Injectable hydrogel, preparation method and application thereof

By using a hydrogel precursor solution composed of methacrylamide xanthan gum, sulfonated betaine methacrylate, and epigallocatechin gallate, the problems of long gelation time, phototoxicity, and barrier function decay of existing hydrogels are solved, achieving a rapid, safe, and effective anti-adhesion effect.

CN122141023APending Publication Date: 2026-06-05JIANGSU PROVINCE HOSPITAL (THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU PROVINCE HOSPITAL (THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY)
Filing Date
2026-02-28
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Existing hydrogels have several drawbacks in preventing postoperative abdominal adhesions, including long gelation time, potential phototoxicity, weakened barrier function, insufficient anti-adhesion ability, unsustainable antioxidant and anti-inflammatory functions, and inconvenient operation.

Method used

Xanthan gum methacrylamide (XGMA) was used as the photocrosslinking material, sulfonated betaine methacrylate (SBMA) as the zwitterionic monomer, and epigallocatechin gallate (EGCG) as the polyphenol compound. An XG-SB@EG hydrogel precursor solution containing the photoinitiator lithium phenyl-2,4,6-trimethylbenzoylphosphonate (LAP) was prepared. A single-phase composite network was formed by blue light irradiation, which rapidly crosslinked in situ to form a hydrogel with anti-protein adsorption, anti-oxidation, and anti-inflammatory functions.

Benefits of technology

It achieves rapid gelation, avoids phototoxicity, provides excellent mechanical strength and biocompatibility, significantly reduces the incidence of postoperative abdominal adhesions, has sustained antioxidant and anti-inflammatory effects, and improves the anti-adhesion effect.

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Abstract

The present application relates to the technical field of hydrogel, and particularly relates to an injectable hydrogel, a preparation method and application, and the preparation method of the injectable hydrogel comprises the following steps: configuring a 0.1% photoinitiator solution, adding a photocrosslinking material into the photoinitiator solution, so that the final concentration is 1wt%-5wt%, and stirring until completely dissolved; continuously adding a zwitterionic monomer, so that the final concentration is 2wt%-5wt%; finally adding a polyphenol compound, so that the final concentration is 0.5wt%-5wt%, and continuously mixing to obtain a uniform and transparent XG-SB@EG hydrogel precursor solution; applying the XG-SB@EG hydrogel precursor solution to a target area, using blue light with a wavelength of 365nm-405nm, and irradiating for 60s-120s with a light intensity of 25mW / cm2, so that the XG-SB@EG hydrogel can be formed in situ. The present application has significant advantages in terms of gel forming speed, injectability, safety, functional durability and overall anti-adhesion efficiency.
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