A repair anti-aging skin care composition and method of making same

Abstract

The application belongs to the technical field of skin care products, and discloses a kind of repair anti-aging skin care composition and preparation method thereof;The composition comprises ceramide complex, polyphenol supramolecular complex, polyol humectant, emollient oil, oil-soluble emulsifier, water-soluble thickener, ectoine, preservative, chelating agent and pH regulator;The ceramide complex is compounded by ceramide NP, ceramide AP, ceramide EOP, phytosphingosine and cholesterols according to molar ratio, and the polyphenol supramolecular complex is ternary inclusion nanocomposite formed by oligomeric procyanidins, hydroxypropyl-beta-cyclodextrin and ceramide NP through supramolecular self-assembly;The composition has barrier repair and anti-aging dual effects, and solves the problem that ceramide repair components and polyphenol anti-aging components are difficult to be stable in the same formula system.

Description

Technical Field

[0001] This invention belongs to the field of skin care technology, specifically relating to a repairing and anti-aging skin care composition and its preparation method. Background Technology

[0002] Skin barrier repair and anti-aging are two core demands in the functional skincare market. With the gradual improvement of cosmetic regulatory systems and consumers' deepening understanding of product efficacy, skincare products that combine barrier repair and anti-aging functions have become a research hotspot. The application of naturally derived active ingredients in these products is becoming increasingly widespread; however, how to achieve both barrier repair and anti-aging effects in a single formulation system remains a major technical challenge in cosmetic formulation development.

[0003] Ceramides are a core component of the intercellular lipids in the stratum corneum, accounting for approximately 40% to 50% of the total lipids in the stratum corneum, and play a crucial role in maintaining the integrity of the skin barrier structure and function. Functional skincare products containing ceramides have been proven to reduce transepidermal water loss, improve stratum corneum structure, and increase lipid content. However, ceramides require precise temperature and process control in formulation; they must be fully melted at specific temperatures to effectively integrate into the product system. If improper process control results in ceramides existing in undissolved crystalline form in the final product, their barrier-repairing efficacy will be significantly weakened. Regarding natural anti-aging active ingredients, proanthocyanidins possess strong antioxidant and anti-inflammatory activities, showing promising application prospects in delaying skin aging. However, proanthocyanidins exhibit poor physicochemical stability and low bioavailability, typically requiring encapsulation technology or specific formulation strategies to improve their stability and transdermal delivery efficiency.

[0004] Cyclodextrin inclusion technology is a commonly used supramolecular delivery method in the cosmetics industry, which can improve the solubility, stability, and compatibility of active ingredients through molecular inclusion. However, most existing technologies only target the inclusion or stabilization of single active ingredients, and there is a lack of effective means to synergistically integrate ceramide-based repairing ingredients with polyphenol-based anti-aging ingredients at the supramolecular level, making it difficult to meet consumers' integrated demand for both repair and anti-aging effects. Summary of the Invention

[0005] In order to overcome the above-mentioned defects of the prior art, the embodiments of the present invention provide a repair and anti-aging skin care composition and its preparation method, which solves the problem that ceramide repair ingredients and polyphenol anti-aging ingredients are difficult to coexist stably and synergistically in the same formulation system and cannot simultaneously and efficiently achieve the dual effects of barrier repair and anti-aging.

[0006] To address the above problems, the present invention provides the following technical solution: A repairing and anti-aging skincare composition, by weight, comprises the following components: 0.5-5.0 parts ceramide complex, 0.1-3.0 parts polyphenol supramolecular complex, 3.0-15.0 parts polyol moisturizer, 2.0-8.0 parts moisturizing oil, 1.0-5.0 parts oil-soluble emulsifier, 0.05-1.0 parts water-soluble thickener, 0.01-1.0 parts ectoine, 0.01-0.5 parts preservative, 0.01-0.1 parts chelating agent, 0.01-0.5 parts pH adjuster, and water to make up to 100 parts.

[0007] Furthermore, the ceramide complex is composed of ceramide NP, ceramide AP, ceramide EOP, phytosphingosine, and cholesterol in a molar ratio of 1:0.5~1.5:0.1~0.8:0.5~2.0:0.5~2.0.

[0008] Furthermore, the pH adjuster is citric acid monohydrate and sodium hydroxide, with a mass ratio of citric acid monohydrate to sodium hydroxide of 1:0.4~1.2.

