Preparation of wearable microneedle sensor and application of wearable microneedle sensor in early visual detection of in-situ melanoma
By preparing gold-etched cuprous oxide and silver-encapsulated nanoparticles combined with porous microneedles and surface-enhanced Raman scattering technology, the problems of long detection time, high invasiveness, high cost and low sensitivity in the detection of skin melanoma have been solved, realizing non-invasive, rapid and immediate early detection of skin melanoma.
Patent Information
- Application Number
- CN202610150669.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-02-03
- Publication Date
- 2026-06-09
AI Technical Summary
Existing technologies for detecting melanoma in the skin suffer from problems such as long detection time, high invasiveness, high cost, low sensitivity, and poor compliance. In particular, microneedle technology has difficulty achieving high sensitivity and real-time analysis due to the small sample size and easy degradation of the interstitial fluid extracted from the dermal layer of the skin.
A wearable microneedle sensor was fabricated using a method of gold etching of cuprous oxide and silver-encapsulated nanoparticles, combined with porous microneedles, colorimetric visualization, and surface-enhanced Raman scattering techniques. Qualitative and quantitative detection of tyrosinase was achieved by using catechol-modified gold etching of cuprous oxide and silver-encapsulated nanoparticles.
It enables non-invasive, rapid, and immediate early visual detection of skin melanoma, reducing patient suffering and infection risks, improving detection sensitivity and accuracy, making it suitable for frequent screening, and at a lower cost.