Soybean phospholipid powder and preparation method thereof

Abstract

The application discloses a soybean phospholipid powder and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The soybean phospholipid powder comprises soybean phospholipid and hydrophobic colloidal silicon dioxide; the hydrophobic colloidal silicon dioxide is prepared by hydrophilic colloidal silicon dioxide and is subjected to gas-phase surface hydrophobic modification by hexamethyldisilazane, and the specific surface area is controlled to be 100-200 m² / g. Based on the principle of 'hydrophobic interface isolation', the specific modified silicon dioxide is used to form a dense and continuous hydrophobic coating layer on the surface of phospholipid particles, and multiple synergistic technical effects of inhibiting moisture absorption, preventing caking, isolating oxygen and improving powder fluidity are realized. The preparation process adopts a full-process dry treatment, and the prepared product has good fluidity and better stability than existing products.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical preparations, specifically relating to a soybean phospholipid powder and its preparation method. Background Technology

[0002] Soybean lecithin possesses various physiological functions, including protecting the liver, improving cardiovascular health, and nourishing cell membranes, and has a wide range of applications. However, natural soybean lecithin powder is highly hygroscopic, easily absorbing moisture and clumping during storage, resulting in poor product flowability. Simultaneously, its unsaturated fatty acids are prone to oxidation and rancidity, leading to product quality deterioration, shortened shelf life, and even worse stability in high-humidity environments. Soybean lecithin powder is a powder made from soybean lecithin powder and is used to treat hepatitis, fatty liver, cirrhosis, toxic hepatitis, arteriosclerosis, and neurasthenia. Due to the aforementioned characteristics of soybean lecithin powder, soybean lecithin powder preparations require stringent requirements for production environment and packaging / storage. Summary of the Invention

[0003] The purpose of this invention is to provide a soybean phospholipid powder with high moisture resistance and long-term stability, and its preparation method, in order to solve the three major technical problems of soybean phospholipid powder being prone to moisture absorption and clumping, easy oxidation and rancidity, and poor flowability.

[0004] The soybean lecithin powder of the present invention comprises soybean lecithin and hydrophobic colloidal silica, wherein, by mass percentage, soybean lecithin is 98.0%-99.5% and hydrophobic colloidal silica is 0.5%-2.0%;

[0005] The hydrophobic colloidal silica is prepared by hydrophilic colloidal silica through hexamethyldisilazane vapor phase surface hydrophobic modification, and its specific surface area is 100-200 m² / g.

[0006] The hydrophobic colloidal silica is uniformly coated on the surface of soybean lecithin particles in the form of a continuous insulating layer, thereby preventing the intrusion of water vapor and oxygen.

[0007] Preferably, the soybean phospholipids are 98.0% and the hydrophobic colloidal silica is 2.0%.

[0008] The present invention provides a method for preparing soybean phospholipid powder:

[0009] (1) Pretreatment: Soybean lecithin is softened at 40-45℃ and then passed through a 100-mesh sieve; hydrophobic colloidal silica is dried to a moisture content of ≤2.0% and then passed through a 100-mesh sieve for later use.

[0010] (2) Mixing and coating: The pretreated soybean lecithin and hydrophobic colloidal silica are put into a three-dimensional motion mixer, the temperature is controlled at ≤50℃, and the mixture is sealed for 25-35 minutes. The hydrophobic colloidal silica is uniformly attached to the surface of the soybean lecithin particles by means of the shear and dispersion force generated by the three-dimensional motion, forming a hydrophobic isolation layer.

[0011] (3) Drying: The mixed powder obtained in step (2) is dried at 50-58℃ and vacuum degree of -0.08MPa to -0.09MPa for 1.5-2h, and the moisture content of the finished product is controlled to be ≤3.0%.

[0012] (4) Granulation: The material dried in step (3) is subjected to air jet pulverization or high-speed granulation to break up agglomerates, and then passed through a 120-mesh sieve to collect the fine powder that passes through the sieve.

[0013] (5) Packaging: The granulated powder is sealed and packaged under nitrogen protection to obtain the final product.

[0014] Invention effects:

[0015] (1) Excellent resistance to moisture absorption and caking: The present invention uses hydrophobic colloidal silica, which can build a continuous hydrophobic protective layer on the surface of soybean phospholipid particles to block the adsorption and penetration of water vapor; the formulation product was placed under accelerated conditions of 40℃±2℃ / 75%RH±5%RH for 6 months, and the accelerated test sample powder showed no caking or stickiness, which completely improved the disadvantage of natural soybean phospholipid being very easy to absorb moisture and caking.

