Multipoint point-to-point optical quantum stimulation system and stimulation method

Abstract

The present application relates to the technical fields of biomedical engineering, and particularly relates to a multi-point site-to-site light quantum stimulation system and a stimulation method, comprising: a tunable light source module, a transmission module, a fixed plate and a control module, wherein the tunable light source module generates light rays meeting preset stimulation conditions, the transmission module transmits the light rays to the fixed plate through a plurality of transmission optical fibers, the fixed plate is provided with a hole array corresponding to the transmission optical fibers one by one, the light rays are incident on the target retina through the holes, the fixed plate further comprises a plurality of micro-shielding baffles, the micro-shielding unit is provided with a shielding baffle corresponding to the hole to shield the outgoing light rays of the hole, and the control module adjusts the target shielding baffle according to a shielding instruction, thereby solving the problems of inaccurate retinal multi-point stimulation and insufficient applicability in complex visual scenes in the related art, and improving the accuracy of retinal multi-point stimulation and the applicability of the retinal multi-point stimulation system.

Description

Technical Field

[0001] This invention relates to the field of biomedical engineering technology, and in particular to a multi-point point-to-point photonic quantum stimulation system and stimulation method. Background Technology

[0002] The retina is an important component of the visual system, and research on stimulation of different points on the retina helps to deepen our understanding of the mechanisms of vision formation and retinal pathology.

[0003] Among the related technologies, there are several main schemes for stimulating the retina. In method (1), a low-power objective lens (or a long focal length lens) is used to achieve multi-point stimulation in a three-dimensional large range. In method (2), a shift register is used to decode the external digital signal into a control signal. Based on AND gate logic control combined with switching signals and PWM signals, independent switching and light intensity adjustment of any single or multiple points in a 4×4 array are achieved, reducing false stimulation of surrounding tissues. In method (3), a spontaneous parametric downconversion dual-photon source (such as pump light irradiating a PPKTP crystal) is used to generate polarized photon pairs. Multiple beam displacers (BD) and waveplates (half-wave plates / quarter-wave plates) are combined to decompose the photons into multiple spatial modes to simulate extremely complex quantum states. In method (4), multiple lasers are used to simultaneously irradiate the fundus through light deflection devices, stimulating more cell tissues.

[0004] However, the related technologies have the following problems: Scheme (1) Using a low-magnification objective lens will reduce the effective numerical aperture (NA), which will lead to a larger femtosecond laser focal spot volume and less concentrated energy, ultimately reducing the excitation efficiency of light stimulation. Scheme (2) The dimming has a high-frequency flicker problem and limited accuracy. The array size is prone to control delay and low light source adaptability. Scheme (3) The energy consumption is high and thermal noise will easily interfere with the stability of quantum states. Moreover, the system only supports a fixed encoding method and has low adaptability. Scheme (4) The optical wedge deflection angle is fixed and there is no real-time alignment correction function for the eye axis. Processing and assembly errors will easily affect the fundus illumination effect. The stimulation site and light intensity cannot be adjusted, making it difficult to adapt to different groups of people and diverse training needs. Therefore, it limits the research of complex visual scenes and urgently needs to be solved. Summary of the Invention

[0005] This invention provides a multi-point point-to-point photonic quantum stimulation system and method to solve the problems of inaccuracy and insufficient applicability in complex visual scenarios of multi-point retinal stimulation in related technologies, thereby improving the accuracy of multi-point retinal stimulation and the applicability of multi-point retinal stimulation systems.

[0006] To achieve the above objectives, a first aspect of the present invention provides a multi-point point-to-point photonic quantum stimulation system, comprising: a tunable light source module, a transmission module, a fixing plate, a micro-masking unit, and a control module. The tunable light source module generates light that meets preset stimulation conditions. The transmission module includes multiple transmission optical fibers for transmitting the light to the fixing plate. The fixing plate includes an array of holes and multiple micro-masking baffles. The hole array includes multiple holes corresponding one-to-one with the multiple transmission optical fibers, allowing the light to be incident on a target retina through the holes. The micro-masking unit includes multiple baffles corresponding one-to-one with the multiple holes, and the baffles are used to block the light emitted from the holes. The control module determines a target baffle based on a received baffle command and adjusts the target baffle to block the light emitted from the corresponding holes.

