Atomized liquid and method of making same

Abstract

This application provides an atomizing liquid and its preparation method, wherein the atomizing liquid comprises the following components in parts by weight: 50-68 parts distilled water; 10-20 parts propylene glycol; 7-8 parts nicotine salt; 20-28 parts water-soluble flavoring; 0.5-2 parts humectant; 0.15-0.5 parts cooling agent; 0.8-1.5 parts sweetener; and 0.05-0.15 parts pH adjuster. The atomizing liquid and its preparation method provided in this application, comprising specific parts by weight of distilled water, propylene glycol, nicotine salt, and other components, effectively alleviate the burning and dryness in the throat caused by high nicotine concentrations by optimizing the formula ratio and preparation process. It has the advantages of reducing throat irritation and improving user comfort at high nicotine concentrations.

Description

Technical Field

[0001] This application belongs to the field of atomizing liquid technology, and particularly relates to an atomizing liquid and its preparation method. Background Technology

[0002] As consumers demand greater discretion and safety, the industry is shifting towards low-fog and fog-free technology. Most existing smokeless electronic atomizers use a high-aqueous phase water-based system, abandoning glycerin to achieve a low-fog effect.

[0003] Currently, the core technology of smokeless electronic atomizers is a high-aqueous-phase system. By completely eliminating glycerin, the carrier for large vapor production, the proportion of water phase is significantly increased, resulting in extremely faint or nearly invisible exhaled aerosols, suitable for discreet use. However, existing technologies have significant drawbacks: the high-aqueous-phase system lacks nicotine encapsulation and sustained-release capabilities, and mass-produced products have low nicotine concentrations, failing to meet the needs of heavy users; the ethanol system is volatile and irritates the throat; the polyethylene glycol (PEG) system is prone to degradation at high temperatures, posing a safety risk; and the simple 1,2-propanediol (PG) system has poor moisturizing properties, insufficient stability, and irritates the throat.

[0004] In summary, existing solutions cannot simultaneously meet the requirements of high nicotine content and low irritation while ensuring safety by eliminating glycerin, PEG, and ethanol. Summary of the Invention

[0005] In view of this, the purpose of this application is to provide an atomizing liquid and its preparation method, which combines the advantages of high nicotine and low irritation under the safe premise of no glycerin, no PEG and no ethanol.

[0006] This application provides an atomizing liquid comprising the following components in parts by weight: 50-68 parts distilled water; 10-20 parts of propylene glycol; 7-8 parts nicotine salt; 20-28 parts of water-soluble fragrance; 0.5 to 2 parts of lubricant; Cooling agent 0.15~0.5 parts; Sweetener 0.8~1.5 parts; pH adjuster 0.05~0.15 parts.

[0007] In some embodiments, propylene glycol includes 1,3-propanediol and 1,2-propanediol.

[0008] In some embodiments, the mass ratio of 1,3-propanediol to 1,2-propanediol is (1~4):1.

[0009] In some embodiments, the nicotine concentration in the atomizing liquid is 28~32 mg / ml.

[0010] In some embodiments, the pH of the atomizing fluid is 5.5 to 6.5.

[0011] In some embodiments, the nicotine salt includes one or more of nicotine benzoate, nicotine succinate, and nicotine tartrate.

[0012] In some embodiments, the water-soluble flavoring includes one of the following: peppermint water-soluble flavoring, mung bean paste water-soluble flavoring, and white peach water-soluble flavoring.

[0013] In some embodiments, the humectant includes one of trehalose, mannitol, sorbitol, erythritol, and sodium hyaluronate.

[0014] In some embodiments, the cooling agent includes one of WS-23, WS-3, and WS-27.

[0015] In some embodiments, the sweetener includes one of sucralose, steviol glycosides, and neotame.

[0016] In some embodiments, the pH adjuster includes at least one of malic acid and citric acid.

[0017] In some embodiments, the humectant is trehalose, the cooling agent is WS-23, the sweetener is sucralose, and the pH adjuster is malic acid.

[0018] Secondly, this application also proposes a method for preparing an atomizing liquid, comprising the following steps: Provide the above-mentioned raw materials; Prepare cooling agent pre-solution, humectant solution, and nicotine salt solution respectively; Mix the above solution with the remaining raw materials and filter to obtain the atomizing liquid.

[0019] In some embodiments, the preparation of the cooling agent pre-solution, the humectant solution, and the nicotine salt solution includes: Add the cooling agent to a portion of 1,3-propanediol and stir until completely dissolved to obtain a pre-solution of the cooling agent; Add the wetting agent to a portion of distilled water and stir until completely dissolved to obtain a wetting agent solution; Add the nicotine salt to the remaining distilled water and stir until completely dissolved to obtain a nicotine salt solution.

[0020] In some embodiments, the above solution is mixed with the remaining raw materials and filtered to obtain the atomizing liquid, comprising: Add the cooling agent pre-solution, humectant solution, nicotine salt solution, and sweetener to the mixing container in sequence, and stir until well mixed; Then add water-soluble flavoring to the container and continue stirring to mix; Continue adding the remaining 1,3-propanediol and 1,2-propanediol, and stir at 20-25°C for 30-60 minutes until the system is homogeneous and transparent; Finally, add a pH adjuster to adjust the pH of the system to 5.5-6.5, filter, and the atomized liquid is obtained.

[0021] This application provides an atomizing liquid and its preparation method, comprising specific weight parts of distilled water, propylene glycol, nicotine salts, and other components. By optimizing the formula ratio and preparation process, it effectively alleviates the burning and dry sensation in the throat caused by high nicotine concentrations, and has the advantages of reducing throat irritation and improving user comfort at high nicotine concentrations.

