Cosmetic preparations containing adenosine

Abstract

This invention relates to a sprayable hair conditioner in the form of an oil-in-water emulsion, comprising at least one water-soluble oil component (A), at least one nonionic emulsifier (B), at least one co-emulsifier (C), and water, wherein the water content is equal to 65-90 wt.%, component (A) is provided in an amount of 1.5 to 25 wt.%, and components (B) and (C) are provided in a total amount of 1 to 12 wt.%. A key feature of this invention is that adenosine is provided in an amount of 0.01 to 3 wt.%. This invention also relates to a method for preparing a sprayable aqueous formulation of adenosine, wherein an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A), said oil component (A) having an average droplet diameter of less than 1 μm (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water)), and the amount of the finely dispersed emulsion of oil component (A) is such that the formulation contains 1.5 to 20 wt.% of the emulsified oil component (A). The emulsion reaches its phase inversion temperature during or after production and before mixing with the adenosine solution. This invention also relates to the use of a sprayable aqueous formulation containing adenosine for cosmetic treatment of the skin, particularly the scalp, comprising less than 18 wt.% ethanol.

Description

[0001] This invention relates to the field of hair care products. Specifically, it relates to a sprayable aqueous formulation containing adenosine, which has skin and hair care effects.

[0002] This invention relates to a hair conditioner with hair care effects, such as preventing hair loss and promoting hair growth. Adenosine is an active ingredient used in various cosmetic formulations, such as hair conditioners, to prevent hair loss and promote hair growth. Such formulations are preferably sprayed onto the scalp and hair for ease of application and should not make the hair feel heavy after application.

[0003] It is desirable to be able to use high concentrations of adenosine in these formulations to achieve satisfactory results for users. Currently, high concentrations of adenosine, between 0.1 wt.% and 1.5 wt.%, can only be applied in sprayable formulations with an ethanol content of at least 20 wt.%. Adenosine cannot be stably incorporated into sprayable formulations with significantly lower ethanol contents. However, formulations with such high ethanol content result in severe scalp dryness and faster fading of dyed hair in consumers. Therefore, it is desirable to provide a formulation that overcomes the aforementioned drawbacks.

[0004] Therefore, the object of the present invention is to provide a stable, sprayable aqueous formulation in which adenosine is present in a high concentration and does not dry out the scalp.

[0005] Surprisingly, it was discovered that this objective could be achieved using an oil-in-water emulsion containing adenosine.

[0006] Therefore, the first subject of this application is a sprayable hair conditioner in the form of an oil-in-water emulsion, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one co-emulsifier (C), and water, wherein The water content is 60-90 wt.%. The component (A) is present in an amount of 1.5 to 25 wt.%. The components (B) and (C) are present in a total amount of 1 to 12 wt.%. Its characteristic is that the adenosine content is 0.01-3 wt.%.

[0007] The formulation according to the invention contains a water-insoluble oil component (A) in an amount of 1.5 to 25 wt.%, preferably 5.0 to 20 wt.%, and particularly preferably 10 to 15 wt.%. The water-insoluble oil component (A) is preferably selected from fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

[0008] Fatty acid esters with an alkyl chain length of C8 to C36 are preferably those esterified with a saturated alcohol with an alkyl chain length of C3 to C26. Preferably, for example, it is a saturated C8-C26 fatty acid ester. 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 OOH) esters and / or isopropyl myristate. Based on the formulation according to the invention, these fatty acid esters are preferably used in amounts of 5.0 to 25 wt.%, particularly preferably 7 to 20 wt.%, and especially preferably 8 to 15 wt.%.

[0009] Natural triglycerides can be vegetable triglycerides, such as the liquid fraction of olive oil, almond oil, peanut oil, sunflower oil, soybean oil, rapeseed oil, palm oil, and coconut oil or palm kernel oil, or mixtures thereof. Natural triglycerides can also be animal-derived triglycerides, such as the liquid fraction of cow's foot oil and / or tallow. When using natural triglycerides, they are preferably vegetable triglycerides according to the present invention. Synthetic triglycerides can be those obtained by esterification of glycerol with fatty acids having 8-22 carbon atoms, such as triglycerides of caprylic-capric acid mixtures, triglycerides from industrial oleic acid or from palmitic-oleic acid mixtures, or mixtures thereof. Natural or synthetic triglycerides, fatty acid esters, or mixtures thereof are preferably those that are liquid at 20°C and 1013 mbar. However, higher melting point triglycerides and esters conforming to the given chemical formula can also be used, in amounts such that the mixture of oil components remains liquid at 20°C and 1013 mbar. Based on the formulation according to the invention, these triglycerides are preferably used in amounts of 1.5 to 25 wt.%, particularly preferably 5.0 to 15 wt.%.

