Sample automatic quality control method and sample analysis system

Abstract

This application relates to an automated sample quality control method and a sample analysis system. The method is used in a sample analysis system, which includes at least one analysis module. The method includes: determining a first quality control item for the first analysis module; acquiring status information of a quality control sample matching the first quality control item, the status information of the quality control sample including available quantity information and location information; determining a first quality control list based on the available quantity information of the quality control sample, the first quality control list being used to instruct the first analysis module to use the quality control sample to perform testing for the first quality control item; detecting the availability status of a detection reagent matching the first quality control list; and retrieving the quality control sample to execute the first quality control list based on the location information of the quality control sample. The technical solution provided by this application can improve scheduling efficiency.

Description

Technical Field

[0001] This application relates to the field of automatic quality control technology, and in particular to an automatic quality control method and sample analysis system for samples. Background Technology

[0002] In clinical testing laboratories, quality control is required for the testing process of sample analysis instruments to ensure the reliability of test results. Quality control refers to the process where users put quality control samples with known concentrations into the sample analysis instrument for testing, and the test results are compared with the known concentrations of the quality control samples to reflect whether the testing quality of the sample analysis instrument is under control or out of control.

[0003] In related technologies, sample analysis instruments can achieve automated quality control by setting up quality control refrigerators on cascaded sample analysis pipelines. However, the automated quality control method based on quality control refrigerators cannot add quality control items to the quality control list during the scheduling process. It must wait for the quality control racks to return to the quality control refrigerators after scheduling before new automated quality control items can be added. This method increases user waiting time and reduces testing efficiency for newly added quality control items. Summary of the Invention

[0004] To address or partially address the problems existing in related technologies, this application provides an automated sample quality control method and a sample analysis system.

[0005] This application provides a first aspect of an automated sample quality control method for a sample analysis system. The sample analysis system includes at least one analysis module, comprising: determining a first quality control item for the first analysis module; acquiring status information of a quality control sample matching the first quality control item, the status information of the quality control sample including available quantity information and location information; determining a first quality control list based on the available quantity information of the quality control sample, the first quality control list being used to instruct the first analysis module to use the quality control sample to perform testing for the first quality control item; detecting the availability status of a detection reagent matching the first quality control list; and retrieving the quality control sample to execute the first quality control list based on the location information of the quality control sample.

[0006] This application first determines the available remaining quantity information of the quality control samples matching the first quality control list and the available status of the test reagents matching the first quality control list. Then, based on the location information of the quality control samples matching the first quality control list, it retrieves the quality control samples to execute the first quality control list. It is not limited to the location of the quality control samples in the quality control process, and allows the quality control samples to generate the first quality control list during the scheduling process. Based on the location of the quality control samples matching the first quality control list, it instructs the first analysis module to use the quality control samples to test the first quality control items, thereby improving scheduling efficiency. It can also avoid the possibility of extending the automatic quality control time due to insufficient resources during the flow of quality control samples, thus improving the detection efficiency in the quality control process.

[0007] In an optional implementation, the sample analysis system includes at least two analysis modules. After determining the first quality control list, it checks whether the quality control sample has been assigned to an existing quality control list. Based on the existence of an existing quality control list and the location information of the quality control sample, it determines whether to add the first quality control list to the existing quality control list and determines a second quality control list. Based on the second quality control list, it controls and schedules the quality control sample to an analysis module that matches the second quality control list, so that the analysis module performs quality control analysis on the quality control sample.

[0008] In an optional implementation, after executing the second quality control checklist, the number of times an analysis module is out of control as shown by the quality control analysis is calculated. When the number of out-of-control times is less than a threshold, a second quality control checklist is generated, which includes the out-of-control quality control items and the out-of-control analysis modules.

[0009] In an optional implementation, determining whether to add the first quality control list to the original quality control list and determine the second quality control list based on the location information of the quality control sample includes: when the quality control sample is in the quality control sample storage refrigerator, using the first quality control list as the second quality control list; or, when the quality control sample is outside the quality control sample storage refrigerator, adding the first quality control list to the original quality control list to obtain the second quality control list.

[0010] In an optional implementation, the detection of the availability status of the test reagents matching the first quality control list includes: when the quality control sample is in the quality control sample storage refrigerator, directly determining that the test reagents matching the first quality control list are in an available state; when the quality control sample is outside the quality control sample storage refrigerator, controlling and scheduling the quality control sample to the track change position of the analysis module to be arrived at according to the original quality control list information of the second quality control list, and determining that the test reagents matching the first quality control list are in an available state when the quality control sample is in the track change position.

