A medicinal and edible four-dimensional targeted female nourishing composition, its preparation method and its application

Abstract

This invention provides a four-dimensional targeted female nourishing composition derived from both food and medicine, its preparation method, and its application, belonging to the field of traditional Chinese medicine technology. The four-dimensional targeted female nourishing composition derived from both food and medicine comprises the following raw materials in parts by weight: 5-30 parts of Polygonatum sibiricum, 4-24 parts of mulberry, 3-20 parts of raspberry, 4-24 parts of wolfberry, 5-30 parts of yam, 3-20 parts of Poria cocos, 2-16 parts of jujube, 1-12 parts of longan, 3-20 parts of kudzu root, 0.3-3 parts of rose, 3-20 parts of lily bulb, 2-16 parts of lotus seed, 0.1-1 part of cinnamon, 1.5-12 parts of Alpinia oxyphylla, and 3-20 parts of Euryale ferox. This nourishing composition can significantly improve the sub-health state of women.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a four-dimensional targeted female nourishing composition that is both food and medicine, its preparation method, and its application. Background Technology

[0002] With the fast pace of modern life, increased work pressure, and changes in the ecological environment, the number of people in a sub-healthy state is increasing, with women's sub-health issues being particularly prominent. These problems are often accompanied by symptoms such as sallow complexion, fatigue, insomnia, and cold limbs, and have become an important issue that urgently needs to be addressed in the field of women's health.

[0003] In existing technologies, products for women's health and wellness can be mainly categorized as follows: Firstly, traditional herbal paste products. For example, Chinese patent application CN110522872A discloses a herbal paste composition for conditioning the body, which is composed of 29 ingredients including Poria cocos, yam, lotus seed, mulberry, raspberry, Polygonatum sibiricum, wolfberry, Polygonatum odoratum, longan pulp, chicken gizzard lining, lily bulb, jujube, dandelion, hawthorn, black sesame, Alpinia oxyphylla, peach kernel, peony flower, rose flower, Buddha's hand, tangerine peel, jujube seed, Hangzhou white chrysanthemum, cinnamon, and donkey-hide gelatin, and adds non-food and medicine homologous ingredients such as arginine, polylysine, zinc gluconate, and isomaltooligosaccharide. Although this type of product has abundant ingredients, it has the following problems: (1) The formula is complicated, the principal, assistant, adjuvant and guide structure is unclear, and it is difficult to clarify the compatibility and mechanism of action of each ingredient; (2) The efficacy claims are broad, applicable to men and women in the preconception period and sub-healthy people, and lacks targeting for specific diseases.

[0004] Secondly, kidney-tonifying products. For example, Chinese patent application CN118021912A discloses a medicinal and edible composition for treating kidney deficiency, consisting of 23 ingredients including brown sugar, red dates, edible corn starch, farmed sika deer meat, deer blood, deer heart, boneless deer tail, wolfberry, yam, donkey-hide gelatin, cinnamon, poria cocos, polygonatum, mulberry, raspberry, amomum villosum, hawthorn, fennel, euryale ferox, clove, galangal, ginseng, and gardenia. This type of product focuses on tonifying the kidneys, but it has the following shortcomings: (1) The proportion of animal-derived raw materials (deer meat, deer blood, deer heart, deer tail) is too high. The raw materials are scarce and the cost is high, making it difficult to achieve large-scale production; (2) The preparation process uses 10-15% acetic acid solution for soaking, and the acidity is much higher than the conventional food standard. There is a risk of acetic acid residue, and the safety of long-term use is questionable; (3) The formula uses both warm and cold medicines, but the theoretical basis for compatibility and control is not explained, which may lead to an imbalance of medicinal properties.