[0010] The hydrocarbons that are liquid at 20°C and 1013 mbar can be C11 to C16 hydrocarbons, such as straight-chain C11 to C16 hydrocarbons or branched C11 to C16 hydrocarbons. Preferably, for example, they are mixtures of n-undecane and n-tetane or isododecane and / or isohexadecane. Based on the formulation according to the invention, these hydrocarbons are preferably used in amounts of 5.0 to 25 wt.%, particularly preferably 7 to 20 wt.%, and especially preferably 8 to 15 wt.%.

[0011] Therefore, the preferred subject is the formulation as described above, wherein the water-insoluble oil component (A) is selected from fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

[0012] Another preferred subject is a formulation as described above, wherein the water-insoluble oil component (A) is saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10A mixture of triglycerides of OOH ester and octanoic acid-decanoic acid mixture, preferably in an amount of 2.0 to 10 wt.%.

[0013] The formulation according to the invention contains at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C) in a total amount of 1 to 12 wt.%. In the formulation according to the invention, the total amount of nonionic emulsifier (B) and nonionic co-emulsifier (C) is preferably 3.0-10 wt.%, particularly preferably 5.0-8.0 wt.%.

[0014] At least one nonionic emulsifier (B) is preferably derived from one or more alkoxylated C8-C22 fatty alcohols, more preferably alkoxylated C16-C22 fatty alcohols. Particularly preferred are ethoxylated C8-C22 fatty alcohols having 8 to 26 EOs, and particularly preferred are ethoxylated C16-C18 fatty alcohols having 12 to 20 EOs.

[0015] At least one nonionic emulsifier (B) may also preferably be one or more alkyl polyglucosides. In this case, they are preferably C8-C18 polyglucosides, particularly lauryl glucoside, decyl glucoside, and cocoyl glucoside, or mixtures thereof.

[0016] Further preferred is that at least one nonionic emulsifier (B) has an HLB value of 10 to 18.

[0017] Therefore, the preferred subject matter is the formulation listed above, wherein the at least one nonionic emulsifier (B) comprises one or more alkoxylated C16-C22 fatty alcohols.

[0018] Therefore, another preferred subject is a formulation as described above, wherein the at least one nonionic emulsifier (B) comprises one or more alkyl polyglucosides.

[0019] Therefore, another preferred subject is a formulation as described above, wherein the at least one nonionic emulsifier (B) has an HLB value of 10 to 18.

[0020] Therefore, another preferred subject is a formulation as described above, wherein the at least one nonionic emulsifier (B) comprises a mixture of alkoxylated C8-C22 fatty alcohols and / or C8 to C16 polyglucosides.

[0021] Furthermore, a mixture comprising different nonionic emulsifiers (B) is preferred.

[0022] Another preferred subject is a formulation as described above, wherein the nonionic emulsifier (B) comprises a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO).

[0023] The at least one nonionic co-emulsifier (C) is preferably one or more selected from C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitol, C12-C22 fatty alcohols, and mixtures thereof.

[0024] The at least one nonionic co-emulsifier (C) may preferably be a C8-C22 monofatty acid ester of glycerol or a mixture thereof, particularly preferably glyceryl monostearate, glyceryl monolaurate, glyceryl caprylate or a mixture thereof.

[0025] At least one nonionic co-emulsifier (C) may preferably be a C10-C18 monofatty acid ester of sorbitol or a mixture thereof, particularly preferably sorbitol monolaurate, sorbitol monooleate, sorbitol monostearate or a mixture thereof.

