Chemiluminescent material based on spatially segmented response and preparation method and application thereof
By using chemiluminescent materials based on spatial segmentation response and triggering chemiluminescent reactions with specific stimuli, the problem of insufficient sensitivity in existing technologies is solved, and simplified operation and high signal-to-noise ratio biomarker detection and imaging are achieved.
Patent Information
- Application Number
- CN202610544456.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-04-23
- Publication Date
- 2026-07-17
AI Technical Summary
Existing chemiluminescence immunoassay techniques are limited in their application in real-time on-site detection and resource-scarce environments, and FRET technology lacks sensitivity, making it difficult to achieve accurate quantitative detection and high-contrast imaging of trace biomarkers.
By employing chemiluminescent materials based on spatial segmentation response, and utilizing the steric hindrance structure composed of a peroxidase-like catalytic center, a chemiluminescent substrate, and spatially segmented biomolecules, specific stimuli are used to trigger a chemiluminescent reaction under specific conditions, thereby achieving signal activation.
It simplifies the operation process, reduces background noise, and improves the signal-to-noise ratio. It is suitable for in vitro trace biomarker detection and in vivo biomolecular imaging, and is applicable to in vitro trace nucleic acid, protein, and enzyme activity detection and in vivo biomolecular specific imaging.
Smart Images
Figure CN122405261A_ABST