A private part micro-ecological balance deodorant and sterilization and anti-virus private care spray

Abstract

The application discloses a private part care spray capable of balancing private part microecology, removing peculiar smell, killing bacteria and resisting viruses, and belongs to the technical field of private part care and disinfection materials. The private part care spray is prepared by compounding 3.8-6.5 parts of a modified edible bactericide, 3.2-5.5 parts of food-grade lactic acid, 2.2-3.0 parts of modified food-grade gentian root extract and the rest food-grade deionized water. The activity and stability of raw materials are improved through the processes of β-cyclodextrin inclusion modification of the bactericide and compounding of the modified product with the modified food-grade gentian root extract. The product has a killing rate of 99.9% on Neisseria gonorrhoeae, Gardnerella vaginalis, Bacteroides, Streptococcus pyogenes, Candida albicans, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa, an inactivation rate of 99.99% on herpes simplex virus SHV-2 and HPV16 virus, an ammonia removal rate of 95%, a peculiar smell inhibition duration of 48 h and a mucous membrane irritation level of 0, and the preparation process is simple and suitable for industrial production.

Description

Technical Field

[0001] This invention relates to the field of feminine hygiene disinfection materials, and more specifically, to a feminine hygiene spray that balances the microecology of the private area, eliminates odor, kills bacteria, and fights viruses. Background Technology

[0002] Feminine hygiene disinfection products need to combine high efficacy with gentle and safe properties. They must achieve antibacterial and antiviral effects, long-lasting odor removal, and be compatible with the acidic microenvironment of the intimate area (normal pH 3.8-4.5), without irritating delicate mucous membranes or disrupting the balance of beneficial bacteria. Existing products have several drawbacks: some antibacterial ingredients are not food-grade, raising safety concerns; some products have pH values ​​that deviate from the acidic environment of the intimate area, easily causing bacterial imbalance; some contain irritating ingredients such as fragrances and preservatives, posing a risk of allergies; and some have only a short-lived odor-removing effect, failing to eliminate odors at their root.

[0003] Edible disinfectants, as natural and safe antibacterial ingredients, meet edible standards and have a broad and gentle bactericidal spectrum. However, they are easily affected by the environment in their natural state and have a low activity retention rate. Food-grade lactic acid can adjust the pH value of the product to the range suitable for the private parts and help enhance the bactericidal effect. However, the synergistic effect of lactic acid in deodorizing and inhibiting bacteria is limited. Food-grade gentian root extract is rich in natural active ingredients and has anti-inflammatory, soothing, and deodorizing effects. However, the active ingredients in natural extracts have low solubility and are easily lost.

[0004] This solution addresses the shortcomings of low activity, poor stability, and limited efficacy of natural raw materials by modifying an edible disinfectant with β-cyclodextrin inclusion complex (first modified substance). Using this modified inclusion complex as the core component, a food-grade gentian root extract is further modified (second modified substance, containing the first modified substance). Combined with the pH adjustment and synergistic effect of food-grade lactic acid, this solution develops a safe, edible, and mildly compatible intimate spray agent with superior activity, stronger stability, and longer-lasting efficacy. Summary of the Invention

[0005] To address the problems of existing feminine hygiene sprays, such as strong irritation, numerous additives, limited coverage of antibacterial and antiviral effects, and short-lasting odor-eliminating effects, this application provides a feminine hygiene spray that balances the feminine microecology, eliminates odor, and kills bacteria and viruses. This product does not contain fragrances, pigments, alcohol, chlorine-based disinfectants, hypochlorous acid, preservatives, drugs, hormones, or other ingredients that may cause irritation or allergies. It achieves broad-spectrum and highly effective antibacterial and antiviral effects, while being gentle and non-irritating, helping to protect the feminine microecology. The preparation process is simple and suitable for industrial production.

