Nutritional element delivery system, method of making and use thereof
By using a delivery system that loads a nutrient element-quercetin complex onto a porous carrier and encapsulates it with phospholipid materials, the problems of low bioavailability, insufficient stability, and uncontrollable release behavior in existing nutrient supplementation methods are solved, achieving safe and controllable nutrient delivery.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-04-13
- Publication Date
- 2026-07-03
Smart Images
Figure CN122320195A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of nutrient delivery technology, and in particular to a nutrient delivery system based on a nutrient-quercetin complex, a porous carrier loading and phospholipid coating, as well as its preparation method and application. Background Technology
[0002] Trace elements are a class of mineral nutrients present in extremely low amounts in the human body but essential for maintaining life activities. They mainly include iron, zinc, iodine, selenium, copper, and magnesium. Although they constitute a very small proportion of the human body, they are widely involved in important physiological processes such as hematopoiesis, immune regulation, enzyme catalysis, hormone synthesis, maintenance of nerve function, and growth and development. For example, iron is a key element necessary for hemoglobin formation and oxygen transport; zinc plays an important role in immune function regulation, cell proliferation, and growth and development; iodine is important for maintaining thyroid function and metabolism; and selenium has antioxidant properties and helps protect the cardiovascular system. Because the human body cannot synthesize these nutrients on its own and must rely on food or exogenous preparations for intake, trace element deficiency remains a significant nutritional problem affecting population health worldwide.
[0003] Currently, intervention strategies for micronutrient deficiencies mainly include dietary adjustments, oral nutritional supplements, and intravenous supplementation when necessary. Most existing nutritional supplements exist as inorganic salts, organic salts, or chelates, and are typically absorbed primarily in the upper small intestine. However, current supplementation methods generally have several shortcomings. First, some nutrients are easily oxidized or hydrolyzed in the gastrointestinal environment, or they may complex with dietary components such as phytic acid and oxalic acid to form precipitates, thereby reducing their bioavailability. Second, nutrients in their free ionic state can easily irritate the gastrointestinal tract, potentially causing adverse reactions such as nausea, constipation, and diarrhea; certain metal ions may also promote oxidation reactions, inducing the generation of free radicals, thus potentially damaging body tissues. Third, existing formulations have limited protective effects, sustained-release capacity, and targeted release capabilities for nutrients, making it difficult to balance stability, safety, and absorption efficiency. Although some organic chelates or novel formulations improve bioavailability to some extent, they still suffer from high preparation costs and significant differences in efficacy. For those with severe deficiencies, intravenous supplementation can provide rapid intervention, but it is usually expensive, and excessive supplementation may pose certain safety risks.
[0004] Therefore, developing a novel delivery system that is highly safe, bioavailable, protective, and capable of controlled release, and suitable for supplementing various nutrients, especially minerals such as iron, magnesium, and zinc, remains of significant research value and application significance. Summary of the Invention
[0005] The purpose of this invention is to provide a nutrient element delivery system, its preparation method and application, in order to solve the problems of insufficient stability, high irritation and difficulty in controlling release behavior in existing nutrient element supplementation systems.
[0006] The technical solution of the present invention is as follows: On one hand, a nutrient element delivery system is provided, comprising a porous carrier, a nutrient element-quercetin complex loaded on the porous carrier, and an encapsulation layer covering the outer surface of the porous carrier, wherein the nutrient element-quercetin complex is formed by coordination of a nutrient element source with quercetin, and the encapsulation layer is made of a phospholipid material.
[0007] Preferably, the porous carrier is a positively charged modified porous starch.
[0008] Preferably, the positively charged modified porous starch is obtained by modifying porous starch with a cationic modifying agent, wherein the cationic modifying agent is any one or more of cationic cellulose, polyquaternary ammonium salt, chitosan and its quaternized derivatives.
[0009] Preferably, the nutrient source is any one or more of iron, zinc, and magnesium.