[0007] Furthermore, in some embodiments, the micro-shading unit is at least one of a micro-electric light-shielding sheet, a micro-electric louver structure, and a MEMS-based micro-light-shielding valve.

[0008] Furthermore, in some embodiments, it further includes: a driving module, which is connected to the micro-occlusion unit and the control module respectively, and is used to drive the target occlusion plate to block the corresponding hole according to the control command generated by the control module based on the occlusion command.

[0009] Furthermore, in some embodiments, the light emitted from the multiple arrays of holes is at different angles.

[0010] Furthermore, in some embodiments, the control module includes: a receiving unit for receiving the occlusion command; and a first control unit for determining a target occlusion plate according to the occlusion command and adjusting the target occlusion plate to block the emitted light from the corresponding hole.

[0011] Furthermore, in some embodiments, the occlusion command is generated based on the switching frequency and / or switching timing.

[0012] Furthermore, in some embodiments, the control module further includes: a coordinate construction unit, used to determine the three-dimensional coordinate system of the multi-point point-to-point photonic quantum stimulation system with the entrance pupil center corresponding to the target retina as the origin; a determination unit, used to obtain a first distance from the fixed plate to the entrance pupil center, a second distance from the entrance pupil center to the target retina, and the spatial coordinates of each hole based on the three-dimensional coordinate system; and an instruction generation unit, used to determine the pitch angle and azimuth angle of the emitted light from each hole based on the first distance, the second distance, and the spatial coordinates of each hole. A second control unit is used to adjust the corresponding hole according to the pitch angle and azimuth angle of the emitted light from each hole.

[0013] Furthermore, in some embodiments, the three-dimensional coordinate system is:

[0014] ; in, , , The three-dimensional coordinates of a point on the retina. The pitch angle of the emitted light beam. The azimuth angle of the emitted light ray.

[0015] The multi-point point-to-point photonic quantum stimulation system provided by the present invention comprises a tunable light source module that generates light that meets preset stimulation conditions. The transmission module transmits the light through multiple transmission optical fibers to a fixed plate with an array of holes corresponding one-to-one with the transmission optical fibers, so as to be incident on the target retina. The micro-masking unit is provided with a masking plate corresponding one-to-one with the holes. The control module adjusts the target masking plate according to the received masking command to block the light emitted from the corresponding hole. This solves the problems of inaccuracy of multi-point retinal stimulation and insufficient applicability in complex visual scenarios in related technologies, and improves the accuracy of multi-point retinal stimulation and the applicability of the multi-point retinal stimulation system.

[0016] To achieve the above objectives, a second aspect of the present invention provides a multi-point point-to-point photonic quantum stimulation method, comprising the following steps: generating light that meets preset stimulation conditions through a tunable light source module; transmitting the light to a fixed plate through multiple transmission optical fibers; incidenting the light onto a target retina through multiple holes corresponding one-to-one with the multiple transmission optical fibers; blocking the light emitted from the holes by controlling multiple blocking plates corresponding one-to-one with the multiple holes; determining a target blocking plate according to a received blocking instruction, and adjusting the target blocking plate to block the light emitted from the corresponding hole.

[0017] Furthermore, in some embodiments, the plurality of shields are at least one of a micro-electric light-shielding sheet, a micro-electric louver structure, and a MEMS-based micro-light-shielding valve.

[0018] Furthermore, in some embodiments, the method further includes: using control commands generated based on the occlusion command to drive the target occlusion plate to occlude the corresponding hole.

[0019] Furthermore, in some embodiments, the light emitted from the multiple arrays of holes is at different angles.

[0020] Furthermore, in some embodiments, the step of determining a target blocking plate according to a received blocking instruction and adjusting the target blocking plate to block the light emitted from the corresponding hole includes: receiving the blocking instruction; determining a target blocking plate according to the blocking instruction and adjusting the target blocking plate to block the light emitted from the corresponding hole.

