Vascular occlusion device and methods of using same

Abstract

This application relates to the field of interventional medical technology, and in particular to a vascular occlusion device and its method of use. This vascular occlusion device eliminates the need for a locator during use; it accurately determines the location of the blood vessel to be occluded simply by checking for blood flow from the return port. This precise determination of the distance between the fixator inserted into the skin and the blood vessel meets the needs of emergency patients, reduces the number of steps required by the surgeon, and greatly improves surgical efficiency. By reciprocating the rotation of a wrench, the delivery tube moves back and forth, adjusting the angle of the anchor plate to ensure it is fully exposed within both the inner and outer delivery tubes. This guarantees that the anchor plate will adhere tightly to the vessel wall during subsequent vascular occlusion, fundamentally preventing abnormal blood flow and thrombosis, thus ensuring sufficient safety in the vascular occlusion procedure.

Description

Technical Field

[0001] This application relates to the field of interventional medical technology, and in particular to a vascular occlusion device and its method of use. Background Technology

[0002] Complications at the puncture site of vascular access are a major cause of post-catheter interventional procedures. Currently, manual compression (MC) is a common method for achieving hemostasis at the arterial puncture site. However, due to the need to interrupt anticoagulation, prolong bed rest, and patient discomfort, especially for puncture sites larger than 8F requiring prolonged compression, manual compression can no longer fully meet the needs of both doctors and patients. Vascular occlusion devices (occlusion sizes up to 24F) are now widely used medical devices for puncture site hemostasis. They can improve patient comfort, reduce medical staff resources, shorten hemostasis time, and the time required for getting out of bed and discharge, thus reducing post-interventional complications.

[0003] In the prior art, Chinese invention patent application number CN202510328417.9 discloses a balloon vascular occlusion device. The implanted anchor in this device is installed in the gap between the inner and outer delivery tubes. During use, the movement of the outer delivery tube causes the anchor to protrude and adhere to the inner delivery tube. However, due to the significant stress during installation or prolonged stress on the delivery tubing, Figure 1 As shown, the delivery tube undergoes plastic deformation, resulting in poor adhesion of the anchor plate to the delivery tube and an unsuitable unfolding angle. Consequently, when the occlusion device is withdrawn, some anchor plates are pulled out of the blood vessel and cannot adhere tightly to the vessel wall, causing abnormal blood flow and thrombosis. Moreover, the existing occlusion device requires the distance from the skin to the blood vessel to be measured by a locator before the operation, which is not user-friendly for emergency patients.

[0004] Therefore, there is a need to provide an improved technical solution that addresses the shortcomings of the existing technology. Summary of the Invention

[0005] The purpose of this application is to provide a blood vessel occlusion device and its method of use, so as to solve or alleviate the problems existing in the prior art.

[0006] To achieve the above objectives, this application provides the following technical solution: A blood vessel occlusion device, the occlusion device comprising a closure device, a fixator and a guide; The fixture includes a graduated sheath tube, a sheath tube cap is provided at the proximal end of the graduated sheath tube, a connecting hub is provided around the sheath tube cap, and a sealing valve is provided at the center of the connecting hub. The guide includes a guide sheath, a guide handle is provided at the proximal end of the guide sheath, and a guide wire hole extending axially is provided at the center of the guide sheath for the guide wire to pass through; a blood inlet is provided in the middle of the guide sheath, and a first blood return port is provided at the proximal end of the guide sheath. The length of the guide sheath is greater than the length of the graduated sheath. After the guide is inserted into the fixator, the blood inlet on the guide sheath is located outside the graduated sheath, and the blood inlet is located at the distal end near the graduated sheath.

[0007] In the vascular occlusion device described above, preferably, the guide handle is provided with a locking platform and the connecting hub is provided with a limiting boss. When the guide is inserted into the fixator, the locking platform and the limiting boss lock together.

[0008] In the preferred embodiment of the vascular occlusion device described above, the guide sheath has multiple blood inlets evenly distributed in the middle. The guide handle is provided with a second blood return port. When the guide sheath and the guide handle are assembled into place, the first blood return port and the second blood return port overlap.

[0009] Preferably, in the vascular occlusion device described above, the closure device comprises a housing, a rotating cover, a rotating wrench, a turntable, a stainless steel rod, an inner tube assembly, an outer tube assembly, and a sheath.