[0009] Furthermore, the polyphenol supramolecular complex is prepared by the following method: Step 1: Dissolve 5-20 parts by weight of hydroxypropyl-β-cyclodextrin in 80-150 parts by weight of water, and stir at 40-60°C until completely dissolved to obtain a hydroxypropyl-β-cyclodextrin solution. Step 2: Dissolve 0.5-5 parts by weight of ceramide NP in 10-30 parts by weight of anhydrous ethanol, and stir at 50-70°C until completely dissolved to obtain a ceramide NP solution; Step 3: Dissolve 1-8 parts by weight of oligomeric proanthocyanidins in 30-80 parts by weight of water, and adjust the pH to 5.0-6.5 with a citric acid-sodium citrate buffer system to obtain an oligomeric proanthocyanidin solution. Step 4: Under nitrogen protection, slowly add the ceramide NP solution dropwise to the hydroxypropyl-β-cyclodextrin solution, and stir the reaction at 45~65℃ for 1~3h to obtain a ceramide-cyclodextrin inclusion complex dispersion. Step 5: Slowly add the oligomeric proanthocyanidin solution dropwise to the ceramide-cyclodextrin inclusion complex dispersion, stir and react at 35-55℃ for 2-6 hours, remove ethanol by vacuum distillation at 40-50℃, sonicate at 100-300W for 10-30 minutes, concentrate under vacuum at 40-50℃ to 1 / 5-1 / 3 of the original volume, and finally freeze-dry to obtain the polyphenol supramolecular complex.

[0010] Furthermore, the oligomeric proanthocyanidins are prepared by the following method: Step 1: Disperse 10-30 parts by weight of grape seed proanthocyanidins with an average degree of polymerization of 6-20 in 80-200 parts by weight of citric acid aqueous solution with pH 2.0-3.5 to obtain a high-polymer proanthocyanidin suspension. Step 2: Add 0.1 to 2.4 parts by weight of epicatechin to the polymer proanthocyanidin suspension, and stir and react at 60 to 90°C for 3 to 12 hours under nitrogen protection. The third step is to cool the mixture to room temperature after the reaction is complete, adjust the pH to 4.0-5.0 with sodium hydroxide aqueous solution, and then perform membrane separation using a nanofiltration membrane with a molecular weight cutoff of 500-1500, collecting the retentate. Step 4: Concentrate the retentate under reduced pressure at 35-45°C, and then freeze-dry it to obtain oligomeric proanthocyanidins.

[0011] Furthermore, the moisturizing oil is selected from any one of squalane, jojoba seed oil, and shea butter.

[0012] Furthermore, the polyol moisturizer is selected from any one of glycerin, 1,3-butanediol, pentanediol, and hexanediol.

[0013] Furthermore, the oil-soluble emulsifier is selected from either cetearyl glucoside or polyglycerol-10 stearate.

[0014] Furthermore, the water-soluble thickener is selected from either xanthan gum or carbomer.

[0015] Furthermore, the chelating agent is selected from any one of disodium EDTA, tetrasodium EDTA, and sodium phytate.

[0016] Furthermore, the preservative is selected from any one of phenoxyethanol, ethylhexylglycerin, and caprylyl glycol.

[0017] A method for preparing a repairing and anti-aging skincare composition includes the following steps: S1. Mix polyol humectant, ectoine, chelating agent, pH adjuster, water-soluble thickener and water, heat to 70~85℃, stir until uniform, and obtain an aqueous phase mixture; S2. First, mix the ceramide complex with the moisturizing oil at 100~110℃ until the ceramide melts, then add the oil-soluble emulsifier and stir evenly to obtain an oil phase mixture; S3. Add the oil phase mixture to the aqueous phase mixture and homogenize at 75~85℃ and 3000~10000rpm for 3~8min to obtain the primary emulsion; S4. Stir the primary emulsion at 200-800 rpm and cool it to 35-45°C. Pre-disperse the polyphenol supramolecular complex into a slurry with a polyol humectant and add it to the emulsion. Add the preservative at the same time, stir until uniform, continue stirring and cool to room temperature to obtain the final product.