[0021] Furthermore, in some embodiments, the occlusion command is generated based on the switching frequency and / or switching timing.

[0022] Furthermore, in some embodiments, the method further includes: determining a three-dimensional coordinate system of the multi-point point-to-point photonic quantum stimulation system with the entrance pupil center corresponding to the target retina as the origin; obtaining a first distance from the fixed plate to the entrance pupil center, a second distance from the entrance pupil center to the target retina, and the spatial coordinates of each aperture based on the three-dimensional coordinate system; determining the pitch angle and azimuth angle of the emitted light from each aperture based on the first distance, the second distance, and the spatial coordinates of each aperture; and adjusting the corresponding aperture according to the pitch angle and azimuth angle of the emitted light from each aperture.

[0023] Furthermore, in some embodiments, the three-dimensional coordinate system is: ; in, , , The three-dimensional coordinates of a point on the retina. The pitch angle of the emitted light beam. The azimuth angle of the emitted light ray.

[0024] The multi-point point-to-point photonic quantum stimulation method provided by the present invention generates light that meets preset stimulation conditions through a tunable light source module. The transmission module transmits the light to a fixed plate with an array of holes corresponding one-to-one with the transmission optical fibers through multiple transmission optical fibers so as to be incident on the target retina. The micro-masking unit is provided with a masking plate corresponding one-to-one with the holes. The control module adjusts the target masking plate according to the received masking command to block the light emitted from the corresponding hole. This solves the problems of inaccuracy of multi-point retinal stimulation and insufficient applicability in complex visual scenarios in related technologies, and improves the accuracy of multi-point retinal stimulation and the applicability of the multi-point retinal stimulation system.

[0025] Therefore, the present invention has the following beneficial effects: (1) This invention realizes one-to-one correspondence stimulation of multiple points on the retina, and can independently control multiple points at the same time, providing a tool for studying the spatial distribution characteristics of the retina.

[0026] (2) The adjustable light source parameters and adjustable blocking frequency of the control device of the present invention increase the flexibility of the system and can simulate various light stimulation scenarios, such as the effects of light stimulation with different light intensities, wavelengths and frequencies on the retina. (3) The multi-point synchronous / time-division stimulation design of the present invention can simultaneously collect response data from multiple retinal points, shortening the experimental cycle.

[0027] (4) This invention is also applicable to various animal models such as rabbits, mice, and monkeys, as well as in vitro / in vivo retinal experiments, and has universality. Attached Figure Description

[0028] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the following description of the embodiments taken in conjunction with the accompanying drawings, wherein: Figure 1 This is a block diagram of a multi-point point-to-point photonic quantum stimulation system provided according to an embodiment of the present invention; Figure 2 A schematic diagram of a two-dimensional plane (XZ / YZ) cross-section provided according to a specific embodiment of the present invention; Figure 3 This is a schematic diagram of the three-dimensional spatial angle distribution according to a specific embodiment of the present invention; Figure 4 This is a schematic diagram of the structure of a retinal multi-site point-to-point photonic quantum stimulation system according to a specific embodiment of the present invention; Figure 5 This is a schematic diagram of the connection of a stimulation device according to a specific embodiment of the present invention; Figure 6 A front view of a fixing plate according to a specific embodiment of the present invention; Figure 7 This is a flowchart illustrating the multi-site point-to-point photonic quantum stimulation method provided in an embodiment of the present invention. Detailed Implementation

[0029] Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention.

[0030] The multi-point point-to-point photonic quantum stimulation system and stimulation method provided according to embodiments of the present invention will be described below with reference to the accompanying drawings. First, the multi-point point-to-point photonic quantum stimulation system provided according to embodiments of the present invention will be described with reference to the accompanying drawings.

[0031] Figure 1 This is a block diagram of a multi-point point-to-point photonic quantum stimulation system provided according to an embodiment of the present invention.

