Use of deinococcus geothermalis in preparation of medicaments for alleviating or treating mucosal lesions
By using geothermal radiation-resistant cocci and their modified strains, especially the hutH-OE engineered strain, the problem of prevention and treatment of mucosal injury has been solved. By colonizing the mucosal tissue and secreting trans-uric acid, the radiation protection ability of the mucosa is enhanced, thus achieving effective treatment and prevention of radiation-induced mucosal injury.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- FOURTH MILITARY MEDICAL UNIVERSITY
- Filing Date
- 2026-04-22
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies lack effective methods to proactively enhance the resistance of mucous membranes before or in the early stages of radiation exposure, and cannot effectively prevent or alleviate radiation-induced mucosal damage, especially in protecting the integrity of mucosal tissues before or in the early stages of radiation exposure.
By using Deinococcus geothermalis and its metabolite trans-uruconic acid, hutH-OE engineered bacteria were obtained through genetic engineering. This enhanced the radiation protection ability of the mucosa. The colonization of the bacteria in the mucosal tissue and the continuous secretion of trans-uruconic acid by its metabolites under radiation conditions enhanced the epithelial barrier function and DNA damage repair ability.
Geothermal radiation-resistant cocci and their modified strains significantly reduce mucosal inflammation before and after radiation, protect the integrity of mucosal structure, improve symptoms of mucosal damage, and provide rapid and sustained therapeutic and preventive effects, which are superior to existing drugs.
Smart Images
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