[0010] Preferably, the phospholipid material is lecithin or a complex of lecithin and excipients, wherein the excipients are any one or more of cholesterol, fatty acids, glycerides, and surfactants.
[0011] Preferably, the molar ratio of the nutrient source to the quercetin is 1-6:1, and the amount of the porous carrier is 5%-30% of the mass of the nutrient-quercetin complex.
[0012] On the other hand, a method for preparing the nutrient element delivery system described in any one of the above claims is also provided, comprising the following steps: S1: The nutrient source is mixed with quercetin, and the two coordinate to form a nutrient-quercetin complex. S2: Contact the porous carrier with the nutrient element-quercetin complex to obtain a porous carrier loaded with the nutrient element-quercetin complex. S3: Using phospholipid materials and a coating process, a coating layer is formed on the outer surface of the porous carrier loaded with the nutrient element-quercetin complex to obtain the nutrient element delivery system.
[0013] Preferably, in step S1, quercetin is first dissolved in an alcohol solvent or an alcohol / water mixed solvent, then mixed with an aqueous solution of nutrient source, and the pH is adjusted to alkaline to induce coordination self-assembly.
[0014] Furthermore, the invention also provides the application of the nutrient delivery system described in any one of the above-mentioned claims in the preparation of nutrient supplements.
[0015] Preferably, the nutritional supplement is an oral preparation, which includes powder, granules, capsules, tablets, microcapsules, or suspensions.
[0016] The beneficial effects of this invention are: This invention provides a nutrient delivery system with high drug loading capacity and controlled release into the intestine, providing technical support for supplementing the human body with nutrients. Attached Figure Description
[0017] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0018] Figure 1 The image shown is a scanning electron microscope image of the nutrient element-quercetin complex solution in step (1) of Example 1. Figure 2 The image is a scanning electron microscope image of the modified porous starch loaded with the nutrient element-quercetin complex in step (3) of Example 1. Figure 3 The image shows a scanning electron microscope (SEM) image of the CSFQ1@L microcapsule in step (4) of Example 1. Figure 4 This is a schematic diagram showing the drug loading test results of the nutrient element delivery system in Examples 1-4; Figure 5 The graph shows the comparison of hemoglobin values of male SD rats before and after treatment, as well as under different treatment methods, in Example 1. Figure 6 The graph shows the comparison of red blood cell counts in male SD rats before and after treatment, as well as under different treatment methods, in Example 1. Figure 7 This is a comparison of the mean erythrocyte volume of male SD rats before and after treatment, as well as under different treatment methods, in Example 1. Figure 8 The image shows a comparison of hematocrit values of male SD rats before and after treatment, as well as under different treatment methods, in Example 1. Figure 9 This is a comparison of the average red blood cell hemoglobin content of male SD rats before and after treatment, as well as under different treatment methods, in Example 1. Figure 10This is a comparison of liver coefficients in male SD rats before and after treatment, as well as under different treatment methods, in Example 1. Figure 11 This is a comparison of spleen coefficients in male SD rats before and after treatment, as well as under different treatment methods, in Example 1. Figure 12 This is a comparison of iron saturation in male SD rats before and after treatment, as well as under different treatment methods, in Example 1. Figure 13 The graph shows the comparison of serum iron content in male SD rats before and after treatment, as well as under different treatment methods, in Example 1. Figure 14 This is a comparison of the total iron-binding capacity of male SD rats before and after treatment, as well as under different treatment methods, in Example 1. Figure 15 HE slices of the heart, liver, spleen, lung, kidney and small intestine tissues of the male SD rats in Example 1 before and after treatment and under different treatment methods. Detailed Implementation
[0019] The present invention will be further described below with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and technical features described in this application can be combined with each other. It should also be pointed out that, unless otherwise indicated, all technical and scientific terms used in this application have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains. The terms "comprising" or "including" and similar words used in this invention refer to elements or objects preceding the word that encompass the elements or objects listed following the word and their equivalents, without excluding other elements or objects.