[0032] like Figure 1 As shown, the multi-point point-to-point photonic quantum stimulation system includes: a tunable light source module 100, a transmission module 200, a fixing plate 300, a micro-masking unit 400, and a control module 500, wherein... The tunable light source module 100 is used to generate light that meets preset stimulation conditions; the transmission module 200 includes multiple transmission optical fibers for transmitting light to the fixing plate 300 through the multiple transmission optical fibers; the fixing plate 300 includes an array of holes and multiple micro-blocking baffles, the array of holes including multiple holes corresponding to the multiple transmission optical fibers, so that light can be incident on the target retina through the multiple holes; the micro-blocking unit 400 includes multiple baffles corresponding to the multiple holes, the baffles being used to block the light emitted from the holes; the control module 500 is used to determine the target baffle according to the received baffle command, and adjust the target baffle to block the light emitted from the corresponding hole through the target baffle.

[0033] Specifically, the tunable light source module 100 can adjust parameters such as light power, wavelength, and pulse frequency according to experimental requirements. For example, point-to-point matching of light source parameters can be achieved by connecting independent tunable light source channels (or via a beam splitter and optical switch) to different optical fibers, setting differentiated parameters for the stimulation light at different points (e.g., using light with a wavelength of 550nm and a power of 50μW at the central fovea point, and light with a wavelength of 650nm and a power of 30μW at the peripheral points), simulating the stimulation effect of different types of incident light on different areas of the retina. Alternatively, in this embodiment of the invention, a laser diode array can be used to replace the single light source and optical fiber approach, directly achieving multi-point light output. In the transmission module 200, one end of the optical fiber is connected to the tunable light source module 100, and the other end is inserted into a preset hole in the fixing plate 300. The rigid structure of the optical fiber ensures that the direction of the emitted light is fixed, avoiding light scattering or deflection.

[0034] Furthermore, in some embodiments, the micro-shading unit 400 is at least one of a micro-electric light-shielding sheet, a micro-electric louver structure, and a MEMS-based micro-light-shielding valve.

[0035] As some possible ways to achieve this, the micro-electric light-shielding sheet can be a thin metal sheet or a plastic sheet with high light-shielding properties. The MEMS-based micro-light-shielding valve can be a MEMS micromirror array, which can control the timing of stimulation by reflecting light and achieve the actual effect of multi-point shading.

[0036] Furthermore, in some embodiments, it also includes: a driving module 600, which is connected to the micro-occlusion unit 400 and the control module 500 respectively, and is used to drive the target occlusion plate to block the corresponding hole according to the control command generated by the control module 500 based on the occlusion command.

[0037] Furthermore, in some embodiments, the control module 500 includes: a receiving unit 501 for receiving a blocking command; and a first control unit 502 for determining a target blocking plate according to the blocking command and adjusting the target blocking plate to block the light emitted from the corresponding hole.

[0038] As one possible approach, each micro-shading unit 400 is controlled by an independent micro-driving element to achieve rapid and precise position switching (e.g., shading or exposure). For example, each micro-shading unit 400 can be controlled by electromagnetic drive, that is, by controlling the closing and opening states of the light-shielding sheet through the on and off states of a micro electromagnet, thus achieving the switching between shading and exposure. Alternatively, each micro-shading unit 400 can be controlled by piezoelectric drive, that is, by utilizing the electro-deformation properties of piezoelectric materials to drive the light-shielding sheet to make a small displacement and complete the shading action. Yet another example is that each micro-shading unit 400 can be controlled by motor drive, that is, a micro stepper motor drives the light-shielding sheet to move through a linkage mechanism, which is suitable for scenarios requiring large displacement or high load.

[0039] Furthermore, in some embodiments, the occlusion command is generated based on the switching frequency and / or switching timing.

[0040] For example, the user can set the switching frequency of the occlusion through the host computer software or hardware knob. The control module 500 sends pulse signals to each micro-drive element according to the set frequency to control the occlusion-exposure switching cycle of the light-shielding sheet. For example, in this embodiment of the invention, the frequency can be set to 10Hz, at which time each light-shielding sheet completes 10 cycles of occlusion, exposure, and occlusion per second. Alternatively, in this embodiment of the invention, different occlusion frequencies or occlusion sequences can be set for occlusion units at different locations. For example, a 50Hz occlusion frequency can be set for the fiber optic hole at the central point of the retina, and a 20Hz frequency can be set for the surrounding points to simulate the time response differences of different areas of the retina to light stimulation.

