Lactobacillus plantarum DC76 and application thereof

By isolating Lactobacillus plantarum DC76 from fermented soybeans, the problem of low survival rate of existing lactobacilli in the gastrointestinal environment has been solved, achieving inhibition of various pathogenic bacteria and improvement of the intestinal barrier, thereby enhancing the health of livestock and poultry.

CN122405482APending Publication Date: 2026-07-17INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI
Filing Date
2026-04-14
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

The existing Lactobacillus plantarum has insufficient survival rate and colonization ability in the acidic environment and bile salt conditions of the gastrointestinal tract, resulting in poor application effects in animals and limited effects on intestinal barrier repair and immune regulation.

Method used

Lactobacillus plantarum DC76 was isolated from fermented soybeans, a traditional food from Guizhou. It has acid and bile salt resistance and significant inhibitory effects on a variety of animal pathogens. It can be used to prepare preparations that regulate the intestinal microecological balance and improve the intestinal barrier function.

Benefits of technology

Lactobacillus plantarum DC76 maintains high activity in the intestine, significantly inhibits pathogenic bacteria such as Escherichia coli and Salmonella, enhances intestinal barrier integrity, reduces inflammatory response, improves intestinal morphology and structure, reduces diarrhea rate in livestock and poultry, and improves the health level of livestock and poultry.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明提供一种植物乳杆菌(Lactiplantibacillus plantarum)DC76及其应用,所述菌株分离自贵州传统发酵食品豆豉,已于 2025 年 11 月 26 日保藏于广东省微生物菌种保藏中心,保藏号为GDMCC No.67360。该菌株具备优异的耐酸、耐胆盐特性,对大肠杆菌、沙门氏菌、巴氏杆菌等多种动物致病菌具有显著抑制作用;可调节肠道微生态平衡,上调肠道紧密连接蛋白 ZO‑1、Occludin 表达,增强肠道屏障完整性、降低肠道通透性,修复受损肠道屏障,同时调节肠道免疫微环境、减轻炎症反应。本发明所述菌株可用于制备动物饲料添加剂、微生态制剂及生物发酵剂,在畜禽健康养殖及替抗领域具有良好应用前景。
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