[0011] In an optional embodiment, the analysis module is provided with a buffer device connected to the analysis module, the quality control sample storage refrigerator is located in at least one of the analysis modules, and the outlet of the quality control sample storage refrigerator is connected to the buffer device; the step of controlling and scheduling the quality control sample to the analysis module matching the second quality control list according to the second quality control list, so that the analysis module performs quality control analysis on the quality control sample, includes: when the quality control sample is in the quality control sample storage refrigerator, transferring the quality control sample from the quality control sample storage refrigerator to the buffer device, controlling the buffer device to adjust the temperature of the quality control sample to a preset temperature; controlling and scheduling the quality control sample so that the quality control sample is sequentially transferred from the buffer device to the sample loading position on the first analysis module corresponding to the second quality control list, and controlling the corresponding first analysis module to pick up the quality control sample required for its respective quality control item for testing of the quality control item.

[0012] In an optional implementation, the step of controlling and scheduling the quality control samples to the analysis modules matching the second quality control list according to the second quality control list, so that the analysis modules perform quality control analysis on the quality control samples, includes: controlling and scheduling the quality control samples so that the quality control samples are sequentially transferred from the track-changing position to the sample loading positions on the remaining analysis modules corresponding to the second quality control list, and controlling the corresponding remaining analysis modules to absorb the quality control samples required for their respective quality control items for testing the quality control items.

[0013] In an optional implementation, the method further includes: after all analysis modules in the second quality control list have finished adding samples, controlling the scheduling of the quality control samples to return to the quality control sample storage refrigerator; or, when the number of out-of-control times reaches the threshold, stopping the generation of a new quality control list.

[0014] A second aspect of this application provides a sample analysis system, characterized in that it comprises: a quality control sample storage refrigerator for storing and identifying quality control samples required for testing; one or more cascaded analysis modules for performing quality control analysis on the quality control samples, the analysis modules including a reagent compartment for storing and identifying detection reagents required for testing; and a controller for executing the method described above.

[0015] In an optional embodiment, each analysis module is equipped with a buffer device connected to the analysis module, the quality control sample storage refrigerator is located in the analysis module, and the outlet of the quality control sample storage refrigerator is connected to the buffer device.

[0016] A third aspect of this application provides an electronic device, comprising: Processor; and A memory that stores executable code, which, when executed by the processor, causes the processor to perform the method described above.

[0017] A fourth aspect of this application provides a computer-readable storage medium having executable code stored thereon, which, when executed by a processor of a vehicle, causes the processor to perform the method described above.

[0018] A fifth aspect of this application provides a computer program product or computer program including computer instructions stored in a computer-readable storage medium. A processor of a computer device reads the computer instructions from the computer-readable storage medium and executes the computer instructions, causing the computer device to perform the method described above.

[0019] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit this application. Attached Figure Description

[0020] The above and other objects, features and advantages of this application will become more apparent from the more detailed description of exemplary embodiments of this application taken in conjunction with the accompanying drawings, wherein the same reference numerals generally represent the same components in the exemplary embodiments of this application.

[0021] Figure 1 This is a schematic diagram of the sample analysis system shown in this application; Figure 2 This is another schematic diagram of the sample analysis system shown in this application; Figure 3 This is a flowchart illustrating the automated quality control method for samples shown in this application; Figure 4 This is another schematic diagram of the automatic quality control method for samples shown in this application; Figure 5 This is a schematic diagram of the interface of the quality control checklist shown in this application; Figure 6 This is another structural schematic diagram of the sample analysis system shown in this application; Figure 7 This is a schematic diagram of the structure of the electronic device shown in this application. Detailed Implementation

[0022] Embodiments of this application will now be described in more detail with reference to the accompanying drawings. While embodiments of this application are shown in the drawings, it should be understood that this application may be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided to make this application more thorough and complete, and to fully convey the scope of this application to those skilled in the art.

[0023] The terminology used in this application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The singular forms “a,” “the,” and “the” used in this application and the appended claims are also intended to include the plural forms unless the context clearly indicates otherwise. It should also be understood that the term “and / or” as used herein refers to and includes any or all possible combinations of one or more of the associated listed items.