[0016] (2) Outstanding antioxidant capacity, the product is not easy to go rancid: The hydrophobic isolation layer isolates oxygen from contact with the unsaturated fatty acids inside the phospholipid, effectively delaying the auto-oxidation of oil; the formulation product is placed under accelerated conditions of 40℃±2℃ / 75%RH±5%RH for 6 months, and the peroxide value of the accelerated test sample is ≤3.0. The product has no rancid odor during storage and the quality is stable.

[0017] (3) Improve powder flowability: Hydrophobic colloidal silica acts as a physical spacer between particles, greatly reducing the cohesive force of the powder and ensuring accurate dispensing dosage and smooth production.

[0018] (4) High safety of preparation process: The whole process is dry processing, with no risk of solvent residue, and the physiological activity of soybean phospholipids is preserved to the maximum extent; the process is simple, production control is convenient, and it is easy to carry out industrial mass production.

[0019] (5) Significantly extended product shelf life: The product can be stored at room temperature in a sealed container for more than 24 months, making it suitable for long-distance transportation and warehousing. Detailed Implementation

[0020] The technical solution of the present invention will be described in detail below through specific embodiments, but it is only used to help understand the present invention and enable those skilled in the art to implement or use the present invention, and does not constitute any limitation on the present invention.

[0021] Example 1

[0022] This embodiment provides a soybean phospholipid powder, which, by mass percentage, contains: 99.5% soybean phospholipid and 0.5% hydrophobic colloidal silica (modified with hexamethyldisilazane, with a specific surface area of ​​100 m² / g).

[0023] Preparation method:

[0024] (1) Pretreatment: Soybean lecithin was softened at 40°C and passed through a 100-mesh sieve; hydrophobic colloidal silica was dried to a moisture content of 1.8% and passed through a 100-mesh sieve for later use.

[0025] (2) Mixing and coating: The pretreated soybean lecithin and hydrophobic colloidal silica were added to a three-dimensional motion mixer, and the temperature was controlled at ≤50℃. The mixture was then sealed and mixed for 35 minutes. During this process, the hydrophobic colloidal silica adhered tightly to the surface of the lecithin particles, forming a hydrophobic barrier layer.

[0026] (3) Drying: The mixed powder obtained in step (2) is dried at 50°C and vacuum degree -0.085MPa for 2 hours, and the output moisture content is 2.7%.

[0027] (4) Granulation: The material dried in step (3) is crushed by air jet milling to break up the agglomerates, and then passed through a 120-mesh sieve to collect the fine powder that passes through the sieve.

[0028] (5) Packaging: The granulated powder is sealed and packaged under nitrogen protection to obtain the final product.

[0029] Example 2

[0030] This embodiment provides a soybean lecithin powder, which, by mass percentage, contains: 98.0% soybean lecithin and 2.0% hydrophobic colloidal silica (modified with hexamethyldisilazane, with a specific surface area of ​​150 m² / g).

[0031] Preparation method:

[0032] (1) Pretreatment: Soybean lecithin was softened at 43°C and passed through a 100-mesh sieve; hydrophobic colloidal silica was dried to a moisture content of 1.5% and passed through a 100-mesh sieve for later use.

[0033] (2) Mixing and coating: Add the pretreated soybean lecithin and hydrophobic colloidal silica to a three-dimensional motion mixer, control the temperature to ≤50℃, and mix in a sealed manner for 30 minutes, so that the hydrophobic colloidal silica can be evenly attached to the surface of soybean lecithin particles by means of the shearing and dispersing force generated by the three-dimensional motion, forming a hydrophobic isolation layer.

[0034] (3) Drying: The mixed powder obtained in step (2) is dried at 55°C and vacuum degree -0.09MPa for 1.8h, and the output moisture content is 2.4%.

[0035] (4) Granulation: The material dried in step (3) is granulated at high speed to break up agglomerates, and then passed through a 120-mesh sieve to collect the fine powder that passes through the sieve.

[0036] (5) Packaging: The granulated powder is sealed and packaged under nitrogen protection to obtain the final product.

[0037] Example 3

[0038] A soybean lecithin powder, by mass percentage: 99.0% soybean lecithin, 1.0% hydrophobic colloidal silica (modified with hexamethyldisilazane, specific surface area 200m² / g).

[0039] Preparation method:

[0040] (1) Pretreatment: Soybean lecithin was softened at 45°C and passed through a 100-mesh sieve; hydrophobic colloidal silica was dried to a moisture content of 1.7% and passed through a 100-mesh sieve for later use.

[0041] (2) Mixing and coating: Add the pretreated soybean lecithin and hydrophobic colloidal silica to a three-dimensional motion mixer, control the temperature to ≤50℃, and mix in a sealed manner for 25 minutes. This allows the hydrophobic colloidal silica to adhere evenly to the surface of the soybean lecithin particles by means of the shearing and dispersing forces generated by the three-dimensional motion, forming a hydrophobic isolation layer.

