayed, as shown in the image. Figure 5 As shown, this enables real-time calculation and aesthetically pleasing result display through web front-end technology. Simultaneously, it can respond to the input of statistical precision in the microscope parameter input interface, obtain the input statistical precision, and generate report results based on that precision.

[0112] By standardizing the calculation of microscope parameters, diagnostic discrepancies caused by equipment differences and human calculation errors can be reduced, thus improving diagnostic consistency. Actual testing shows that using the microscope parameter calculation system employing the microscope parameter processing method provided in this application reduces the calculation time for nuclear division counts from an average of 8 minutes to 10 seconds, improving parameter conversion efficiency and lowering the calculation error rate. This reduces the likelihood of duplicate examinations or misdiagnosis due to calculation errors.

[0113] It should be noted that the specific limitations of the above steps can be found in the specific limitations of a microscope parameter processing method described above.

[0114] It should be understood that although the steps in the flowcharts of the embodiments described above are shown sequentially according to the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless explicitly stated herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least some steps in the flowcharts of the embodiments described above may include multiple steps or multiple stages. These steps or stages are not necessarily completed at the same time, but can be executed at different times. The execution order of these steps or stages is not necessarily sequential, but can be performed alternately or in turn with other steps or at least some of the steps or stages in other steps. It is understood that the steps in different embodiments can be freely combined as needed, and all non-contradictory solutions formed by such combinations are within the scope of protection of this application.

[0115] Based on the same inventive concept, this application also provides a microscope parameter processing apparatus for implementing the microscope parameter processing method described above. The solution provided by this apparatus is similar to the solution described in the above method; therefore, the specific limitations in one or more microscope parameter processing apparatus embodiments provided below can be found in the limitations of the microscope parameter processing method described above, and will not be repeated here.

[0116] In an exemplary embodiment, as shown in FIG6, a microscope parameter processing apparatus is provided, including:

[0117] The microscope parameter input module 610 is used to obtain the input microscope parameters in response to a microscope parameter input operation triggered in the displayed microscope parameter input interface.

[0118] The report results display module 620 is used to respond to the microscope parameter calculation operation triggered in the microscope parameter input interface and display the report results display interface. The report results display interface contains the report results of the target field of view number corresponding to multiple different types of tumors. The target field of view number is the number of nuclear divisions required to observe each type of tumor within the field of view of the target microscope based on the diagnostic criteria of each type of tumor. The target microscope is the microscope corresponding to the microscope parameters.

[0119] In one embodiment, the report result display module 620 is specifically used to respond to the microscope parameter calculation operation, obtain the actual field of view area corresponding to the target microscope according to the microscope parameters; the actual field of view area is used to characterize a high-power field of view of the target microscope; determine the target field of view number according to the ratio between the field of view area threshold corresponding to each type of tumor and the actual field of view area; the field of view area threshold is the field of view area required for observing and counting nuclear division numbers through a microscope in the diagnostic criteria for tumors; generate report results according to the target field of view number, and display a report result display interface containing the report results.

[0120] In one embodiment, the report result display module 620 is also used to obtain the actual field diameter based on the ratio between the number of eyepiece fields of view and the magnification of the objective lens; and to obtain the actual field of view area corresponding to the target microscope based on the actual field diameter.

[0121] In one embodiment, the report result display module 620 is also used to obtain the required grading area threshold for each grade of each type of tumor; and to obtain the number of target fields of view required for each grade of tumor based on the actual field area and the grading area threshold.

[0122] In one embodiment, the device is further configured to: obtain the microscopic area in response to a microscope parameter input operation triggered in the displayed microscope parameter input interface; obtain the general field of view number based on the ratio between the microscopic area and the actual field of view area in response to a microscope parameter calculation operation triggered in the microscope parameter input interface; the general field of view number is the number of nuclear divisions required within the field of view of the microscopic area; generate a report result containing the general field of view number; and display a report result display interface containing the report result.

[0123] In one embodiment, the microscope parameter input module 620 is further configured to, in response to a trigger operation on each microscope parameter input control in the microscope parameter input interface, display a selection list of microscope parameters corresponding to the microscope parameter input control; the selection list displays at least two parameter values ​​corresponding to the microscope parameters; and in response to a selection operation on the parameter values ​​in the parameter selection list, obtain the input microscope parameters.