[0024] It should be understood that although the terms "first," "second," "third," etc., may be used in this application to describe various information, this information should not be limited to these terms. These terms are only used to distinguish information of the same type from one another. For example, without departing from the scope of this application, first information may also be referred to as second information, and similarly, second information may also be referred to as first information. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, "multiple" means two or more, unless otherwise explicitly specified.

[0025] In related technologies, automated quality control can be achieved by setting up quality control refrigerators on the sample analysis pipeline. However, this refrigerator-based automated quality control method cannot add quality control items to the quality control list during the scheduling process of the quality control racks. It must wait for the quality control racks to return to the refrigerator after scheduling before new automated quality control items can be added. This method increases user waiting time and reduces testing efficiency for newly added quality control items.

[0026] To address the aforementioned issues, this application provides an automatic quality control method for samples, which allows quality control samples to generate corresponding quality control lists during the scheduling process, thereby improving scheduling efficiency.

[0027] The technical solution of this application is described in detail below with reference to the accompanying drawings.

[0028] This application discloses an automatic quality control method for samples, used in a sample analysis system, which includes at least one analysis module.

[0029] The sample analysis system may include multiple cascaded analysis modules, which may be immunoassay analyzers, biochemical analyzers, blood analyzers, etc. In this embodiment, the sample analysis system is composed of two identical chemiluminescence immunoassay analyzers, but the sample analysis system may also be composed of analyzers with different functions, such as one biochemical analyzer and one immunoassay analyzer.

[0030] like Figure 1As shown, in the sample analysis system of this embodiment, the system includes a host computer, an immunoassay analyzer M1 (hereinafter referred to as analyzer M1), and an immunoassay analyzer M2 (hereinafter referred to as analyzer M2). The host computer is connected to analyzers M1 and M2. Quality control software can be deployed on the host computer, which can execute automated sample quality control methods. The quality control software can pre-determine quality control plans for multiple analysis modules in the sample analysis system. For example, in clinical testing, a blood sample analyzer can be set up with a quality control trigger mechanism based on the number of samples, such as requiring a quality control sample test or inspection every 50 blood samples. Alternatively, it could consider time intervals, such as requiring quality control before and after each day's testing.

[0031] It should be noted that the quality control sample storage refrigerator in the sample analysis system can be located on the analysis module. Either each analysis module can be equipped with a quality control sample storage refrigerator, or a quality control sample storage refrigerator can be located on a single analysis module. The quality control samples stored in the refrigerator can be used by multiple analysis modules. In at least one embodiment, the analysis module is equipped with a buffer device connected to the analysis module, the quality control sample storage refrigerator is located in at least one analysis module, and the outlet of the quality control sample storage refrigerator is connected to the buffer device. The analysis modules are connected by rails. The buffer device can be referenced in patent application publication number CN118275718A.

[0032] like Figure 2 As shown, an example is taken where a quality control sample storage refrigerator is installed on analyzer M1, while analyzer M2 does not have a quality control sample storage refrigerator. Analyzer M1 is equipped with a buffer device M1, and analyzer M2 is equipped with a buffer device M2. The outlet of the quality control sample storage refrigerator is connected to analyzer M1 through buffer device M1. Analyzers M1 and M2 are connected by a track used to transfer test samples / quality control samples between analyzers M1 and M2. The transfer path of the quality control samples in the sample analysis system can be: quality control sample storage refrigerator - buffer device M1 - analyzer M1, or quality control sample storage refrigerator - buffer device M1 - analyzer M1 - analyzer M2. Generally, the temperature of the quality control samples in the quality control sample storage refrigerator is the refrigeration temperature. When the analysis module uses the quality control samples for quality control analysis, the temperature of the quality control samples needs to be adjusted to be close to human body temperature. In order to shorten the heating time of the quality control samples, the buffer device is used to perform a warming process on the quality control samples. This warming process means that the buffer device adjusts the temperature of the quality control samples from the refrigeration temperature to at least room temperature.

[0033] Figure 3 This is a flowchart illustrating the automated quality control method for samples shown in this application.

[0034] See Figure 3The automatic quality control method for samples mainly includes steps S301 to S305.

[0035] Step S301: Determine the first quality control item for the first analysis module.

[0036] After the sample analysis system is powered on, the quality control software in the host computer monitors which analysis module and which test item needs quality control. The test item is the quality control item. For example, if the sex hormone measurement item in analyzer M1 needs quality control, then analyzer M1 is the first analysis module and the sex hormone measurement item is the first quality control item.