[0022] Specifically, by using a specially formulated mild component adapted to the water-based smokeless system, the technical shortcoming of the existing system, which lacks a dedicated mild moisturizing component, is overcome. This achieves a low-smoke or smokeless effect without adding glycerin, polyethylene glycol, or ethanol to the formula. At the same time, the nicotine concentration of the e-liquid is controlled to 30mg / ml. Through the synergistic effect of the components, the throat irritation caused by nicotine is weakened, and the problems of throat scratching, dryness, and strong discomfort when entering the throat under high nicotine conditions are improved. This balances the satisfaction of high nicotine smoking cessation with a mild throat feel. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of this application, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is a schematic flowchart of the method for preparing the atomizing liquid provided in the embodiments of this application; Figure 2 This is a schematic flowchart of step S30 in the method for preparing atomizing liquid provided in the embodiments of this application. Detailed Implementation

[0025] In the following description, specific details such as particular system architectures and techniques are set forth for illustrative purposes and not for limitation, in order to provide a thorough understanding of the embodiments of this application. However, those skilled in the art will understand that the embodiments of this application can also be implemented in other embodiments without these specific details. In other instances, detailed descriptions of well-known systems, apparatuses, circuits, and methods are omitted so as not to obscure the description of the embodiments of this application with unnecessary detail.

[0026] It should also be understood that the term "and / or" as used in the specification of embodiments of this application and the appended claims refers to any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0027] It should be noted that when a component is referred to as being "fixed to" or "set on" another component, it can be directly on or indirectly on that other component. When a component is referred to as being "connected to" another component, it can be directly connected to or indirectly connected to that other component.

[0028] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", and "outer" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the embodiments of this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of this application.

[0029] Furthermore, in the description of the embodiments and the appended claims of this application, the terms "first," "second," "third," etc., are used only for distinguishing descriptions and should not be construed as indicating or implying relative importance.

[0030] In the description of embodiments in this application, references to "some embodiments" or "some embodiments" mean that one or more embodiments of this application include a specific feature, structure, or characteristic described in connection with that embodiment. Therefore, the phrases "in some embodiments," "in some embodiments," "in other embodiments," "in still other embodiments," etc., appearing in different parts of this specification do not necessarily refer to the same embodiments, but rather mean "one or more, but not all, embodiments," unless otherwise specifically emphasized. The terms "comprising," "including," "having," and variations thereof mean "including but not limited to," unless otherwise specifically emphasized. "A plurality" refers to two or more.

[0031] In the development of high-aqueous-phase aqueous systems for smokeless electronic atomizers, the low viscosity and small droplet size of aqueous solvents prevent nicotine from being effectively encapsulated and released. When the nicotine concentration increases, throat irritation symptoms appear, and it is difficult to balance the high nicotine satisfaction with throat comfort. This problem directly affects the applicability of the product and user acceptance.

[0032] In discreet usage scenarios such as offices, when users use existing high-nicotine-concentration water-based atomizing liquids, the lack of an effective nicotine slow-release mechanism triggers throat irritation during inhalation, affecting the user experience and preventing the product from meeting the nicotine needs of heavy users.

[0033] Therefore, this application provides an atomizing liquid comprising the following components in parts by weight: 50-68 parts distilled water; 10-20 parts of propylene glycol; 7-8 parts nicotine salt; 20-28 parts of water-soluble fragrance; 0.5 to 2 parts of lubricant; Cooling agent 0.15~0.5 parts; Sweetener 0.8~1.5 parts; pH adjuster 0.05~0.15 parts.

[0034] This embodiment provides an atomizing fluid whose components include distilled water, propylene glycol, nicotine salts, water-soluble flavorings, humectants, cooling agents, sweeteners, and pH adjusters. These components are combined in specific weight ratios to achieve low irritation, smokeless and low-atomization effects, and stable flavor at high nicotine concentrations.

[0035] For ease of understanding, the following explains some key terms in this embodiment: Atomizing fluid, typically referring to liquids used in electronic atomization devices, produces an extremely low or almost invisible amount of aerosol after atomization. This type of atomizing fluid is designed to meet the needs of use in public places or scenarios with strict limitations on vapor production, in order to minimize disturbance to the surrounding environment.

[0036] Distilled water, as the main solvent component of this atomizing fluid, has high purity and is free of minerals and other impurities. In the atomizing fluid, distilled water helps to form a high-aqueous-phase system, thereby achieving a low-fog or fog-free atomization effect.

[0037] Propylene glycol, as a common carrier and solvent, plays a role in dissolving other components in atomized liquids, providing a certain throat hit, and acting as a humectant. During atomization, it can assist in the formation of aerosols and affect the taste and stability of the atomized liquid.

[0038] Nicotine salts are salt compounds formed by the combination of nicotine and organic acids. Compared to free nicotine, nicotine salts, when atomized and inhaled, typically provide a smoother throat feel, reduce irritation, and improve nicotine absorption efficiency, thus better meeting the user's nicotine needs.

[0039] Water-soluble flavorings are key components that impart specific flavors and aromas to the atomized liquid. Since this atomized liquid is a highly aqueous system, flavorings with good water solubility are selected to ensure that the flavorings dissolve uniformly in the liquid, avoiding stratification or precipitation, thereby providing a stable and consistent flavor experience.

[0040] Lubricants, used in nebulizer solutions, improve throat sensation and reduce discomfort such as dryness and burning that may be caused by high nicotine concentrations or certain components. They enhance comfort by forming a lubricating film or increasing humidity in the throat.

[0041] Cooling agents are used to provide a refreshing or icy sensory experience in the e-liquid. This component enhances the overall flavor profile of the e-liquid and delivers a unique refreshing sensation to the user.

[0042] pH adjusters are used to adjust the pH value of the nebulizer to a specific range. A suitable pH value has a significant impact on the stable presence of nicotine salts, the solubility of other components, and the user's throat comfort. By precisely adjusting the pH value, the overall performance and user experience of the nebulizer can be optimized.

