Anti-inflammatory antioxidant gallic acid glycoside and preparation method and application thereof
By using Bifidobacterium adolescentis sucrose phosphorylase to catalyze the formation of an α-O-glycosidic bond at the C4 hydroxyl group of gallic acid, the problems of poor water solubility and low bioavailability of gallic acid were solved, and the efficient preparation of anti-inflammatory and antioxidant gallic acid glycosides was achieved, expanding its application in chronic inflammatory and oxidative stress diseases.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HEFEI UNIV OF TECH
- Filing Date
- 2026-04-27
- Publication Date
- 2026-07-17
AI Technical Summary
Gallic acid has poor water solubility in physiological environments and is easily metabolized and decomposed, resulting in low bioavailability. Existing enzymatic glycosylation technologies suffer from problems such as poor regioselectivity, high cost of glycosyl donors, and limited substrate specificity, making it difficult to achieve efficient and large-scale preparation of α-glycoside derivatives.
Using sucrose phosphorylase derived from Bifidobacterium adolescentis, with sucrose as the glycosyl donor, a glucose moiety is directionally transferred to the C4 hydroxyl group of gallic acid through an enzymatic reaction to form an α-O-glycosidic bond. Gallic acid-4-O-α-D-glucopyranoside is synthesized by utilizing its unique catalytic specificity and high selectivity.
The synthesis of gallic acid glycosides with high selectivity was achieved, increasing its water solubility by 9 times, enhancing its anti-inflammatory and antioxidant activities, expanding its application potential in chronic inflammation and oxidative stress-related diseases, and solving the technical problem of low bioavailability.
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