Polycationic heptamethine cyanine dyes, methods of synthesis and use thereof
By designing a multi-cationic heptamethrin dye, which utilizes electrostatic adsorption and near-infrared light excitation to generate reactive oxygen species, the problems of poor water solubility and weak selective recognition ability of existing photosensitizers are solved, achieving efficient killing and imaging of multidrug-resistant bacteria.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- DALIAN UNIV OF TECH
- Filing Date
- 2026-03-31
- Publication Date
- 2026-07-17
AI Technical Summary
Existing photosensitizers have poor water solubility, weak selective recognition ability for bacteria, and low reactive oxygen production, making it difficult to effectively kill multidrug-resistant bacteria, especially Gram-negative bacteria.
A multi-cationic heptamethrin dye was developed, which utilizes a positively charged quaternary ammonium salt photosensitizer to adsorb onto bacteria via electrostatic interaction, enhancing bacterial penetration and generating highly efficient reactive oxygen species under near-infrared light excitation, thereby enabling bacterial imaging and killing.
Under in vitro conditions, the multi-cationic heptamethrin dye exhibits highly efficient fluorescence imaging and killing ability against Gram-positive and Gram-negative bacteria, significantly improving the bactericidal efficacy against multidrug-resistant bacteria while avoiding damage to normal cells.
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Figure CN122405018A_ABST