[0043] In this application, distilled water serves as the base solvent for the atomizing fluid, with a dosage of 50-68 parts. The use of distilled water helps to construct a high-aqueous-phase system, significantly reducing aerosol visibility during atomization and achieving a smokeless or low-fog effect. Propylene glycol is used in the atomizing fluid at a dosage of 10-20 parts. As an important carrier and solvent, propylene glycol can dissolve various active ingredients and influences the taste and throat hit of the atomizing fluid. Nicotine salts are used at a dosage of 7-8 parts. Nicotine salts, as a source of nicotine, aim to provide effective nicotine delivery while reducing throat irritation. Water-soluble flavorings are used at a dosage of 20-28 parts. Water-soluble flavorings are used to impart specific flavors to the atomizing fluid. In practical applications, various water-soluble flavorings, such as fruit or tobacco flavorings, can be selected according to market demand. A humectant is used at a dosage of 0.5-2 parts. The humectant aims to improve the throat feel of the vaping liquid and reduce the dryness and irritation that may result from high nicotine concentrations. Glycerin or sorbitol can be considered as humectants. The cooling agent is used in an amount of 0.15 to 0.5 parts. The cooling agent is used to provide a refreshing sensory experience. In addition to the cooling agents mentioned in this application, menthol can also be used as a cooling agent. The sweetener is used in an amount of 0.8 to 1.5 parts. The sweetener is used to enhance the sweetness of the vaping liquid and improve the overall taste. Aspartame or sodium saccharin can be considered as sweeteners. The pH adjuster is used in an amount of 0.05 to 0.15 parts. The pH adjuster is used to adjust the pH value of the vaping liquid to a suitable range to ensure the stability of the nicotine salts and user comfort.

[0044] This embodiment of the application, by employing a specific weight proportion of nicotine salts in conjunction with a lubricant, achieves a significant reduction in throat irritation and dryness while providing a high level of nicotine satisfaction. This contrasts sharply with existing technologies, such as single 1,2-propanediol systems, which suffer from a lack of effective lubrication, resulting in highly irritating high-nicotine systems. The solution in this embodiment allows heavy users to obtain their required nicotine intake without sacrificing comfort.

[0045] Furthermore, the atomizing fluid in this embodiment is based on a high proportion of distilled water, constructing a high-aqueous-phase system, thereby achieving a smokeless or low-vapor atomization effect. This is fundamentally different from early electronic atomizer products that pursued large vapor production and some solutions that used glycerin as the atomizing carrier. Simultaneously, this embodiment avoids using ethanol as a matrix, thus circumventing the problems of ethanol systems being volatile, having flavor degradation, and exacerbating throat irritation. This embodiment also does not use polyethylene glycol (PEG) as a core matrix, thus eliminating the safety controversy surrounding the potential generation of harmful substances from PEG during high-temperature atomization. The formulation design of this embodiment, through the precise proportioning of each component, ensures the overall stability of the atomizing fluid.

[0046] In summary, the atomizing fluid of this embodiment successfully achieves a balance between high nicotine concentration, low throat irritation, smokeless and low-fog operation, and long-lasting and stable flavor without introducing potentially defective components such as glycerin, PEG, or ethanol. This provides the industry with a safe, efficient, and user-friendly solution.

[0047] In some embodiments, this application further proposes that the propylene glycol in the aforementioned atomizing liquid includes 1,3-propanediol and 1,2-propanediol. 1,3-propanediol possesses good solubility, hygroscopicity, and low irritation. In the atomizing liquid, it can act as an effective solvent, aiding in the dissolution of nicotine salts and water-soluble flavorings, and influencing the throat hit sensation. Possible methods for obtaining it include bio-fermentation or chemical synthesis. 1,2-propanediol, on the other hand, has good safety profiles and is widely used in the food, pharmaceutical, and daily chemical industries. In the atomizing liquid, its main function is as a solvent and smoke generator, contributing to the production of rich vapor and affecting the taste and smoothness of the atomizing liquid.

[0048] This application's solution specifically limits the propylene glycol component to a combination of 1,3-propanediol and 1,2-propanediol, enabling the atomizing liquid to effectively balance vapor production, flavor smoothness, and throat hit while maintaining good solubility. 1,2-propanediol typically has good vapor production capabilities and a relatively mild flavor, while 1,3-propanediol may provide a stronger throat hit and a superior solubility for certain nicotine salts or water-soluble flavorings. By rationally proportioning these two propylene glycols, the overall performance of the atomizing liquid can be optimized, avoiding problems such as flavor irritation or insufficient vapor production that might result from using only propylene glycol, thereby improving the user experience. This combination allows nicotine salts and water-soluble flavorings to dissolve more stably in the system and ensures that all components are released evenly during atomization, resulting in a stable and pleasant atomization effect.

[0049] In some embodiments, this application further proposes that the mass ratio of 1,3-propanediol to 1,2-propanediol in the above-mentioned atomizing fluid is (1~4):1. This mass ratio defines the relative content of the two propylene glycols in the formulation. For example, the mass ratio can be 1:1, that is, the mass of 1,3-propanediol and 1,2-propanediol are equal; or it can be 4:1, that is, the mass of 1,3-propanediol is four times that of 1,2-propanediol. The setting of the above specific ratio range is intended to optimize the overall performance of the atomizing fluid by precisely controlling the synergistic effect of the two propylene glycols.

