Animal model of cerebral microbleed and method for preparing the same
By delivering Col4a1-targeting gRNA to edit the COL4A1 gene in an animal model, reducing the elasticity of the blood-brain barrier, an animal model similar to human cerebral microbleeds was established. This solves the problem of the lack of effective therapeutic targets in existing technologies and enables pathological research and therapeutic screening of cerebral microbleeds.
CN122228017APending Publication Date: 2026-06-16ACHO UNIVERSITY SCHOOL- IND -ACADEMIC COOP GROUP
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ACHO UNIVERSITY SCHOOL- IND -ACADEMIC COOP GROUP
- Filing Date
- 2024-09-06
- Publication Date
- 2026-06-16
Smart Images
Figure CN122228017A_ABST
Abstract
The present application relates to a cerebral microbleeds animal model, characterized in that the cerebral microbleeds are induced by Col4a1-targeted gRNA (guide RNA) packaged in AAV-BR1.
Need to check novelty before this filing date? Find Prior Art