Process for the synthesis of 2-aminothiophene derivatives
A method for synthesizing 2-aminothiophene derivatives in one step using inexpensive potassium thiocyanate inorganic salt and (E)-2-benzoyl-3-phenylacrylonitrile by electrolysis in acetonitrile and aqueous solvent solves the problems of using toxic solvents and harsh conditions in existing technologies, and achieves high-yield synthesis of multi-substituted thiophene skeletons.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- NINGXIA MEDICAL UNIV
- Filing Date
- 2026-05-08
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for synthesizing 2-aminothiophene derivatives require highly toxic reaction solvents and sulfur substrates with irritating odors. The reaction times are long and the conditions are harsh, making them unsuitable for large-scale production.
Using (E)-2-benzoyl-3-phenylacrylonitrile and inexpensive, low-toxicity potassium thiocyanate as raw materials, a multi-substituted thiophene skeleton was constructed in one step under electrostatic conditions in acetonitrile and water solvent, avoiding precious metal catalysts and exogenous oxidants, and achieving the simultaneous introduction of sulfur and nitrogen sources.
The reaction conditions are mild, with outstanding atom and step economy, and high yield, making it suitable for large-scale production of various substituted 2-aminothiophene derivatives.
Smart Images
Figure CN122406244A_ABST