[0050] This application's solution is based on the aforementioned basic components of the atomizing liquid, and specifies that propylene glycol is composed of 1,3-propanediol and 1,2-propanediol. Furthermore, by limiting the mass ratio of 1,3-propanediol to 1,2-propanediol to (1~4):1, precise control over the key physicochemical properties of the atomizing liquid is achieved. 1,2-Propanediol, with its excellent atomization performance and flavor-dissolving ability, is the core component for generating rich vapor and delivering flavor; while 1,3-propanediol has advantages in providing a stable base, adjusting viscosity, reducing irritation, and improving mouthfeel smoothness. When these two propylene glycols are combined in a specific mass ratio, they can form a synergistic effect. For example, a relatively high content of 1,3-propanediol can effectively reduce the overall irritation of the atomizing liquid and provide a smoother throat feel; while a relatively high content of 1,2-propanediol ensures sufficient vapor production and more direct flavor release. By controlling the mass ratio within the range of (1~4):1, it is possible to ensure that the atomizing fluid maintains good atomization efficiency and vapor production while also ensuring a comfortable taste and stable flavor presentation. This avoids problems such as uneven atomization, flavor distortion, or excessive irritation that may result from the use of propylene glycol alone or improper proportions. This precise ratio control allows the overall performance of the atomizing fluid to achieve an optimal balance, thereby improving product stability and user experience.

[0051] In some embodiments, this application further proposes that the nicotine concentration in the atomizing liquid is 28-32 mg / ml. Specifically, the nicotine concentration in the atomizing liquid can be 28 mg / ml, 29 mg / ml, 29.5 mg / ml, 30 mg / ml, 31 mg / ml, 32 mg / mL, etc. Here, nicotine concentration refers to the mass of nicotine contained in each unit volume of atomizing liquid. Precise control of the nicotine concentration is crucial to ensuring the efficacy, safety, and user experience of the atomizing liquid. Concentrations that are too high or too low may lead to adverse consequences, such as excessive irritation, increased risk of addiction, or failure to meet user needs. The setting of this concentration range is usually determined based on a comprehensive consideration of market demand, user feedback, regulatory requirements, and factors such as the solubility and stability of nicotine salts.

[0052] The solution proposed in this application precisely limits the nicotine concentration in the atomizing liquid to the range of 28-32 mg / ml, ensuring that the atomizing liquid provides a basic vaping experience while stably and effectively delivering nicotine. In the aforementioned component system containing distilled water, propylene glycol, nicotine salts, water-soluble flavorings, humectants, cooling agents, sweeteners, and pH adjusters, nicotine salts, as the main active ingredient, directly determine the physiological intensity of the atomizing liquid. By controlling the nicotine concentration at 28-32 mg / ml, it avoids insufficient user experience due to excessively low concentrations, or increased irritation or potential health risks due to excessively high concentrations.

[0053] In some embodiments, this application further proposes that the pH of the aforementioned atomizing liquid is 5.5 to 6.5. Specifically, the pH value of the atomizing liquid can be 5.5, 5.6, 5.8, 6.0, 6.1, 6.2, 6.3, 6.4, 6.5, etc. pH value is an indicator of the acidity or alkalinity of a solution, typically ranging from 0 to 14, where a pH of 7 indicates neutrality, less than 7 indicates acidity, and greater than 7 indicates alkalinity. Controlling the pH value of the atomizing liquid within the slightly acidic range of 5.5 to 6.5 ensures the stable existence of nicotine salts in the solution, preventing premature decomposition or crystallization. Furthermore, a suitable pH value also helps optimize the taste of the atomizing liquid, making it closer to the experience of natural tobacco and reducing throat irritation. Achieving pH control within a specific range can usually be done by adding acidic or alkaline substances. For example, organic acids such as malic acid and citric acid can be added to lower the pH value, or alkaline substances such as sodium hydroxide and sodium bicarbonate can be added to raise the pH value.

[0054] In some embodiments, this application further proposes preferred selections for key components in the aforementioned atomizing liquid. Nicotine salts include one or more of benzoic acid nicotine salts, succinic acid nicotine salts, and tartaric acid nicotine salts. Nicotine salts are compounds formed by combining nicotine with organic acids, designed to provide a smoother inhalation experience and more effective nicotine delivery. Their function is to provide nicotine components to meet the user's nicotine needs. Besides benzoic acid nicotine salts, succinic acid nicotine salts, and tartaric acid nicotine salts, nicotine salts can also be lactic acid nicotine salts, citrate nicotine salts, etc.

[0055] Water-soluble flavorings include one of the following: peppermint water-soluble flavoring, mung bean paste water-soluble flavoring, or white peach water-soluble flavoring. Water-soluble flavorings are key components that impart specific flavors and aromas to atomized liquids. Their solubility ensures uniform dispersion within the liquid, thus providing a consistent taste experience. Their role is to enhance the sensory appeal of the atomized liquid and offer a diverse range of flavor options. Besides peppermint, mung bean paste, and white peach water-soluble flavorings, water-soluble flavorings can also include tobacco water-soluble flavorings, fruit water-soluble flavorings (such as strawberry and mango), and dessert water-soluble flavorings (such as vanilla and chocolate).

[0056] Humectants include one of the following: trehalose, mannitol, sorbitol, erythritol, and sodium hyaluronate. Humectants are primarily used to improve the taste of nebulized liquids, making them smoother and richer, and helping to reduce throat irritation. Their function is to enhance the overall inhalation comfort of the nebulized liquid. Besides trehalose, mannitol, sorbitol, erythritol, and sodium hyaluronate, humectants can also be glycerin, glycerol, polyethylene glycol, etc.

[0057] The cooling agent includes one of WS-23, WS-3, and WS-27. The cooling agent is used to provide a cooling sensation during atomization, enhancing the user's sensory experience. Its function is to give the atomized liquid a unique refreshing property. Besides WS-23, WS-3, and WS-27, the cooling agent can also be menthol, menthone, menthyl lactate, etc. The sweetener includes one of sucralose, steviol glycosides, and neotame.