[0006] Firstly, this application provides a feminine hygiene spray that balances the microecology of the private parts, eliminates odor, kills bacteria, and fights viruses, employing the following technical solution: A feminine hygiene spray that balances the microecology of the private parts, eliminates odor, kills bacteria, and fights viruses, contains 3.8-6.5 parts of modified edible antibacterial agent, 3.2-5.5 parts of food-grade lactic acid, 2.2-3.0 parts of modified food-grade gentian root extract, and the remainder of food-grade deionized water. The pH value of the spray reagent is 2.8-3.8, and the spray particle size is 10-50 μm; The spray reagent does not contain any fragrances, alcohol, pigments, preservatives, chlorine disinfectants, hypochlorous acid, drugs, hormones, or other irritating ingredients. Furthermore, the content of heavy metals such as mercury, lead, and arsenic meets the requirements of the "National Food Safety Standard for the Use of Food Additives" (GB2760). All raw materials and modified carriers are food-grade, and the entire product is edible.

[0007] Optionally, the modified edible antibacterial agent is a food-grade β-cyclodextrin-modified edible antibacterial agent, which is prepared by combining food-grade β-cyclodextrin and food-grade edible antibacterial agent at a mass ratio of 1:1.2-1.5, with an inclusion rate ≥90%; the edible antibacterial agent is food-grade ε-polylysine hydrochloride or food-grade lysozyme, with a purity ≥99% and an effective ingredient content ≥6.0%, meeting the GB2760 edible standard.

[0008] Optionally, the modified food-grade gentian root extract is a food-grade gentian root extract formulated with a modified edible antibacterial agent and enhanced with the modified edible antibacterial agent. It is prepared by compounding the modified edible antibacterial agent and the food-grade gentian root extract at a mass ratio of 0.3:1, with an effective component dissolution rate ≥95%. The food-grade gentian root extract is a food-grade water extract, odorless and non-irritating.

[0009] Optionally, the food-grade lactic acid content is ≥98%, and the acidity (calculated as lactic acid) is ≥85.0%, which meets the requirements of GB2760. It is used to adjust the pH value of the product to the range suitable for private parts, and at the same time, it works synergistically with the dual-modified raw materials to enhance the bactericidal and deodorizing effects.

[0010] Optionally, the food-grade β-cyclodextrin is a food-grade low-substituted β-cyclodextrin with a purity of ≥98%, meeting the GB2760 edible standard, and can be used as a modified carrier to improve the stability and water solubility of the antibacterial agent.

[0011] Secondly, this application provides a method for preparing a feminine hygiene spray that balances the microecology of the private parts, eliminates odor, kills bacteria, and fights viruses, using the following technical solution: S1. Take the formula amount of food-grade deionized water, add the formula amount of modified food-grade gentian root extract, stir at 25℃ and 280rpm for 15min until completely dissolved, and obtain a transparent modified extract base. S2. Take the amount of modified edible antibacterial agent powder in the formula and slowly add it to the base liquid. Stir at 300 rpm for 20 minutes until it is evenly dispersed. S3. Take the prescribed amount of food-grade lactic acid and add it dropwise to the above system while stirring (350 rpm) to adjust the pH value to 2.8-3.8. The product is homogenized once under high pressure at 15MPa (S4), filtered through a 0.22μm food-grade sterile filter membrane, and then filled into food-grade spray bottles to obtain the finished product. The preparation method of the modified edible antibacterial agent includes the following steps: S1. Take 10g of food-grade β-cyclodextrin, add 80ml of food-grade deionized water, heat to 55℃, stir at 300rpm for 30min until completely dissolved, to obtain β-cyclodextrin aqueous solution. S2. Take 12-15g of food-grade edible disinfectant (ε-polylysine hydrochloride or lysozyme), add 20ml of food-grade deionized water, stir at 25℃ for 15min until uniformly dispersed, and obtain the disinfectant dilution. S3. Slowly add the diluted disinfectant solution dropwise into the β-cyclodextrin aqueous solution, keep the temperature constant at 55℃ and stir at 350rpm for 80min to complete the inclusion. S4. Cool to room temperature, filter through a 0.45μm food-grade filter membrane, freeze-dry at -40℃ and 0.08MPa for 24h, pulverize and pass through a 200-mesh sieve to obtain modified edible antibacterial agent powder with an inclusion rate ≥90% and an effective ingredient retention rate ≥98%.

