Flavonol derivatives containing piperazine-isopropanolamine and preparation method and application thereof

By synthesizing flavonol derivatives containing piperazine-isopropanolamine, the problem of insufficient inhibitory activity of flavonols against plant pathogenic microorganisms in existing technologies has been solved, especially the inhibitory effect on Phytophthora capsici and Bacterium thuringiensis of rice has been significantly enhanced.

CN122167378APending Publication Date: 2026-06-09GUIZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUIZHOU UNIV
Filing Date
2026-02-14
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing technologies do not yet combine piperazine with isopropanolamine and introduce it into the flavonol structure to enhance the inhibitory activity against plant pathogenic microorganisms, especially the inhibitory effect against Phytophthora capsici and Bacterium thuringiensis of rice.

Method used

A series of flavonol derivatives containing piperazine-isopropanolamine were designed and synthesized. Piperazine and isopropanolamine were introduced into the molecular skeleton of flavonols through a six-step synthetic method to form novel compounds. The specific steps include using substituted o-hydroxyacetophenone, substituted benzaldehyde, 1,3-dibromopropane, piperazine, epibromopropane and other raw materials, reacting under alkaline conditions and purifying them.

Benefits of technology

Compound 17 exhibited the strongest antibacterial activity against Phytophthora capsici, significantly inhibited the growth of rice bacterial blight pathogen, and enhanced the antibacterial activity of flavonols.

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Abstract

The application discloses a flavonol derivative containing piperazine-isopropyl alcohol amine and a preparation method and application thereof, and belongs to the technical field of pesticide synthesis. The application introduces piperazine-isopropyl alcohol amine with excellent activity into the structure of flavonol, and synthesizes a series of flavonol derivatives containing piperazine-isopropyl alcohol amine. Through activity test of the synthesized compounds on inhibition of plant pathogenic bacteria, it is found that the synthesized flavonol derivatives containing piperazine-isopropyl alcohol amine can effectively inhibit plant pathogenic bacteria, especially pepper phytophthora blight bacteria ( P.c ) and rice bacterial leaf blight bacteria ( Xoo ).
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