A photobiomodulation method for improving high glucose-induced injury of human renal tubular epithelial cells and application thereof

By treating high-glucose-induced human renal tubular epithelial cells with specific photobiological regulation parameters, the problem of effective intervention for renal fibrosis in existing technologies has been solved, cell proliferation and migration capabilities have been improved, related signaling pathways have been inhibited, and the progression of diabetic nephropathy has been delayed.

CN122441002APending Publication Date: 2026-07-24NINGBO MEDICAL CENT LIHUILI HOSPITACL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NINGBO MEDICAL CENT LIHUILI HOSPITACL
Filing Date
2026-06-24
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing technologies cannot effectively target and repair damaged high-glucose-induced human renal tubular epithelial cells, and the application of existing photobiological regulation therapy in DKD has not yet formed a standardized intervention system, lacking effective intervention methods for renal fibrosis.

Method used

High glucose-induced human renal tubular epithelial cells were treated with specific light parameters (590nm–1050nm), energy density (4–10J/cm2), and power density (30–50mw/cm2) to regulate oxidative stress, inflammatory response, and apoptosis. Cell proliferation and migration were improved by downregulating the interstitial fibrosis marker α-SMA, upregulating E-cadherin expression, and inhibiting the PI3K/AKT/Smad2 signaling pathway.

Benefits of technology

It significantly improves the proliferation and migration of renal tubular epithelial cells induced by high glucose, downregulates interstitial fibrosis markers, inhibits the PI3K/AKT/Smad2 signaling pathway, blocks renal tubular epithelial cell damage, and delays the progression of diabetic nephropathy.

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Abstract

The application provides a photobiomodulation method for improving high-sugar-induced human renal tubular epithelial cell damage, the photobiomodulation method comprising the step of treating high-sugar-induced human renal tubular epithelial cells by light irradiation; the light irradiation simultaneously satisfies the following conditions: light irradiation wavelength 530nm-1050nm, energy density 2-10J / cm 2 And power density 10-50mw / cm 2 ; the application also comprises the application of the photobiomodulation method in the preparation of a non-drug intervention product for improving high-sugar-induced renal tubular epithelial cell damage, and in the preparation of a drug or auxiliary treatment instrument for improving diabetic nephropathy; the photobiomodulation method can regulate cell activity, inhibit the level of interstitial fibrosis and related signal pathways, and become a potential treatment method for DKD.
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