Compound containing phenanthridone skeleton as well as preparation method and application thereof
Through a series of chemical reaction steps, the problem of limited sources of phenanthrene skeletal compounds in existing technologies has been solved, realizing a simple and mild synthetic method that provides a foundation for large-scale production.
Patent Information
- Application Number
- CN202610305025.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-03-13
- Publication Date
- 2026-06-05
AI Technical Summary
In the existing technology, 5-benzyl-1,3,8,9-tetramethoxyphenanthridine-6(5H)-one and 5-benzyl-8-(cyclohexylmethoxy)-1,3,9-trimethoxyphenanthridine-6(5H)-one can only be extracted from the secondary metabolites of marine fungi Aspergillus, and the source is very limited, making it difficult to meet the needs of large-scale production.
A series of chemical reaction steps, including substitution, hydrolysis, intramolecular coupling and reduction, were used to prepare compounds containing phenanthrene ketone skeletons. The specific steps included the reaction of compound 1 with an alkylating agent, the hydrolysis of compound 3, the synthesis of compound 5, the intramolecular coupling of compound 6 and the debenzylation of compound 8. The compounds were synthesized under mild alkaline conditions and with appropriate catalysts.
This provides a simple and mild synthetic method that solves the problem of limited sources, lays the foundation for large-scale production of these natural active products, and achieves efficient preparation of the compounds.