[0041] Furthermore, the control device 500 can achieve hardware synchronization with the tunable light source module 100 (e.g., through a synchronization pulse signal) to ensure the timing matching of light blocking and light emission. For example, when the light source emits light, the light-blocking sheet is exposed, and when the light source is turned off, the light-blocking sheet is blocked, thereby achieving precise synchronization of "light stimulation-blocking" and improving control accuracy.

[0042] Furthermore, in some embodiments, the control module 500 further includes: a coordinate construction unit 503, used to determine the three-dimensional coordinate system of the multi-point point-to-point photonic quantum stimulation system with the entrance pupil center corresponding to the target retina as the origin; a determination unit 504, used to obtain the first distance from the fixed plate 300 to the entrance pupil center, the second distance from the entrance pupil center to the target retina, and the spatial coordinates of each hole based on the three-dimensional coordinate system; an instruction generation unit 505, used to determine the pitch angle and azimuth angle of the emitted light from each hole based on the first distance, the second distance, and the spatial coordinates of each hole; and a second control unit 506, used to adjust the corresponding hole according to the pitch angle and azimuth angle of the emitted light from each hole.

[0043] In some embodiments, the light rays emitted from the array of multiple apertures are at different angles.

[0044] As one possible way to achieve this, Figure 2 A schematic diagram of a two-dimensional plane (XZ / YZ) cross-section provided according to a specific embodiment of the present invention, as shown below. Figure 2 As shown, first, a two-dimensional coordinate system is established with the center of the entrance pupil as the origin (e.g., the Z-axis is along the visual axis, and the X or Y-axis is perpendicular to the visual axis). For any point on the fixed plate 300... The light travels from point P to the center of the entrance pupil, and then projects onto the point on the retina. According to the principle of similar triangles, angle That is, the angle between the ray and the z-axis, which satisfies: ; Therefore, when the two-dimensional cross-section is XZ, the tangent of the angle is... When the two-dimensional cross-section is YZ, the tangent of the angle is... ,but ,in, The distance from the entrance pupil to the plate; Let be the coordinates of this point in the direction perpendicular to the z-axis. The distance from the entrance pupil to the retina of the target organism's eye.

[0045] Furthermore, in a three-dimensional coordinate system, the retina is a curved surface, and the center of the entrance pupil is located behind the entrance pupil. For any point on the fixed plate Calculate the spatial angle between it and the center of the entrance pupil, i.e., the direction angle of the light ray, including the azimuth angle. and pitch angle Among them, azimuth angle Let the angle between the XY plane and the X-axis satisfy the following condition: Pitch angle The angle between the ray and the Z-axis, i.e., the angle in the two-dimensional plane. .

[0046] Furthermore, in some embodiments, the three-dimensional coordinate system is: ; in, , , The three-dimensional coordinates of a point on the retina. The pitch angle of the emitted light beam. The azimuth angle of the emitted light ray.

[0047] Specifically Figure 3 This is a schematic diagram of the three-dimensional spatial angle distribution provided according to a specific embodiment of the present invention, such as... Figure 3 As shown, with the center of the entrance pupil as the origin and the Z-axis as the polar axis, the polar radius is the distance from the entrance pupil to the retina. azimuth The azimuth angle of the point on the fixed plate is consistent with that of the fixed plate. Pitch angle The pitch angle is consistent with the point on the fixed plate. Therefore, for any point on the fixed plate The corresponding three-dimensional angle is the pitch angle along the Z-axis. Azimuth angles in the XY plane By determining these two angles, the direction of light in three-dimensional space can be completely determined and mapped onto the three-dimensional curved surface of the retina.

[0048] The multi-point point-to-point photonic quantum stimulation system provided by the present invention comprises a tunable light source module that generates light that meets preset stimulation conditions. The transmission module transmits the light through multiple transmission optical fibers to a fixed plate with an array of holes corresponding one-to-one with the transmission optical fibers, so as to be incident on the target retina. The micro-masking unit is provided with a masking plate corresponding one-to-one with the holes. The control module adjusts the target masking plate according to the received masking command to block the light emitted from the corresponding hole. This solves the problems of inaccuracy of multi-point retinal stimulation and insufficient applicability in complex visual scenarios in related technologies, and improves the accuracy of multi-point retinal stimulation and the applicability of the multi-point retinal stimulation system.