[0012] The preparation method of the modified food-grade gentian root extract includes the following steps: S1. Take 10g of food-grade dried gentian root, crush it through a 100-mesh sieve, add 100ml of food-grade deionized water, and extract at a constant temperature of 80℃ for 90min. S2. While still hot, filter through a 0.45μm food-grade filter membrane, collect the filtrate, and concentrate it to 1 / 5 of the original volume (about 20ml) to obtain a concentrated extract of gentian root. S3. Take 3g of the above modified edible antibacterial agent powder and add it to the concentrated extract of gentian root. Stir at 25℃ and 280rpm for 20min until completely dissolved to complete the compound modification and obtain modified food-grade gentian root extract with an active ingredient dissolution rate ≥95%. S4. Store in a sealed container at 4°C for later use. When needed, it can be reconstituted with food-grade deionized water.

[0013] In summary, this application has the following beneficial effects: 1. Using food-grade β-cyclodextrin as an inclusion carrier, it solves the problems of poor water solubility, susceptibility to environmental influences, and rapid loss of activity of natural edible disinfectants. After inclusion, the retention rate of effective ingredients is increased to ≥98%, and the bactericidal targeting is enhanced. At the same time, the cavity structure of β-cyclodextrin can adsorb odor molecules, which helps to improve the deodorization effect. No non-food-grade ingredients are added throughout the process, maintaining edibility and gentleness. 2. Using modified edible antibacterial agent as a compound component, its solubilizing and synergistic effects are utilized to improve the dissolution rate (≥95%) of anti-inflammatory and deodorizing active ingredients in food-grade gentian root extract. At the same time, it achieves synergistic effects of "antibacterial + anti-inflammatory + deodorizing", solving the problems of low solubility and single efficacy of active ingredients in natural food-grade gentian root extract. Moreover, the first modified substance is its core component, and the modification logic is coherent and in line with the laws of natural chemistry. 3. The synergistic effect of dual-modified raw materials and food-grade lactic acid, compared with the unmodified solution, increases the sterilization rate and virus inactivation rate by ≥0.5%, increases the retention rate of effective ingredients by ≥8% after 3 months of storage at room temperature, increases the odor suppression time by ≥30 hours, and further reduces the inhibition rate of lactobacillus (<3%), while maintaining the same mucosal mildness (0-level irritation), thus preserving the core advantages of edibility and non-irritation throughout the process. Detailed Implementation

[0014] To make this application easier to understand, the following detailed description will be provided with reference to embodiments. These embodiments are for illustrative purposes only and are not intended to limit the scope of application of this application. Unless otherwise specified, the raw materials or components used in this application can be obtained commercially or by conventional methods.

[0015] Some of the raw materials used in the preparation examples and embodiments: food-grade deionized water (CAS No.: 7732-18-5) was purchased from Wahaha Group and meets the GB17323-1998 standard for bottled drinking purified water; food-grade lysozyme (purity ≥99.5%, CAS No.: 9001-63-2) was purchased from Wuhan Yuanda Hongyuan Co., Ltd.; food-grade L-arginine (purity ≥99%, CAS No.: 74-79-3) was purchased from Anhui Huaheng Biotechnology Co., Ltd.; β-cyclodextrin (food grade, purity ≥99%, CAS No.: 7585-39-9) was purchased from Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.; γ-aminopropyltriethoxy Silane (food grade, CAS No.: 919-30-2) was purchased from Hangzhou Jessica Chemical Co., Ltd.; disodium EDTA (purity ≥99.5%, CAS No.: 6381-92-6) was purchased from COFCO Group; glycerol (purity ≥99.7%, CAS No.: 56-81-5) was purchased from Zhejiang Jiahe Energy Chemical Co., Ltd.; citric acid (purity ≥99.5%, CAS No.: 77-92-9) was purchased from Shandong Yingxuan Industrial Co., Ltd. (for pH adjustment only); xanthan gum (food grade, purity ≥99%, CAS No.: 11138-66-2) was purchased from Henan Longli Biotechnology Co., Ltd.

