A self-adaptive control method for nutrient supply and metabolic response in fermentation process

By using gridded modeling and multi-point online sensing monitoring of the bioreactor, the differences in metabolic response are analyzed in real time, triggering a segmented pulse feeding strategy. This solves the problem of metabolic imbalance caused by centralized feeding and improves the stability and consistency of the fermentation process.

CN122146945APending Publication Date: 2026-06-05XIAN INT UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XIAN INT UNIV
Filing Date
2026-03-10
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

In existing fermentation processes, the centralized feeding method limits the ability to sense the metabolic state inside the bioreactor, making it difficult to detect differences in metabolic response at different spatial locations, thus causing localized metabolic imbalances and process fluctuations and affecting product consistency.

Method used

By using gridded modeling of the bioreactor and fusion of multi-point online sensor data, a spatial metabolic response characteristic field is constructed. Dissolved oxygen and pH fluctuations are monitored in real time, the feeding efficiency coefficient is calculated, and the switching between segmented and pulsed feeding strategies is triggered. Combined with tail gas carbon dioxide feedback, closed-loop adaptive control of nutrient supply and metabolic response is achieved.

Benefits of technology

It improves the stability of the fermentation process and the consistency of the product, optimizes the nutrient supply rhythm, reduces the risk of local metabolic imbalance, and improves resource utilization efficiency.

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Abstract

The application discloses a kind of adaptive control methods of fermentation process nutrition supply and metabolic response, it is related to fermentation control technical field, for solving in large volume, high feed rate fermentation process in local area causes metabolic imbalance, process fluctuation intensifies and the problem of product consistency decline, by carrying out gridding treatment to the interior space of bioreactor, construct unified spatial coordinate system, in combination with multipoint online sensor array, real-time acquisition different spatial position's dissolved oxygen concentration and pH fluctuation data, reconstruct the spatial metabolic response characteristics in fermentation process, in feed process, based on response delay and difference calculation comprehensive evaluation index identifies metabolic risk, when detecting local imbalance, trigger feed strategy switching mechanism, by segmenting and pulse type regulation to feed flow and duration, in combination with tail gas carbon dioxide concentration feedback judges metabolic state recovery situation, improve fermentation stability, resource utilization and product consistency.
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