[0010] In the blood vessel occlusion device described above, preferably, the housing is provided with two positioning bosses, which are used to position the rotary wrench.

[0011] Preferably, in the blood vessel occlusion device described above, the housing is further provided with a bottom boss, which is used to limit the rotation of the wrench.

[0012] In the vascular occlusion device described above, preferably, the two positioning protrusions are located in front of the bottom protrusion.

[0013] In the preferred embodiment of the blood vessel occlusion device described above, the outer tube assembly consists of a delivery outer tube and an outer tube handle, wherein the outer tube handle is movably disposed inside the housing. The outer tube handle is provided with a first waist hole, the housing is provided with an arc-shaped hole, the stainless steel rod passes through both the first waist hole and the arc-shaped hole, and both ends of the stainless steel rod are fixed to the rotating cover. The outer tube handle is provided with a second waist hole, which is parallel to the first waist hole. A sliding shaft is provided on the turntable, and the sliding shaft is assembled in the second waist hole so that the sliding shaft slides along the second waist hole. The turntable is rotatably disposed inside the housing.

[0014] In the vascular occlusion device described above, preferably, the inner tube assembly consists of a delivery inner tube, an anchor plate, collagen, a propulsion tube, a suture, and an inner tube handle, wherein the anchor plate is assembled between the delivery inner tube and the delivery outer tube.

[0015] This application also provides a method of using a vascular occlusion device, the method of using the above-mentioned vascular occlusion device, the method of using the device includes the following steps: Step 1: Insert the guide into the fixator and then enter the blood vessel along the guidewire; when pulsating blood flow begins to appear at the blood return port of the guide, repeat this process twice to confirm, record the distance at this time, and then advance the fixator at least 1cm further. Step 2: Remove the guide and guide wire, keeping the fixator in place; Step 3: Keep the retainer stationary in its original position and insert the closure into the retainer; Step 4: Turn the rotary wrench to the bottom boss on the housing to retract the outer conveying tube so that the anchor plate is exposed in the outer conveying tube; Step 5: Rotate the wrench between the two positioning bosses on the housing to move the outer tube forward so that one side of the far end of the outer tube lifts the anchor plate. Step 6: Turn the rotary wrench again to the bottom boss of the housing to push up the anchor plate on the other side of the far end of the outer tube. Step 7: Keep the retainer stationary in place, then retract the closure device to pull out the collagen and propulsion tube installed in the delivery tube. Step 8: Continue to retract the closure device to fold the collagen, then push the advance tube forward. The advance tube pushes the knot on the suture forward to complete the locking of the collagen. Step 9: Finally, cut off the excess sutures to complete the closure of the blood vessel.

[0016] Compared with the closest prior art, the technical solution of this application has the following beneficial effects: When using this vascular occlusion device, the guide is first inserted into the fixator. Then, the combined guide and fixator are inserted into the blood vessel along the guidewire. As the guide sheath is gradually inserted into the blood vessel, the inlet on the guide sheath is inserted into the blood vessel. At this time, blood enters the guide sheath from the inlet and then flows out from the return port. That is, when blood is observed flowing out of the return port of the guide sheath, it can be determined that the distal end of the fixator is at the puncture site of the blood vessel to be occluded. In other words, this vascular occlusion device does not require the intervention of a locator. It can accurately determine the location of the blood vessel to be occluded simply by judging whether there is blood flowing out of the return port. This also allows for precise determination of the distance between the fixator inserted into the skin and the blood vessel, which not only meets the needs of emergency patients but also reduces the number of steps for doctors and greatly improves the efficiency of the operation.

[0017] By reciprocating the rotation of the wrench, the delivery tube is moved back and forth, thereby adjusting the angle of the anchor plate. This ensures that the anchor plate is fully exposed between the delivery tube and the delivery tube, guaranteeing that the anchor plate can completely adhere to the vessel wall during subsequent vascular occlusion. This fundamentally avoids abnormal blood flow and thrombosis, ensuring sufficient safety in the vascular occlusion procedure. Attached Figure Description