[0124] In one embodiment, the report result display module 620 is also configured to display the report result display interface in response to a trigger operation of the microscope parameter calculation button control in the microscope parameter input interface.

[0125] In one embodiment, the device is further configured to play a preset animation at the display position of the target control when the target control is triggered; the target control is either a microscope parameter input control or a microscope parameter calculation button control.

[0126] In one embodiment, the device is further configured to, when the microscope parameter input interface is displayed on a mobile terminal, acquire the adjusted style size of the microscope parameter input interface; match the adjusted style size with the mobile terminal; and display the microscope parameter input interface according to the adjusted style size.

[0127] Each module in the aforementioned microscope parameter processing device can be implemented entirely or partially through software, hardware, or a combination thereof. These modules can be embedded in or independent of the processor in a computer device, or stored in the computer device's memory as software, so that the processor can call and execute the corresponding operations of each module.

[0128] In an exemplary embodiment, a computer device is provided, which may be a terminal, and its internal structure diagram is shown in Figure 7. The computer device includes a processor, memory, input / output interface, communication interface, display unit, and input device. The processor, memory, and input / output interface are connected via a system bus, and the communication interface, display unit, and input device are also connected to the system bus via the input / output interface. The processor of the computer device provides computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and internal memory. The non-volatile storage medium stores an operating system and computer programs. The internal memory provides an environment for the operation of the operating system and computer programs in the non-volatile storage medium. The input / output interface of the computer device is used for exchanging information between the processor and external devices. The communication interface of the computer device is used for wired or wireless communication with external terminals; wireless communication can be achieved through Wi-Fi, mobile cellular networks, Near Field Communication (NFC), or other technologies. When the computer program is executed by the processor, it implements a microscope parameter processing method. The display unit of the computer device is used to form a visually visible image and may be a display screen, a projection device, or a virtual reality imaging device.

[0129] Those skilled in the art will understand that Figure 7 The structure shown is merely a block diagram of a portion of the structure related to the present application and does not constitute a limitation on the computer device to which the present application is applied. Specific computer devices may include more or fewer components than those shown in the figure, or combine certain components, or have different component arrangements.

[0130] In one embodiment, a computer device is provided, including a memory and a processor. The memory stores a computer program, and the processor executes the computer program to implement the steps in the various embodiments of the microscope parameter processing method described above.

[0131] In one embodiment, a computer-readable storage medium is provided having a computer program stored thereon, which, when executed by a processor, implements the steps of the microscope parameter processing method described above.

[0132] In one embodiment, a computer program product is provided, including a computer program that, when executed by a processor, implements the steps described in various embodiments of a computational microscope parameter processing method.

[0133] It should be noted that the user information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, data stored, data displayed, etc.) involved in this application are all information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of the relevant data must comply with relevant regulations.

[0134] Those skilled in the art will understand that all or part of the processes in the above embodiments can be implemented by a computer program instructing related hardware. The computer program can be stored in a non-volatile computer-readable storage medium, and when executed, it can include the processes of the embodiments of the above methods. Any references to memory, databases, or other media used in the embodiments provided in this application can include at least one of non-volatile memory and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetic resistive random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory can include random access memory (RAM) or external cache memory, etc. By way of illustration and not limitation, RAM can take many forms, such as Static Random Access Memory (SRAM) or Dynamic Random Access Memory (DRAM). The databases involved in the embodiments provided in this application may include at least one type of relational database and non-relational database. Non-relational databases may include, but are not limited to, blockchain-based distributed databases. The processors involved in the embodiments provided in this application may be general-purpose processors, central processing units, graphics processing units, digital signal processors, programmable logic devices, quantum computing-based data processing logic devices, artificial intelligence processors, etc., and are not limited to these.

[0135] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this application.

[0136] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of this patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this application should be determined by the appended claims.

Claims

1. A method for processing microscope parameters, characterized in that, The method includes: In response to a microscope parameter input operation triggered in the displayed microscope parameter input interface, the input microscope parameters are obtained; In response to the microscope parameter calculation operation triggered in the microscope parameter input interface, a report result display interface is displayed. The report result display interface contains report results for the number of target fields of view corresponding to multiple different types of tumors. The number of target fields of view is the number of nuclear divisions required to observe each type of tumor within the field of view of the target microscope, based on the diagnostic criteria for each type of tumor. The target microscope is the microscope corresponding to the microscope parameters.