[0026] At least one nonionic co-emulsifier (C) may preferably be a C12-C22 fatty alcohol, particularly preferably cetearyl alcohol, myristyl alcohol, behenyl alcohol or a mixture thereof.

[0027] Therefore, the preferred subject matter is the formulation listed above, wherein the at least one nonionic co-emulsifier (C) comprises one or more selected from C8-C22 monoglycerides, sorbitol C10-C18 monoglycerides, C12-C22 fatty alcohols, and mixtures thereof.

[0028] Therefore, another preferred subject is a formulation as listed above, wherein the at least one nonionic co-emulsifier (C) comprises C12-C22 monofatty acid glycerides or mixtures thereof, with glyceryl monostearate being particularly preferred.

[0029] Therefore, another preferred subject is a formulation as listed above, wherein the at least one nonionic co-emulsifier (C) comprises sorbitol C10-C18 monofatty acid esters or mixtures thereof, particularly preferably sorbitol monolaurate, sorbitol monooleate, sorbitol monostearate or mixtures thereof.

[0030] Therefore, another preferred subject is a formulation as described above, wherein the at least one nonionic co-emulsifier (C) has a C12-C22 fatty alcohol or a mixture thereof, particularly preferably cetearyl alcohol.

[0031] Furthermore, a mixture of different nonionic co-emulsifiers (C) is preferred.

[0032] Therefore, another preferred subject is a formulation as listed above, wherein the nonionic coemulsifier (C) has a mixture of monoacylglycerols (mainly stearic acid (C18) and palmitic acid (C16) glycerols (INCI: monostearate)) and cetearyl alcohol.

[0033] Therefore, another preferred subject is the formulation as described above, wherein The nonionic emulsifier (B) is a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). The nonionic co-emulsifier (C) is a mixture of monoacylglycerols (mainly stearic acid (C18) and palmitic acid (C16) glycerols (INCI: monostearate)) and cetearyl alcohol, and the total amount of components (B) and (C) is preferably 3.0 to 10 wt.%, particularly preferably 5.0 to 8.0 wt.%.

[0034] Therefore, another preferred subject is the formulation as described above, wherein The nonionic emulsifier (B) is a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). The nonionic co-emulsifier (C) comprises a mixture of monoglycerides (primarily stearic acid (C18) and palmitic acid (C16) glycerides (INCI: glyceryl monostearate)) and cetearyl alcohol, and The water-insoluble oil component (A) is saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 A mixture of triglycerides of OOH) esters and a mixture of caprylic-capric acid, or saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 OOH) ester, or a mixture of n-undecane and n-tetrazane, or isopropyl myristate.

[0035] The hair conditioner for which protection is sought contains 0.01 to 3.0 wt.% adenosine. Adenosine is a nucleotide and consists of the nucleobase adenine and the sugar β-D-ribose. Preferred formulations contain 0.05-3.0 wt.%, particularly preferably 0.1-2 wt.%, especially 0.1-1.0 wt.% adenosine. Furthermore, formulations containing 0.2 to 1.5 wt.%, especially 0.5 to 1.0 wt.% adenosine are also preferred.

[0036] Therefore, the preferred subject is a hair conditioner containing 0.1 to 2.0 wt.%, particularly 0.1 to 1.0 wt.%, of adenosine.

[0037] The claimed hair conditioner contains adenosine as an active ingredient. The hair conditioner may also contain adenosine derivatives, such as adenosine-5'-phosphate. Preferably, the claimed formulation contains only a limited amount of adenosine derivatives, such as adenosine-5'-phosphates, such as adenosine monophosphate (INCI: adenosine phosphate), adenosine diphosphate, and / or adenosine triphosphate (INCI: adenosine triphosphate). Preferably, the formulation contains less than 0.5 wt.%, particularly preferably less than 0.2 wt.%, especially less than 0.1 wt.% of adenosine phosphates. Specifically, it is preferable that the formulation does not contain adenosine phosphates. In this context, "not containing adenosine phosphates" means that adenosine phosphates are neither added as a separate ingredient nor incorporated into the claimed formulation through formulations of other ingredients, for example, in an amount of at most 0.001 wt.% based on the total mass of the formulation.

