Hydrogel-based composition for mitochondrial protection, cosmetic and skin repair, and use thereof

By combining a hydrogel carrier with mitochondrial protective fluid and synergistic active ingredients, the stability and transdermal issues of mitochondria in the field of skin beauty are solved, achieving effective protection of mitochondria and skin repair, and enhancing the energy metabolism and antioxidant capacity of skin cells.

CN122140887APending Publication Date: 2026-06-05QILU SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QILU SCHOOL OF MEDICINE
Filing Date
2026-01-08
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

In existing technologies, the application of mitochondria in the field of skin beauty suffers from poor in vitro stability, weak transdermal ability, and a lack of comprehensive protection system, thus failing to fully realize its role in skin repair.

Method used

This product utilizes a hydrogel-based mitochondrial-protective cosmetic and skin repair composition, which includes a mitochondrial protection system and synergistic active ingredients. It uses a mitochondrial protection solution composed of mannitol, ATP, trehalose, etc., combined with antioxidant ingredients such as ascorbate palmitate, glutathione, and niacinamide. It is delivered transdermally via microneedles or ice needles to enhance mitochondrial stability and transdermal delivery capabilities.

Benefits of technology

It achieves effective protection and transdermal delivery of mitochondria, improves in vitro stability, significantly improves the energy metabolism of skin cells, enhances cell repair ability, reduces skin problems such as wrinkles, sagging, and pigmentation, and provides an anti-inflammatory microenvironment.

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Abstract

The application belongs to the technical field of biological medicine and medical cosmetology, and particularly relates to a kind of composition for mitochondrial protection type cosmetology and skin repair based on hydrogel and application thereof, the composition comprises a mitochondrial protection system and a synergistic active ingredient, the mitochondrial protection system comprises a hydrogel and a mitochondrial protection solution, the hydrogel comprises a synthetic polymer, and the mitochondrial protection solution comprises 200-300 mM mannitol, 0.2-5 mM ATP and 0-5% w / v trehalose; the synergistic active ingredient comprises a mixture of one or more of 0.01-0.1% ascorbyl palmitate, 0.1-1 mM glutathione and 0.5-2% nicotinamide. The composition is applied to microneedle repair, ice needle patch preparation and mask preparation and other aspects; through microneedle repair, ice needle patch or mask and other forms, effective delivery of mitochondria is realized, all-round care and repair are provided for the skin, and the delivery capacity is improved.
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