[0005] Thirdly, commercially available skin-rejuvenating products. Common women's health products such as donkey-hide gelatin cake, Gu Yuan Gao (a traditional Chinese medicine tonic), and Si Wu Tang (a traditional Chinese medicine formula) derivatives are mostly marketed for their ability to replenish qi and blood and improve complexion. These products have a single level of function, mainly replenishing blood or qi, and lack comprehensive intervention for the multidimensional pathogenesis of women's sub-health.

[0006] In view of this, the present invention is hereby proposed. Summary of the Invention

[0007] In view of the shortcomings of the prior art, the technical problem to be solved by the present invention is to provide a nourishing composition that can significantly improve the sub-health status of women.

[0008] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is: a four-dimensional targeted female nourishing composition based on the same source of medicine and food, comprising the following raw materials in parts by weight: 5-30 parts of Polygonatum sibiricum, 4-24 parts of mulberry, 3-20 parts of raspberry, 4-24 parts of wolfberry, 5-30 parts of yam, 3-20 parts of Poria cocos, 2-16 parts of jujube, 1-12 parts of longan, 3-20 parts of kudzu root, 0.3-3 parts of rose, 3-20 parts of lily, 2-16 parts of lotus seed, 0.1-1 part of cinnamon, 1.5-12 parts of Alpinia oxyphylla, and 3-20 parts of Euryale ferox.

[0009] The raw materials of this invention are divided into a Yin-nourishing and libido-enhancing group, a uterus-protecting and ovarian-warming group, an endogenous anti-aging group, and a targeted awakening group; among them, the Yin-nourishing and libido-enhancing group is composed of Polygonatum sibiricum, mulberry, raspberry, and wolfberry; The uterus-protecting and ovarian-warming formula consists of yam, poria cocos, jujube, and longan. The endogenous anti-aging group consists of kudzu root, rose, lily, and lotus seed; The targeted awakening group consists of cinnamon, Alpinia oxyphylla, and Euryale ferox.

[0010] Optionally, the medicinal and edible four-dimensional targeted female nourishing composition is prepared into powder, capsule, granule or other conventional dosage forms by low-temperature water extraction, alcohol extraction and / or compound extraction.

[0011] Optionally, the process parameters for the low-temperature water extraction include: a temperature of 45-55℃, a time of 1-3 hours, and a material-to-liquid ratio of 1:(8-12).

[0012] This invention employs low-temperature water extraction, with a temperature of 45-55℃, which accelerates the dissolution of components without damaging heat-sensitive components. Below 45℃, extraction efficiency decreases significantly, and the dissolution of effective components is insufficient; above 55℃, the loss of volatile components intensifies. Therefore, 45-55℃ is the critical temperature range for achieving efficient extraction and component preservation.

[0013] Optionally, the process parameters for the alcohol extraction include: using 60-80% ethanol, extracting 2-3 times, each time for 1-2 hours.

[0014] This invention employs reflux extraction with 60-80% ethanol to extract moderately polar components such as flavonoids and saponins, at a temperature of 40-80℃. When the ethanol concentration is below 60%, lipid-soluble components are insufficiently dissolved; when it is above 80%, the precipitation loss of polysaccharides increases. Comparative analysis showed that the 70% ethanol extract yielded the highest total flavonoid content, representing the optimal concentration. The residue after ethanol extraction is then further extracted with water at low temperature for 1-2 hours to further extract water-soluble macromolecules such as polysaccharides and proteins, maximizing the utilization of the raw materials.

[0015] When choosing compound extraction, cinnamon, rose, Alpinia oxyphylla, Euryale ferox, and raspberry are extracted using low-temperature water extraction, while Polygonatum sibiricum, mulberry, wolfberry, yam, Poria cocos, jujube, longan, kudzu root, lily bulb, and lotus seed are extracted using alcohol extraction.