[0020] On one hand, the present invention provides a nutrient element delivery system, including a porous carrier, a nutrient element-quercetin complex loaded on the porous carrier, and a coating layer covering the outer surface of the porous carrier. The nutrient element-quercetin complex is formed by coordination of a nutrient element source and quercetin, and the coating layer is made of a phospholipid material.
[0021] In this invention, the carrier is the porous carrier, which has the characteristics of high porosity and strong adsorption, and can improve the drug loading rate of the drug molecules.
[0022] Quercetin is a powerful natural flavonoid polyphenol antioxidant. Its molecule contains ortho- and 3-hydroxy-4-one structures, providing multiple coordination sites, resulting in high nutrient loading and stable complexation, while avoiding the precipitation problems associated with tannins. The complex is stable in the acidic environment of the stomach, and in the small intestine, it can moderately dissociate in response to pH changes, exhibiting favorable "gastric stability-intestinal release" kinetics. Quercetin also possesses excellent antioxidant capacity; when the nutrient is iron, it can inhibit the generation of free radicals induced by the Fenton reaction, thereby reducing oxidative stress and intestinal damage. Furthermore, its natural source endows it with good biocompatibility and safety, contributing to improved nutrient absorption and utilization. Furthermore, it possesses numerous health benefits, including significant anti-inflammatory, cardiovascular protection, immune regulation, anti-allergy, neuroprotection, blood sugar regulation, and potential anti-cancer properties. By chelating and coordinating with nutrient ions such as iron, zinc, and copper to form stable complexes, it can enhance bioavailability, stability, and synergistic effects, demonstrating unique potential in the fields of nutritional supplementation and targeted delivery, while also possessing high-efficiency loading, controlled release, and bioprotective functions.
[0023] The phospholipid material is naturally sourced, has low toxicity, good biocompatibility and biodegradability, and can effectively encapsulate and protect drugs, improve stability and bioavailability, making it an ideal drug delivery material in the biopharmaceutical field.
[0024] In summary, this invention enables the construction of a composite delivery system with good stability, sustained-release properties, and biocompatibility, thereby improving the protective ability, solubility, and bioavailability of active ingredients in the gastrointestinal tract, promoting the efficient absorption of trace elements, reducing irritation and side effects, and achieving safe, controllable, and targeted delivery of nutrients or drugs.
[0025] In one specific embodiment, the porous carrier is a positively charged modified porous starch. In this embodiment, using positively charged modified porous starch as the porous carrier allows it to adsorb and accommodate the nutrient element-quercetin complex using its porous structure. Furthermore, the electrostatic interaction between the positive charge on its surface and the negatively charged or locally electron-rich sites on the surface of the nutrient element-quercetin complex further enhances the load stability, thereby reducing load loss during cleaning, drying, and storage.
[0026] In one specific embodiment, the positively charged modified porous starch is obtained by modifying porous starch with a cationic modifying agent, wherein the cationic modifying agent is any one or more of cationic cellulose, polyquaternary ammonium salt, chitosan and its quaternized derivatives.
[0027] It should be noted that the purpose of modifying porous starch with cationic modifying reagent is to make the modified porous starch positively charged, thereby making it more conducive to adsorption and binding with the nutrient element-quercetin complex; the cationic modifying reagent in the above embodiments is only the preferred agent of the present invention, and other cationic modifying reagents with good biocompatibility and capable of achieving this purpose in the prior art can also be applied to the present invention.
[0028] In one specific embodiment, the nutrient source is any one or more of iron, zinc, and magnesium. Optionally, the nutrient source is a soluble inorganic salt, an organic salt, or a hydrate thereof.
[0029] In one specific embodiment, the phospholipid material is lecithin or a complex of lecithin and excipients, wherein the excipients are any one or more of cholesterol, fatty acids, glycerides, and surfactants.