[0049] It should be noted that, in embodiments of the present invention, the tunable light source module 100 can also be replaced with a flash light source (e.g., a micro LED array), which can be directly connected to the holes in the fixing plate, or a hole can be drilled in the middle of the fixing plate to introduce the main stimulation light source, with auxiliary light sources in the surrounding holes. For example, a hole can be drilled in the center of the fixing device to connect a high-power stimulation light source as the main light source (simulating central visual stimulation), and low-power flash light sources can be connected in the surrounding holes as auxiliary light sources (simulating peripheral visual stimulation); or micro flash LEDs can be directly embedded in each hole, and the light emission timing and parameters of the LEDs can be controlled by a circuit board. Regardless of whether the light source is transmitted through optical fiber, directly embedded in the hole, or introduced from the center hole, as long as the precise geometric correspondence between the holes of the fixing device and the retinal points is used to achieve "point-to-point" stimulation, combined with the occlusion / timing control of the control device, multi-point precise stimulation of the retina can be achieved.

[0050] To enable those skilled in the art to better understand the multi-point point-to-point photonic quantum stimulation system of the present invention, the following explanation will be provided in conjunction with specific embodiments.

[0051] Figure 4 This is a schematic diagram of the structure of a retinal multi-site point-to-point photonic quantum stimulation system according to a specific embodiment of the present invention. Figure 5 This is a schematic diagram of the connection of a stimulation device according to a specific embodiment of the present invention, in conjunction with... Figure 4 and Figure 5 One side of the fixing device (i.e., the fixing plate) is connected to the stimulation device (i.e., the tunable light source module and the transmission module), which is responsible for generating and transmitting stimulation light that meets the preset conditions; the other side is connected to the control device, which includes a micro-masking unit and control lines, and is responsible for regulating the light blocking of the aperture. When the components work together, the light from the stimulation device is transmitted to the aperture of the fixing device through the optical fiber, and the control device adjusts the light of the corresponding aperture through the micro-masking unit, thereby achieving precise photon stimulation of the target retina.

[0052] Figure 6 A front view of a fixing plate according to a specific embodiment of the present invention, wherein, Figure 6 (a) is a front view of the hole array. Figure 6 (b) is a front view of the aperture array carrying micro-occlusion units. Figure 6 (a) The small white dots distributed inside represent holes. The holes are arranged in a regular array and their coordinates correspond to the X and Y coordinate system. Figure 6 (b) shows the black dots arranged in a regular array, which is consistent with... Figure 6 The hole array layout in (a) remains consistent. Figure 6 (a) and Figure 6 (b) The circle in the center indicates the position of the same specific hole in the array, which can clearly show the two different forms of hole array structure.

[0053] To demonstrate the effectiveness of the multi-point point-to-point photonic quantum stimulation system of the present invention, the following explanation will be provided in conjunction with specific embodiments.

[0054] As one possible implementation, the multi-point photonic quantum stimulation system of this invention was used to conduct experiments on multi-point photonic stimulation of the rabbit's retina in vivo. Adult New Zealand rabbits (weighing 2-3 kg) were selected, anesthetized, and fixed on the experimental table. The pupils were dilated and the eyeballs were kept stable. The coordinates of the hole in the fixation device were calculated according to the target points on the retina (e.g., fovea, nasal side, temporal side). If the target point on the retina X = 1 mm, then the hole in the fixation device x = 16 mm. An optical fiber was inserted into the corresponding hole in the fixing plate and connected to a tunable light source (wavelength 550nm, power 30μW). The occlusion frequency was set to 50Hz at the central fovea and 20Hz at the peripheral points. Time-division stimulation was applied to three points on the retina (10s stimulation per point, 5s interval). The electrical signal response at each point was acquired using an electrooculography (ERG) recorder, and the differences in amplitude and latency were analyzed. ERG signals from different points on the retina were successfully recorded.

