Guarana fast dissolving film and method of preparation thereof

Abstract

The application discloses a guarana mouth dissolving film and a preparation method thereof. The application provides a guarana mouth dissolving film, which is characterized in that the film comprises the following components in mass parts: 3-20 parts of guarana powder, 1-10 parts of sulfobutyl ether-beta-cyclodextrin sodium, 30-80 parts of other film-forming materials and 2-20 parts of a plasticizer. The preparation method of the guarana mouth dissolving film comprises the following steps: defoaming of a film solution and film forming. The guarana mouth dissolving film with higher film forming strength and better taste is obtained by improving the material of the guarana mouth dissolving film.

Description

Technical Field

[0001] This invention relates to a guarana oral soluble film and its preparation method. Background Technology

[0002] Guarana (scientific name: *Paullina cupana* Kunth.) belongs to the genus *Paullina* in the family Sapindaceae. The seeds of guarana contain guaranaine, a chemical component similar to caffeine. Studies have shown that guarana extract has energizing, fatigue-relieving, energy-boosting, and antidepressant effects, thus guarana is widely used in the food, beverage, and pharmaceutical industries. However, guarana extract has a strong bitter taste, and the higher the concentration, the more pronounced the bitterness.

[0003] Existing technologies related to commercially available products containing guarana extract and guarana-based foods include beverages, compressed sugar tablets, chewing gum, etc.

[0004] To dilute the bitterness of guarana, commercially available products have attempted methods such as reducing the concentration of guarana through dilution and controlling the release rate of guarana. However, liquid beverages are not conducive to storage and transportation, while solid beverages are inconvenient to prepare; compressed candies and chewing gum are all slow-release products of guarana extract, and their energizing effect is relatively slow.

[0005] Existing technologies have attempted to improve formulations and change the method of intake. CN115553464A uses inclusion technology to thoroughly mix inclusion materials with guarana extract in water, partially encapsulating the guarana extract within the inclusion material to prepare an inclusion complex; then, the above inclusion complex solution is thoroughly stirred with a supportive matrix, a freeze-drying protectant, and a flavoring agent to dissolve or mix. This product dissolves rapidly in water and is absorbed through the sublingual venous plexus. Its disadvantages include the inability to slowly and steadily release the guarana extract, and the relatively complex preparation method, which is not conducive to large-scale industrial production.

[0006] CN102960526A discloses a method for preparing chewing gum containing guarana extract. The guarana extract component in the formula has an energizing function, and the gum base, high-intensity sweetener, and menthol significantly improve the bitter taste of guarana extract. This patented technology can continuously provide guarana extract, but the vast majority is absorbed through the gastrointestinal tract, and its energizing effect is weaker than that of the oral mucosa.

[0007] CN117562256A provides a guarana oral membrane for absorption via the oral mucosa. By ingesting guarana extract through the oral mucosa, the energizing effect is more rapid. However, due to the limited carrier volume, the product of this patent cannot load a larger amount of guarana composition, making it difficult to accurately control the release rate of guarana. Furthermore, it cannot continuously release guarana extract for a long time and has a certain risk of caking. A drying step is required after granulation.

[0008] In summary, existing beverages and other products containing guarana extract still have drawbacks. Preparations containing guarana extract are prone to caking. Therefore, we need to find a new product containing guarana extract. Summary of the Invention

[0009] To address the problems of insufficient film strength and poor taste in existing guarana oral dissolving films, this invention provides a guarana oral dissolving film and its preparation method. This film exhibits high film-forming strength and a superior taste compared to other guarana oral dissolving films.

[0010] A guarana oral soluble film, characterized in that it comprises the following parts by weight: 3-20 parts guarana powder, 1-10 parts sodium sulfobutyl ether-β-cyclodextrin, 30-80 parts other film-forming materials, and 2-20 parts plasticizer.

[0011] In one embodiment, the mass fraction of the guarana powder is 5-12 parts, for example, 5 parts, 8 parts, 10 parts, or 12 parts.

[0012] In one embodiment, the other film-forming material is one or more of hydroxypropyl cellulose and polyethylene oxide.

[0013] In one embodiment, the other film-forming material comprises 48.5-60 parts by mass, for example, 48.5 parts, 52.5 parts, 58 parts, or 60 parts.

[0014] In one embodiment, the plasticizer is glycerin.

[0015] In one embodiment, the plasticizer is present in parts by weight of 5-7 parts, for example, 5 parts or 7 parts.

[0016] In one embodiment, the average molecular weight of the sodium sulfobutyl-β-cyclodextrin is 2150-2200.

[0017] In one embodiment, the sodium sulfobutyl ether-β-cyclodextrin is present in a mass fraction of 5-8.5 parts, for example, 5 parts, 7 parts, 8 parts, or 8.5 parts.

[0018] In one embodiment, the guarana oral dissolving film further includes 5.2-37 parts by weight of a flavoring agent; the flavoring agent is preferably one or more of a sweetener, a salter, a flavoring agent, and a cooling agent; the flavoring agent is preferably 13.5-16.5 parts by weight, for example 13.5 parts, 15 parts, 15.5 parts, or 16.5 parts.