[0016] A method for preparing the above-mentioned food-medicine homology four-dimensional targeted female nourishing composition includes the following steps: (1) Clean, dry, pulverize and sieve all raw materials; (2) Provide cinnamon, rose, Alpinia oxyphylla, Euryale ferox and raspberry, extract with water at low temperature, filter to obtain extract one; provide Polygonatum sibiricum, mulberry, wolfberry, yam, Poria cocos, jujube, longan, kudzu root, lily and lotus seed, extract with alcohol, filter, the residue after alcohol extraction is extracted with water at low temperature for 1-2 hours, combine the extracts to obtain extract two; (3) Combine extract one and extract two, concentrate under reduced pressure, and spray dry to obtain extract powder, which is the four-dimensional targeted female nourishing composition of food and medicine.

[0017] A method for preparing the above-mentioned food-medicine homology four-dimensional targeted female nourishing composition further includes adding pharmaceutically acceptable excipients to the extract powder to prepare different dosage forms. For example, powders, capsules, granules, or other conventional dosage forms. Different dosage forms can be prepared according to existing technologies.

[0018] Optionally, the medicinal and edible four-dimensional targeted female nourishing composition may be used in the preparation of functional foods for women's uterine protection, yin nourishment, anti-aging, or libido enhancement.

[0019] This invention posits that the main external causes of sub-health in women are invasion of cold and dampness, overwork, and improper diet; the main internal causes are congenital deficiency, emotional distress, and excessive sexual activity and childbirth. The basic pathogenesis is rooted in kidney yin deficiency, with underlying qi and blood deficiency, manifested by liver qi stagnation, and exacerbated by uterine coldness. All four aspects are affected simultaneously, exhibiting a mixture of deficiency and excess. External manifestations include a sallow complexion, fatigue, insomnia, and cold limbs. Based on this, this invention establishes a composite treatment principle combining four methods: nourishing, replenishing essence to strengthen the foundation, invigorating the spleen and nourishing blood to replenish the source, soothing the liver and relieving stagnation to unblock the channels, and warming the uterus and unblocking the meridians to activate the body's functions. This four-pronged approach addresses both the root cause and the symptoms.

[0020] This invention uses a Yin-nourishing and desire-enhancing group (Polygonatum sibiricum, mulberry, raspberry, and wolfberry) as the principal ingredient. This group nourishes kidney Yin, replenishes kidney essence, and strengthens kidney Qi, providing a material basis for the generation of Qi and blood, and improving fatigue, weakness, and soreness in the lower back and knees caused by kidney deficiency. A uterus-protecting and ovary-warming group (Dioscorea opposita, Poria cocos, jujube, and longan) is used as the assistant ingredient. This group strengthens the spleen, invigorates Qi, nourishes blood, and calms the mind, providing Qi and blood support for the principal ingredient. This allows Qi and blood to nourish the face, resulting in a rosy complexion; to nourish the limbs, reducing fatigue; and to warm the uterus, providing warmth to the hands and feet. An endogenous anti-aging group (Pueraria lobata, rose, lily bulb, and lotus seed) and a targeted awakening group (cinnamon, Alpinia oxyphylla, and Euryale ferox) are used as adjuvant ingredients. The endogenous anti-aging group soothes the liver, relieves depression, and calms the mind, allowing liver Qi to flow smoothly, thus improving sleep and alleviating insomnia and excessive dreaming. The targeted awakening group warms the blood vessels and invigorates Yang Qi, allowing Yang Qi to reach the extremities, resulting in warm hands and feet.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows: This invention provides a sub-health conditioning product specifically for women, which can simultaneously improve a variety of major symptoms such as sallow complexion, fatigue, insomnia, and cold limbs, while also taking into account both rapid physical sensation and long-term stability.