2. The method according to claim 1, characterized in that, The response to the microscope parameter calculation operation triggered in the microscope parameter input interface, displaying the report results interface, includes: In response to the microscope parameter calculation operation, the actual field of view area corresponding to the target microscope is obtained according to the microscope parameters; the actual field of view area is used to characterize a high-power field of view of the target microscope; The target number of fields of view is determined based on the ratio between the field of view area threshold corresponding to each type of tumor and the actual field of view area; the field of view area threshold is the field of view area required for observing and counting nuclear divisions under a microscope in the diagnostic criteria for the tumor. Based on the target number of fields of view, the report results are generated, and a report results display interface containing the report results is displayed.

3. The method according to claim 2, characterized in that, The microscope parameters include the number of eyepiece fields of view and the objective lens magnification of the target microscope; The step of obtaining the actual field of view area corresponding to the target microscope based on the microscope parameters includes: The actual field diameter is obtained by the ratio between the eyepiece field of view number and the objective lens magnification. The actual field of view area corresponding to the target microscope is obtained based on the actual field of view diameter.

4. The method according to claim 2, characterized in that, The field of view area threshold includes a grading area threshold, which is the field of view area required for the number of nuclear divisions used in tumor diagnostic criteria for grading and diagnosing tumors. The determination of the target field of view number based on the ratio between the visual field area threshold corresponding to each type of tumor and the actual visual field area includes: Obtain the required grading area thresholds for each grade of each type of tumor; Based on the actual field of view area and the grading area threshold, the number of target fields of view required for each of the multiple grades of the tumor is obtained.

5. The method according to claim 2, characterized in that, The microscope parameters also include the area under the microscope, and the method further includes: In response to a microscope parameter input operation triggered in the displayed microscope parameter input interface, the microscopic area is obtained; In response to a microscope parameter calculation operation triggered in the microscope parameter input interface, the general field of view number is obtained based on the ratio between the under-microscope area and the actual field of view area; the general field of view number is the number of nuclear divisions required within the field of view range of the under-microscope area. Generate a report containing the general field of view count, and display the report results interface containing the report results.

6. The method according to any one of claims 1 to 5, characterized in that, The microscope parameter input interface displays microscope parameter input controls and microscope parameter calculation button controls; there are at least two microscope parameter input controls; the process of obtaining the input microscope parameters in response to a microscope parameter input operation triggered in the displayed microscope parameter input interface includes: In response to a trigger operation on each of the microscope parameter input controls in the microscope parameter input interface, a selection list of microscope parameters corresponding to the microscope parameter input control is displayed; the selection list displays at least two parameter values ​​corresponding to the microscope parameter. In response to the selection of the parameter value in the parameter selection list, the input microscope parameters are obtained; The response to the microscope parameter calculation operation triggered in the microscope parameter input interface, displaying the report results interface, includes: In response to the triggering operation of the microscope parameter calculation button control in the microscope parameter input interface, the report result display interface is displayed.

7. The method according to claim 6, characterized in that, The method further includes: When the target control is triggered, a preset animation is played at the display position of the target control; the target control is either a microscope parameter input control or a microscope parameter calculation button control.

8. The method according to claim 1, characterized in that, The method further includes: When the microscope parameter input interface is displayed on a mobile terminal, the adjusted style size for the microscope parameter input interface is obtained; the adjusted style size is matched with the mobile terminal. The microscope parameter input interface is displayed according to the adjusted style size.

9. A microscope parameter processing device, characterized in that, The device includes: The microscope parameter input module is used to obtain the input microscope parameters in response to the microscope parameter input operation triggered in the displayed microscope parameter input interface. The report results display module is used to respond to the microscope parameter calculation operation triggered in the microscope parameter input interface and display the report results display interface. The report results display interface contains report results for the number of target fields of view corresponding to multiple different types of tumors. The number of target fields of view is the number of nuclear divisions required to observe each type of tumor within the field of view of the target microscope, based on the diagnostic criteria for each type of tumor. The target microscope is the microscope corresponding to the microscope parameters.

10. A computer device comprising a memory and a processor, wherein the memory stores a computer program, characterized in that, When the processor executes the computer program, it implements the steps of the method according to any one of claims 1 to 8.

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