[0058] Sweeteners are used to adjust the sweetness of the atomizing liquid, making it taste better and more in line with user preferences. Their function is to balance the overall flavor of the atomizing liquid, providing a pleasant sweetness. Besides sucralose, steviol glycosides, and neotame, sweeteners can also include aspartame, sodium saccharin, xylitol, and others.

[0059] pH adjusters include at least one of malic acid and citric acid. pH adjusters are used to maintain the pH value of the vaping liquid within a specific range, which is crucial for the stability of nicotine salts and the overall taste of the vaping liquid. Their function is to optimize the absorption efficiency of nicotine salts and reduce throat irritation. Besides malic acid and citric acid, pH adjusters can also be lactic acid, tartaric acid, phosphoric acid, etc.

[0060] In application, selecting specific nicotine salts, such as nicotine benzoate, nicotine succinate, or nicotine tartrate, ensures the stable presence of nicotine in the vaping liquid and optimizes its release characteristics during atomization, thus providing a smoother and more effective nicotine delivery experience. Simultaneously, using specific types of water-soluble flavorings, such as peppermint, mung bean paste, or white peach, imparts a unique and stable flavor profile to the vaping liquid, avoiding off-flavors or uneven flavor due to inappropriate flavor selection. The optimal selection of humectants, such as trehalose, mannitol, sorbitol, erythritol, or sodium hyaluronate, effectively improves the taste of the vaping liquid, making it smoother and more mellow, and reducing throat irritation. Specific selections of cooling agents, such as WS-23, WS-3, or WS-27, provide a lasting and comfortable cooling sensation, enhancing the overall inhalation experience. The optimal selection of sweeteners, such as sucralose, steviol glycosides, or neotame, allows for precise adjustment of the sweetness of the atomized liquid, satisfying users' sweetness preferences without masking the original flavor. Finally, by choosing malic acid or citric acid as pH adjusters, the pH value of the atomized liquid can be more precisely controlled, maintaining it within the suitable range of 5.5–6.5. This not only contributes to the stability and absorption efficiency of nicotine salts but also further optimizes the overall taste of the atomized liquid, reducing irritation. The synergistic effect of these specific components allows the atomized liquid to significantly improve the comfort, consistency, and satisfaction of the user experience while maintaining its basic functions.

[0061] In some embodiments, the scheme of this application forms a synergistic system by specifically selecting trehalose as the humectant, WS-23 as the cooling agent, sucralose as the sweetener, and malic acid as the pH adjuster. The addition of trehalose not only provides excellent moisturizing and lubricating effects and improves the taste of the atomized liquid, but also stabilizes other active ingredients, especially flavorings, thereby ensuring flavor persistence and consistency. WS-23, as a cooling agent, provides a pure and strong cooling sensation; its menthol-free characteristic allows the overall aroma of the atomized liquid to be fully expressed, avoiding the flavor masking that traditional cooling agents may cause. Sucralose, as a sweetener, with its high sweetness and good stability, imparts a pleasant sweetness to the atomized liquid without introducing additional calories or affecting other components. Malic acid precisely adjusts the pH of the atomized liquid to the target range, which is crucial for the stability of nicotine salts and the overall taste of the atomized liquid. Its unique sweet and sour flavor also complements the water-soluble flavorings well, enhancing the complexity and appeal of the overall flavor. This specific combination allows the components to promote each other, jointly creating a nebulizer with a smooth texture, moderate cooling sensation, pleasant sweetness, stable flavor, and precisely controlled pH value, thus overcoming the technical challenge of achieving the best balance among multiple component selections.

[0062] This application uses a combination of 1,3-propanediol and trehalose as a moisturizing system. 1,3-propanediol has a moisturizing and softening effect, reducing the throat irritation caused by smoke; trehalose has good water-locking and mucosal affinity, helping to maintain the moisture stability of the atomizing liquid during atomization. The synergistic effect of these two substances effectively neutralizes the irritation caused by high concentrations of nicotine (≥20 mg / mL, preferably 28~32 mg / mL), resulting in a smooth inhalation, moderate throat hit, and no noticeable throat scraping or dryness. Simultaneously, 1,3-propanediol has good solubility for the cooling agent WS-23, serving as its dedicated solvent and replacing anhydrous ethanol used in traditional formulations, thereby reducing the ethanol content in the system. The addition of trehalose further enhances the homogeneity and stability of the system, helping to inhibit the crystallization of the cooling agent, prevent flavor stratification, and reduce moisture loss during storage. 1,2-Propanediol is used only as a trace auxiliary component, mainly as a carrier for flavorings, sweeteners, and other excipients, and does not undertake core moisturizing or solubilizing functions. This design reduces the irritation that may be caused by high proportions of PG from the source, allowing the atomized liquid to still have comprehensive performance of low irritation, low smoke, stable and long-lasting, safe and mild even at high nicotine concentrations.

[0063] It should be noted that the humectant system formed by the combination of 1,3-propanediol and trehalose achieves its synergistic effect mainly through four dimensions: physical film formation, hydration stability, solvent optimization, and mucosal protection. This effectively neutralizes the irritation caused by high concentrations of nicotine and improves the stability of the atomizing liquid system.

[0064] 1,3-Propanediol, with hydroxyl groups at both ends, possesses excellent moisturizing and softening properties. It can form a continuous, soft, hydrophilic basement membrane on the surface of the pharyngeal mucosa, buffering the direct stimulation of mucosal nerves by smoke through physical barrier effects, reducing throat irritation and a scratchy sensation. Simultaneously, it exhibits excellent solubility for the cooling agent WS-23, serving as a dedicated solvent to replace anhydrous ethanol and reduce the content of irritating components in the system. Trehalose, as a non-reducing disaccharide, has extremely strong water-locking and mucosal affinity. It can construct a dense hydration network on and within the basement membrane formed by 1,3-propanediol. On one hand, it firmly fixes water molecules, reducing moisture loss during atomization and storage, thus preventing throat dryness. On the other hand, it enhances the membrane's adhesion durability through hydrogen bonding with mucosal proteins, further strengthening the mucosal protective effect.