[0030] In the above embodiments, the lecithin exhibits good biocompatibility, film-forming properties, and amphiphilicity, enabling it to form a relatively continuous coating layer on the particle surface. This coating layer effectively seals the pores of drug-loaded porous particles, isolates them from external media, and slows down diffusion. Especially in oral delivery scenarios, the coating layer made from lecithin helps reduce the rapid release of nutrients in the gastric environment and promotes their further release and absorption in the intestinal environment.
[0031] Compared to common encapsulation materials such as chitosan, gelatin, and starch, lecithin has significant advantages in nutritional supplements. Its amphiphilic structure allows it to form liposomes or nanoemulsion systems, achieving high iron encapsulation rates and improving system stability while reducing nutrient ion leakage. Its structure remains stable in the acidic environment of the stomach, effectively protecting nutrients from premature release. Once in the small intestine, it breaks down under the action of bile salts and enzymes, achieving a controllable "gastric protection—intestinal release" kinetic. Lecithin can also reduce the probability of nutrients such as iron participating in the Fenton reaction through physical barrier action, thereby alleviating oxidative stress. Furthermore, its natural origin, good biocompatibility, and low toxicity promote intestinal absorption and reduce irritation.
[0032] In one specific embodiment, the molar ratio of the nutrient source to the quercetin is 1-6:1, and the amount of the porous carrier is 5%-30% of the mass of the nutrient-quercetin complex. Optionally, the molar ratio is preferably 1-4:1, more preferably 4:1. Optionally, the amount of the porous carrier is preferably 10%-20%, more preferably 15%.
[0033] On the other hand, the present invention also provides a method for preparing the nutrient element delivery system according to any one of the above claims, comprising the following steps: S1: The nutrient source is mixed with quercetin, and the two coordinate to form a nutrient-quercetin complex.
[0034] In one specific embodiment, quercetin is first dissolved in an alcohol solvent or an alcohol / water mixture, then mixed with an aqueous solution of a nutrient source, and the pH is adjusted to alkaline. The mixture is stirred at room temperature for 0.5-2 hours to allow coordination self-assembly, thereby obtaining the nutrient-quercetin complex. In this embodiment, adjusting the pH to alkaline improves the self-assembly efficiency of quercetin and the nutrient source.
[0035] S2: Contact the porous carrier with the nutrient element-quercetin complex to obtain a porous carrier loaded with the nutrient element-quercetin complex.
[0036] S3: Using phospholipid materials and a coating process, a coating layer is formed on the outer surface of the porous carrier loaded with the nutrient element-quercetin complex to obtain the nutrient element delivery system.
[0037] In one specific embodiment, the coating process is any one of spray drying coating, solvent evaporation coating, anti-solvent deposition coating, emulsion template coating, and coaxial spraying / coaxial electrostatic atomization coating. It should be noted that the coating process in this embodiment is only a preferred process of the present invention; other existing technologies capable of forming a phospholipid coating layer on the surface of a porous carrier loaded with the nutrient element-quercetin complex are also applicable to the present invention.
[0038] In one specific embodiment, the phospholipid material is dissolved or dispersed in an organic solvent or an organic solvent / water mixture, wherein the organic solvent is any one or more of ethanol, isopropanol, and acetone; then it is mixed with a drug-loaded porous carrier and formed into an encapsulation layer by atomization, solvent evaporation, or anti-solvent curing.
[0039] In one specific embodiment, the phospholipid material participates in the coating to form the encapsulation layer in the form of a dispersion, suspension, micelle, liposome precursor liquid or emulsion.
[0040] In this invention, the preparation method first utilizes the coordination interaction between the nutrient source and quercetin to form a nutrient-quercetin complex, thereby improving the stability of the nutrient through coordination. Secondly, a porous carrier is used to achieve efficient loading of the nutrient-quercetin complex, increasing the loading capacity. Finally, phospholipid materials are used to coat the surface of the loaded particles, constructing a protective coating layer on the outer layer of the particles. This reduces load exposure, improves the adaptability to the gastrointestinal environment during oral administration, enhances the stability of the system in the gastrointestinal environment, and improves release behavior.