[0019] In one embodiment, the guarana oral soluble membrane further includes 3-20 parts by weight of an energy substance; the energy substance is a commonly used energy substance in the art, preferably taurine; the mass fraction of the energy substance is preferably 7-9 parts, for example 7 parts, 8 parts, or 9 parts.

[0020] In one embodiment, the guarana oral dissolving film is used as an anti-fatigue or anti-depressant oral dissolving film.

[0021] In one embodiment, the guarana oral soluble film is composed of the following parts by weight: 3-20 parts guarana powder, 1-10 parts sodium sulfonyl ether-β-cyclodextrin, 30-80 parts other film-forming materials, 2-20 parts plasticizer, 5.2-37 parts flavoring agent, and 3-20 parts energy substance.

[0022] In one embodiment, the other film-forming materials are hydroxypropyl cellulose and polyoxyethylene; the preferred mass ratio of the hydroxypropyl cellulose to the polyoxyethylene is (22-32):(25-30.5) parts, for example, 32:28 parts, 31:27 parts, 22:30.5 parts, or 23.5:25 parts.

[0023] In one embodiment, the sweetener is a commonly used sweetener in the art, preferably xylitol, acesulfame potassium, or sucralose.

[0024] In one embodiment, the salting agent is a commonly used salting agent in the art, preferably sodium chloride.

[0025] In one embodiment, the mass ratio of the sweetener to the salty agent is (2-3):(2-3), for example, 2:2 or 3:3.

[0026] In one embodiment, the flavoring is a commonly used flavoring in the art, such as wintergreen flavoring, pepper flavoring, strawberry flavoring, citrus flavoring, or passion fruit flavoring.

[0027] In one embodiment, the mass ratio of the sweetener to the flavoring is (2-3):(9-10), for example, 2:9, 2:10, 3:10, or 3:9.

[0028] In one embodiment, the cooling agent is WS-23; WS-23 is N,2,3-trimethyl-2-isopropylbutyramide.

[0029] In one embodiment, the mass ratio of the sweetener to the cooling agent is (2-3):(0.5-1), for example, 2:0.5, 2:1, or 3:0.5.

[0030] In one embodiment, the guarana powder is produced by Hebei Danming Biotechnology Co., Ltd., with batch number 245080.

[0031] In one embodiment, the hydroxypropyl cellulose is produced by Wuhan Xinweiye Chemical Co., Ltd., with batch number W462407023.

[0032] In one embodiment, the polyoxyethylene is produced by Sichuan Laitejuxin Pharmaceutical Excipients Co., Ltd., with batch number LT256543161.

[0033] In one embodiment, the guarana oral soluble film is composed of the following parts by weight: 5 parts guarana powder, 32 parts hydroxypropyl cellulose, 28 parts polyoxyethylene, 8.5 parts sodium sulfonyl-β-cyclodextrin, 8 parts taurine, 2 parts xylitol, 2 parts sodium chloride, 9 parts wintergreen flavoring, 0.5 parts WS-23, and 5 parts glycerin.

[0034] In one embodiment, the guarana oral soluble film is composed of the following parts by weight: 8 parts guarana powder, 31 parts hydroxypropyl cellulose, 27 parts polyoxyethylene, 7 parts sodium sulfobutyl-β-cyclodextrin, 7 parts taurine, 2 parts acesulfame potassium, 2 parts sodium chloride, 10 parts peppermint flavoring, 1 part WS-23, and 5 parts glycerin.

[0035] In one embodiment, the guarana oral soluble film is composed of the following parts by weight: 8 parts guarana powder, 31 parts hydroxypropyl cellulose, 27 parts polyoxyethylene, 7 parts sodium sulfobutyl-β-cyclodextrin, 7 parts taurine, 2 parts acesulfame potassium, 2 parts sodium chloride, 10 parts strawberry flavoring, 1 part WS-23, and 5 parts glycerin.

[0036] In one embodiment, the guarana oral soluble film is composed of the following parts by weight: 10 parts guarana powder, 22 parts hydroxypropyl cellulose, 30.5 parts polyoxyethylene, 7 parts sodium sulfonyl-β-cyclodextrin, 7 parts taurine, 3 parts xylitol, 3 parts sodium chloride, 10 parts citrus flavoring, 0.5 parts WS-23, and 7 parts glycerin.

[0037] In one embodiment, the guarana oral soluble film is composed of the following parts by weight: 12 parts guarana powder, 23.5 parts hydroxypropyl cellulose, 25 parts polyoxyethylene, 8 parts sodium sulfonyl-β-cyclodextrin, 9 parts taurine, 3 parts xylitol, 3 parts sodium chloride, 9 parts passion fruit flavor, 0.5 parts WS-23, and 7 parts glycerin.

