Bone strength tailored bone cement compositions

By adjusting the mixing ratio of PMMA and microbeads, a bone cement composition that matches individual bone strength was prepared, solving the problem that existing bone cements cannot match bone strength and achieving the effects of reducing fracture risk and promoting bone regeneration.

CN122341402APending Publication Date: 2026-07-03ZENEI BIOLOGICAL CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZENEI BIOLOGICAL CO LTD
Filing Date
2023-10-20
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Existing bone cement materials cannot effectively match individual bone strength, leading to an increased risk of fractures. Furthermore, bone mineral density measurement methods are prone to misjudgment and cannot accurately assess the fracture risk in osteoporosis.

Method used

By adjusting the mixing ratio of polymethyl methacrylate (PMMA) and microspheres to satisfy the formula 0.0014x²-0.0221x+0.1816≤P/M≤0.0014x²-0.0165x+2.243, a bone cement composition matching individual bone strength was prepared. Porous microspheres and hydrogels were added to promote bone regeneration.

Benefits of technology

It provides bone cement that matches individual bone strength, improving the effectiveness of fracture treatment, reducing fracture risk, and avoiding the need for secondary surgery.

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Abstract

This invention relates to a bone cement composition, characterized in that: as a bone cement composition comprising polymethyl methacrylate (PMMA) and microbeads, the mixing ratio of said PMMA and microbeads satisfies 0.0014x 2 ‑0.0221x+0.1816≤P / M≤0.0014x 2 -0.0165x + 2.243 (P is the weight (g) of polymethyl methacrylate, M is the weight (g) of microbeads, and x is the bone strength value, ranging from 1.5 to 45). According to the present invention, the mixing ratio of polymethyl methacrylate and microbeads for providing a customized bone cement composition with bone strength and mechanical properties (strength) similar to those of the bone cement recipient can be determined. Therefore, when the prepared bone cement composition and bone cement are applied to the bone cement recipient, a rapid therapeutic effect can be achieved.
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