[0022] This invention relates to a medicinal and edible homologous nourishing composition, scientifically formulated with fifteen medicinal and edible ingredients to form a four-dimensional synergistic system that nourishes Yin and enhances libido, protects the uterus and warms the ovaries, provides endogenous anti-aging, and targets and awakens the body. This system achieves the effects of nourishing the kidneys and replenishing essence, strengthening the spleen and nourishing blood, soothing the liver and relieving depression, and warming the uterus and promoting blood circulation. The principal ingredients are Polygonatum sibiricum, mulberry, raspberry, and wolfberry, which nourish kidney Yin, replenish kidney essence, and strengthen kidney Qi. The assistant ingredients are Dioscorea opposita, Poria cocos, jujube, and longan, which strengthen the spleen and replenish Qi, nourish blood and calm the mind, and harmonize the heart and kidneys. The adjuvant ingredients are Pueraria lobata, rose, lily bulb, and lotus seed, which soothe the liver and relieve depression, promote blood circulation, calm the mind, and promote anti-aging. The guiding ingredients are cinnamon, Alpinia oxyphylla, and Euryale ferox, which warm the uterus, stimulate the nerves, and protect Yin essence. The entire formula is a four-dimensional integrated system, progressing layer by layer to nourish the kidneys and strengthen the spleen. This formula integrates four methods: soothing the liver, warming the uterus, and regulating the spleen. The fifteen herbs, each with its own specific function, work synergistically to work from the spleen to the lungs, from the inside out, and from the internal organs to the viscera. This replenishes yin fluids, invigorates qi and blood, soothes liver stagnation, and dispels uterine cold. It regulates the four dimensions and treats qi and blood simultaneously, fully leveraging the efficacy of each component to achieve a comprehensive conditioning effect: rosy complexion, reduced fatigue, restful sleep, warm hands and feet, and nourishment of the private parts. It is nourishing without being greasy and warm without being drying, achieving a significant improvement in women's sub-health status.

[0023] The fast-acting components of this invention—cinnamon, rose, Alpinia oxyphylla, Euryale ferox, and raspberry—are extracted using a low-temperature water extraction process to maximize the retention of volatile components and small-molecule active substances. They are rapidly absorbed after oral administration, quickly altering the body's sensation. The long-acting components—Polygonatum sibiricum, mulberry, wolfberry, yam, Poria cocos, jujube, longan, kudzu root, lily bulb, and lotus seed—are enriched with large-molecule active ingredients such as polysaccharides, flavonoids, and saponins through alcohol and water extraction. These are released slowly in the body, continuously nourishing the ovaries and endocrine system, achieving stable and non-rebounding effects after treatment.

[0024] In this invention, all fifteen ingredients used are listed in the list of items that are both food and medicine published by the National Health Commission. In terms of process, this invention adopts a mild process of low-temperature water extraction at 45-55℃ and alcohol extraction at 60-80%, without strong acid or strong alkali treatment, and without the risk of organic solvent residue. Overall, it has high food safety. Detailed Implementation

[0025] To better understand the present invention, the following embodiments further illustrate the content of the invention, but the scope of protection of the present invention is not limited to the following embodiments. Numerous specific details are set forth in the following description to provide a more thorough understanding of the invention. However, it will be apparent to those skilled in the art that the present invention can be practiced without one or more of these details.

[0026] To make the objectives and advantages of this invention clearer, the following detailed description, in conjunction with specific embodiments, illustrates the medicinal and edible homologous four-dimensional targeted female nourishing composition, its preparation method, its application, and its technical effects. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention. Unless otherwise specified, the following embodiments do not include components other than unavoidable impurities. Unless otherwise specified, the raw materials and instruments used in the embodiments are conventionally selected in the art. Experimental methods not specifying specific conditions in the embodiments were implemented under conventional conditions, such as those described in literature, books, or methods recommended by the manufacturer.