[0018] Compared with the prior art, the beneficial effects of the present invention are: This invention first encapsulates ceramide NP with hydroxypropyl-β-cyclodextrin to form a binary inclusion complex, then introduces oligomeric proanthocyanidins for ternary assembly, constructing an oligomeric proanthocyanidins-hydroxypropyl-β-cyclodextrin-ceramide NP ternary inclusion nanocomposite. The supramolecular composite integrates oil-soluble ceramide and water-soluble polyphenol into the same nanostructure. On one hand, the inclusion effect of the cyclodextrin cavity enhances the water dispersibility of ceramide, allowing it to be uniformly distributed in the aqueous phase. On the other hand, the steric hindrance effect and hydrogen bond network of the supramolecular assembly inhibit the oxidative degradation of oligomeric proanthocyanidins, extending their active period. During the preparation of the composition… In this process, the ceramide complex and moisturizing oil are first melted and mixed at a suitable temperature to ensure that the ceramide participates in the subsequent emulsification in a dissolved state, avoiding undissolved crystals remaining in the final product and affecting the barrier repair effect. After the oil phase and water phase are homogenized to form a primary emulsion, the polyphenol supramolecular complex is added in a pre-dispersed form at a lower temperature to avoid prolonged heating and damage to the supramolecular structure. The process design of this invention enables ceramide repair ingredients and polyphenol anti-aging ingredients to coexist stably and synergistically in the same O / W type emulsion. The product has dual skin care functions of barrier repair and anti-aging, and the preparation process is continuous and controllable, making it suitable for large-scale production. Attached Figure Description

[0019] Figure 1 This is a comparison chart of the polyphenol activity retention rate of this invention. Detailed Implementation

[0020] To facilitate understanding of the present invention, the present invention will be described more fully and in detail below with reference to the accompanying drawings and preferred embodiments, but the scope of protection of the present invention is not limited to the following specific embodiments.

[0021] Unless otherwise defined, all technical terms used herein have the same meaning as commonly understood by those skilled in the art. The technical terms used herein are for the purpose of describing particular embodiments only and are not intended to limit the scope of the invention.

[0022] Unless otherwise specified, all raw materials, reagents, instruments and equipment used in this invention can be purchased from the market or prepared by existing methods.

[0023] Example 1 A repairing and anti-aging skincare composition of the present invention comprises, by weight, the following components: 0.5 parts ceramide complex, 0.1 parts polyphenol supramolecular complex, 3.0 parts glycerin, 2.0 parts squalane, 1.0 part cetearyl glucoside, 0.05 parts xanthan gum, 0.01 parts ectoine, 0.01 parts phenoxyethanol, 0.01 parts disodium EDTA, 0.01 parts pH adjuster, and water to make up to 100 parts; The ceramide complex is composed of ceramide NP, ceramide AP, ceramide EOP, phytosphoprotein, and cholesterol in a molar ratio of 1:0.5:0.1:0.5:0.5. The pH adjuster is composed of citric acid monohydrate and sodium hydroxide in a mass ratio of 1:0.4.

[0024] The polyphenol supramolecular complex was prepared by the following method: Step 1: Dissolve 5 parts by weight of hydroxypropyl-β-cyclodextrin in 80 parts by weight of water, and stir at 40°C until completely dissolved to obtain a hydroxypropyl-β-cyclodextrin solution; Step 2: Dissolve 0.5 parts by weight of ceramide NP in 10 parts by weight of anhydrous ethanol and stir at 50°C until completely dissolved to obtain a ceramide NP solution. Step 3: Dissolve 1 part by weight of oligomeric proanthocyanidins in 30 parts by weight of water, and adjust the pH to 5.0 with a citric acid-sodium citrate buffer system to obtain an oligomeric proanthocyanidin solution. Step 4: Under nitrogen protection, the ceramide NP solution is slowly added dropwise to the hydroxypropyl-β-cyclodextrin solution, and the mixture is stirred at 45°C for 1 hour to obtain a ceramide-cyclodextrin inclusion complex dispersion. Step 5: Slowly add the oligomeric proanthocyanidin solution dropwise to the ceramide-cyclodextrin inclusion complex dispersion, stir and react at 35°C for 2 hours, remove ethanol by vacuum distillation at 40°C, sonicate at 100W for 10 minutes, concentrate under vacuum at 40°C to 1 / 5 of the original volume, and finally freeze-dry to obtain the polyphenol supramolecular complex.