[0018] The accompanying drawings, which form part of this application, are used to provide a further understanding of this application. The illustrative embodiments and descriptions of this application are used to explain this application and do not constitute an undue limitation of this application. Wherein: Figure 1 This is a schematic diagram showing that some of the anchor pieces have been removed from the blood vessel in the background art. Figure 2 This is a schematic diagram of a blood vessel occlusion device provided according to some embodiments of this application; Figure 3 This is a schematic diagram of a fixator provided according to some embodiments of this application; Figure 4 This is a schematic diagram of a bootloader provided according to some embodiments of this application; Figure 5 This is a schematic diagram of a closure provided according to some embodiments of this application; Figure 6 This is a schematic diagram of the housing of a closure provided according to some embodiments of this application; Figure 7 This is a schematic cross-sectional view of a closure provided according to some embodiments of this application; Figure 8 This is a schematic diagram of an outer tube assembly provided according to some embodiments of this application; Figure 9 This is a schematic diagram of an inner tube assembly provided according to some embodiments of this application; Figure 10 This is a schematic diagram of step 1 of the usage method provided according to some embodiments of this application; Figure 11 This is a schematic diagram of step 2 of the usage method provided according to some embodiments of this application; Figure 12 This is a schematic diagram of step 3 of the usage method provided according to some embodiments of this application; Figure 13 This is a schematic diagram of step 4 of the usage method provided according to some embodiments of this application; Figure 14 This is a schematic diagram of step 5 of the usage method provided according to some embodiments of this application; Figure 15This is a schematic diagram of step 6 of the usage method provided according to some embodiments of this application; Figure 16 This is a schematic diagram of step 7 of the usage method provided according to some embodiments of this application; Figure 17 This is a schematic diagram of step 8 of the usage method provided according to some embodiments of this application; Figure 18 This is an enlarged view of collagen being secured by knots according to some embodiments of this application.

[0019] Explanation of reference numerals in the attached figures: 1. Closure device; 2. Fixing device; 3. Guide device; 21. Graduated sheath; 22. Sheath cap; 23. Connecting hub; 24. Sealing valve; 231. Limiting boss; 31. Guide sheath; 32. Guide handle; 311. Blood inlet; 312. First blood return port; 321. Locking platform; 322. Second blood return port; 11. Housing; 12. Rotating cover; 13. Rotating wrench; 14. Cable transfer table; 15. Stainless steel rod; 16. 17. Inner tube assembly; 18. Outer tube assembly; 19. Sheath; 10. Slot; 112. Limiting slot; 113. Positioning boss; 114. Bottom boss; 171. Conveying outer tube; 172. Outer tube handle; 1721. Movable buckle; 1722. First waist hole; 1723. Second waist hole; 161. Conveying inner tube; 162. Anchor plate; 163. Glue; 164. Raw material; 165. Propulsion tube; 166. Suture; 1777. Inner tube handle. Detailed Implementation

[0020] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention are within the scope of protection of the present invention.

[0021] In the description of this invention, the terms "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," and "bottom," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and do not require the invention to be constructed and operated in a specific orientation; therefore, they should not be construed as limitations on the invention. The terms "connected" and "linked" used in this invention should be interpreted broadly. For example, they can refer to a fixed connection or a detachable connection; they can refer to a direct connection or an indirect connection through intermediate components. Those skilled in the art can understand the specific meaning of the above terms according to the specific circumstances.

[0022] The present application will now be described in detail with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in the embodiments of the present application can be combined with each other.

[0023] According to specific embodiments of this application, such as Figure 1-18 As shown, this application provides a blood vessel occlusion device, which includes a closure device 1, a fixator 2, and a guide device 3; The fixture 2 includes a graduated sheath 21, a sheath cap 22 is provided at the proximal end of the graduated sheath 21, a connecting hub 23 is provided around the sheath cap 22, and a sealing valve 24 is provided at the center of the connecting hub 23. In this embodiment, the graduated sheath 21 is made of HDPE material, and its surface is marked with graduation marks by laser. The proximal end of the graduated sheath 21 is connected to the sheath cap 22 by insert injection molding or glue. The sheath cap 22 is connected to the connecting hub 23 by a snap-fit.

[0024] The guide device 3 includes a guide sheath 31, with a guide handle 32 at the proximal end of the guide sheath 31. A guide wire hole extending axially is provided at the center of the guide sheath 31 for the guide wire to pass through. A blood inlet 311 is provided in the middle of the guide sheath 31, and a first blood return port 312 is provided at the proximal end of the guide sheath 31. In this embodiment, the distal end of the guide sheath 31 is tapered. The guide sheath 31 is made of LDPE material with a hardness of 30-35 degrees. After manufacturing, the guide sheath 31 is connected to the guide handle 32 by glue or insert injection molding. A guide wire hole (not shown) with a diameter of φ0.90-0.95 mm is designed at the center of the guide sheath 31 for the passage of a 0.35-inch guide wire.