[0038] Therefore, the preferred subject is a hair conditioner containing less than 0.5 wt.%, particularly less than 0.2 wt.%, especially less than 0.1 wt.% of one or more ingredients derived from adenosine-5'-phosphate.

[0039] Therefore, the preferred subject is a hair conditioner containing 0.05 to 3.0 wt.%, particularly preferably 0.1 to 2 wt.%, especially 0.1 to 1.0 wt.%.

[0040] Therefore, another preferred subject is the formulation as described above, wherein The nonionic emulsifier (B) is a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). The nonionic co-emulsifier (C) comprises a mixture of monoglycerides (primarily stearic acid (C18) and palmitic acid (C16) glycerides (INCI: glyceryl monostearate)) and cetearyl alcohol, and The water-insoluble oil component (A) is saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 A mixture of triglycerides of OOH) esters and a mixture of caprylic-capric acid, or saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 OOH) ester, or a mixture of n-undecane and n-tridecane, or isopropyl myristate, and The adenosine content is 0.05-3.0 wt.%, particularly preferred to be 0.1-2 wt.%, especially 0.5-1.0 wt.%.

[0041] Therefore, another preferred subject is the formulation as described above, wherein The nonionic emulsifier (B) is a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). The nonionic co-emulsifier (C) comprises a mixture of monoglycerides (primarily stearic acid (C18) and palmitic acid (C16) glycerides (INCI: glyceryl monostearate)) and cetearyl alcohol, and The water-insoluble oil component (A) is saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 A mixture of triglycerides of OOH) esters and a mixture of caprylic-capric acid, or saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 OOH) ester, or a mixture of n-undecane and n-tridecane, or isopropyl myristate, and The adenosine content is 0.05 to 3.0 wt.%, particularly preferably 0.1 to 2 wt.%, especially 0.5 to 1.0 wt.%, and it has less than 0.5 wt.%, particularly preferably less than 0.2 wt.%, especially preferably less than 0.1 wt.% of one or more components derived from adenosine-5'-phosphate.

[0042] The aqueous implementation contains 65 to 90 wt.% water. Preferably, it contains 70 to 85 wt.%, and particularly preferably 70 to 80 wt.% water. The water is primarily used to adjust the concentration of the previously defined ingredients to a range suitable for an aqueous sprayable hair conditioner.

[0043] Preferably, the claimed formulation has a pH value of 2.0 to 11.0 at 20°C, more preferably 3.0 to 7.0, particularly preferably 4.0 to 6.0, and especially preferably 4.5 to 5.5. Therefore, the preferred subject matter is the formulation as described above, wherein the formulation has a pH value of 2.0 to 11.0 at 20°C, more preferably 3.0 to 7.0, particularly preferably 4.0 to 6.0, and especially preferably 4.5 to 5.5. All pH values ​​given in this application are applicable to measurements at 20°C.

[0044] To ensure improved skin compatibility compared to compositions with high ethanol content, the claimed hair conditioner preferably contains less than 18 wt.%, particularly preferably up to 10 wt.%, and especially preferably up to 5 wt.% of ethanol.

[0045] Therefore, the preferred subject is a hair conditioner as described above, which contains less than 18 wt.%, particularly preferably up to 10 wt.%, and especially preferably up to 5 wt.% ethanol.

[0046] Furthermore, it is preferred that the hair conditioner containing the claimed protection contains a maximum of 5 wt%, particularly preferred less than 1 wt%, especially preferred less than 0.5 wt% ethanol, or contains no ethanol.

[0047] In this context, "ethanol-free" means that ethanol is neither added as a separate ingredient nor introduced into the claimed formulation via other ingredients, for example, in an amount of up to 2 wt.% based on the total mass of the formulation. Therefore, another preferred subject is a hair conditioner as described above, containing up to 5 wt.%, particularly preferably less than 1 wt.%, particularly preferably less than 0.5 wt.%, even more preferably less than 0.1 wt.% of ethanol, or ethanol-free thereof.

[0048] To ensure the stability of the composition and achieve a fine distribution of components, it is important that the oil component (A) exists as small droplets in the emulsion. According to the invention, it is preferred that the average droplet diameter of the oil component (A) is less than 1 μm, more preferably less than 600 nm, and more preferably less than 300 nm (measured using an instrument based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water)).