[0016] Unless otherwise specified, all raw materials used in the examples and comparative examples are conventional products that can be purchased from the market.

[0017] Preparation Example Preparation Example 1: S1. Take 10g of food-grade β-cyclodextrin, add 80ml of food-grade deionized water, heat to 55℃, stir at 300rpm for 30min until completely dissolved, to obtain β-cyclodextrin aqueous solution. S2. Take 13g of food-grade ε-polylysine hydrochloride (purity 99.5%, active ingredient 6.2%), add 20ml of food-grade deionized water, stir at 25℃ for 15min until uniformly dispersed to obtain a diluted disinfectant solution; S3. Slowly add the diluted disinfectant solution dropwise into the β-cyclodextrin aqueous solution, and react at a constant temperature of 55℃ and a stirring speed of 350rpm for 80min. S4. Cool to room temperature, filter through a 0.45μm food-grade filter membrane, freeze-dry at -40℃ and 0.08MPa for 24h, pulverize and pass through a 200-mesh sieve to obtain modified edible antibacterial agent powder (inclusion rate 92%, effective ingredient retention rate 98.5%).

[0018] Preparation Example 2: S1. Take 10g of food-grade β-cyclodextrin, add 80ml of food-grade deionized water, heat to 55℃, stir at 300rpm for 30min until completely dissolved, to obtain β-cyclodextrin aqueous solution. S2. Take 14g of food-grade lysozyme (purity 99.2%, active ingredient 6.0%), add 20ml of food-grade deionized water, stir at 25℃ for 15min until uniformly dispersed to obtain a diluted disinfectant solution; S3. Slowly add the diluted disinfectant solution dropwise into the β-cyclodextrin aqueous solution, and react at a constant temperature of 55℃ and a stirring speed of 350rpm for 80min. S4. Cool to room temperature, filter through a 0.45μm food-grade filter membrane, freeze-dry at -40℃ and 0.08MPa for 24h, pulverize and pass through a 200-mesh sieve to obtain modified edible antibacterial agent powder (inclusion rate 91%, effective ingredient retention rate 98.2%).

[0019] Preparation Example 3: Modified food-grade gentian root extract (combined with the product of Preparation Example 1) S1. Take 10g of food-grade dried gentian root, crush it through a 100-mesh sieve, add 100ml of food-grade deionized water, and extract at a constant temperature of 80℃ for 90min. S2. While still hot, filter through a 0.45μm food-grade filter membrane, collect the filtrate, and concentrate it to 20ml to obtain a concentrated extract of gentian root. S3. Take 3g of the modified edible antibacterial agent powder prepared in Preparation Example 1, add it to the concentrated extract of gentian root, stir at 25℃ and 280rpm for 20min until completely dissolved, and obtain the modified food-grade gentian root extract (active ingredient dissolution rate 96%). S4. Seal and refrigerate for later use.

[0020] Preparation Example 4: S1. Take 10g of food-grade dried gentian root, crush it through a 100-mesh sieve, add 100ml of food-grade deionized water, and extract at a constant temperature of 80℃ for 90min. S2. While still hot, filter through a 0.45μm food-grade filter membrane, collect the filtrate, and concentrate it to 20ml to obtain a concentrated extract of gentian root. S3. Take 3g of the modified edible antibacterial agent powder prepared in Preparation Example 2, add it to the concentrated extract of gentian root, stir at 25℃ and 280rpm for 20min until completely dissolved, and obtain the modified food-grade gentian root extract (active ingredient dissolution rate 95.5%). S4. Seal and refrigerate for later use. Example 1

[0021] Raw material formula (parts by weight): 4.8 parts modified edible antibacterial agent (product of preparation example 1), 3.2 parts food-grade lactic acid, 2.2 parts modified food-grade gentian root extract (product of preparation example 3), and 89.8 parts food-grade deionized water.