[0037] Step S302: Obtain the status information of the quality control sample that matches the first quality control item. The status information of the quality control sample includes available margin information and location information.

[0038] Considering that quality control samples may be located anywhere in the sample analysis system and are not limited to the storage of quality control samples in the refrigerator for related technologies, in this step, after detecting that the sex hormone item in analyzer M1 needs to be quality controlled, in addition to detecting the available remaining information of the quality control sample corresponding to the detected sex hormone, it is also necessary to detect the current position of the quality control sample in the sample analysis system.

[0039] Step S303: Based on the available remaining quantity information of the quality control samples, determine the first quality control list. The first quality control list is used to instruct the first analysis module to use the quality control samples to test the first quality control item.

[0040] Based on the available remaining quantity of quality control samples obtained from step S302, and in conjunction with the sex hormone items determined from step S301, it can be determined in step S303 whether the available remaining quantity of quality control samples is sufficient for detecting sex hormone items. If the quality control sample resources are insufficient, then automatic quality control will not be performed on the analyzer M1. If the resources are sufficient, then a first quality control list corresponding to the sex hormone items will be determined. The first quality control list can be used to instruct the analyzer M1 to use the quality control samples to test the sex hormone items.

[0041] Step S304: Check the availability of test reagents that match the first quality control list.

[0042] After determining the first quality control list from step S303, the system does not immediately begin retrieving and executing the first quality control list. Instead, it first checks the availability of test reagents in analyzer M1 that match the first quality control list. This first quality control list includes sex hormone items for analyzer M1; therefore, it can be determined whether there are sufficient test reagents matching the sex hormone items. If reagent resources are insufficient, automatic quality control is not executed. However, if reagent resources are sufficient, step S305 can be implemented.

[0043] Step S305: Based on the location information of the quality control sample, retrieve the quality control sample and execute the first quality control checklist.

[0044] As can be seen from the aforementioned records, the location of the quality control sample may be any point in the sample analysis system. Therefore, there are two main possible outcomes regarding the location of the quality control sample: one is that the quality control sample is in the quality control sample storage refrigerator, and the other is that the quality control sample is not in the quality control sample storage refrigerator.

[0045] If the quality control sample is in the quality control sample storage refrigerator, it is first transferred from the quality control sample storage refrigerator to the buffer device M1. At this time, the temperature of the quality control sample is close to the refrigeration temperature of the quality control sample storage refrigerator, which is not suitable for the analyzer M1 to detect the quality control sample at this temperature. Therefore, the buffer device M1 is used to warm up the quality control sample, that is, to adjust the temperature of the quality control sample to room temperature. After that, the quality control sample is transferred from the buffer device M1 to the sample dispensing position of the analyzer M1, and the analyzer M1 picks up the quality control sample for sex hormone testing.

[0046] If the quality control sample is not in the quality control sample storage refrigerator, it means that the quality control sample may be in the quality control process at this time. This quality control process corresponds to the original quality control checklist. In this case, after the quality control samples matching all quality control items in the original quality control checklist have been added, automatic quality control can continue to be performed according to the first quality control checklist.

[0047] The automated sample quality control method of this application will be further described below. See [link to relevant documentation]. Figure 4 This application discloses an automatic quality control method for samples, which includes steps S401 to S406.

[0048] Step S401: Determine the first quality control item for the first analysis module.

[0049] Step S401 can be referred to step S301, and will not be described in detail here.

[0050] Step S402: Obtain the status information of the quality control sample that matches the first quality control item. The status information of the quality control sample includes available margin information and location information.

[0051] Step S402 can be referred to step S302, and will not be described in detail here.

[0052] Step S403: Based on the available remaining quantity information of the quality control samples, determine the first quality control list. The first quality control list is used to instruct the first analysis module to use the quality control samples to test the first quality control item.

[0053] Step S403 can be referred to step S303, and will not be described in detail here.

[0054] Step S404: Check whether the quality control samples have been assigned to the original quality control list. Based on the existence of the original quality control list and the location information of the quality control samples, determine whether to add the first quality control list to the original quality control list and determine the second quality control list. A portion of the quality control list interface is shown below. Figure 5 As shown.