[0049] Therefore, the preferred subject is a hair conditioner as described above, wherein the average droplet diameter of the oil component (A) is less than 1 μm, preferably less than 600 nm, more preferably less than 300 nm, and this average droplet diameter is measured using an instrument based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water).

[0050] As described above, the water-based sprayable hair conditioner can be easily applied by the user to the relevant area. Because it is sprayable, it can be distributed finely and evenly. To ensure good sprayability, the hair treatment composition according to the invention preferably does not contain thickening ingredients, such as polyquaternium salt polymers known under the INCI names Polyquaternium-10 and Polyquarternium-37, provided that this is compatible with economical operation, i.e., provided that small amounts of the corresponding substances are not introduced as minor components or impurities in industrial standard ingredients. Based on the total weight of the hair treatment composition, the amount of such equivalent thickening ingredients contained in the hair treatment composition according to the invention is preferably at most 2 wt.%, more preferably at most 0.5 wt.%, and particularly preferably at most 0.1 wt.%.

[0051] According to the invention, the hair conditioner, as described above, preferably has a viscosity of up to 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s, as measured using a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM), to ensure good sprayability.

[0052] Therefore, the preferred subject is a hair conditioner as described above, having a viscosity of up to 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, especially 1.0 to 20.0 mPa*s, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM).

[0053] Compositions capable of addressing the aforementioned objectives are prepared in a specific manner. Therefore, another subject of this application is a method for preparing a sprayable aqueous formulation of adenosine, wherein an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A), wherein the oil component (A) has an average droplet diameter of less than 1 μm (measured by an instrument based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water)), the amount of the finely dispersed emulsion of said oil component (A) such that the formulation contains 1.5 to 20 wt.% of the emulsified oil component (A), wherein the emulsion is brought to a phase inversion temperature during or after its preparation and before mixing with the adenosine solution.

[0054] In the preferred method, the average droplet diameter of the oil component (A) is preferably less than 600 nm, more preferably less than 300 nm.

[0055] Furthermore, it is preferred that the aqueous solution of adenosine has a temperature of up to 50°C, preferably up to 45°C, and / or the temperature of the finely dispersed emulsion of oil component (A) is 30 to 50°C, preferably 30 to 40°C, the temperature being measured directly before the mixed solution and emulsion.

[0056] A particularly preferred method is that the finely dispersed emulsion of the oil component (A) is a PIT emulsion that further comprises at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C).

[0057] Furthermore, the method according to the invention is preferred, wherein the pH of the preparation is adjusted to a value of 2-11, preferably 3.0-7.0.

[0058] Therefore, the preferred subject matter is the claimed method as described above, wherein the aqueous solution of adenosine has a temperature of up to 50°C, preferably up to 45°C, and / or the temperature of the finely dispersed emulsion of the oil component (A) is 30 to 50°C, preferably 30 to 40°C, the temperature being measured directly before mixing the solution and emulsion.

[0059] Therefore, another preferred subject is the claimed method as described above, wherein the finely dispersed emulsion of the oil component (A) is a PIT emulsion further containing at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C).

[0060] Therefore, another preferred subject is the method claimed as described above, wherein the pH of the formulation is adjusted to a value of 3.0 to 7.0.

[0061] Therefore, a particularly preferred subject is the claimed method as described above, wherein the finely dispersed emulsion of the oil component (A) is a PIT emulsion further containing at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C), and wherein the pH of the formulation is adjusted to a value of 3.0 to 7.0, wherein, if applicable, the aqueous solution of adenosine has a temperature of up to 50°C, preferably up to 45°C, and / or the temperature of the finely dispersed emulsion of the oil component (A) is 30 to 50°C, preferably 30 to 40°C, the temperature being measured directly before mixing the solution and the emulsion.

[0062] The foregoing has already described stable aqueous compositions containing high concentrations of adenosine. Therefore, another subject of this application is the use of sprayable aqueous emulsions with an ethanol content of less than 18 wt.% to stabilize adenosine.

[0063] Another subject of this application is the use of adenosine-containing sprayable aqueous formulations with an ethanol content of less than 18 wt.% for cosmetic treatment of the skin, particularly the scalp.