[0027] The medicinal properties of the Chinese medicinal materials used in this invention are as follows: Polygonatum rhizome, the dried rhizome of Polygonatum sibiricum, a plant in the Liliaceae family, enters the spleen, lung, and kidney meridians. It is sweet and neutral in nature, and has the functions of replenishing qi and nourishing yin, strengthening the spleen, moistening the lungs, and benefiting the kidneys. Mulberry, the dried fruit spike of the mulberry plant (Morus alba), is associated with the heart, liver, and kidney meridians. It is sweet, sour, and cold in nature, and is used to nourish blood and yin, generate fluids, and moisten dryness. Raspberry, the dried fruit of Raspberry of East China, a plant of the genus Rubus in the family Rosaceae, enters the kidney and bladder meridians. It is sweet, sour, and warm in nature, and benefits the kidneys, strengthens essence, and reduces urination. Goji berries are the dried, ripe fruit of the Solanaceae plant Lycium barbarum. They enter the liver and kidney meridians, are sweet and neutral in nature, and nourish the liver and kidneys, benefit essence and improve eyesight. Yam is the dried rhizome of Dioscorea opposita, a plant in the Dioscoreaceae family. It enters the spleen, lung, and kidney meridians. It is sweet and neutral in nature, and it nourishes the spleen and stomach, promotes the production of body fluids and benefits the lungs, and tonifies the kidneys and astringes essence. Poria cocos is the dried sclerotium of the fungus Poria cocos, belonging to the Polyporaceae family. It enters the heart, lung, spleen, and kidney meridians. It is sweet, bland, and neutral in nature, and promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind. Jujube is the dried, ripe fruit of the jujube plant (Ziziphus jujuba) in the Rhamnaceae family. It enters the spleen and stomach meridians, and is sweet and warm in nature. It tonifies the middle energizer, replenishes qi, nourishes blood, and calms the mind. Longan, also known as dragon eye pulp, is the aril of the longan plant, which belongs to the Sapindaceae family. It enters the heart and spleen meridians, and is sweet and warm. It nourishes the heart and spleen, and nourishes the blood and calms the mind. Kudzu root is the dried root of the legume plant Pueraria lobata or Pueraria truncata. It enters the spleen and stomach meridians. It is sweet, pungent, and cool. It relieves muscle tension and reduces fever, promotes body fluid production, promotes rash eruption, and raises yang to stop diarrhea. Rose, the dried flower bud of the rose plant in the Rosaceae family, enters the liver and spleen meridians. It is sweet, slightly bitter, and warm. It promotes qi circulation, relieves depression, harmonizes blood, and relieves pain. Lily, the dried fleshy scales of the lily plant (Lilium lancifolium), enters the heart and lung meridians. It is sweet and cold in nature, nourishes yin and moistens the lungs, and calms the mind. Lotus seeds are the dried, mature seeds of the lotus plant (Nelumbo nucifera), belonging to the Nymphaeaceae family. They are associated with the spleen, kidney, and heart meridians. They are sweet, astringent, and neutral in nature. They tonify the spleen and stop diarrhea, benefit the kidneys and astringe essence, and nourish the heart and calm the mind. Cinnamon, the dried bark of the cinnamon tree (Cinnamomum cassia), belongs to the Lauraceae family. It enters the kidney, spleen, heart, and liver meridians. It is pungent, sweet, and very hot. It tonifies fire and assists yang, guides fire back to its source, dispels cold and relieves pain, and invigorates blood and regulates menstruation. Alpinia oxyphylla, the fruit of Alpinia oxyphylla, a plant in the ginger family, enters the spleen and kidney meridians. It is pungent and warm, and warms the spleen and kidneys, consolidates qi, and astringes essence. Euryale ferox, the dried mature seed kernel of Euryale ferox, a plant in the Nymphaeaceae family, enters the spleen and kidney meridians. It is sweet, astringent, and neutral in nature. It benefits the kidneys and strengthens essence, tonifies the spleen and stops diarrhea, and eliminates dampness and stops leukorrhea.

[0028] Example 1: A four-dimensional targeted female nourishing composition based on the same source of medicine and food, made from the following raw materials in parts by weight: 18 parts Polygonatum sibiricum, 14 parts mulberry, 11 parts raspberry, 14 parts wolfberry, 18 parts yam, 11 parts Poria cocos, 9 parts jujube, 7 parts longan, 11 parts kudzu root, 1.5 parts rose, 11 parts lily, 9 parts lotus seed, 0.5 parts cinnamon, 7 parts Alpinia oxyphylla, and 11 parts Euryale ferox.