[0055] In one embodiment of step S404, when the quality control sample is in the quality control sample storage refrigerator, the first quality control list is used as the second quality control list. Theoretically, there may be a situation where an existing quality control list exists and the quality control sample is in the quality control sample storage refrigerator. In this case, the first quality control list could be added to the existing quality control list. However, in practice, this situation almost never occurs. Therefore, when the quality control sample is in the quality control sample storage refrigerator, the first quality control list can be directly used as the second quality control list.

[0056] In another embodiment of step S404, when the quality control sample is outside the quality control sample storage refrigerator, the first quality control list is added to the original quality control list to obtain the second quality control list. In this embodiment, the fact that the quality control sample is outside the quality control sample storage refrigerator also indicates that the quality control sample is currently in the automatic quality control process corresponding to the original quality control list. Generally, the first quality control list is added to the original quality control list, and the added quality control list serves as the second quality control list. In this embodiment, the second quality control list contains information from both the first and original quality control lists. Therefore, in the scheduling of quality control samples, automatic quality control can be performed based on the information from the original quality control list in the second quality control list, followed by automatic quality control based on the information from the first quality control list in the second quality control list.

[0057] Step S405: Check the availability of test reagents that match the first quality control list.

[0058] As can be seen from step S404, the quality control sample may or may not be in the quality control sample storage refrigerator. Therefore, step S404 can have two embodiments.

[0059] When the quality control sample is in the quality control sample storage refrigerator, in one embodiment of step S405, it is directly determined that the test reagents matching the first quality control list are in an available state. After determining the second quality control list (i.e., the first quality control list) from one embodiment of step S404, the second quality control list is not directly retrieved and executed. Instead, the availability of test reagents matching the first quality control list is directly checked first. The second quality control list involves the sex hormone items of analyzer M1. Therefore, it can be determined whether there are enough test reagents matching the sex hormone items. If the reagent resources are insufficient, automatic quality control is not executed. When the reagent resources are sufficient, step S406 can be implemented.

[0060] In another embodiment of step S405, when the quality control sample is outside the quality control sample storage refrigerator, for example, the required quality control sample has already been used to perform the sex hormone quality control project at analyzer M2 and is already in a warming state in the buffer device of analyzer M1. Based on the original quality control list information of the second quality control list, the quality control project of analyzer M2 is first executed, and the quality control sample is transferred from the buffer device M1 to analyzer M2. When the quality control sample arrives at the track-changing position of analyzer M2, it is determined that the test reagent matching the first quality control list in analyzer M1 is in a usable state. Generally, when the quality control sample is transferred between multiple analysis modules, the identification of the quality control sample can be scanned when the quality control sample is at the track-changing position between analysis modules. The host computer can accurately obtain the positional relationship and available balance information corresponding to the quality control sample. Similarly, the positional relationship and available balance information corresponding to the quality control sample can be obtained in a similar manner when the quality control sample enters or leaves the buffer device. Therefore, in this embodiment, the sample addition process for this quality control can be completed first based on the original quality control list information in the second quality control list. Then, regardless of whether the quality control sample is on the buffer device or the analysis module, the corresponding quality control sample will reach the corresponding track-changing position of the analysis module. When the quality control sample is at the track-changing position, it is then determined that the detection reagent matching the first quality control list is in a usable state.

[0061] It should be noted that the quality control sample can be located outside the quality control sample storage refrigerator, either in the buffer device or the analysis module. If the quality control sample is located in the buffer device, after the buffer device adjusts the temperature of the quality control sample to the preset temperature, it controls and schedules the quality control sample from the buffer device to the sample loading position of the corresponding analysis module, and after loading, it controls and schedules the quality control sample to the switching position of the analysis module it will arrive at. There are two possibilities when the quality control sample is in the buffer device: one is waiting for it to warm up in the buffer device, and the other is waiting for the analysis module to load it. If the quality control sample is located in the analysis module, after loading it in the analysis module, it controls and schedules the quality control sample to the switching position of the analysis module it will arrive at. The quality control sample being located in the analysis module can specifically be in the sample loading buffer area, sample loading area, or single-machine switching area of ​​the analysis module.

[0062] Step S406: According to the second quality control list, control and schedule the quality control samples to the analysis module that matches the second quality control list, so that the analysis module performs quality control analysis on the quality control samples.

[0063] As can be seen from step S405, there are some differences in the scheduling of quality control samples when they are stored in a refrigerator and when they are not. Therefore, step S406 can have two embodiments.