[0065] Regarding solvent system stability, the solubilizing effect of 1,3-propanediol synergistically enhances the system uniformity of trehalose. Trehalose effectively inhibits WS-23 crystallization and flavor stratification, compensating for the insufficient system stability when 1,3-propanediol is used alone. With their synergistic effect, stable dispersion of flavorings, sweeteners, and other excipients can be achieved without relying on a high proportion of 1,2-propanediol (PG). Trace amounts of PG act only as excipient carriers, not participating in core moisturizing or solubilizing, thus reducing the additional irritation caused by a high proportion of PG from the formulation source. In summary, the softening film-forming, solubilizing, and moisturizing functions of 1,3-propanediol complement and reinforce the water-locking, stabilizing, and mucosal affinity functions of trehalose, jointly forming a stable double-layered hydrating protective film on the throat mucosa. This synergistically neutralizes high nicotine irritation and modulates the throat hit, ensuring that the atomized liquid maintains low irritation, low smoke, stable and long-lasting performance, and is safe and gentle even at high nicotine concentrations.

[0066] Secondly, this application proposes a method for preparing an atomizing liquid, such as... Figure 1 As shown, it includes the following steps: S10. Provide the raw materials described in the first aspect; S20. Prepare the cooling agent pre-solution, the humectant solution, and the nicotine salt solution respectively; S30. Mix the above solution with the remaining raw materials and filter to obtain the atomizing liquid.

[0067] The present application employs a step-by-step pre-dissolution process to pre-form a homogeneous solution of cooling agents, humectants, and nicotine salts, thus avoiding phase separation caused by direct contact between poorly soluble components in a high-aqueous-phase system. Specifically, the preparation of the cooling agent pre-solution ensures that cooling agents such as WS-23 are fully dissolved in a locally high-concentration solvent environment, effectively overcoming the technical deficiency of limited low-temperature solubility of cooling agents in a single aqueous-phase system; the independent preparation of the humectant solution ensures complete dispersion of humectants such as trehalose, preventing local supersaturation precipitation due to concentration gradients during mixing; and the pre-formation of the nicotine salt solution further ensures the stable existence of high-concentration nicotine salts (28~32 mg / ml) in the aqueous phase, preventing increased throat irritation caused by direct contact with other components.

[0068] In step S20, in some embodiments, this application further proposes steps for preparing the cooling agent pre-solution, the humectant solution, and the nicotine salt solution, respectively, including: S21. Add the cooling agent to a portion of 1,3-propanediol and stir until completely dissolved to obtain a pre-solution of the cooling agent; S22. Add the wetting agent to a portion of distilled water and stir until completely dissolved to obtain a wetting agent solution; S23. Add nicotine salt to the remaining distilled water and stir until completely dissolved to obtain a nicotine salt solution.

[0069] This application's solution effectively solves the solubility problem that may be encountered when directly mixing the three key components—cooling agent, humectant, and nicotine salt—by pre-preparing them into separate solutions. Specifically, the cooling agent is typically a fat-soluble substance or a substance that dissolves better in specific organic solvents. Adding it to a portion of 1,3-propanediol and stirring thoroughly utilizes the excellent dissolving power of 1,3-propanediol to ensure complete dissolution of the cooling agent and the formation of a stable pre-solution, preventing precipitation or uneven dispersion during subsequent aqueous phase mixing. Simultaneously, although the humectant and nicotine salt are well-soluble in water, to ensure uniform distribution in the final product and avoid clumping or slow dissolution due to localized high concentrations, they are pre-dissolved separately in a portion of distilled water and the remaining distilled water. This stepwise pre-dissolution strategy allows each component to fully dissolve in its most suitable solvent environment, forming a homogeneous and stable mother liquor. When these pre-solutions are mixed with the remaining raw materials in subsequent steps, they are already dissolved and can disperse more quickly and evenly throughout the system. This avoids problems such as incomplete dissolution, product inhomogeneity, and even impact on product stability that may occur with direct mixing. This pretreatment method ensures the precise proportions and uniform distribution of each component in the final atomized liquid, laying the foundation for obtaining a high-quality atomized liquid with a stable taste.

[0070] It should be noted that there is no requirement for the order of steps S21, S22 and S23; each step can be performed sequentially or simultaneously.

[0071] In step S30, in some embodiments, such as Figure 2 As shown, this application further proposes a step of mixing the above solution with the remaining raw materials and filtering to obtain the atomizing liquid, including: S31. Add the cooling agent pre-solution, humectant solution, nicotine salt solution, and sweetener to the mixing container in sequence, and stir until well mixed. S32. Then add water-soluble flavoring to the container and continue stirring and mixing; S33. Continue to add the remaining 1,3-propanediol and 1,2-propanediol, and stir at 20~25℃ for 30~60 minutes until the system is homogeneous and transparent; S34. Finally, add a pH adjuster to adjust the pH of the system to 5.5-6.5, filter, and the atomized liquid is obtained.

