An analysis method for detecting amoxicillin residues in feather and application
The detection of amoxicillin residues in feathers by liquid chromatography-tandem mass spectrometry overcomes the shortcomings of existing detection methods, achieving high sensitivity and accuracy in the detection of amoxicillin residues in feathers, and providing a new detection approach and technical support.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SOUTH CHINA AGRICULTURAL UNIVERSITY
- Filing Date
- 2026-04-21
- Publication Date
- 2026-07-17
AI Technical Summary
Current technologies lack effective methods for detecting amoxicillin residues in feathers, especially methods using liquid chromatography-tandem mass spectrometry, which have not been reported, making it impossible to accurately monitor the risk of drug residues in animal-derived foods.
The method employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) involved cryogenic grinding of feathers with liquid nitrogen, extraction with acetonitrile-formic acid aqueous solution, purification using an HLB hydrophilic-lipophilic equilibrium column, separation using a C8 reversed-phase column, and electrospray ionization negative ion multiple reaction monitoring (MRM) mode to detect amoxicillin residues in feathers.
This method has high sensitivity and good stability, and can accurately determine the amoxicillin residue in feathers. The detection limit and quantitation limit are 8 µg/kg and 20 µg/kg, respectively. It is an economical, environmentally friendly and practical detection method.
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