Separation and purification method of medium-chain carboxylic acid

By employing anaerobic fermentation of biomass organic waste, alkalization concentration, acidification extraction, and vacuum distillation, the technical challenges in the separation and purification of medium-chain carboxylic acids have been solved, achieving high-yield and high-purity production of medium-chain carboxylic acids.

CN122404129APending Publication Date: 2026-07-17RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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Patent Information

Application Number
CN202610667532.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-14
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing medium-chain carboxylic acid separation and purification technologies suffer from problems such as emulsification, high solvent costs, product loss, environmental pollution, limited material lifespan, high chemical consumption, and high energy consumption, and there is a lack of effective separation and purification methods.

Method used

The method involves anaerobic fermentation of biomass organic waste, followed by anaerobic fermentation centrifugation and filtration to clarify the solution. The solution is then centrifuged and filtered again, adjusted to alkalinity, concentrated, extracted with non-polar and/or weakly polar solvents, and finally distilled under reduced pressure. This method includes pretreatment, alkalization concentration, acidification extraction, and reduced pressure distillation steps. The resulting medium-chain carboxylic acid carbon chain is then separated and purified. Note that the temperature is a key technical factor to address this issue.

Benefits of technology

It achieves high yield and purity of medium-chain carboxylic acids, extends the carbon chain through anaerobic fermentation, minimizes losses during concentration, has a high extraction rate, and improves product purity, reaching the highest level in the international field.

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Abstract

The invention provides a separation and purification method of medium-chain carboxylic acid, and belongs to the technical field of chemical separation and purification. The invention provides a separation and purification method of medium-chain carboxylic acid, which comprises the steps of pretreatment, alkalization and concentration, acidification and extraction, reduced pressure distillation and the like, in the pretreatment stage, carbon chain lengthening is realized through anaerobic fermentation, then filtration is performed, clarified fermentation liquor is alkalized and concentrated, carboxylic acid is converted into carboxylate which is not easy to volatilize in an alkaline environment, and the carboxylic acid is separated and purified. Therefore, the loss in the concentration process is small. After the concentrated solution is centrifuged to remove and separate out solids, the pH is adjusted to be acidic, and a non-polar and / or weak-polar solvent is selected for extraction, so that the extraction rate of target medium-chain carboxylic acid, the recovery rate of short-chain carboxylic acid and the product purity can be improved. According to the separation and purification method, the baijiu vinasse is used as a raw material for separation and purification of the n-hexanol, the yield of the n-hexanoic acid is 77%, the mass purity is 87%, and the total acid purity is 97%.
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