[0041] In another aspect, the present invention also provides the application of the nutrient delivery system described in any one of the above claims in the preparation of nutrient supplements.
[0042] In one specific embodiment, the nutritional supplement is an oral preparation, which includes powder, granules, capsules, tablets, microcapsules, or suspensions.
[0043] Example 1 A nutrient delivery system is prepared by the following steps: (1) Preparation of nutrient element-quercetin complex First, dissolve quercetin in a small amount of ethanol, then dilute it with a large amount of deionized water, and then mix it with the nutrient source (FeSO4·7H2O) at a molar ratio of 1:1, wherein the total mass of deionized water is greater than 99% of the total mass. Add potassium hydroxide to adjust the pH to alkaline, stir at room temperature for 1 hour, so that iron ions and quercetin self-assemble to form a nutrient-quercetin complex, and obtain a nutrient-quercetin complex solution. (2) Preparation of modified porous starch 100 mg of porous starch was dispersed in 1 mL of deionized water, 0.2 mL of polyquaternium-10 (15 mg / mL) was added, the mixture was shaken for 30 s, centrifuged at 2000 g for 2 min, and washed three times with deionized water to obtain positively charged modified porous starch. (3) Using the modified porous starch to load the nutrient element-quercetin complex The positively charged modified porous starch was mixed with the nutrient element-quercetin complex solution from step (1) at a ratio of 15% of the total mass of quercetin and minerals. The mixture was shaken for 30 min, washed three times with deionized water, and dried to obtain modified porous starch loaded with nutrient element-quercetin complex. (4) Modified porous starch loaded with nutrient element-quercetin complex encapsulated by lecithin Lecithin is dissolved or uniformly dispersed in an appropriate amount of organic solvent or organic / water mixed solvent to form a lecithin precursor solution. Modified porous starch loaded with nutrient element-quercetin complex obtained in step (3) is then added to it to form a uniformly dispersed system. Subsequently, spray drying is used for coating, so that the droplets are rapidly atomized and lecithin is deposited on the particle surface, self-assembled and formed a stable coating layer during the solvent evaporation process. Finally, the dried powder is collected to obtain a relatively uniformly encapsulated composite particle, and the nutrient element delivery system is obtained and named CSFQ1@L microcapsules.
[0044] Example 2 Unlike Example 1, in step (1) of this example, the molar ratio of nutrient source to quercetin is 2:1, and the obtained nutrient delivery system is named CSFQ2@L microcapsules.
[0045] Example 3 Unlike Example 1, in step (1) of this example, the molar ratio of nutrient source to quercetin is 3:1, and the obtained nutrient delivery system is named CSFQ3@L microcapsules.
[0046] Example 4 Unlike Example 1, in step (1) of this example, the molar ratio of nutrient source to quercetin is 4:1, and the obtained nutrient delivery system is named CSFQ4@L microcapsules.
[0047] Example 5 Unlike Example 4, in step (1) of this example, the nutrient source is replaced with MgSO4·7H2O, and the obtained nutrient delivery system is named CSMQ4@L microcapsules.
[0048] Example 5 Unlike Example 4, in step (1) of this example, the nutrient source is replaced with ZnSO4·7H2O, and the obtained nutrient delivery system is named CSZQ4@L microcapsules.
[0049] Test Example 1 The complex solutions of step (1) in each embodiment were observed using scanning electron microscopy, with the results of Example 1 as follows: Figure 1 As shown. From Figure 1 It can be seen that quercetin and the nutrient source have successfully formed a nanostructured chelate.
