A liquid preparation containing an extract of tinospora cordifolia and a process for its preparation

By employing synergistic processing of sodium alginate and calcium gluconate, programmed cooling, and high-pressure microfluidic homogenization, the problems of low component transfer efficiency and poor stability in liquid formulations of *Tinospora sinensis* extract during industrial scale-up and long-term storage were solved, achieving high clarity and stability while maintaining a good taste.

CN122398876APending Publication Date: 2026-07-17YANGLING CHARISMA BIO PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YANGLING CHARISMA BIO PHARMA CO LTD
Filing Date
2026-06-01
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing liquid formulations of *Tetrapanax papyriferus* extract suffer from problems such as low efficiency of active ingredient transfer, difficulty in removing colloidal impurities, decreased clarity, and poor physical stability during industrial scale-up and long-term storage.

Method used

The initial extract was treated with sodium alginate and calcium gluconate in a synergistic manner, combined with programmed cooling and refrigeration, and the use of trehalose, fructooligosaccharides, poloxamer 188 and hydroxypropyl-β-cyclodextrin, as well as high-pressure microfluidic homogenization to adjust the pH value, forming a stable calcium alginate flocculation network, solubilizing and refining particles, and controlling the interfacial state of colloidal particles.

Benefits of technology

It improves the transfer rate of active ingredients, reduces precipitation during storage, improves the clarity and long-term physical stability of the formulation, and maintains a high chlorogenic acid content and good taste.

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Abstract

The application discloses a kind of liquid preparation containing Tongguan Teng extract and preparation method thereof, belong to preparation manufacturing technical field.The method with Tongguan Teng as raw material, by deionized water soaking, decoction and filtration obtains initial extract liquid;Again through sodium alginate and calcium gluconate collaborative processing, and by program cooling, cold storage, filtration and concentration, improve the stability of extract liquid.Subsequently add flavouring agent, preservative, hydroxypropyl-β-cyclodextrin and poloxamer 188 are solubilized, taste is covered and dispersed stable, after adjusting pH by homogenization, defoaming, constant volume, filtration, filling and sterilization, and the stable liquid preparation containing Tongguan Teng extract is prepared.The liquid preparation containing Tongguan Teng extract prepared by the application shows lower centrifugal precipitation rate, good stability, smaller average particle size and lower PDI value, while the content of chlorogenic acid is maintained at a higher level, and the taste is better.
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