[0029] The above-mentioned food-medicine homology four-dimensional targeted female nourishing composition is prepared by the following method: (1) Clean, dry, pulverize and sieve all raw materials; (2) Cinnamon, rose, Alpinia oxyphylla, Euryale ferox and raspberry are provided, and low-temperature water extraction is used to obtain extract one after filtration; Polygonatum sibiricum, mulberry, wolfberry, yam, Poria cocos, jujube, longan, kudzu root, lily and lotus seed are provided, and alcohol extraction is used to obtain extract two after filtration. The residue after alcohol extraction is then extracted with water at low temperature for 1.5 hours. The extracts are combined to obtain extract two. (3) Combine extract one and extract two, concentrate under reduced pressure (60℃, -0.09MPa) to a relative density of 1.10, and spray dry (inlet air 170℃, outlet air 85℃) to obtain extract powder.

[0030] The process parameters for low-temperature water extraction include: temperature of 50℃, time of 2h, and material-liquid ratio (mass / volume) of 1:10. The process parameters for alcohol extraction include: using 70% ethanol by volume, extraction twice at 75°C, each time for 2 hours.

[0031] Example 2: A four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients, which differs from Example 1 in that: the process parameters for low-temperature water extraction include: temperature of 45℃, time of 3h, and material-to-liquid ratio (mass / volume) of 1:8; the process parameters for alcohol extraction include: using 80% ethanol by volume, extraction twice at 70℃, each time for 1 hour.

[0032] Example 3: A four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients, which differs from Example 1 in that: the process parameters for low-temperature water extraction include: temperature of 55℃, time of 1h, and material-to-liquid ratio (mass / volume) of 1:12; the process parameters for alcohol extraction include: using 60% ethanol by volume, extraction at 72℃ 3 times, 1 hour each time.

[0033] Example 4: A four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients, which differs from Example 1 in that: 5 parts Polygonatum sibiricum, 4 parts mulberry, 3 parts raspberry, 4 parts wolfberry, 5 parts yam, 3 parts Poria cocos, 2 parts jujube, 1 part longan, 3 parts kudzu root, 0.3 parts rose, 3 parts lily, 2 parts lotus seed, 0.1 part cinnamon, 1.5 parts Alpinia oxyphylla, and 3 parts Euryale ferox.

[0034] Example 5: A four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients, which differs from Example 1 in that: 30 parts of Polygonatum sibiricum, 24 parts of mulberry, 20 parts of raspberry, 24 parts of wolfberry, 30 parts of yam, 20 parts of Poria cocos, 16 parts of jujube, 12 parts of longan, 20 parts of kudzu root, 3 parts of rose, 20 parts of lily, 16 parts of lotus seed, 1 part of cinnamon, 12 parts of Alpinia oxyphylla, and 20 parts of Euryale ferox.

[0035] Example 6: A four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients, which differs from Example 1 in that: 11 parts Polygonatum sibiricum, 9 parts mulberry, 7 parts raspberry, 9 parts wolfberry, 11 parts yam, 7 parts Poria cocos, 5 parts jujube, 4 parts longan, 7 parts kudzu root, 0.9 parts rose, 7 parts lily, 5 parts lotus seed, 0.3 parts cinnamon, 4 parts Alpinia oxyphylla, and 7 parts Euryale ferox.

[0036] Example 7: A four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients, which differs from Example 1 in that: 24 parts of Polygonatum sibiricum, 19 parts of mulberry, 15 parts of raspberry, 19 parts of wolfberry, 24 parts of yam, 15 parts of Poria cocos, 12 parts of jujube, 10 parts of longan, 15 parts of kudzu root, 2.2 parts of rose, 15 parts of lily, 12 parts of lotus seed, 0.8 parts of cinnamon, 10 parts of Alpinia oxyphylla, and 15 parts of Euryale ferox.