[0025] The oligomeric proanthocyanidins were prepared by the following method: Step 1: Disperse 10 parts by weight of grape seed proanthocyanidins with an average degree of polymerization of 6 in 80 parts by weight of citric acid aqueous solution with pH 2.0 to obtain a high-polymer proanthocyanidin suspension. Step 2: Add 0.1 parts by weight of epicatechin to the polymer proanthocyanidin suspension and stir at 60°C for 3 hours under nitrogen protection. The third step is to cool the mixture to room temperature after the reaction is complete, adjust the pH to 4.0 with sodium hydroxide aqueous solution, and then perform membrane separation through a nanofiltration membrane with a molecular weight cutoff of 500, and collect the retentate. Step 4: Concentrate the retentate under reduced pressure at 35°C, and then freeze-dry it to obtain oligomeric proanthocyanidins.

[0026] The preparation method of the repair and anti-aging skin care composition in this embodiment includes the following steps: S1. Mix glycerol, ectoine, disodium EDTA, pH adjuster, xanthan gum and water, heat to 70°C, and stir until homogeneous to obtain an aqueous mixture; S2. First, mix the ceramide complex with squalane at 100°C until the ceramide melts, then add cetearyl glucoside and stir until homogeneous to obtain an oil phase mixture; S3. Add the oil phase mixture to the aqueous phase mixture and homogenize at 3000 rpm for 3 min at 75°C to obtain the primary emulsion; S4. Stir the primary emulsion at 200 rpm and cool it to 35°C. Pre-disperse the polyphenol supramolecular complex with glycerol to a slurry state and add it to the emulsion. At the same time, add phenoxyethanol and stir until homogeneous. Continue stirring and cool to room temperature to obtain the final product.

[0027] Example 2 A repairing and anti-aging skincare composition of the present invention comprises, by weight, the following components: 3.0 parts ceramide complex, 1.5 parts polyphenol supramolecular complex, 9.0 parts glycerin, 5.0 parts squalane, 3.0 parts cetearyl glucoside, 0.5 parts xanthan gum, 0.5 parts ectoine, 0.3 parts phenoxyethanol, 0.05 parts disodium EDTA, 0.25 parts pH adjuster, and water to make up to 100 parts; The ceramide complex is composed of ceramide NP, ceramide AP, ceramide EOP, phytosphoprotein, and cholesterol in a molar ratio of 1:1.0:0.45:1.25:1.25. The pH adjuster is composed of citric acid monohydrate and sodium hydroxide in a mass ratio of 1:0.8.

[0028] The polyphenol supramolecular complex was prepared by the following method: Step 1: Dissolve 12 parts by weight of hydroxypropyl-β-cyclodextrin in 115 parts by weight of water, and stir at 50°C until completely dissolved to obtain a hydroxypropyl-β-cyclodextrin solution; Step 2: Dissolve 2.5 parts by weight of ceramide NP in 20 parts by weight of anhydrous ethanol, and stir at 60°C until completely dissolved to obtain a ceramide NP solution; Step 3: Dissolve 4.5 parts by weight of oligomeric proanthocyanidins in 55 parts by weight of water, and adjust the pH to 5.8 using a citric acid-sodium citrate buffer system to obtain an oligomeric proanthocyanidin solution. Step 4: Under nitrogen protection, the ceramide NP solution is slowly added dropwise to the hydroxypropyl-β-cyclodextrin solution, and the mixture is stirred at 55°C for 2 hours to obtain a ceramide-cyclodextrin inclusion complex dispersion. Step 5: Slowly add the oligomeric proanthocyanidin solution dropwise to the ceramide-cyclodextrin inclusion complex dispersion, stir and react at 45°C for 4 hours, remove ethanol by vacuum distillation at 45°C, sonicate at 200W for 20 minutes, concentrate under vacuum at 45°C to 1 / 4 of the original volume, and finally freeze-dry to obtain the polyphenol supramolecular complex.

[0029] The oligomeric proanthocyanidins were prepared by the following method: Step 1: Disperse 20 parts by weight of grape seed proanthocyanidins with an average degree of polymerization of 14 in 140 parts by weight of citric acid aqueous solution with pH 2.8 to obtain a high-polymer proanthocyanidin suspension. Step 2: Add 1.2 parts by weight of epicatechin to the polymer proanthocyanidin suspension and stir at 75°C for 7 hours under nitrogen protection. Step 3: After the reaction is complete, cool to room temperature, adjust the pH to 4.5 with sodium hydroxide aqueous solution, and perform membrane separation through a nanofiltration membrane with a molecular weight cutoff of 1000, and collect the retentate; Step 4: Concentrate the retentate under reduced pressure at 40°C, and then freeze-dry it to obtain oligomeric proanthocyanidins.