[0022] Preparation steps: S1. Take 89.8 ml of food-grade deionized water, add 2.2 parts of modified food-grade gentian root extract, stir at 25℃ and 280 rpm for 15 min to obtain a transparent base solution; S2. Add 4.8 parts of modified edible antibacterial agent powder, stir at 300 rpm for 20 minutes until evenly dispersed; S3. Add 3.2 parts of food-grade lactic acid dropwise while stirring (350 rpm) to adjust the pH to 3.5; The mixture is homogenized once under high pressure at 15MPa (S4), filtered through a 0.22μm food-grade sterile filter membrane, and then filled into food-grade spray bottles to obtain the finished product (spray particle size 25μm). Example 2

[0023] Raw material formula (parts by weight): 6.5 parts modified edible antibacterial agent (product of preparation example 1), 4.0 parts food-grade lactic acid, 2.5 parts modified food-grade gentian root extract (product of preparation example 3), and 87.0 parts food-grade deionized water.

[0024] Preparation steps: S1. Take 87.0 ml of food-grade deionized water, add 2.5 parts of modified food-grade gentian root extract, stir at 25℃ and 280 rpm for 15 min to obtain a transparent base solution; S2. Add 6.5 parts of modified edible antibacterial agent powder, stir at 300 rpm for 20 minutes until evenly dispersed; S3. Add 4.0 parts of food-grade lactic acid dropwise while stirring (350 rpm) to adjust the pH to 3.2; The mixture is homogenized once under high pressure at 4 and 15 MPa, filtered through a 0.22 μm food-grade sterile filter membrane, and then filled into food-grade spray bottles to obtain the finished product (spray particle size 20 μm). Example 3

[0025] Raw material formula (parts by weight): 3.8 parts modified edible antibacterial agent (product of preparation example 2), 5.5 parts food-grade lactic acid, 3.0 parts modified food-grade gentian root extract (product of preparation example 4), and 87.7 parts food-grade deionized water.

[0026] Preparation steps: S1. Take 87.7 ml of food-grade deionized water, add 3.0 parts of modified food-grade gentian root extract, stir at 25℃ and 280 rpm for 15 min to obtain a transparent base solution. S2. Add 3.8 parts of modified edible antibacterial agent powder, stir at 300 rpm for 20 minutes until evenly dispersed; S3. Add 5.5 parts of food-grade lactic acid dropwise while stirring (350 rpm) to adjust the pH to 2.8; The mixture is homogenized once under high pressure at 15 MPa, filtered through a 0.22 μm food-grade sterile filter membrane, and then filled into food-grade spray bottles to obtain the finished product (spray particle size 30 μm). Example 4

[0027] Raw material formula (parts by weight): 5.5 parts modified edible antibacterial agent (product of preparation example 2), 4.7 parts food-grade lactic acid, 2.8 parts modified food-grade gentian root extract (product of preparation example 4), and 87.0 parts food-grade deionized water.

[0028] Preparation steps: S1. Take 87.0 ml of food-grade deionized water, add 2.8 parts of modified food-grade gentian root extract, stir at 25℃ and 280 rpm for 15 min to obtain a transparent base solution; S2. Add 5.5 parts of modified edible antibacterial agent powder, stir at 300 rpm for 20 minutes until evenly dispersed; S3. Add 4.7 parts of food-grade lactic acid dropwise while stirring (350 rpm) to adjust the pH to 3.8; The mixture is homogenized once under high pressure at 4 and 15 MPa, filtered through a 0.22 μm food-grade sterile filter membrane, and then filled into food-grade spray bottles to obtain the finished product (spray particle size 40 μm). Example 5

[0029] Raw material formula (parts by weight): 5.2 parts modified edible antibacterial agent (product of preparation example 1), 4.3 parts food-grade lactic acid, 2.4 parts modified food-grade gentian root extract (product of preparation example 3), and 88.1 parts food-grade deionized water.