[0055] As another possible implementation, this invention's multi-point-to-point photonic quantum stimulation system investigates the synergistic response mechanism of multiple points on the rat retina to synchronized photonic stimulation. First, a fixing plate with four holes is set up, corresponding to the nasal, temporal, superior, and inferior points on the rat retina, respectively. The coordinates of the holes can be calculated using a formula. Each hole is equipped with a collimating fiber collimator to ensure parallel light incidence. Four optical fibers are connected to the same light source (wavelength 520nm, power 30μW, split by a beam splitter). Four blocking units are set up to work synchronously at a blocking frequency of 20Hz, achieving synchronized photonic stimulation of the four points. The position of the fixing plate is adjusted so that the four beams are incident on the target points, stimulating the four points synchronously for 30 seconds. Multi-channel electrophysiological signals of the retina are acquired, and the signal synchronicity and amplitude relationship between the points are analyzed, recording the synchronized ERG signals of the four points.

[0056] Next, the multi-point point-to-point photonic quantum stimulation method according to an embodiment of the present invention is described with reference to the accompanying drawings.

[0057] Figure 7 This is a flowchart illustrating the multi-site point-to-point photonic quantum stimulation method provided in an embodiment of the present invention.

[0058] like Figure 7 As shown, this multi-site point-to-point photoquantum stimulation method includes the following steps: In step S701, light that meets preset stimulation conditions is generated by the tunable light source module; In step S702, light is transmitted to the fixed plate through multiple transmission optical fibers; In step S703, light is incident on the target retina through multiple holes that correspond one-to-one with multiple transmission optical fibers; In step S704, multiple baffles, each corresponding to a specific hole, are used to block the light emitted from the holes. In step S705, a target blocking plate is determined according to the received blocking instruction, and the target blocking plate is adjusted to block the light emitted from the corresponding hole.

[0059] Furthermore, in some embodiments, the multiple shields are at least one of micro-electric light-shielding sheets, micro-electric louver structures, and MEMS-based micro-light-shielding valves.

[0060] Furthermore, in some embodiments, the method further includes: using control commands generated based on occlusion commands to drive a target occlusion plate to occlude the corresponding hole.

[0061] Furthermore, in some embodiments, the light emitted from the multiple aperture arrays is at different angles.

[0062] Furthermore, in some embodiments, determining a target shielding plate according to a received shielding instruction and adjusting the target shielding plate to block the light emitted from the corresponding hole includes: receiving a shielding instruction; determining a target shielding plate according to the shielding instruction and adjusting the target shielding plate to block the light emitted from the corresponding hole.

[0063] Furthermore, in some embodiments, the occlusion command is generated based on the switching frequency and / or switching timing.

[0064] Furthermore, in some embodiments, the method further includes: determining a three-dimensional coordinate system for the multi-point point-to-point photonic quantum stimulation system with the entrance pupil center corresponding to the target retina as the origin; obtaining a first distance from the fixed plate to the entrance pupil center, a second distance from the entrance pupil center to the target retina, and the spatial coordinates of each hole based on the three-dimensional coordinate system; determining the pitch angle and azimuth angle of the emitted light from each hole based on the first distance, the second distance, and the spatial coordinates of each hole; and adjusting the corresponding hole according to the pitch angle and azimuth angle of the emitted light from each hole.

[0065] Furthermore, in some embodiments, the three-dimensional coordinate system is: ; in, , , The three-dimensional coordinates of a point on the retina. The pitch angle of the emitted light beam. The azimuth angle of the emitted light ray.

[0066] It should be noted that the foregoing explanation of the multi-point point-to-point photonic quantum stimulation system embodiment also applies to the multi-point point-to-point photonic quantum stimulation method of this embodiment, and will not be repeated here.

