A biopsy marker with real-time ultrasonographic visualization function and a preparation method thereof

By using biodegradable aliphatic polyester polymers and inorganic salt porogens to prepare porous scaffolds, and filling them with high acoustic impedance gas, the problems of poor ultrasound imaging and easy displacement of existing breast tissue markers are solved. This achieves strong and long-lasting ultrasound imaging and controllable degradation, is compatible with existing operating procedures, and ensures patient safety.

CN122399062APending Publication Date: 2026-07-17LEAPMED MEDICAL TECH

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LEAPMED MEDICAL TECH
Filing Date
2026-04-16
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing breast tissue markers are not well visualized under ultrasound, are prone to displacement, have short visualization time, and cannot be degraded. Metal clips pose a risk of foreign body retention, affecting patient health and imaging examinations.

Method used

Biodegradable aliphatic polyester polymer materials are used to prepare biopsy markers. A porous scaffold is formed by an inorganic salt porogen, which is then filled with a high acoustic impedance gas to form a stable gas-liquid interface to enhance ultrasound imaging. The markers are then completely degraded in vivo.

Benefits of technology

It achieves strong and long-lasting imaging effect under ultrasound, with precise positioning, avoids the risk of foreign body retention, has good biocompatibility and safety, is compatible with existing operating procedures, and has a controllable degradation cycle.

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Abstract

本发明提供一种具有实时超声显影功能的活检标记物及其制备方法。本发明的活检标记物的制备方法,包括如下步骤:将生物可降解高分子材料的单体按比例混合,制备得到生物可降解高分子聚合物;将其溶于溶剂中,形成粘稠溶液;将无机盐致孔剂加入所述粘稠溶液中,形成糊状物;将糊状物填入模具中,待溶剂完全挥发后,将所述模具进行干燥;从模具中取出固化的复合圆柱棒,浸入水中,使无机盐致孔剂溶解沥滤出去,得到支架圆柱体;干燥,并抽真空,再充入核心气体,待所述核心气体充分扩散并吸附到所述支架圆柱体的微孔中,即制备得到所述活检标记物。该方法制备的活检标记物具有卓越的超声显影性,降解周期可控,且具有良好的生物相容性和安全性。
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