Mechanochemical method for deuterated organic compounds

By using a mechanochemical method to perform HD exchange in the presence of a catalyst, the high cost and low efficiency of existing methods for deuterated organic compounds have been solved. This method enables the preparation of deuterated organic compounds with high degree of deuteration and high conversion rate, while reducing side reactions and solvent usage.

CN122422281APending Publication Date: 2026-07-17MERCK PATENT GMBH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MERCK PATENT GMBH
Filing Date
2024-12-18
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing methods for deuterated organic compounds are costly and inefficient, and it is difficult to achieve high deuteration degree and high conversion rate under mild conditions, often leading to side reactions and solubility problems.

Method used

HD exchange is carried out in the presence of a catalyst using a mechanochemical method. Deuteration is achieved through mechanical force and energy input. The combination of organic compounds and deuterium sources is subjected to grinding, milling, and vibration mixing to avoid high temperatures and large amounts of solvents.

Benefits of technology

It achieves high deuteration degree, low side reaction, high conversion rate and fast reaction time under mild conditions, improving process efficiency and environmental compatibility.

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Abstract

本发明涉及一种通过机械化学处理来氘代有机化合物的方法。
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Citation Information

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