[0042] (3) Drying: The mixed powder obtained in step (2) is dried at 58°C and vacuum degree -0.08MPa for 1.5h, and the output moisture content is 2.8%.

[0043] (4) Granulation: The material dried in step (3) is subjected to air jet pulverization to break up the agglomerates, and then passed through a 120-mesh sieve to collect the fine powder that passes through the sieve.

[0044] (5) Packaging: The granulated powder is sealed and packaged under nitrogen protection to obtain the final product.

[0045] Comparative Example 1

[0046] A soybean lecithin powder, by mass percentage, contains: 98.0% soybean lecithin and 2.0% unmodified hydrophilic colloidal silica, processed in the same way as in Example 2.

[0047] Comparative Example 2

[0048] A soybean lecithin powder, made solely from soybean lecithin without any added ingredients.

[0049] Preparation method:

[0050] (1) Pretreatment: Soybean lecithin is softened at 43℃ and then passed through a 100-mesh sieve for later use.

[0051] (2) Drying: The pretreated soybean lecithin was dried at 55℃ and vacuum degree -0.09MPa for 1.8h, and the output moisture content was 2.3%.

[0052] (3) Granulation: The material dried in step (2) is subjected to air jet pulverization to break up the agglomerates, and then passed through a 120-mesh sieve to collect the fine powder that passes through the sieve.

[0053] (4) Packaging: The granulated powder is sealed and packaged under nitrogen protection to obtain the final product.

[0054] Experimental Example 1

[0055] The stability of the samples prepared in Examples 1-3 and Comparative Examples 1-2 was investigated. They were placed under accelerated conditions of 40℃±2℃ / 75%RH±5%RH for 6 months. The properties, acid value, peroxide value, loss on drying, phosphorus content, and angle of repose of the samples were measured. The results are shown in the table below:

[0056] As can be seen from the data in the table above, after 6 months of accelerated testing, the properties, acid value, peroxide value, loss on drying, phosphorus content, and angle of repose of Examples 1-3 of the present invention showed no significant changes, indicating excellent product stability. After 6 months of accelerated testing, Comparative Examples 1-2 showed moisture absorption and clumping, resulting in poor powder flowability and inferior product stability compared to the products of the embodiments of the present invention. This demonstrates that hydrophobic colloidal silica is a necessary technical feature for achieving the technical effects of the present invention, ultimately leading to the selection of the preferred formulation and process of the present invention.

Claims

1. A soybean lecithin powder, characterized in that, By weight percentage: soybean lecithin 98.0%-99.5%, hydrophobic colloidal silica 0.5%-2.0%.

2. The soybean lecithin powder according to claim 1, characterized in that, The hydrophobic colloidal silica is prepared by hydrophilic colloidal silica through hexamethyldisilazane vapor phase surface hydrophobic modification, and its specific surface area is 100-200 m² / g.

3. The soybean lecithin powder according to claim 1, characterized in that, The hydrophobic colloidal silica is uniformly coated on the surface of soybean lecithin particles in the form of a continuous insulating layer, thereby preventing the intrusion of water vapor and oxygen.

4. The soybean lecithin powder according to claim 1, characterized in that, Optimal ratio: 98.0% soybean lecithin, 2.0% hydrophobic colloidal silica.

5. A method for preparing the soybean phospholipid powder according to claims 1-4, characterized in that, Includes the following steps: (1) Pretreatment: Soybean lecithin is softened at 40-45℃ and then passed through a 100-mesh sieve; hydrophobic colloidal silica is dried to a moisture content of ≤2.0% and then passed through a 100-mesh sieve for later use. (2) Mixing and coating: The pretreated soybean lecithin and hydrophobic colloidal silica are put into a three-dimensional motion mixer, the temperature is controlled at ≤50℃, and the mixture is sealed for 25-35 minutes. The hydrophobic colloidal silica is uniformly attached to the surface of the soybean lecithin particles by means of the shear and dispersion force generated by the three-dimensional motion, forming a hydrophobic isolation layer. (3) Drying: The mixed powder obtained in step (2) is dried at 50-58℃ and vacuum degree of -0.08MPa to -0.09MPa for 1.5-2h, and the moisture content is controlled to be ≤3.0%. (4) Granulation: The material dried in step (3) is subjected to air jet pulverization or high-speed granulation to break up agglomerates, and then passed through a 120-mesh sieve to collect the fine powder that passes through the sieve. (5) Packaging: The granulated powder is sealed and packaged to obtain the final product.

6. The method for preparing soybean phospholipid powder according to claim 5, characterized in that, The sealing and packaging process described in step (5) is carried out under nitrogen protection.

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