Large stock displacement bicyclic 2-pyridinone compounds and uses
By optimizing the structure of bicyclic 2-pyridone compounds, the problems of short wavelength and poor stability of existing fluorescent dyes have been solved, and long-wavelength emission and large Stokes shift of the compounds have been achieved, which can be applied to cancer cell imaging and photodynamic therapy.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- XIHUA UNIV
- Filing Date
- 2025-01-17
- Publication Date
- 2026-07-17
AI Technical Summary
Existing bicyclic 2-pyridone fluorescent dyes have short emission wavelengths, small Stokes shifts, and poor photostability, which limits their application in fluorescent probes.
A class of bicyclic 2-pyridone compounds was designed and synthesized. By optimizing the molecular structure, the emission wavelength and Stokes shift were increased, and the photostability was improved. Specifically, various derivatives such as DHIP-TPA and DHIP-MTPA were synthesized and applied to the preparation of medical imaging agents, optical imaging agents and staining agents.
The emission wavelength of the compound was extended to over 500-600 nm, with a large Stokes shift, making it suitable for cancer cell imaging and photodynamic therapy, especially type I photodynamic therapy, and capable of effectively killing tumor cells in hypoxic environments.
Smart Images
Figure CN122404321A_ABST