[0050] Test Example 2 The surface morphology of the drug-loaded material in step (3) of each embodiment was observed using scanning electron microscopy, with the results of Example 1 as follows: Figure 2 As shown. From Figure 2 It can be seen that the chelate formed by quercetin and the nutrient source is loaded onto the porous carrier.
[0051] Test Example 3 The surface morphology of the drug-loaded material in step (4) of each embodiment was observed using scanning electron microscopy, with the results of Example 1 as follows: Figure 3 As shown. From Figure 3 It can be seen that lecithin successfully encapsulates the porous drug-loaded material.
[0052] Test Example 4 The drug loading of the drug-loaded material in step (4) of each embodiment was tested using a digestion method and an ultraviolet spectrophotometer. The results of embodiments 1-4 are as follows: Figure 4 As shown. From Figure 4 It can be seen that the drug loading capacity increases with the increase of the amount of nutrient source used.
[0053] Application Example 1 Twenty-one male SD rats, 3-4 weeks old, were purchased from Chengdu Dashuo Experimental Animal Co., Ltd. They were housed at the Experimental Animal Center of Sichuan University West China Campus throughout the experiment, with an ambient temperature of 20-26℃ and humidity of 40-70%, a 12-hour diurnal cycle, and free access to water and food. After acclimatization for 3 days, the 21 rats were randomly divided into 7 groups (n=3 / group). One group was randomly selected as the normal control group (Control group), which was fed a standard diet throughout the experiment. The remaining 18 rats were fed a low-iron diet (12 ppm iron content) throughout the experiment. During the modeling period, tail amputation and bloodletting were performed once a week to establish an iron deficiency anemia rat model. After four weeks (28 days), blood was collected from the tails of 25 model rats to measure blood routine indicators. Rats with hemoglobin (Hb) values <100 g / L were considered to have successfully established the iron deficiency anemia model.
[0054] After establishing the iron deficiency anemia (IDA) model, 18 rats were randomly divided into 6 groups: iron deficiency anemia group (IDA group), FeSO4 control group (FeSO4 group, administered FeSO4 at a dose of 3 mg Fe / kg / day), polysaccharide iron complex control group (ICP group, administered polysaccharide iron complex capsules at a dose of 3 mg Fe / kg / day), high-dose experimental group of the present invention (HSFE group, administered CSFQ1@L microcapsules of Example 1 at a dose of 5 mg Fe / kg / day), medium-dose experimental group of the present invention (MSFE group, administered CSFQ1@L microcapsules of Example 1 at a dose of 3 mg Fe / kg / day), and low-dose experimental group of the present invention (LSFE group, administered CSFQ1@L microcapsules of Example 1 at a dose of 1 mg Fe / kg / day). The administration was continued for three weeks (28 days). During the gavage period, except for the normal control group, all other groups had free access to deionized water and low-iron feed. The weight of all rats was recorded weekly, and the animal condition was observed. After feeding, all experimental rats were fasted for 12 hours but allowed free access to water. Blood was collected via the abdominal aorta after anesthesia with ether. The blood was used for routine blood tests and centrifuged to obtain serum, which was then stored at -80°C for later use. Subsequently, the heart, liver, spleen, lungs, kidneys, thymus, and small intestine were quickly harvested, cleaned, and weighed. Some tissues were fixed in 4% paraformaldehyde, while the remainder was stored at -80°C.
[0055] Blood routine indicators in rats were detected using a fully automated blood analyzer. The experimental results are as follows: Figures 5-9 As shown. From Figures 5-9 It can be seen that the corresponding blood routine indicators in each experimental group returned to normal levels after treatment. Compared with commercially available iron supplements, the iron supplement of this invention is superior to commercially available iron supplements in terms of the recovery of hemoglobin value and red blood cell count.