[0064] All information provided for the formulation is also directly applicable to the method and use.

[0065] This applies in particular to, but not limited to, the data and properties of components (A), (B), and (C), ethanol content, viscosity, measurement method, pH value, and other specified components.

[0066] The subject matter for which protection is sought is further described, but not exhaustively, by the following items: Project 1: A sprayable hair conditioner in the form of an oil-in-water emulsion, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one co-emulsifier (C), and water, wherein... The water content is 65-90 wt.%. The component (A) is present in an amount of 1.5 to 25 wt.%. The components (B) and (C) are present in a total amount of 1 to 12 wt.%. Its characteristic is that the adenosine content is 0.01-3 wt.%.

[0067] Project 2: The formulation according to Project 1, wherein the formulation contains less than 0.5 wt.%, particularly preferably less than 0.2 wt.%, especially less than 0.1 wt.% of one or more components derived from adenosine-5′-phosphate.

[0068] Project 3: According to one of the aforementioned projects, the average droplet diameter of the oil component (A) is less than 1 μm, preferably less than 600 nm, more preferably less than 300 nm, which is measured using an instrument based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water).

[0069] Project 4: A formulation according to one of the preceding projects, wherein the formulation has a viscosity of up to 150 mPa*s at 20°C, particularly preferably 0.8 to 50 mPa*s, especially 1 to 20 mPa*s, which is measured using a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM).

[0070] Item 5: A formulation according to one of the preceding items, wherein the pH of the formulation at 20°C is 2.0 to 11.0, preferably 3.0 to 7.0, particularly preferably 4.0 to 6.0, and particularly preferably 4.2 to 5.5.

[0071] Project 6: A formulation according to one of the preceding projects, wherein the at least one water-insoluble oil component (A) is selected from fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

[0072] Item 7: A formulation according to one of the foregoing items, wherein the at least one nonionic emulsifier (B) is one or more of alkoxylated C8-C22 fatty alcohols, preferably alkoxylated C16-C22 fatty alcohols.

[0073] Item 8: A formulation according to one of the preceding items, wherein the at least one nonionic emulsifier (B) is one or more derived from alkyl polyglucosides.

[0074] Item 9: A formulation according to one of the preceding items, wherein the at least one nonionic emulsifier (B) has an HLB value of 10 to 18.

[0075] Item 10: A formulation according to one of the preceding items, wherein the at least one nonionic co-emulsifier (C) is selected from one or more of C8-C22 monofatty acid glycerides, C10-C18 monofatty acid dehydrated sorbitol esters, C12-C22 fatty alcohols and mixtures thereof.

[0076] Item 11: A formulation according to one of the preceding items, wherein the formulation contains less than 18 wt.%, preferably up to 10 wt.%, particularly preferably up to 5 wt.%, more preferably less than 1 wt.% of ethanol.

[0077] Item 12: A formulation according to one of the preceding items, wherein the formulation contains 0.05 to 3.0 wt.%, particularly preferably 0.1 to 2 wt.%, especially 0.1 to 1.0 wt.% of adenosine.

[0078] Project 13: A method for preparing a sprayable aqueous formulation of adenosine, wherein an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A), said oil component (A) having an average droplet diameter of less than 1 μm (measured by an instrument based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water)), the amount of said finely dispersed emulsion of said oil component (A) being such that the formulation contains 1.5 to 20 wt.% of the emulsified oil component (A), said emulsion having reached the phase inversion temperature during or after its preparation and before mixing with the adenosine solution.

[0079] Project 14: Use of aquatic sprayable formulations containing adenosine with an ethanol content of less than 18 wt.% for cosmetic treatment of the skin, especially the scalp.

[0080] Exemplary implementation scheme: The following compositions (Examples 1-3 and E1-E3) were prepared in the same manner: For production, the (co)emulsifier is converted into a PIT emulsion together with the oil component and water (the ratio of (co)emulsifier to oil component to water is 1:2 to 1:3), thereby bringing the emulsion to the phase inversion temperature during or after production. Subsequently, an aqueous adenosine solution (1.5% to 2.5%) is added. The temperature of the PIT emulsion is up to 35°C, and the temperature of the adenosine solution is up to 50°C. After cooling to room temperature (20°C), fragrance is (optionally) added. Optional ingredients such as fragrance and preservatives are introduced via the adenosine solution.