[0025] The length of the guide sheath 31 is greater than the length of the graduated sheath 21. After the guide 3 is inserted into the fixator 2, the blood inlet 311 on the guide sheath 31 is located outside the graduated sheath 21, and the blood inlet 311 is located at the distal end near the graduated sheath 21.

[0026] When using this vascular occlusion device, the guide 3 is first inserted into the fixator 2. Then, the combined guide 3 and fixator 2 are inserted into the blood vessel along the guide wire. As the guide sheath 31 is gradually inserted into the blood vessel, the blood inlet 311 on the guide sheath 31 is inserted into the blood vessel. At this time, blood enters the guide sheath 31 from the blood inlet 311 and then flows out from the blood return port of the guide sheath 31. That is, when blood is observed flowing out of the blood return port of the guide sheath 31, it can be determined that the distal end of the fixator 2 is at the puncture site of the blood vessel to be occluded. In other words, this vascular occlusion device does not require the intervention of a locator. It can accurately determine the location of the blood vessel to be occluded simply by judging whether there is blood flowing out of the blood return port. That is, it can accurately determine the distance between the fixator 2 inserted into the skin and the blood vessel. This not only meets the needs of emergency patients but also reduces the operation steps of doctors and greatly improves the efficiency of surgery.

[0027] The guide handle 32 is provided with a locking platform 321, and the connecting hub 23 is provided with a limiting boss 231. When the guide 3 is inserted into the retainer 2, the locking platform 321 and the limiting boss 231 lock together. In this embodiment, when the guide 3 is inserted into the retainer 2 and the two are assembled, the locking platform 321 and the limiting boss 231 lock together, so that the guide 3 and the retainer 2 remain relatively fixed.

[0028] The guide sheath 31 has multiple blood inlets 311 evenly distributed in the middle; the guide handle 32 is provided with a second blood return port 322. When the guide sheath 31 and the guide handle 32 are assembled into place, the first blood return port 312 and the second blood return port 322 overlap each other.

[0029] In this embodiment, multiple blood inlets 311 are provided to facilitate the entry of blood into the guide sheath 31. The guide handle 32 is provided with a second blood return port 322. When the guide sheath 31 and the guide handle 32 are assembled in place, the first blood return port 312 and the second blood return port 322 overlap, so that the blood entering the guide sheath 31 can flow out through the first blood return port 312 and the second blood return port 322, thereby facilitating the accurate determination of the relative position between the distal end of the fixator 2 and the part of the blood vessel to be blocked.

[0030] The closure device 1 consists of a housing 11, a rotating cover 12, a rotating wrench 13, a cable turner 14, a stainless steel rod 15, an inner tube assembly 16, an outer tube assembly 17, and a sheath 18. In this embodiment, the operating principle of the closure device 1 is basically the same as that of the closure device body in a balloon vascular closure device of patent number 202510328417.9. The difference lies in the details of the housing 11 and the outer tube assembly 17 of the closure device 1 in this application. In this application, the housing 11 of the closure device 1 is provided with two positioning bosses 113; the outer tube handle 172 of the outer tube assembly 17 is provided with two waist holes.

[0031] The housing 11 is provided with two positioning bosses 113, which are used to position the rotary wrench 13.

[0032] The housing 11 is also provided with a bottom boss 114, which is used to limit the rotation wrench 13.

[0033] Two positioning bosses 113 are located in front of the bottom boss 114.

[0034] In this embodiment, the bottom boss 114 on the housing 11 is used to limit the rotation wrench 13, and the rotation wrench 13 cannot pass over the bottom boss 114; the positioning boss 113 on the housing 11 is used to temporarily position the rotation wrench 13, and the rotation wrench 13 can pass over the positioning boss 113; and the two positioning bosses 113 are arranged in front of the bottom boss 114 so that the rotation wrench 13 can first rotate to the bottom and then rotate back to between the two positioning bosses 113, so that the rotation wrench 13 can drive the outer tube assembly 17 to complete the surgical action of retraction and forward movement.