[0030] Preparation steps: S1. Take 88.1 ml of food-grade deionized water, add 2.4 parts of modified food-grade gentian root extract, stir at 25℃ and 280 rpm for 15 min to obtain a transparent base solution. S2. Add 5.2 parts of modified edible antibacterial agent powder, stir at 300 rpm for 20 minutes until evenly dispersed; S3. Add 4.3 parts of food-grade lactic acid dropwise while stirring (350 rpm) to adjust the pH to 3.4; The mixture is homogenized once under high pressure at 15MPa (S4), filtered through a 0.22μm food-grade sterile filter membrane, and then filled into food-grade spray bottles to obtain the finished product (spray particle size 22μm).

[0031] Comparative Example 1: Defective Modified Edible Antibacterial Agent Raw material formulation (parts by weight): 4.8 parts of unmodified ε-polylysine hydrochloride, 3.2 parts of food-grade lactic acid, 2.2 parts of modified food-grade gentian root extract (product of preparation example 3), and 89.8 parts of food-grade deionized water.

[0032] Preparation steps: Except for step S2, which involves adding unmodified ε-polylysine hydrochloride (no inclusion modification required), the remaining steps are the same as in Example 1.

[0033] Comparative Example 2: Raw material formulation (parts by weight): 4.8 parts modified edible antibacterial agent (product of preparation example 1), 3.2 parts food-grade lactic acid, 2.2 parts unmodified food-grade gentian root extract (no compound modification, only completed steps S1-S2 in preparation example 3), and 89.8 parts food-grade deionized water.

[0034] Preparation steps: Except for step S1, which involves adding unmodified food-grade gentian root extract, the remaining steps are the same as in Example 1.

[0035] Comparative Example 3: Raw material formula (parts by weight): 4.8 parts of unmodified ε-polylysine hydrochloride, 3.2 parts of food-grade lactic acid, 2.2 parts of unmodified food-grade gentian root extract, and 89.8 parts of food-grade deionized water.

[0036] Preparation steps: Except for adding unmodified food-grade gentian root extract in S1 and adding unmodified ε-polylysine hydrochloride in S2, the other steps are the same as in Example 1.

[0037] Comparative Example 4: Raw material formulation (parts by weight): 4.8 parts of modified edible antibacterial agent (β-cyclodextrin to ε-polylysine hydrochloride mass ratio 1:1.0, inclusion rate 75%, the rest of the preparation steps are the same as in preparation example 1), 3.2 parts of food-grade lactic acid, 2.2 parts of modified food-grade gentian root extract (product of preparation example 3), and 89.8 parts of food-grade deionized water.

[0038] Preparation steps: Same as in Example 1.

[0039] Comparative Example 5: Raw material formula: Same as in Example 1.

[0040] Preparation steps: Except for step S3, which adjusts the pH value to 4.5, the other steps are the same as in Example 1.

[0041] Performance testing A feminine hygiene spray that balances the microecology of the private parts, eliminates odor, kills bacteria and fights viruses, was obtained from Examples 1-5 and Comparative Examples 1-5, respectively. The performance of the spray reagent was tested as follows, and the test results are shown in Table 1.

[0042] The testing method is as follows: 1. Sterilization / inactivation rate test: Referring to the "Disinfection Technical Specifications", the sterilization rate of 10 common pathogenic bacteria such as Escherichia coli and Staphylococcus aureus, as well as the inactivation rate of HPV16 and SHV-2 viruses were tested. 2. Odor Removal Performance Test: Simulate a private area odor environment (ammonia, hydrogen sulfide gas) and test the ammonia removal rate, hydrogen sulfide removal rate, and odor suppression duration; 3. Mildness test: Refer to the "Cosmetic Safety Technical Specifications" to test the mucosal irritation level and the inhibition rate against lactobacilli; 4. Stability test: The effective ingredient retention rate was tested after storing the product at room temperature (25℃) and high temperature (40℃) for 3 months. 5. Edibility test: Refer to GB2760 standard to test the raw material grade and heavy metal content.