[0064] When the quality control samples are in the quality control sample storage refrigerator, in one embodiment of step S406, the quality control samples are transferred from the quality control sample storage refrigerator to the buffer device, and the buffer device is controlled to adjust the temperature of the quality control samples to a preset temperature; the quality control samples are controlled and scheduled so that they are sequentially transferred from the buffer device to the sample dispensing positions on the first analysis modules corresponding to the second quality control list, and the corresponding first analysis modules are controlled to pick up the quality control samples required for their respective quality control items for testing. In this embodiment, the quality control samples are transferred from the quality control sample storage refrigerator to the buffer device, and the buffer device is controlled to adjust the temperature of the quality control samples to room temperature; the quality control samples are controlled and scheduled so that they are sequentially transferred from the buffer device to the sample dispensing positions on the first analysis modules corresponding to the second quality control list (i.e., the first quality control list), and the corresponding first analysis modules are controlled to pick up the quality control samples required for their respective quality control items for testing. For example, if the quality control sample is in the quality control sample storage refrigerator, it is first transferred from the quality control sample storage refrigerator to the buffer device M1. At this time, the temperature of the quality control sample is close to the refrigeration temperature of the quality control sample storage refrigerator, which is not suitable for the analyzer M1 to test the quality control sample at this temperature. Therefore, the buffer device M1 is used to warm up the quality control sample, that is, to adjust the temperature of the quality control sample to human body temperature. After that, the quality control sample is transferred from the buffer device M1 to the sample dispensing position of the analyzer M1, and the analyzer M1 picks up the quality control sample to perform sex hormone testing.

[0065] If the quality control sample is not in the quality control sample storage refrigerator, it indicates that the quality control sample may be in the quality control process at this time. This quality control process corresponds to the original quality control list. Therefore, after the quality control samples matching all quality control items in the original quality control list have been added, automatic quality control can continue to be performed according to the first quality control list. Therefore, in another embodiment of step S406, knowing from another embodiment of step S405 that the quality control sample is at the track-changing position, that is, when the quality control sample is outside the quality control sample storage refrigerator, the quality control sample is controlled and scheduled so that the quality control sample is sequentially transferred from the track-changing position to the sample addition position on the remaining analysis module corresponding to the second quality control list, and the corresponding remaining analysis module is controlled to absorb the quality control samples required for their respective quality control items for testing.

[0066] It should be noted that after all analytical modules in the second quality control list have been sampled, the control and scheduling system returns the quality control samples to the quality control sample storage refrigerator.

[0067] As can be seen, the embodiments of this application allow for the addition of quality control items during the quality control scheduling process of quality control samples, without the need to create a quality control list (i.e., the first quality control list in this embodiment) after the quality control samples are returned to the quality control sample storage refrigerator, thereby improving the efficiency of quality control scheduling. In addition, before the quality control samples are warmed up, the available remaining information of the quality control samples will be checked to avoid extending the automatic quality control time due to insufficient quality control sample resources during the flow of quality control samples, thereby improving the detection efficiency in the quality control process.

[0068] To avoid repeatedly executing automatic quality control until the quality control materials are exhausted after a quality control failure, as a preferred embodiment of this application, after executing the second quality control list, the number of times an analytical module shows a failure in quality control analysis is calculated. When the number of failures is less than a threshold, a second quality control list is generated, which includes the failed quality control items and the failed analytical modules. When the number of failures reaches the threshold, the generation of the second quality control list stops. This embodiment can limit the number of consecutive failures of quality control items in analytical modules, i.e., add a limit function to the maximum number of times automatic quality control can be executed. After the number of consecutive failures in automatic quality control reaches the limit, the automatic quality control for that item is stopped, thus avoiding the waste of quality control samples and reagent resources. like Figure 6 As shown, this application embodiment provides a sample analysis system, including: a quality control sample storage refrigerator for storing and identifying quality control samples required for testing; one or more cascaded analysis modules, each analysis module being used to perform quality control analysis on the quality control samples, and each analysis module including a reagent compartment for storing and identifying the detection reagents required for testing; and a controller for executing the method described above. In this embodiment, the controller can be the aforementioned host computer.

[0069] Furthermore, each analysis module is equipped with a buffer device connected to the analysis module, and a quality control sample storage refrigerator is located in at least one analysis module, with the outlet of the quality control sample storage refrigerator connected to the buffer device.

