Porcine epidemic diarrhea virus variant strain and application thereof

By isolating and purifying the variant strain GX2506 of porcine epidemic diarrhea virus and its S gene sequence, an inactivated vaccine and ELISA kit were prepared, which solved the problem of poor control effect of existing vaccines, achieved efficient vaccine immunization and accurate antibody detection, and supported the prevention and diagnosis of porcine epidemic diarrhea virus.

CN122146623APending Publication Date: 2026-06-05CHINA ANIMAL HUSBANDRY IND
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Patent Information

Application Number
CN202610310841.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-13
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Existing PEDV vaccines are insufficient to effectively control large-scale piglet mortality caused by the G2 variant strain, and traditional isolation and culture methods are difficult, resulting in low viral titers and a lack of effective vaccines and diagnostic methods.

Method used

A variant strain of porcine epidemic diarrhea virus, GX2506, and its S gene sequence were isolated and purified to prepare an inactivated vaccine and an ELISA kit for the prevention and diagnosis of porcine epidemic diarrhea virus disease.

Benefits of technology

It has a high proliferation titer and moderate pathogenicity, and can induce high levels of neutralizing antibodies, providing effective vaccine prevention and control and accurate antibody detection, supporting the prevention and diagnosis of porcine epidemic diarrhea virus.

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Abstract

The invention provides a porcine epidemic diarrhea virus variant strain and application thereof. According to the invention, a porcine epidemic diarrhea virus variant strain GX2506 is separated from porcine intestinal tissues and is subjected to passage purification, and the microbial preservation number of the porcine epidemic diarrhea virus variant strain GX2506 is CGMCC (China General Microbiological Culture Collection Center) No.47089. The isolated strain can stably proliferate on passage cells to generate typical cytopathy. The porcine epidemic diarrhea virus variant isolate provided by the invention has excellent immunogenicity; the vaccine prepared from the isolated strain can induce piglets to generate high-level neutralizing antibodies; meanwhile, the ELISA kit prepared from the isolated strain can well detect the porcine epidemic diarrhea virus antibody in serum.
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