A nano-delivery system based on dual synergistic tumor therapy
By constructing a metal-organic framework nanodelivery system that integrates chemiluminescent reagents, energy transfer materials, and the CRISPR-Cas9 gene editing system, the problems of limited tissue penetration depth and inhibition of the antioxidant system in tumor treatment were solved, achieving efficient and precise synergistic therapeutic effects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HAINAN MEDICAL UNIV
- Filing Date
- 2026-04-23
- Publication Date
- 2026-07-17
AI Technical Summary
Among existing tumor treatment technologies, photodynamic therapy and chemodynamic therapy have problems such as limited tissue penetration depth and insufficient H2O2 concentration in the tumor microenvironment, and lack effective inhibition of the antioxidant system, resulting in poor treatment effects; graphene quantum dot diagnostic and treatment systems have limited functions and cannot achieve dynamic synergy between diagnosis and treatment.
A metal-organic framework-based nanodelivery system was constructed, integrating chemiluminescent reagents, energy transfer materials, and a CRISPR-Cas9 gene editing system. Utilizing the tumor microenvironment's responsive release and nuclear targeting capabilities, it achieves synergistic therapy through self-powered reactive oxygen species generation and gene editing.
It achieves enhanced efficacy in tumor treatment, breaks through the limitations of tissue penetration depth, significantly improves drug accumulation efficiency at the tumor site, reduces systemic toxicity, provides treatment effect assessment through real-time monitoring, and has good biocompatibility.
Smart Images
Figure CN122399052A_ABST