[0070] like Figure 6 As shown, the sample analysis system includes a host computer and a sample manager, analysis module 1, analysis module 2, analysis module 3, and analysis module 4, all connected to the host computer. The number of quality control sample storage refrigerators (referred to as quality control refrigerators) is configured according to requirements. Each analysis module can be configured with one quality control refrigerator. In this embodiment, both analysis module 1 and analysis module 2 are equipped with quality control refrigerators. The sample manager is used to manage the test tube racks. When test tubes are pushed in from here, the quality control racks are scanned and then enter the quality control refrigerators. After being unloaded from the quality control refrigerators, the quality control racks return to the sample manager. The quality control racks are used to hold quality control samples.

[0071] It should be noted that the scheduling of quality control samples in the sample analysis system has been described in detail in the above method embodiments, and will not be repeated here.

[0072] Figure 7 This is a schematic diagram of the structure of the electronic device shown in this application.

[0073] See Figure 7 The electronic device 700 includes a memory 701 and a processor 702.

[0074] The processor 702 can be a Central Processing Unit (CPU), or other general-purpose processors, digital signal processors (DSPs), application-specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. The general-purpose processor can be a microprocessor or any conventional processor.

[0075] Memory 701 may include various types of storage units, such as system memory, read-only memory (ROM), and permanent storage devices. ROM may store static data or instructions required by processor 702 or other modules of the computer. Permanent storage devices may be read-write storage devices. Permanent storage devices may be non-volatile storage devices that retain stored instructions and data even when the computer is powered off. In some embodiments, permanent storage devices use mass storage devices (e.g., magnetic or optical disks, flash memory) as permanent storage devices. In other embodiments, permanent storage devices may be removable storage devices (e.g., floppy disks, optical drives). System memory may be a read-write storage device or a volatile read-write storage device, such as dynamic random access memory. System memory may store some or all of the instructions and data required by the processor during operation. Furthermore, memory 701 may include any combination of computer-readable storage media, including various types of semiconductor memory chips (e.g., DRAM, SRMIM, SDRMIM, flash memory, programmable read-only memory), and disks and / or optical disks may also be used. In some embodiments, memory 701 may include a removable storage device that is readable and / or writable, such as a laser disc (CD), a read-only digital multifunction optical disc (e.g., DVD-ROM, dual-layer DVD-ROM), a read-only Blu-ray disc, a high-density optical disc, a flash memory card (e.g., SD card, mini SD card, Micro-SD card, etc.), a magnetic floppy disk, etc. Computer-readable storage media do not contain carrier waves or transient electronic signals transmitted wirelessly or via wired connections.

[0076] The memory 701 stores executable code, which, when processed by the processor 702, can cause the processor 702 to execute part or all of the methods described above.

[0077] Furthermore, the method according to this application can also be implemented as a computer program or computer program product, which includes computer program code instructions for performing some or all of the steps in the method described above.

[0078] Alternatively, this application may be implemented as a computer-readable storage medium (or a non-transitory machine-readable storage medium or a machine-readable storage medium) storing executable code (or computer program or computer instruction code) thereon, which, when executed by a processor of a server (or server, etc.), causes the processor to perform part or all of the steps of the above-described method according to this application.

[0079] Embodiments of this application also provide a computer program product or computer program, which includes computer instructions stored in a computer-readable storage medium. A processor of a computer device reads the computer instructions from the computer-readable storage medium and executes the computer instructions, causing the computer device to perform any of the methods described in the above embodiments.

[0080] The computer-readable storage medium may include: read-only memory (ROM), random access memory (RAM), solid-state drives (SSDs), or optical discs, etc. The random access memory may include resistive random access memory (ReRAM) and dynamic random access memory (DRAM). The sequence numbers of the embodiments described above are for descriptive purposes only and do not represent the superiority or inferiority of the embodiments.

[0081] Those skilled in the art will understand that all or part of the steps of the above embodiments can be implemented by hardware or by a program instructing related hardware. The program can be stored in a computer-readable storage medium, such as a read-only memory, a disk, or an optical disk.

[0082] The various embodiments of this application have been described above. These descriptions are exemplary and not exhaustive, nor are they limited to the disclosed embodiments. Many modifications and variations will be apparent to those skilled in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen to best explain the principles, practical application, or improvement of the technology in the market, or to enable others skilled in the art to understand the embodiments disclosed herein.

