A micro-nanoparticle preparation microfluidic device

By designing micro- and nano-particles with detachable chip adapters and heating components to prepare microfluidic devices, the compatibility and temperature stability issues of existing devices have been solved, enabling flexible preparation and improved stability of nano-sized particles and micron-sized microspheres.

CN122399693APending Publication Date: 2026-07-17SHANGHAI PENGZAN BIOTECHNOLOGY CO LTD

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI PENGZAN BIOTECHNOLOGY CO LTD
Filing Date
2026-06-03
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing microfluidic devices are difficult to use simultaneously for the preparation of nanoscale particles and micron-scale microspheres, and external infusion tubing can cause sample retention and temperature fluctuations that affect the stability of the preparation.

Method used

Design a microfluidic device for preparing micro and nanoparticles. It adopts a detachable chip adapter and microfluidic chip, which can flexibly switch between the preparation of nano-sized particles and micron-sized microspheres, reduce the need for external infusion tubing, use a heating component to maintain temperature stability, and connect to the microfluidic chip through a sealed liquid storage component.

Benefits of technology

It enables the flexible preparation of nanoscale particles and micron-scale microspheres on the same device, reducing sample retention and temperature fluctuations, and improving the stability and applicability of the preparation.

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Abstract

本申请涉及微流控技术领域,公开了一种微纳米颗粒制备微流控设备,包括设备主体、微混合装置和送液装置,微混合装置包括至少两种规格的芯片适配器及微流控芯片,芯片适配器用于选择性装载纳米级颗粒制备用第一微流控芯片或微米级微球制备用第二微流控芯片;送液装置包括储液组件,储液组件与当前装载的微流控芯片密封对接并形成进液通路。同时,设备还可以包括加热组件和观察模块,加热组件对应微混合装置和送液装置设置,用于对芯片侧和送液侧进行加热,观察模块用于获取微流控芯片内的流体状态图像。该设备能够兼容不同尺度颗粒制备,减少样品输送滞留,提高温控稳定性,并便于观察液滴生成及芯片运行状态。
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