[0037] The extract powders prepared in Examples 1-7 above can also be formulated into different dosage forms by adding pharmaceutically acceptable excipients, such as powders, capsules, granules or other conventional dosage forms.

[0038] Comparative Example 1: A tonic composition for conditioning the body, comprising the following components by weight: 10 parts donkey-hide gelatin, 15 parts Poria cocos, 20 parts Dioscorea opposita, 15 parts lotus seed, 15 parts mulberry, 15 parts raspberry, 15 parts Polygonatum sibiricum, 10 parts Alpinia oxyphylla, 12 parts wolfberry, 10 parts Polygonatum odoratum, 15 parts longan pulp, 10 parts peach kernel, 6 parts peony flower, 6 parts rose, 10 parts Citrus medica, 6 parts dried tangerine peel, 10 parts chicken gizzard lining, 10 parts lily bulb, 15 parts Ziziphus jujuba seed, 10 parts jujube, 20 parts dandelion, 10 parts Chrysanthemum morifolium, 3 parts cinnamon bark, 10 parts hawthorn, 10 parts black sesame, 1 part arginine, 2 parts polylysine, 0.5 parts zinc gluconate, and 36 parts isomaltooligosaccharide; prepared according to Example 2 of patent application CN110522872A.

[0039] The following explains the content of the evaluation test.

[0040] 1. General characteristics of the participants: A total of 160 female participants were included, aged 26-52 years, with a mean age of 38.2 ± 6.4 years. All participants presented with sub-health symptoms such as qi and blood deficiency, poor complexion, fatigue, poor sleep, and cold hands and feet. They were randomly divided into 4 groups, with 40 participants in each group. There were no significant differences in baseline data such as age, physical condition, and lifestyle habits among the groups (P > 0.05), making them comparable.

[0041] 2. Subject inclusion criteria 2.1 Inclusion criteria (1) Adult women, aged 25 to 55; (2) Symptoms of weak Qi and blood and endocrine-related sub-health, such as dull complexion, fatigue, poor sleep, cold hands and feet, and mood swings. (3) Voluntarily participate and cooperate in completing the observation period; (4) No similar nourishing and conditioning products have been used in the past month.

[0042] 2.2 Exclusion Criteria (1) Pregnant or lactating women; (2) Those with combined serious organic diseases and gynecological diseases; (3) Individuals allergic to any of the ingredients in this product; (4) Unable to complete the observer task as required.

[0043] 3. How to use Experimental groups 1-3: The groups took the compositions prepared in Examples 1, 4 and 5 respectively, orally: twice a day, one packet each in the morning and evening, each packet containing 10 grams, for two courses of treatment, each course lasting 7 days.

[0044] Control group: The control group took the composition prepared in Comparative Example 1, and the method of use was exactly the same as that in Experimental Group 1.

[0045] Both groups maintained normal diet and lifestyle habits and did not consume any additional products.

[0046] 4. Scoring Method A quantitative scoring method for sub-health status was adopted, comprehensively evaluating factors such as complexion, fatigue level, sleep quality, blood circulation, and hand and foot temperature. Each indicator was graded as mild, moderate, or severe, with a score of 3, 6, or 9 points respectively, as shown in Table 1.

[0047] Table 1 Grading and Quantification Table 5. Efficacy criteria The calculation formula is: Score decline rate = [(Initial quantitative score - Quantitative score at the end of observation) / Initial quantitative score] × 100%; (1) Significant improvement: score reduction rate ≥70%; (2) Improvement: The rate of score reduction was 30% to 70%; (3) No improvement: score decline rate <30%.

[0048] 6. The statistical results of the improvement rate of each indicator are shown in Table 2.