[0056] Rat serum was collected and tested according to the instructions in the test kit. Serum iron content and total iron-binding capacity were measured in each group, and iron saturation was calculated. The organ coefficient of each component was calculated using the formula (organ coefficient (g / 100g) = organ weight / rat body weight * 100). The experimental results are as follows: Figures 10-14 As shown. From Figures 10-14 It can be seen that after treatment with this invention, the splenomegaly and liver shrinkage caused by iron deficiency anemia can be restored to normal levels, and the serum iron index can also be restored to normal levels, indicating that the iron supplementation effect of this invention is significant.
[0057] After organ fixation with paraformaldehyde, the tissues were sequentially dehydrated with graded ethanol, cleared with xylene, embedded in paraffin, and sectioned. The sections were then dewaxed and rehydrated. After rehydration, the sections were stained with hematoxylin and eosin, then dehydrated, cleared, and mounted. The tissue morphology and structure were observed under a microscope. The experimental results are as follows: Figure 15 As shown. From Figure 15 As can be seen, there were no significant changes in the tissue morphology of the treatment group compared with the normal group, indicating that the present invention has excellent biocompatibility.
[0058] It should be noted that the above test examples and application examples are only some of the test examples and application examples of the present invention. The nutrient element delivery system of the present invention obtained by replacing the nutrient element source in Examples 5-6, as well as by changing the dosage of the agent, the temperature and time of the preparation method, etc., all have similar performance (good stability, sustained release performance and biocompatibility).
[0059] The above description is merely a representative embodiment of the present invention and is not intended to limit the present invention in any way. Any embodiment made by those skilled in the art without departing from the scope of the present invention and utilizing the disclosed technical content is an equivalent embodiment of the present invention. Any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.
Claims
1. A nutrient element delivery system, characterized in that, The invention includes a porous carrier, a nutrient element-quercetin complex loaded on the porous carrier, and a coating layer covering the outer surface of the porous carrier. The nutrient element-quercetin complex is formed by coordination of a nutrient element source with quercetin, and the coating layer is made of a phospholipid material.
2. The nutrient delivery system of claim 1, wherein, The porous carrier is a positively charged modified porous starch.
3. The nutrient delivery system of claim 2, wherein, The positively charged modified porous starch is obtained by modifying porous starch with a cationic modifying agent, wherein the cationic modifying agent is any one or more of cationic cellulose, polyquaternary ammonium salt, chitosan and its quaternized derivatives.
4. The nutrient delivery system of claim 1, wherein, The nutrient source is any one or more of iron, zinc, and magnesium.
5. The nutrient delivery system of claim 1, wherein, The phospholipid material is lecithin or a complex of lecithin and excipients, wherein the excipients are any one or more of cholesterol, fatty acids, glycerides, and surfactants.
6. The nutrient delivery system according to any one of claims 1 to 5, wherein, The molar ratio of the nutrient source to the quercetin is 1-6:1, and the amount of the porous carrier is 5%-30% of the mass of the nutrient-quercetin complex.
7. The method for preparing the nutrient element delivery system according to any one of claims 1-6, characterized in that, Includes the following steps: S1: The nutrient source is mixed with quercetin, and the two coordinate to form a nutrient-quercetin complex. S2: Contact the porous carrier with the nutrient element-quercetin complex to obtain a porous carrier loaded with the nutrient element-quercetin complex. S3: Using phospholipid materials and a coating process, a coating layer is formed on the outer surface of the porous carrier loaded with the nutrient element-quercetin complex to obtain the nutrient element delivery system.
8. The method for preparing the nutrient element delivery system according to claim 7, characterized in that, In step S1, quercetin is first dissolved in an alcohol solvent or an alcohol / water mixed solvent, then mixed with an aqueous solution of nutrient source, and the pH is adjusted to alkaline to induce coordination self-assembly.
9. The use of the nutrient delivery system as described in any one of claims 1-6 in the preparation of nutrient supplements.
10. The application according to claim 9, characterized in that, The nutritional supplement is an oral preparation, which includes powder, granules, capsules, tablets, microcapsules, or suspensions.