A pyrazolobenzazepinone compound, and a preparation method and application thereof
By synthesizing pyrazolobenzozahexacyclic ketones, the deficiency of central nervous system immune regulation in sepsis has been addressed, providing a treatment strategy that improves antioxidant activity and cardiac function, and reducing the mortality rate of sepsis.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- BENGBU MEDICAL COLLEGE
- Filing Date
- 2026-04-30
- Publication Date
- 2026-07-17
AI Technical Summary
Current technologies for treating sepsis have not fully explored the central nervous system's immune regulation mechanisms, leading to high mortality rates and a lack of effective strategies for central nervous system immune regulation.
Pyrazolobenzozahexacyclic ketones were designed and synthesized, and compounds with antioxidant activity were prepared through cyclization reactions. These compounds were used to prepare drugs for treating sepsis, and their effect on improving cardiac function impairment in sepsis was tested in a mouse model.
The compound exhibited antioxidant activity comparable to or even higher than edaravone, was able to improve cardiac function impairment caused by sepsis, and provided a potential strategy for central nervous system immune regulation to reduce the clinical risk of sepsis.
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Figure CN122404342A_ABST