[0030] The preparation method of the repair and anti-aging skin care composition in this embodiment includes the following steps: S1. Mix glycerol, ectoine, disodium EDTA, pH adjuster, xanthan gum and water, heat to 78°C, and stir until homogeneous to obtain an aqueous mixture; S2. First, mix the ceramide complex with squalane at 105°C until the ceramide melts, then add cetearyl glucoside and stir until homogeneous to obtain an oil phase mixture; S3. Add the oil phase mixture to the aqueous phase mixture and homogenize at 80°C and 6500 rpm for 5 min to obtain the primary emulsion; S4. Stir the primary emulsion at 500 rpm and cool it to 40°C. Pre-disperse the polyphenol supramolecular complex with glycerol to a slurry state and add it to the emulsion. Add phenoxyethanol at the same time, stir until uniform, continue stirring and cool to room temperature to obtain the final product.

[0031] Example 3 A repairing and anti-aging skincare composition of the present invention comprises, by weight, the following components: 5.0 parts ceramide complex, 3.0 parts polyphenol supramolecular complex, 15.0 parts glycerin, 8.0 parts squalane, 5.0 parts cetearyl glucoside, 1.0 part xanthan gum, 1.0 part ectoine, 0.5 parts phenoxyethanol, 0.1 parts disodium EDTA, 0.5 parts pH adjuster, and water to make up to 100 parts; The ceramide complex is composed of ceramide NP, ceramide AP, ceramide EOP, phytosphoprotein, and cholesterol in a molar ratio of 1:1.5:0.8:2.0:2.0. The pH adjuster is composed of citric acid monohydrate and sodium hydroxide in a mass ratio of 1:1.2.

[0032] The polyphenol supramolecular complex was prepared by the following method: Step 1: Dissolve 20 parts by weight of hydroxypropyl-β-cyclodextrin in 150 parts of water, and stir at 60°C until completely dissolved to obtain a hydroxypropyl-β-cyclodextrin solution; Step 2: Dissolve 5 parts by weight of ceramide NP in 30 parts by weight of anhydrous ethanol, and stir at 70°C until completely dissolved to obtain a ceramide NP solution; Step 3: Dissolve 8 parts by weight of oligomeric proanthocyanidins in 80 parts by weight of water, and adjust the pH to 6.5 with a citric acid-sodium citrate buffer system to obtain an oligomeric proanthocyanidin solution. Step 4: Under nitrogen protection, the ceramide NP solution is slowly added dropwise to the hydroxypropyl-β-cyclodextrin solution, and the mixture is stirred at 65°C for 3 hours to obtain a ceramide-cyclodextrin inclusion complex dispersion. Step 5: Slowly add the oligomeric proanthocyanidin solution dropwise to the ceramide-cyclodextrin inclusion complex dispersion, stir and react at 55℃ for 6 hours, remove ethanol by vacuum distillation at 50℃, sonicate at 300W for 30 minutes, concentrate under vacuum at 50℃ to 1 / 3 of the original volume, and finally freeze-dry to obtain the polyphenol supramolecular complex.

[0033] The oligomeric proanthocyanidins were prepared by the following method: Step 1: Disperse 30 parts by weight of grape seed proanthocyanidins with an average degree of polymerization of 20 in 200 parts by weight of citric acid aqueous solution with pH 3.5 to obtain a high-polymer proanthocyanidin suspension. The second step is to add 2.4 parts by weight of epicatechin to the polymer proanthocyanidin suspension and stir and react at 90°C for 12 hours under nitrogen protection. The third step is to cool the mixture to room temperature after the reaction is complete, adjust the pH to 5.0 with sodium hydroxide aqueous solution, and then perform membrane separation through a nanofiltration membrane with a molecular weight cutoff of 1500, collecting the retentate. Step 4: Concentrate the retentate under reduced pressure at 45°C, and then freeze-dry it to obtain oligomeric proanthocyanidins.

[0034] The preparation method of the repair and anti-aging skin care composition in this embodiment includes the following steps: S1. Mix glycerol, ectoine, disodium EDTA, pH adjuster, xanthan gum and water, heat to 85°C, and stir until homogeneous to obtain an aqueous mixture; S2. First, mix the ceramide complex with squalane at 110°C until the ceramide melts, then add cetearyl glucoside and stir until homogeneous to obtain an oil phase mixture; S3. Add the oil phase mixture to the aqueous phase mixture and homogenize at 85°C and 10,000 rpm for 8 min to obtain the primary emulsion; S4. Stir the primary emulsion at 800 rpm and cool it to 45°C. Pre-disperse the polyphenol supramolecular complex with glycerol to a slurry state and add it to the emulsion. At the same time, add phenoxyethanol and stir until homogeneous. Continue stirring and cool to room temperature to obtain the final product.

