Process for the preparation of a pyrrolopyrimidine derivative and intermediates thereof
By optimizing the preparation process of pyrrolopyrimidine derivatives, the selectivity and drug resistance issues of existing FGFR inhibitors have been solved, enabling the efficient and low-cost preparation of high-purity compounds, thus providing a new option for anti-tumor drugs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- KANGBAIDA (SICHUAN) BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-12-03
- Publication Date
- 2026-06-05
AI Technical Summary
Existing FGFR inhibitors suffer from insufficient selectivity and drug resistance in cancer treatment, and also have high toxicity and side effects. There is a need to develop a new generation of FGFR2 and/or FGFR3 inhibitors with high activity and high selectivity.
A process for preparing pyrrolopyrimidine derivatives is provided, which synthesizes the target compound through a multi-step reaction under different solvent and reagent conditions, including the use of acidic and basic reagents, and optimizes the reaction solvent combination to improve the simplicity of operation, cost-effectiveness and product purity.
The preparation of pyrrolopyrimidine derivatives with high yield and high purity has been achieved, making them suitable for industrial production and showing potential application prospects in anti-tumor drugs.
Smart Images
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