An electrochemical sensor based on cross-linked cross-shaped DNA framework and Au@ZnCoN-C substrate and a preparation and detection method thereof
By using an electrochemical sensor based on a cross-linked cross DNA framework and an Au@ZnCoN-C substrate, combined with a RecJf exonuclease-mediated target cyclic amplification strategy, the problems of high cost, complex operation, and insufficient sensitivity of ciprofloxacin detection methods have been solved, achieving highly sensitive, rapid, and specific detection of ciprofloxacin.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HENAN PROD QUALITY INSPECTION TECH RES INST
- Filing Date
- 2026-03-24
- Publication Date
- 2026-07-17
AI Technical Summary
Existing ciprofloxacin detection methods are costly, complex to operate, and lack sufficient sensitivity, making it difficult to meet the requirements for accurate on-site detection.
An electrochemical sensor based on a cross-linked cross DNA framework and an Au@ZnCoN-C substrate is employed, combined with a RecJf exonuclease-mediated target amplification strategy. The high conductivity and large specific surface area of the Au@ZnCoN-C substrate are utilized to provide signal amplification, immobilize and embed signal molecules through the cross-linked cross DNA framework, thereby achieving sensitive detection.
This study provides a simple, fast-responding, and highly specific method for the detection of ciprofloxacin, enabling accurate quantitative detection of ciprofloxacin residues in actual food samples, and has good practical application value.
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Figure CN122409786A_ABST