[0035] The outer tube assembly 17 consists of a conveying outer tube 171 and an outer tube handle 172, with the outer tube handle 172 movably disposed inside the housing 11. The outer tube handle 172 has a first waist hole 1722, and the housing 11 has an arc-shaped hole. A stainless steel rod 15 passes through both the first waist hole 1722 and the arc-shaped hole, with both ends of the stainless steel rod 15 fixed to the rotating cover 12. In this embodiment, when the rotating wrench 13 drives the rotating cover 12 to rotate, the stainless steel rod 15 can drive the outer tube handle 172 to move axially. The outer tube handle 172 and the conveying outer tube 171 are connected by insert injection molding or adhesive. A slot 111 is provided in the housing 11, and a movable buckle 1721 is provided on the outer tube handle 172, slidingly disposed in the slot 111.

[0036] The outer tube handle 172 is provided with a second waist hole 1723, which is parallel to the first waist hole 1722. A sliding shaft is provided on the turntable 14, which is fitted into the second waist hole 1723, so that the sliding shaft slides along the second waist hole 1723. The turntable 14 is rotatably disposed in the housing 11.

[0037] In this embodiment, the extension directions of the first waist hole 1722 and the second waist hole 1723 are perpendicular to the moving direction of the outer tube handle 172. When the rotating cover 12 rotates to drive the outer tube handle 172 to move, the movement of the outer tube handle 172 can drive the rotating table 14 to rotate, so that the sewing thread 165 wound on the rotating table 14 can always be in a moderately taut state.

[0038] The inner tube assembly 16 consists of a delivery inner tube 161, an anchor plate 162, collagen glue 163, a propulsion tube 164, a suture 165, and an inner tube handle 166, wherein the anchor plate 162 is assembled between the delivery inner tube 161 and the delivery outer tube 171.

[0039] In this embodiment, the distal end of the suture 165 is pressed to prevent it from being pulled out. The distal end of the inner delivery tube 161 is designed with an acute angle to allow space during the assembly of the anchor plate 162. The suture 165 passes sequentially through the anchor plate 162, collagen glue 163, and push tube 164 before being installed with other parts. The proximal end is completely hidden inside the inner delivery tube 161. Then, the inner delivery tube 161 is inserted into the outer delivery tube 171, and the anchor plate 162 is squeezed between the two. The inner tube handle 166 is designed with a locking boss that is installed in the limiting groove 112 of the housing 11. The sheath 18 is slidably installed on the distal end of the outer tube assembly 17 to provide temporary protection for the distal end of the outer tube assembly 17.

[0040] This application also provides a method of using a vascular occlusion device, the method of using the above-mentioned vascular occlusion device, the method of using the device includes the following steps: Step 1: Insert the guide 3 into the fixator 2, and then enter the blood vessel along the guide wire; when the blood return port of the guide 3 begins to show fluctuating blood flow, repeat this process twice to confirm, record the distance at this time, and then advance the fixator 2 at least 1cm further. Step 2: Remove the guide 3 and guide wire, keeping the retainer 2 in place; Step 3: Keep the retainer 2 stationary in its original position and insert the closure 1 into the retainer 2; Step 4: Rotate the rotary wrench 13 to the bottom boss 114 on the housing 11, and retract the outer conveying tube 171 so that the anchor plate 162 is exposed in the outer conveying tube 171; Step 5: Rotate the wrench 13 between the two positioning bosses 113 on the housing 11, and move the outer delivery tube 171 forward so that one side of the far end of the outer delivery tube 171 pushes up the anchor plate 162. Step 6: Rotate the rotary wrench 13 again to the bottom boss 114 of the housing 11 so that the other side of the far end of the delivery tube 171 pushes up the anchor plate 162. Step 7: Fixer 2 remains stationary in its original position. Retract closure 1 to pull out collagen glue 163 and push tube 164 installed in inner delivery tube 161. Step 8: Continue to retract the closure device 1, folding the collagen glue 163. Then, push the advance tube 164 forward. The advance tube 164 pushes the knot on the suture 165 forward to complete the locking of the collagen glue 163. Step 9: Finally, cut off the excess sutures at 165 degrees to complete the closure of the blood vessel.

[0041] In this embodiment, by reciprocating the rotation wrench 13, the delivery outer tube 171 is driven to move back and forth, thereby adjusting the angle of the anchor plate 162 so that the anchor plate 162 is fully exposed from the delivery inner tube 161 and the delivery outer tube 171. This ensures that the anchor plate 162 can be completely attached to the blood vessel wall during subsequent vascular occlusion, thereby fundamentally avoiding abnormal blood flow and thrombosis, and ensuring sufficient safety of the vascular occlusion surgery.