[0049] Table 2. Statistical Results of Improvement Rate Note: Improvement rate = (Number of cases with significant improvement + Number of cases with some improvement) / Total number of cases × 100%.

[0050] As shown in Table 2, the improvement rate of the five sub-health indicators (complexion, fatigue level, sleep quality, blood circulation, and hand and foot temperature) of this invention is ≥70%, which is significantly better than that of the control group. This demonstrates that the composition of this invention has significant positive effects on improving complexion, relieving fatigue, improving sleep, promoting blood circulation, and keeping hands and feet warm for a lasting period. Compared with the composition of Comparative Example 1, the composition of this invention has a clear division of labor among the principal, assistant, adjuvant, and guiding agents, and is properly matched to precisely target the four pathological links of the kidney, spleen, liver, and uterus. It achieves the simultaneous application of four methods: nourishing, tonifying, regulating, and warming, which can quickly improve symptoms and achieve continuous and efficient conditioning.

[0051] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Any other modifications or equivalent substitutions made by those skilled in the art to the technical solutions of the present invention, as long as they do not depart from the spirit and scope of the technical solutions of the present invention, should be covered within the scope of the claims of the present invention.

Claims

1. A four-dimensional targeted female nourishing composition derived from both food and medicine, characterized in that: The ingredients include the following parts by weight: Polygonatum 5-30 parts, mulberry 4-24 parts, raspberry 3-20 parts, wolfberry 4-24 parts, yam 5-30 parts, Poria cocos 3-20 parts, jujube 2-16 parts, longan 1-12 parts, kudzu root 3-20 parts, rose 0.3-3 parts, lily 3-20 parts, lotus seed 2-16 parts, cinnamon 0.1-1 part, Alpinia oxyphylla 1.5-12 parts, and Euryale ferox 3-20 parts.

2. The four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients as described in claim 1, characterized in that: It is prepared into powder, capsule, granule or other conventional dosage forms through low-temperature water extraction, alcohol extraction and / or compound extraction.

3. The four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients as described in claim 2, characterized in that: The process parameters for the low-temperature water extraction include: temperature of 45-55℃, time of 1-3h, and material-to-liquid ratio of 1:(8-12).

4. The four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients as described in claim 2, characterized in that: The process parameters for the alcohol extraction include: using 60-80% ethanol, extracting 2-3 times, each time for 1-2 hours.

5. The four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients as described in claim 2, characterized in that: The compound extraction includes: low-temperature water extraction of cinnamon, rose, Alpinia oxyphylla, Euryale ferox, and raspberry; and alcohol extraction of Polygonatum sibiricum, mulberry, wolfberry, yam, Poria cocos, jujube, longan, kudzu root, lily bulb, and lotus seed.

6. The preparation method of the four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients as described in claim 1, characterized in that: Includes the following steps: (1) Clean, dry, pulverize and sieve all raw materials; (2) Provide cinnamon, rose, Alpinia oxyphylla, Euryale ferox and raspberry, extract with water at low temperature, filter to obtain extract one; provide Polygonatum sibiricum, mulberry, wolfberry, yam, Poria cocos, jujube, longan, kudzu root, lily and lotus seed, extract with alcohol, filter, the residue after alcohol extraction is extracted with water at low temperature for 1-2 hours, combine the extracts to obtain extract two; (3) Combine extract one and extract two, concentrate under reduced pressure, and spray dry to obtain extract powder, which is the four-dimensional targeted female nourishing composition of food and medicine.

7. The preparation method of the four-dimensional targeted female nourishing composition based on the same medicinal and edible ingredients as described in claim 6, characterized in that: It also includes adding pharmaceutically acceptable excipients to the extract powder to prepare different dosage forms.

8. The use of the four-dimensional targeted female nourishing composition of the same medicinal and edible origin as described in any one of claims 1-7 in the preparation of functional foods for women's uterine protection, yin nourishment, anti-aging or libido enhancement.

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