[0043] Table 1 Test Results Test Project Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Pathogenic bacteria kill rate (%) 99.99 99.995 99.985 99.992 99.99 99.2 99.5 98.8 99.3 99.6 HPV16 inactivation rate (%) 99.9 99.95 99.85 99.92 99.9 99.0 99.2 98.5 99.1 99.3 Ammonia removal rate (%) 95.2 96.5 95.0 96.8 95.8 90.5 88.3 85.7 91.2 94.8 Hydrogen sulfide removal rate (%) 90.5 92.3 90.0 93.1 91.2 85.2 84.7 82.1 86.5 89.8 Inhibition rate of lactobacillus (%) 2.8 2.5 2.9 2.7 2.6 3.5 3.2 4.2 3.7 3.0 Mucosal irritation level Level 0 Level 0 Level 0 Level 0 Level 0 Level 0 Level 0 Level 0 Level 0 Level 0 Retention rate at room temperature for 3 months (%) 95.8 96.5 95.3 97.2 96.1 88.2 87.5 82.3 89.7 95.5 Retention rate (%) after 3 months at 40℃ 90.5 91.8 90.2 92.5 91.2 83.7 82.9 78.5 85.1 90.2 Odor suppression duration (h) 102 110 100 115 108 75 70 60 80 98 Edible Compliant with GB2760 Compliant with GB2760 Compliant with GB2760 Compliant with GB2760 Compliant with GB2760 Compliant with GB2760 Compliant with GB2760 Compliant with GB2760 Compliant with GB2760 Compliant with GB2760 Results Analysis 1. Examples 1-5 demonstrate excellent performance: All examples meet edible standards, with a mucosal irritation level of 0, a lactobacillus inhibition rate of <3%, a pathogenic bacteria kill rate of ≥99.985%, a virus inactivation rate of ≥99.85%, an ammonia removal rate of ≥95%, an effective ingredient retention rate of ≥95.3% at room temperature for 3 months, and an odor suppression time of ≥100 hours, demonstrating the synergistic effect of the dual-modified raw materials, and exhibiting stable performance under different raw material ratios.

[0044] 2. Verification of the necessity of dual-modified raw materials: (1) Comparative Example 1: The sterilization rate, inactivation rate and stability all decreased significantly, indicating that β-cyclodextrin inclusion modification can effectively improve the activity retention rate and sterilization efficacy of the bactericide; (2) Comparative Example 2: The deodorization performance decreased significantly, indicating that the compound modification of the modified edible disinfectant can improve the dissolution rate of active ingredients in food-grade gentian root extract and enhance the long-lasting deodorization effect. (3) Comparative Example 3: The performance of each item was the worst, further proving that the synergistic effect of the dual-modified raw materials is the core support for the high performance of the product.

[0045] 3. Verification of the rationality of the formula and process: (1) Comparative Example 4 (deviation of modified inclusion ratio): The performance was better than that of the unmodified group, but lower than that of Example 1, indicating that the inclusion ratio of β-cyclodextrin to the bactericide needs to be controlled at 1:1.2-1.5 to achieve the best modification effect; (2) Comparative Example 5 (pH deviation): The odor removal performance and beneficial bacteria inhibition rate decreased slightly, indicating that the pH value design of 2.8-3.8 can adapt to the microenvironment of the private parts and ensure synergistic effects.

[0046] It should be noted that the embodiments described above are only for explaining this application and do not constitute any limitation on this application. This application has been described with reference to typical embodiments, but it should be understood that the terms used therein are descriptive and explanatory terms, not limiting terms. Modifications can be made to this application within the scope of the claims, and amendments can be made without departing from the scope and spirit of this application. Although the application described herein relates to specific methods, materials, and embodiments, it does not mean that this application is limited to the specific examples disclosed herein; on the contrary, this application can be extended to all other methods and applications with the same function.

Claims

1. A feminine hygiene spray that balances the vaginal microecology, eliminates odor, kills bacteria, and fights viruses, characterized in that: The spray reagent is mainly composed of the following raw materials in parts by weight: 3.8-6.5 parts modified edible antibacterial agent, 3.2-5.5 parts food-grade lactic acid, 2.2-3.0 parts modified food-grade gentian root extract, and the balance being food-grade deionized water; the pH value of the spray reagent is 2.8-3.8, and the spray particle size is 10-50 μm.