[0042] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A vascular occlusion device, comprising: The sealing device includes a closure device, a fixator, and a guide. The fixture includes a graduated sheath tube, a sheath tube cap is provided at the proximal end of the graduated sheath tube, a connecting hub is provided around the sheath tube cap, and a sealing valve is provided at the center of the connecting hub. The guide includes a guide sheath, a guide handle is provided at the proximal end of the guide sheath, and a guide wire hole extending axially is provided at the center of the guide sheath for the guide wire to pass through; a blood inlet is provided in the middle of the guide sheath, and a first blood return port is provided at the proximal end of the guide sheath. The length of the guide sheath is greater than the length of the graduated sheath. After the guide is inserted into the fixator, the blood inlet on the guide sheath is located outside the graduated sheath, and the blood inlet is located at the distal end near the graduated sheath.

2. The vascular plugging device of claim 1, wherein, The guide handle is provided with a locking platform, and the connecting hub is provided with a limiting boss. When the guide is inserted into the retainer, the locking platform and the limiting boss lock together.

3. The vascular plugging device of claim 2, wherein, The guide sheath has multiple blood inlets evenly distributed in the middle section; The guide handle is provided with a second blood return port. When the guide sheath and the guide handle are assembled into place, the first blood return port and the second blood return port overlap.

4. The vascular plugging device of claim 3, wherein, The closure device consists of a housing, a rotating cover, a rotating wrench, a turntable, a stainless steel rod, an inner tube assembly, an outer tube assembly, and a protective sleeve.

5. The vascular plugging device of claim 4, wherein, The housing is provided with two positioning bosses, which are used to position the rotary wrench.

6. The vascular plugging device of claim 5, wherein, The housing is also provided with a bottom boss, which is used to limit the rotation of the wrench.

7. The vascular plugging device of claim 6, wherein, Two positioning bosses are located in front of the bottom boss.

8. The vascular plugging device of claim 7, wherein, The outer tube assembly consists of a delivery outer tube and an outer tube handle, with the outer tube handle being movably disposed inside the housing. The outer tube handle is provided with a first waist hole, the housing is provided with an arc-shaped hole, the stainless steel rod passes through both the first waist hole and the arc-shaped hole, and both ends of the stainless steel rod are fixed to the rotating cover. The outer tube handle is provided with a second waist hole, which is parallel to the first waist hole. A sliding shaft is provided on the turntable, and the sliding shaft is assembled in the second waist hole so that the sliding shaft slides along the second waist hole. The turntable is rotatably disposed inside the housing.

9. The blood vessel occlusion device according to claim 8, characterized in that, The inner tube assembly consists of a delivery inner tube, an anchor plate, collagen, a propulsion tube, sutures, and an inner tube handle. The anchor plate is assembled between the delivery inner tube and the delivery outer tube.

10. A method of using a blood vessel occlusion device, characterized in that, The method of use is the method of using the blood vessel occlusion device according to claim 9, and the method of use includes the following steps: Step 1: Insert the guide into the fixator and then enter the blood vessel along the guidewire; when pulsating blood flow begins to appear at the blood return port of the guide, repeat this process twice to confirm, record the distance at this time, and then advance the fixator at least 1cm further. Step 2: Remove the guide and guide wire, keeping the fixator in place; Step 3: Keep the retainer stationary in its original position and insert the closure into the retainer; Step 4: Turn the rotary wrench to the bottom boss on the housing to retract the outer conveying tube so that the anchor plate is exposed in the outer conveying tube; Step 5: Rotate the wrench between the two positioning bosses on the housing to move the outer tube forward so that one side of the far end of the outer tube lifts the anchor plate. Step 6: Turn the rotary wrench again to the bottom boss of the housing to push up the anchor plate on the other side of the far end of the outer tube. Step 7: Keep the retainer stationary in place, then retract the closure device to pull out the collagen and propulsion tube installed in the delivery tube. Step 8: Continue to retract the closure device to fold the collagen, then push the advance tube forward. The advance tube pushes the knot on the suture forward to complete the locking of the collagen. Step 9: Finally, cut off the excess sutures to complete the closure of the blood vessel.

Images