Probiotic formulations and uses thereof

By controlling the water activity and the types of probiotics combined in the probiotic preparation, the problem of poor live bacteria stability at room temperature was solved, achieving stable preservation of high live bacteria count and improvement of functional gastrointestinal disorders.

CN122140774APending Publication Date: 2026-06-05HANGZHOU GRAND BIOLOGIC PHARMA INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HANGZHOU GRAND BIOLOGIC PHARMA INC
Filing Date
2026-01-28
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Current probiotic preparations have poor live bacteria stability at room temperature, making it difficult to maintain a high number of live bacteria without a cold chain. Furthermore, existing encapsulation technologies offer limited improvement in long-term stability, leading to a decline in product viability during the shelf life and affecting product reliability and efficacy.

Method used

By screening and compounding active ingredients and excipients, the water activity of probiotic preparations is controlled to 0.04-0.3. By combining aerobic bacteria, organic acid-producing bacteria and site-occupying bacteria, and using prebiotics and antioxidants, a dormant state of freeze-dried probiotics is formed, thereby improving the activity stability at room temperature.

Benefits of technology

It significantly improves the live bacteria stability of probiotic preparations at room temperature, extends the number of live bacteria during the shelf life, solves the problem of activity decay at room temperature, achieves stable preservation of high live bacteria count, and improves functional gastrointestinal disorders such as diarrhea and constipation.

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Abstract

The application provides a probiotic preparation and application thereof. The probiotic preparation comprises active ingredients and adjuvants, wherein the active ingredients comprise oxygen scavenging bacteria, organic acid producing bacteria and space-occupying bacteria; the oxygen scavenging bacteria are Weizmannia bacteria, the organic acid producing bacteria are lactobacillus or lactobacillus plantarum, and the space-occupying bacteria are bifidobacterium; the water activity of the probiotic preparation is less than or equal to 0.3, preferably 0.04-0.3, further preferably 0.04-0.2, and more preferably 0.04-0.15. The probiotic preparation has high live bacteria stability when stored at room temperature. Moreover, the probiotic preparation can effectively improve functional gastrointestinal diseases and has bidirectional regulation function, and is suitable for different intestinal motility disorders, such as diarrhea and constipation.
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