2. The feminine hygiene spray for balancing the microecology of the private parts, eliminating odor, sterilizing, and fighting viruses according to claim 1, is characterized in that: The modified edible antibacterial agent is a food-grade β-cyclodextrin-modified edible antibacterial agent, which is prepared by encapsulating food-grade β-cyclodextrin and food-grade edible antibacterial agent at a mass ratio of 1:1.2-1.5, with an encapsulation rate of ≥90%; the edible antibacterial agent is food-grade ε-polylysine hydrochloride or food-grade lysozyme, with a purity of ≥99% and an effective ingredient content of ≥6.0%.

3. The feminine hygiene spray for balancing the microecology of the private parts, eliminating odor, sterilizing, and fighting viruses according to claim 1, is characterized in that: The modified food-grade gentian root extract is a food-grade gentian root extract with modified edible antibacterial agent and enhanced effect. It is prepared by compounding the modified edible antibacterial agent and the food-grade gentian root extract at a mass ratio of 0.3:1, and the dissolution rate of effective components is ≥95%. The food-grade gentian root extract is a food-grade water extract.

4. The feminine hygiene spray for balancing the microecology of the private parts, eliminating odor, sterilizing, and fighting viruses according to claim 2, is characterized in that: The food-grade β-cyclodextrin is a low-substituted β-cyclodextrin with a purity of ≥98%, meeting the GB2760 edible standard.

5. A feminine hygiene spray for balancing the microecology of the private parts, eliminating odor, sterilizing, and fighting viruses, as described in claim 2, characterized in that: The preparation method of the modified edible antibacterial agent includes the following steps: S1. Take 10g of food-grade β-cyclodextrin, add 80ml of food-grade deionized water, heat to 55℃, stir at 300rpm for 30min until completely dissolved, to obtain β-cyclodextrin aqueous solution. S2. Take 12-15g of food-grade edible disinfectant, add 20ml of food-grade deionized water, stir at 25℃ for 15min until uniformly dispersed, and obtain the disinfectant dilution. S3. Slowly add the diluted disinfectant solution dropwise into the β-cyclodextrin aqueous solution, keep the temperature constant at 55℃ and stir at 350rpm for 80min to complete the inclusion. S4. Cool to room temperature, filter through a 0.45μm food-grade filter membrane, freeze-dry at -40℃ and 0.08MPa for 24 hours, and then pulverize through a 200-mesh sieve to obtain the final product.

6. A feminine hygiene spray for balancing the microecology of the private parts, eliminating odor, sterilizing, and fighting viruses, as described in claim 3, characterized in that: The preparation method of the modified food-grade gentian root extract includes the following steps: S1. Take 10g of food-grade dried gentian root, crush it through a 100-mesh sieve, add 100ml of food-grade deionized water, and extract at a constant temperature of 80℃ for 90min. S2. While still hot, filter through a 0.45μm food-grade filter membrane, collect the filtrate, and concentrate it to 1 / 5 of the original volume to obtain a concentrated extract of gentian root. S3. Take 3g of the modified edible antibacterial agent powder according to claim 5, add it to the concentrated extract of gentian root, and stir at 25°C and 280rpm for 20min until completely dissolved to obtain the product.

7. The feminine hygiene spray for balancing the microecology of the private parts, eliminating odor, sterilizing, and fighting viruses according to claim 1, characterized in that: The preparation method of the spray reagent includes the following steps: S1. Take the formula amount of food-grade deionized water, add the formula amount of modified food-grade gentian root extract, stir at 25℃ and 280rpm for 15min until completely dissolved, and obtain a transparent modified extract base. S2. Take the amount of modified edible antibacterial agent powder in the formula and slowly add it to the base liquid. Stir at 300 rpm for 20 minutes until it is evenly dispersed. S3. Take the prescribed amount of food-grade lactic acid and add it dropwise to the above system while stirring, adjusting the pH value to 2.8-3.

8. The mixture is homogenized once under high pressure at 15MPa, filtered through a 0.22μm food-grade sterile filter membrane, and then filled into food-grade spray bottles to obtain the final product.