Devices, systems, and methods for organoid analysis
By combining high-density probes and machine learning models, the challenge of measuring the internal electrical activity of organoids has been solved, enabling comprehensive recording of electrical signals and improving the efficiency and accuracy of drug screening and disease simulation.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- DIAGNOSTIC BIOCHIP CO
- Filing Date
- 2024-09-27
- Publication Date
- 2026-06-19
AI Technical Summary
Existing technologies struggle to efficiently and comprehensively measure electrical activity from within organoids, especially the three-dimensional structure of brain organoids. Traditional methods cannot accurately record electrical signals from neural circuits, and existing equipment is difficult to scale up and manufacture.
High-density probes are used to penetrate organoids, and machine learning models are combined to identify biomarkers, enabling automated and comprehensive measurement of electrical activity. High-throughput recording is performed using a combination of readout head and plate, multi-point measurements are conducted inside the organoid using probe arrays, and data analysis is performed using machine learning models.
This technology enables efficient and comprehensive measurement of the internal electrical activity of organoids, improving the efficiency and accuracy of drug screening, reducing human error, and making it suitable for large-scale drug screening and disease simulation.
Smart Images
Figure CN122249546A_ABST