Degradable pressure sensing fiber and preparation method and application thereof

By combining biodegradable pressure sensing fibers with LC resonant circuits, the long-term retention and infection risks of existing implantable intravascular pressure sensors have been solved, achieving stable pressure monitoring and wireless early warning, thus meeting the safety and biodegradability requirements of implantable devices.

CN122406535APending Publication Date: 2026-07-17FUDAN UNIVERSITY

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIVERSITY
Filing Date
2026-04-24
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing implantable intravascular pressure sensors suffer from problems such as long-term retention, high risk of infection, and poor biomechanical compatibility with vascular tissue, making it difficult to achieve stable pressure monitoring and difficult to gradually degrade after the task is completed.

Method used

Using biodegradable pressure sensing fibers, a multi-layer structure consisting of a gold/collagen composite conductive electrode, a polycitrate dielectric layer, and a polycaprolactone encapsulation layer, combined with an LC resonant circuit, is used to achieve wireless passive signal reading. The fibers are embedded in a biodegradable vascular stent for pressure monitoring and gradually degrade after the monitoring period.

Benefits of technology

It achieves stable and continuous monitoring of intravascular pressure, avoids the risk of infection, ensures the mechanical matching between the sensor and the blood vessel, and is gradually absorbed after the functional period, reducing the safety hazards caused by long-term retention and providing wireless early warning of early pathological conditions.

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Abstract

本发明属于生物传感技术领域,具体为一种可降解压力传感纤维及其制备方法。本发明以胶原蛋白手术缝合线为柔性基底,通过热蒸镀金形成导电电极层,在其外层构筑聚柠檬酸酯介电层,并进一步包覆聚己内酯形成封装层,制备得到具有同轴多层结构的可降解压力传感纤维;该纤维可通过嵌入到血管支架孔隙中实现稳定集成,减少对血流动力学的干扰;本发明在实现血管内压力原位连续监测的同时兼顾材料可降解性与生物安全性,在智能血管支架、植入式生物监测及精准医疗领域具有重要应用价值。
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