[0081] Example formulation:

[0082] 1INCI: Glyceryl stearate (and) cetearyl alcohol polyether-20 (and) cetearyl alcohol polyether-12 (and) cetearyl alcohol (and) cetyl palmitate 2 INCI: Cetearyl alcohol polyether-12 3 INCI: Cocoyl octanoate / decanoate 4 INCI: Undecane (and) Tridecane The following emulsions (E1-E3) and solutions (V1) are provided: For V1, dissolve an appropriate amount of adenosine in water.

[0083] 1 INCI: Glyceryl stearate (and) cetearyl alcohol polyether-20 (and) cetearyl alcohol polyether-12 (and) cetearyl alcohol (and) cetyl palmitate 2 INCI: Cetearyl alcohol polyether-12 3 INCI: Cocoyl octanoate / decanoate 4 INCI: Undecane (and) Tridecane It has been shown that PIT emulsions can stabilize the amount of adenosine used and yield stable, sprayable compositions with suitable viscosity (E1-E3). Aqueous compositions containing adenosine but without an oil phase and emulsifier are unstable; precipitates form after 24 hours (V1).

[0084] For composition E1, the particle size of the oil phase and the viscosity of the composition were determined: Average particle size: 62 nm Instrument: Zetasizer Nano ZS Cuvette: Square, 12mm rim length, polystyrene cuvette (model DTS0012); Dilution: Dilute 0.25g of composition E1 in 9.75g of water and measure. Viscosity: 7.5-10 mPa*s (based on multiple repetitions and measurements) Instrument: Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM, 20℃)

Claims

1. A sprayable hair conditioner in the form of an oil-in-water emulsion, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one co-emulsifier (C), and water, wherein The water content is 65-90 wt.%. The component (A) is present in an amount of 1.5 to 25 wt.%. The components (B) and (C) are present in a total amount of 1 to 12 wt.%. Its features are, The adenosine content is 0.01-3 wt.%.

2. The formulation according to any one of the preceding claims, characterized in that, It has a pH of 2.0 to 11.0, preferably 3.0 to 7.0, more preferably 4.0 to 6.0, and particularly preferably 4.5 to 5.5 at a temperature of 20°C.

3. The formulation according to any one of the preceding claims, wherein the at least one water-insoluble oil component (A) is selected from fatty acid esters having a fatty acid alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

4. The formulation according to any one of the preceding claims, wherein the at least one nonionic emulsifier (B) is one or more of alkoxylated C8-C22 fatty alcohols, preferably alkoxylated C16-C22 fatty alcohols.

5. The formulation according to any one of the preceding claims, wherein the at least one nonionic emulsifier (B) is one or more derived from alkyl polyglucosides.

6. The formulation according to any one of the preceding claims, wherein the at least one nonionic co-emulsifier (C) is one or more of C8-C22 monofatty acid glycerides, C10-C18 monofatty acid dehydrated sorbitol esters, C12-C22 fatty alcohols and mixtures thereof.

7. The formulation according to any one of the preceding claims, wherein the formulation contains less than 18 wt.%, preferably up to 10 wt.%, particularly preferably up to 5 wt.%, and more preferably less than 1 wt.% of ethanol.

8. The formulation according to any one of the preceding claims, wherein the formulation comprises 0.05 to 3.0 wt.%, particularly preferably 0.1 to 2 wt.%, especially 0.1 to 1.0 wt.% of adenosine.

9. A method for producing a sprayable aqueous formulation of adenosine, wherein an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A), wherein the oil component (A) has an average droplet diameter of less than 1 μm (measured by an instrument based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water)), the amount of the finely dispersed emulsion of the oil component (A) is such that the formulation contains 1.5 to 20 wt.% of the emulsified oil component (A), wherein the emulsion reaches the phase inversion temperature during or after its preparation and before being mixed with the adenosine solution.

10. Sprayable aqueous formulations containing adenosine with an ethanol content of less than 18 wt.% for use in cosmetic treatments of the skin, especially the scalp.

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