Claims

1. An automated quality control method for samples, used in a sample analysis system, the sample analysis system comprising at least one analysis module, characterized in that, include: Determine the first quality control item for the first analysis module; Obtain the status information of the quality control sample that matches the first quality control item. The status information of the quality control sample includes available margin information and location information. Based on the available remaining quantity information of the quality control samples, a first quality control list is determined. The first quality control list is used to instruct the first analysis module to use the quality control samples to test the first quality control item. Check the availability of test reagents that match the first quality control list; Based on the location information of the quality control sample, the quality control sample is retrieved and the first quality control checklist is executed.

2. The method according to claim 1, characterized in that, The sample analysis system includes at least two sample analysis modules. After determining the first quality control list, it checks whether the quality control samples have already been assigned to an existing quality control list. Based on whether an existing quality control list exists and the location information of the quality control samples, determine whether to add the first quality control list to the existing quality control list and determine the second quality control list; According to the second quality control list, the quality control sample is scheduled to the analysis module that matches the second quality control list, so that the analysis module performs quality control analysis on the quality control sample.

3. The method according to claim 2, characterized in that, After executing the second quality control checklist, the number of times an analysis module is out of control as shown by the quality control analysis is calculated. When the number of out-of-control times is less than a threshold, a second quality control checklist is generated, which includes the out-of-control quality control items and the out-of-control analysis modules.

4. The method according to claim 2, characterized in that, The step of determining whether to add the first quality control list to the existing quality control list and determining the second quality control list based on the location information of the quality control samples includes: When the quality control sample is in the quality control sample storage refrigerator, the first quality control list is used as the second quality control list; or, When the quality control sample is outside the refrigerator where the quality control sample is stored, the first quality control list is added to the original quality control list to obtain the second quality control list.

5. The method according to claim 4, characterized in that, The availability status of the test reagents that match the first quality control list includes: When the quality control sample is in the quality control sample storage refrigerator, it is directly determined that the test reagent matching the first quality control list is in a usable state; When the quality control sample is outside the refrigerator where the quality control sample is stored, the quality control sample is controlled and scheduled to the switching position of the analysis module to be arrived at, based on the original quality control list information of the second quality control list. When the quality control sample is at the switching position, it is determined that the detection reagent matching the first quality control list is in a usable state.

6. The method according to claim 4 or 5, characterized in that, The analysis module is equipped with a buffer device connected to the analysis module. The quality control sample storage refrigerator is located in at least one of the analysis modules, and the outlet of the quality control sample storage refrigerator is connected to the buffer device. The step of controlling and scheduling the quality control samples to the analysis module matching the second quality control list according to the second quality control list, so that the analysis module performs quality control analysis on the quality control samples, includes: When the quality control sample is in the quality control sample storage refrigerator, the quality control sample is transferred from the quality control sample storage refrigerator to the buffer device, and the buffer device is controlled to adjust the temperature of the quality control sample to a preset temperature; The quality control samples are controlled and scheduled so that they are sequentially transferred from the buffer device to the sample loading positions on the first analysis module corresponding to the second quality control list, and the corresponding first analysis module is controlled to pick up the quality control samples required for its respective quality control items for testing.

7. The method according to claim 5, characterized in that, The step of controlling and scheduling the quality control samples to the analysis module matching the second quality control list according to the second quality control list, so that the analysis module performs quality control analysis on the quality control samples, includes: The quality control samples are controlled and scheduled so that they are sequentially transferred from the track-changing position to the sample loading positions on the remaining analysis modules corresponding to the second quality control list, and the corresponding remaining analysis modules are controlled to pick up the quality control samples required for their respective quality control items for testing.

8. The method according to claim 3, characterized in that, Also includes: After all the analytical modules in the second quality control list have finished adding samples, the control system will schedule the quality control samples to be returned to the quality control sample storage refrigerator. or, When the number of times the system goes out of control reaches the threshold, the generation of a new quality control checklist is stopped.

9. A sample analysis system, characterized in that, include: A quality control sample storage refrigerator is used to store and identify the quality control samples required for testing. One or more cascaded analysis modules, the analysis modules being used to perform quality control analysis on the quality control samples, the analysis modules including a reagent compartment for storing and identifying the test reagents required for testing; A controller for performing the method as described in any one of claims 1 to 8.

10. The sample analysis system according to claim 9, characterized in that, Each analysis module is equipped with a buffer device connected to the analysis module, and the quality control sample storage refrigerator is located in at least one of the analysis modules, with the outlet of the quality control sample storage refrigerator connected to the buffer device.

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