Modular microfluidic organ-on-a-chip and its organ model construction method

CN122278622APending Publication Date: 2026-06-26SHENZHEN COOLRUN LIFE SCI TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENZHEN COOLRUN LIFE SCI TECH CO LTD
Filing Date
2026-05-26
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Existing organ-on-a-chip systems require destructive disassembly to obtain samples after experiments, resulting in sample damage and non-reusability of the chip, increasing costs and affecting the accuracy and reliability of offline characterization results.

Method used

The modular microfluidic organ-on-a-chip design employs a detachable porous membrane culture chamber and an independent perfusion channel structure, allowing for non-destructive disassembly to obtain samples. The chip itself is reusable, and two culture chambers are set up to simulate the interaction between different tissues or organs.

Benefits of technology

It achieves non-destructive sampling, reduces the probability of sample damage, improves the accuracy and reliability of offline characterization results, reduces experimental costs, and facilitates large-scale application.

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Abstract

This invention discloses a modular microfluidic organ-on-a-chip and its organ model construction method, relating to the field of biomedical engineering technology. The modular microfluidic organ-on-a-chip includes a chip body, a first culture chamber, a second culture chamber, and a sealing component. The chip body has a culture hole with its top surface facing downwards. The culture hole passes through the middle of the first perfusion channel and the middle of the second perfusion channel in sequence. The first culture chamber can be inserted into or removed from the culture hole. The second culture chamber can be inserted into the culture hole and located at the top of the first culture chamber or removed from the culture hole. Therefore, the target samples on the first and second porous membranes can be easily obtained without destructive disassembly of the chip body, improving the accuracy and reliability of subsequent offline characterization results. The chip body, the first culture chamber, and the second culture chamber are independent of each other. The chip body can be reused, reducing the overall cost of the experiment and facilitating promotion and application.
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