[0072] The preparation method described in this application ensures the stability and uniformity of the atomized liquid by precisely controlling the order of addition and mixing conditions of each component. First, in a mixing container under stirring, the pre-solution of the cooling agent, the humectant solution, the nicotine salt solution, and the sweetener are added sequentially and stirred thoroughly. This step aims to ensure that these key functional components are fully dissolved and uniformly dispersed, avoiding precipitation or clumping due to excessively high local concentrations. Next, water-soluble flavoring is added and stirring continues. This is to uniformly integrate the flavoring into the system after the main functional components have stabilized, maintaining its flavor integrity and reducing volatility. Then, the remaining 1,3-propanediol and 1,2-propanediol are added as the main solvents, and stirring is continued at a suitable temperature of 20-25°C for 30-60 minutes until the system becomes homogeneous and transparent. This ensures that all components, especially the highly viscous propylene glycol, are thoroughly mixed to form a stable single-phase solution. Finally, the pH of the system is precisely adjusted to 5.5–6.5 by adding a pH adjuster to optimize the stability of the nicotine salt and improve the taste. Filtration is then performed to remove impurities, resulting in a high-purity, highly stable atomized liquid. This step-by-step, orderly, and controlled preparation process effectively solves the problems of uneven component distribution, insufficient dissolution, and poor product stability that may result from simple mixing, ensuring the quality of the final product and the user experience.

[0073] In applications, the preparation container in a stirred state can be a reaction vessel, mixing tank, or stirring bucket equipped with a stirring device. Its function is to provide a closed or semi-closed space for containing and mixing various components. Stirring refers to the continuous motion of the mixture within the container to promote sufficient contact and uniform dispersion between components. The container can be made of corrosion-resistant materials such as stainless steel or glass and can be equipped with heating or cooling jackets to control temperature. The stirring device can include mechanical stirrers (such as paddle, anchor, or turbine stirrers), magnetic stirrers, or ultrasonic stirrers, the choice of which depends on the viscosity, volume, and required mixing intensity of the mixture.

[0074] Adding the cooling agent pre-solution, humectant solution, nicotine salt solution, and sweetener sequentially refers to adding these pre-prepared solutions and sweeteners one by one into the preparation container in a specific order. This sequential addition helps to prevent precipitation, crystallization, or interactions of certain components when their local concentrations are too high, thereby affecting the solubility or product stability.

[0075] Uniform mixing refers to the process of thoroughly mixing all components in a preparation container through continuous mechanical or physical action, achieving a state of macroscopic and microscopic homogeneity. This ensures that the concentration of each active ingredient in the atomized liquid remains consistent at any sampling point, thereby guaranteeing the stability of product quality, taste, and atomization effect. Uniform mixing can be achieved by adjusting the mixing speed, mixing time, and the type of stirrer.

[0076] After adding the water-soluble flavoring, continue stirring and mixing to ensure that the newly added flavoring can be quickly and evenly dispersed throughout the system, avoiding excessively high or low local flavoring concentrations, thereby ensuring the flavor consistency of the final product.

[0077] The remaining 1,3-propanediol and 1,2-propanediol are added as the main solvent and carrier in the atomizing fluid. Some propylene glycol has already been used in the preparation of the presol, and the "remaining" portion is added here to provide sufficient solvent in the system to ensure that all solid or high-viscosity components are completely dissolved and uniformly dispersed, while also adjusting the viscosity and atomization characteristics of the final product.

[0078] Maintaining the temperature at 20-25°C and stirring for 30-60 minutes until the system is homogeneous and transparent is to optimize the dissolution rate and stability of the components. Excessively high temperatures may cause degradation or volatilization of some heat-sensitive components, while excessively low temperatures may reduce dissolution efficiency. Stirring for 30-60 minutes ensures that all components, especially those with slower dissolution rates, have sufficient time to completely dissolve and form a stable, homogeneous system. A homogeneous and transparent system is an important indicator of sufficient mixing and complete dissolution, indicating that the product contains no visible particles, sediment, or stratification.

[0079] Finally, a pH adjuster is added to adjust the system pH to 5.5–6.5 to precisely control the pH of the nebulizer within this specific range. This pH range is crucial for the chemical stability of nicotine salts, effectively preventing their degradation, and also optimizing the taste of the nebulizer, making it smoother and reducing throat irritation. Adjusting the pH after all major components are thoroughly mixed ensures the accuracy of the pH adjustment and the stability of the final product.

[0080] Filtration is the final purification step in the preparation process, designed to remove any tiny insoluble matter, particulate impurities, fibers, or microorganisms that may be present in the nebulizer fluid. Filtration significantly improves the purity, clarity, and safety of the product, ensuring that the nebulizer fluid will not clog the nebulizer during use and meets food-grade or pharmaceutical-grade hygiene standards. Filtration can be performed using filter membranes or filter cartridges with different pore sizes.

[0081] The atomizing liquid and its preparation method provided in this application construct a smokeless solvent system mainly composed of "high aqueous phase + compounded core wetting agent + trace amount of auxiliary 1,2-propanediol". By controlling the total alcohol ratio, it achieves the technical effect of low vapor production when inhaled and near-smokeless when inhaled. The formulation does not contain thermally degradable components or highly irritating traditional solvents, enabling the atomizing liquid to maintain mild, stable, and safe performance even at high nicotine concentrations.

[0082] Example Example 1 S10. Provide the raw materials described in the first aspect; Distilled water 56.43g, 1,3-propanediol 9.0g, trehalose 1g, 1,2-propanediol 5g, nicotine benzoate 7g, water-soluble flavoring 20g, cooling agent WS-23 0.27g, sucralose 1.2g, malic acid 0.1g.

[0083] S20. Prepare the cooling agent pre-solution, the humectant solution, and the nicotine salt solution respectively; S21. Add 0.27g of cooling agent to 2g of 1,3-propanediol and stir until completely dissolved to obtain a pre-solution of cooling agent; S22. Add 1g of trehalose to 10g of distilled water and stir until completely dissolved to obtain a humectant solution; S23. Add 7g of nicotine benzoate to the remaining distilled water and stir until completely dissolved to obtain a nicotine salt solution.