[0035] Comparative Example The main difference between this comparative example and Example 1 is that the polyphenol supramolecular complex is replaced with a mixture consisting of 1 part oligomeric proanthocyanidins, 5 parts hydroxypropyl-β-cyclodextrin and 0.5 parts ceramide NP. The mixture is added together with the preservative in step S4. The remaining components and process steps are the same as in Example 1.

[0036] Effect test: Transepidermal water loss reduction rate: The transepidermal water loss values ​​of the test site before and after the application of the sample were measured according to T / CAFFCI 66-2023, and the percentage reduction after application was calculated. Increase rate of stratum corneum moisture content: According to QB / T 4256-2011, the capacitance value of the stratum corneum of the skin before and after the application of the sample to the test site was determined, and the percentage increase of the capacitance value after application compared with that before application was calculated. DPPH free radical scavenging rate: According to T / SHRH 006-2018, after the sample solution is mixed with DPPH ethanol solution and reacted, the absorbance is measured at a wavelength of 517 nm. The scavenging rate is calculated by the difference in absorbance between the sample group and the blank group. Elastase inhibition rate: The sample solution was mixed with elastase solution and substrate N-succinyl-tripropionyl-p-nitroaniline, and the absorbance at 410 nm was measured after incubation at 37 °C. The inhibition rate was calculated by the difference in absorbance between the sample group and the blank group. Polyphenol activity retention rate: According to ISO / TR 18811:2018, the sample was placed in a constant temperature environment of 45℃ for 30 days and then sampled to determine the content of oligomeric proanthocyanidins in the sample. The percentage of the content after accelerated testing to the initial content was calculated.

[0037]

[0038] By comparing and analyzing the table and Figure 1 According to the relevant data, Examples 1 to 3 were significantly superior to the comparative example in terms of the reduction rate of transepidermal water loss, the increase rate of stratum corneum moisture content, the DPPH free radical scavenging rate, the elastase inhibition rate, and the polyphenol activity retention rate. The comparative example, which used a mixture of oligomeric proanthocyanidins, hydroxypropyl-β-cyclodextrin, and ceramide NP to replace the polyphenol supramolecular complex, lacked the molecular inclusion and stabilizing effects provided by supramolecular self-assembly. The water dispersibility of ceramide was limited, and oligomeric proanthocyanidins were easily oxidized and inactivated in the system, resulting in significantly lower performance indicators compared to the examples. This indicates that the present invention, by forming a ternary inclusion nanocomposite from oligomeric proanthocyanidins, hydroxypropyl-β-cyclodextrin, and ceramide NP through stepwise supramolecular self-assembly, and combined with stepwise homogenization and low-temperature loading processes, enables the repairing and anti-aging components to coexist synergistically and stably in the same system. The composition possesses both excellent barrier repair and anti-aging effects.

[0039] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0040] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. A repairing and anti-aging skincare composition, characterized in that, By weight, it comprises the following components: 0.5-5.0 parts ceramide complex, 0.1-3.0 parts polyphenol supramolecular complex, 3.0-15.0 parts polyol moisturizer, 2.0-8.0 parts moisturizing oil, 1.0-5.0 parts oil-soluble emulsifier, 0.05-1.0 parts water-soluble thickener, 0.01-1.0 parts ectoine, 0.01-0.5 parts preservative, 0.01-0.1 parts chelating agent, 0.01-0.5 parts pH adjuster, and water to 100 parts; The ceramide complex is composed of ceramide NP, ceramide AP, ceramide EOP, phytosphoprotein, and cholesterol in a molar ratio of 1:0.5~1.5:0.1~0.8:0.5~2.0:0.5~2.0; The pH adjuster is citric acid monohydrate and sodium hydroxide, with a mass ratio of citric acid monohydrate to sodium hydroxide of 1:0.4~1.

2.