[0067] The multi-point point-to-point photonic quantum stimulation method provided by the present invention generates light that meets preset stimulation conditions through a tunable light source module. The transmission module transmits the light to a fixed plate with an array of holes corresponding one-to-one with the transmission optical fibers through multiple transmission optical fibers so as to be incident on the target retina. The micro-masking unit is provided with a masking plate corresponding one-to-one with the holes. The control module adjusts the target masking plate according to the received masking command to block the light emitted from the corresponding hole. This solves the problems of inaccuracy of multi-point retinal stimulation and insufficient applicability in complex visual scenarios in related technologies, and improves the accuracy of multi-point retinal stimulation and the applicability of the multi-point retinal stimulation system.

[0068] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0069] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0070] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A multi-point point-to-point photonic quantum stimulation system, characterized in that, include: The system comprises a tunable light source module, a transmission module, a fixing plate, a micro-shading unit, and a control module. The tunable light source module is used to generate light that meets preset stimulation conditions; The transmission module includes multiple transmission optical fibers for transmitting the light to the fixed plate through the multiple transmission optical fibers; The fixing plate includes an array of holes and multiple micro-blocking baffles. The array of holes includes multiple holes that are arranged one-to-one with the multiple transmission optical fibers, so that the light can be incident on the target retina through the multiple holes. The micro-shading unit includes multiple shielding plates that correspond one-to-one with the multiple holes, and the shielding plates are used to block the light emitted from the holes; The control module is used to determine the target blocking plate according to the received blocking command, and adjust the target blocking plate to block the light emitted from the corresponding hole.

2. The multi-point point-to-point photonic quantum stimulation system according to claim 1, characterized in that, The micro-shading unit is at least one of a micro-electric light-shielding sheet, a micro-electric louver structure, and a MEMS-based micro-light-shielding valve.

3. The multi-point point-to-point photonic quantum stimulation system according to claim 1, characterized in that, Also includes: A driving module is connected to both the micro-occlusion unit and the control module, and is used to drive the target occlusion plate to block the corresponding hole according to the control command generated by the control module based on the occlusion command.

4. The multi-point point-to-point photonic quantum stimulation system according to claim 1, characterized in that, The light rays from the multiple arrays of holes are emitted at different angles.

5. The multi-point point-to-point photonic quantum stimulation system according to claim 1, characterized in that, The control module includes: A receiving unit, used to receive the occlusion command; The first control unit is used to determine the target blocking plate according to the blocking command, and adjust the target blocking plate to block the light emitted from the corresponding hole.

6. The multi-point point-to-point photonic quantum stimulation system according to claim 5, characterized in that, The occlusion command is generated based on the switching frequency and / or switching sequence.

7. The multi-point point-to-point photonic quantum stimulation system according to claim 5, characterized in that, The control module further includes: The coordinate construction unit is used to determine the three-dimensional coordinate system of the multi-point point-to-point photonic quantum stimulation system with the entrance pupil center corresponding to the target retina as the origin; The determining unit is used to obtain, based on the three-dimensional coordinate system, a first distance from the fixing plate to the entrance pupil center, a second distance from the entrance pupil center to the target retina, and the spatial coordinates of each hole; The instruction generation unit is used to determine the pitch angle and azimuth angle of the emitted light from each hole based on the first distance, the second distance and the spatial coordinates of each hole; The second control unit is used to adjust the corresponding hole according to the pitch and azimuth angles of the emitted light from each hole.

8. The multi-point point-to-point photonic quantum stimulation system according to claim 7, characterized in that, The three-dimensional coordinate system is: ； in, , , The three-dimensional coordinates of a point on the retina. The pitch angle of the emitted light beam. The azimuth angle of the emitted light ray.

9. A multi-site point-to-point photonic quantum stimulation method, characterized in that, The method includes the following steps: Light that meets preset stimulation conditions is generated through a tunable light source module; The light is transmitted to the fixed plate via multiple optical fibers; The light is directed onto the target retina through multiple holes that correspond one-to-one with the multiple transmission optical fibers; By controlling multiple baffles that are set up one-to-one with the multiple holes, the light emitted from the holes is blocked; The target shield is determined based on the received shielding command, and the target shield is adjusted to block the light emitted from the corresponding hole.

10. The method according to claim 9, characterized in that, The plurality of shields are at least one of a micro-electric light-shielding plate, a micro-electric louver structure, and a MEMS-based micro-light-shielding valve.

Images