[0084] S30. Mix the above solution with the remaining raw materials and filter to obtain the atomizing liquid; S31. Add the cooling agent pre-solution, humectant solution, nicotine salt solution, and sucralose to the mixing container in sequence, and stir until well mixed. S32. Then add water-soluble flavoring to the container and continue stirring and mixing; S33. Continue to add the remaining 1,3-propanediol and 1,2-propanediol, and stir at 25°C for 45 minutes until the system is homogeneous and transparent; S34. Finally, add a pH adjuster to adjust the pH of the system to 6.0, filter, and the atomized liquid is obtained.

[0085] This embodiment uses a 1,3-propanediol compounded with trehalose as the core system, which provides stable dual moisturizing and softening effects. With trace amounts of PG as an auxiliary additive, the smokeless and low-fog effect is achieved. There is no obvious throat irritation or dryness even with high nicotine levels. The aroma concentration is balanced. There is no crystallization or layering during long-term storage. The taste is stable and odorless. All performance aspects are balanced, making it suitable for daily use in all scenarios and highly reproducible for mass production.

[0086] Examples 2-3 This example is essentially the same as Example 1, except for the formulation. Specific differences are shown in the table below:

[0087] In Example 2, the proportion of 1,2-propanediol was further reduced to decrease trace solvent irritation. The synergistic effect of the compound moisturizing system was maximized, trehalose provided long-lasting moisture retention and throat protection, and high content of natural steviol glycosides provided triple neutralization of nicotine irritation, resulting in exceptionally mild smoke and outstanding throat protection. The proportion of water-soluble flavoring was significantly increased, resulting in a rich and mellow aroma, suitable for those who prefer strong flavors and those with sensitive throats. This completely solved the problem of high nicotine irritation, provided stable smoke-free performance, and exhibited excellent storage stability.

[0088] Example 3 relies on the stable synergistic effect of the compound core system. 1,3-Propanediol ensures the complete dissolution of the cooling agent, while trehalose locks in the moisture of the system and improves uniformity. No crystallization or stratification occurs during long-term storage or under normal low-temperature conditions. Nicotine succinate salt with stronger stability is used, which is suitable for bulk storage and market circulation. The nicotine concentration of 30mg / ml is stable, and the smoke-free effect and mild taste remain consistent.

[0089] In the above embodiments, the descriptions of each embodiment have different focuses. For parts that are not described in detail or recorded in a certain embodiment, please refer to the relevant descriptions of other embodiments.

[0090] The above-described embodiments are only used to illustrate the technical solutions of the embodiments of this application, and are not intended to limit them. Although the embodiments of this application have been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this application, and should all be included within the protection scope of the embodiments of this application.

Claims

1. An atomizing liquid, characterized in that, The components include the following parts by weight: 50-68 parts distilled water; 10-20 parts of propylene glycol; 7-8 parts nicotine salt; 20-28 parts of water-soluble fragrance; 0.5 to 2 parts of lubricant; Cooling agent 0.15~0.5 parts; Sweetener 0.8~1.5 parts; pH adjuster 0.05~0.15 parts.

2. The atomizing liquid as described in claim 1, characterized in that, The propylene glycol includes 1,3-propanediol and 1,2-propanediol.

3. The atomizing liquid as described in claim 2, characterized in that, The mass ratio of 1,3-propanediol to 1,2-propanediol is (1~4):

1.

4. The atomizing liquid as described in claim 1, characterized in that, The nicotine concentration in the atomizing liquid is 28~32 mg / ml.

5. The atomizing liquid as described in claim 1, characterized in that, The pH of the atomizing liquid is 5.5~6.

5.

6. The atomizing liquid according to any one of claims 1 to 5, characterized in that, The nicotine salt includes one or more of nicotine benzoate, nicotine succinate, and nicotine tartrate; and / or... The water-soluble flavoring includes one of the following: peppermint water-soluble flavoring, mung bean paste water-soluble flavoring, and white peach water-soluble flavoring; and / or, The moisturizing agent includes one of trehalose, mannitol, sorbitol, erythritol, and sodium hyaluronate; and / or, The cooling agent includes one of WS-23, WS-3, and WS-27; and / or, The sweetener includes one of sucralose, steviol glycosides, and neotame; and / or, The pH adjuster includes at least one of malic acid and citric acid.

7. The atomizing liquid as described in claim 6, characterized in that, The humectant is trehalose, the cooling agent is WS-23, the sweetener is sucralose, and the pH adjuster is malic acid.

8. A method for preparing an atomizing fluid, characterized in that, Includes the following steps: Provide the raw materials as described in any one of claims 1 to 7; Prepare cooling agent pre-solution, humectant solution, and nicotine salt solution respectively; The above solution is mixed with the remaining raw materials and filtered to obtain the atomized liquid.

9. The preparation method according to claim 8, characterized in that, The preparation of the cooling agent pre-solution, humectant solution, and nicotine salt solution respectively includes: Add the cooling agent to a portion of 1,3-propanediol and stir until completely dissolved to obtain a pre-solution of the cooling agent; Add the wetting agent to a portion of distilled water and stir until completely dissolved to obtain a wetting agent solution; Add the nicotine salt to the remaining distilled water and stir until completely dissolved to obtain a nicotine salt solution.

10. The preparation method according to claim 8, characterized in that, The above solution is mixed with the remaining raw materials and filtered to obtain the atomizing liquid, which includes: Add the cooling agent pre-solution, humectant solution, nicotine salt solution, and sweetener to the mixing container in sequence, and stir until well mixed; Then add water-soluble flavoring to the container and continue stirring to mix; Continue adding the remaining 1,3-propanediol and 1,2-propanediol, and stir at 20-25°C for 30-60 minutes until the system is homogeneous and transparent; Finally, add a pH adjuster to adjust the pH of the system to 5.5-6.5, filter, and the atomized liquid is obtained.

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