2. The repairing and anti-aging skincare composition according to claim 1, characterized in that, The polyphenol supramolecular complex was prepared by the following method: Step 1: Dissolve 5-20 parts by weight of hydroxypropyl-β-cyclodextrin in 80-150 parts by weight of water, and stir at 40-60°C until completely dissolved to obtain a hydroxypropyl-β-cyclodextrin solution. Step 2: Dissolve 0.5-5 parts by weight of ceramide NP in 10-30 parts by weight of anhydrous ethanol, and stir at 50-70°C until completely dissolved to obtain a ceramide NP solution; Step 3: Dissolve 1-8 parts by weight of oligomeric proanthocyanidins in 30-80 parts by weight of water, and adjust the pH to 5.0-6.5 with a citric acid-sodium citrate buffer system to obtain an oligomeric proanthocyanidin solution. Step 4: Under nitrogen protection, slowly add the ceramide NP solution dropwise to the hydroxypropyl-β-cyclodextrin solution, and stir the reaction at 45~65℃ for 1~3h to obtain a ceramide-cyclodextrin inclusion complex dispersion. Step 5: Slowly add the oligomeric proanthocyanidin solution dropwise to the ceramide-cyclodextrin inclusion complex dispersion, stir and react at 35-55℃ for 2-6 hours, remove ethanol by vacuum distillation at 40-50℃, sonicate at 100-300W for 10-30 minutes, concentrate under vacuum at 40-50℃ to 1 / 5-1 / 3 of the original volume, and finally freeze-dry to obtain the polyphenol supramolecular complex.

3. The repairing and anti-aging skincare composition according to claim 2, characterized in that, The oligomeric proanthocyanidins were prepared by the following method: Step 1: Disperse 10-30 parts by weight of grape seed proanthocyanidins with an average degree of polymerization of 6-20 in 80-200 parts by weight of citric acid aqueous solution with pH 2.0-3.5 to obtain a high-polymer proanthocyanidin suspension. Step 2: Add 0.1 to 2.4 parts by weight of epicatechin to the polymer proanthocyanidin suspension, and stir and react at 60 to 90°C for 3 to 12 hours under nitrogen protection. The third step is to cool the mixture to room temperature after the reaction is complete, adjust the pH to 4.0-5.0 with sodium hydroxide aqueous solution, and then perform membrane separation through a nanofiltration membrane with a molecular weight cutoff of 500-1500, collecting the retentate. Step 4: Concentrate the retentate under reduced pressure at 35-45°C, and then freeze-dry it to obtain oligomeric proanthocyanidins.

4. The repairing and anti-aging skincare composition according to claim 1, characterized in that, The moisturizing oil is selected from any one of squalane, jojoba seed oil, and shea butter.

5. The repairing and anti-aging skincare composition according to claim 1, characterized in that, The polyol moisturizer is selected from any one of glycerin, 1,3-butanediol, pentanediol, and hexanediol.

6. The repairing and anti-aging skincare composition according to claim 1, characterized in that, The oil-soluble emulsifier is selected from either cetearyl glucoside or polyglycerol-10 stearate.

7. The repairing and anti-aging skincare composition according to claim 1, characterized in that, The water-soluble thickener is selected from either xanthan gum or carbomer.

8. The repairing and anti-aging skincare composition according to claim 1, characterized in that, The chelating agent is selected from any one of disodium EDTA, tetrasodium EDTA, and sodium phytate.

9. The repairing and anti-aging skincare composition according to claim 1, characterized in that, The preservative is selected from any one of phenoxyethanol, ethylhexylglycerin, and caprylyl glycol.

10. A method for preparing a repairing and anti-aging skincare composition according to any one of claims 1 to 9, characterized in that, Includes the following steps: S1. Mix polyol humectant, ectoine, chelating agent, pH adjuster, water-soluble thickener and water, heat to 70~85℃, stir until uniform, and obtain an aqueous phase mixture; S2. First, mix the ceramide complex with the moisturizing oil at 100~110℃ until the ceramide melts, then add the oil-soluble emulsifier and stir evenly to obtain an oil phase mixture; S3. Add the oil phase mixture to the aqueous phase mixture and homogenize at 75~85℃ and 3000~10000rpm for 3~8min to obtain the primary emulsion; S4. Stir the primary emulsion at 200-800 rpm and cool it to 35-45°C. Pre-disperse the polyphenol supramolecular complex into a slurry with a polyol humectant and add it to the emulsion. Add the preservative at the same time, stir until uniform, continue stirring and cool to room temperature to obtain the final product.

Images