[0038] The present invention also provides a method for preparing a guarana oral soluble film, characterized by comprising the following steps: defoaming the film solution and forming a film; wherein the film solution comprises the following parts by weight: 3-20 parts of guarana powder, 1-10 parts of sodium sulfobutyl ether-β-cyclodextrin, 30-80 parts of other film-forming materials and 2-20 parts of plasticizer.

[0039] In one embodiment, the viscosity of the membrane solution is 37.6-39.5 Pa·s, for example 37.6 Pa·s, 37.9 Pa·s, 38.7 Pa·s, or 39.5 Pa·s.

[0040] In one embodiment, the vacuum degree of the defoaming process is -0.095 to -0.1 MPa.

[0041] In one embodiment, the degassing rate is 70-75 mL / min, for example, 70 mL / min or 75 mL / min.

[0042] In one embodiment, the means of forming the film is scraping.

[0043] In one embodiment, the film is transferred onto a thin film after film formation, preferably a plastic film; after being transferred onto the film, it is air-dried for 20-40 minutes, preferably 30 minutes; after air-drying, it is peeled off from the plastic film and cut to obtain the guarana oral solution film.

[0044] In one embodiment, the guarana powder is as defined above.

[0045] In one embodiment, the sodium sulfobutyl-β-cyclodextrin is as defined above.

[0046] In one embodiment, the plasticizer is as defined above.

[0047] In one embodiment, the other film-forming materials are as defined above.

[0048] In one embodiment, the membrane liquid further includes a flavoring agent; the flavoring agent is preferably as defined above.

[0049] In one embodiment, the membrane fluid further includes an energy substance; the energy substance is preferably as defined above.

[0050] In one embodiment, the method for preparing the membrane solution includes the following steps:

[0051] The guarana powder, the sodium sulfobutyl ether-β-cyclodextrin, the flavoring agent, the energy substance, and the plasticizer are mixed and thoroughly mixed. Then, the mixture is further mixed with the other film-forming materials to obtain the film solution. The mixing speed is preferably 280 rpm-300 rpm, for example, 280 rpm or 300 rpm. The secondary mixing speed is preferably 290 rpm-300 rpm, for example, 290 rpm or 300 rpm. The secondary mixing temperature is preferably 30-40℃, for example, 35℃.

[0052] The present invention also provides a guarana oral dissolving membrane, characterized in that it is prepared by the above method, and the guarana oral dissolving membrane is used as an anti-fatigue or anti-depressant oral dissolving membrane.

[0053] The application of a guarana oral dissolving membrane as described above in the preparation of anti-fatigue and antidepressant drugs.

[0054] Without violating common sense in the field, the above-mentioned preferred conditions can be combined arbitrarily to obtain various preferred embodiments of the present invention.

[0055] The reagents and raw materials used in this invention are all commercially available.

[0056] The significant advantages of this invention are as follows: Currently available oral dissolving films still suffer from insufficient strength, and their shape can be damaged during transportation and handling. The film-forming material is the first substance the user's mouth comes into contact with, and its taste directly affects the user experience. Therefore, this invention aims to provide a guarana oral dissolving film composition with higher film-forming material strength and a better taste. A method for preparing the aforementioned guarana oral dissolving film composition is also provided. Detailed Implementation

[0057] The present invention is further illustrated below by way of embodiments, but the invention is not limited to the scope of the embodiments described herein. Experimental methods in the following embodiments that do not specify specific conditions were performed according to conventional methods and conditions, or as selected according to the product instructions.

[0058] Sodium sulfonyl-β-cyclodextrin, with the structural formula C 42 H 70-n O 35 (C4H8SO3Na) n , where n = 6.5 and the average molecular weight is 2163.

[0059]

[0060] Example 1

[0061] All raw materials are calculated in 100 parts by weight. Add 5 parts guarana powder, 8 parts taurine, 8.5 parts sodium sulfobutyl-β-cyclodextrin, 2 parts xylitol, 0.5 parts cooling agent WS-23, 2 parts sodium chloride, 9 parts liquid wintergreen flavoring, and 5 parts glycerin to the reaction flask, and stir at 300 rpm for 3 min to form a mixture.

[0062] Then, 32 parts of hydroxypropyl cellulose and 28 parts of polyoxyethylene were added to the well-stirred mixture. The mixture was stirred at 300 rpm at 35°C to obtain a uniform and continuous film solution.

[0063] When the viscosity of the membrane solution system is controlled at 39.5 Pa·s, it is transferred to a vacuum degassing machine for degassing. The vacuum degree is -0.095 MPa, the exhaust speed is 75 mL / min, and after degassing for 1 hour, it is transferred to a plastic film by scraping. After air drying for 30 minutes, it is peeled off from the plastic film and cut into rectangular blocks of 2.0 cm × 3.0 cm to obtain the guarana oral film agent.

[0064] Example 2

[0065] All raw materials are calculated in 100 parts by weight. Add 8 parts guarana powder, 7 parts taurine, 7 parts sodium sulfobutyl-β-cyclodextrin, 2 parts acesulfame potassium, 1.0 part cooling agent WS-23, 2 parts sodium chloride, 10 parts liquid peppermint flavoring, and 5 parts glycerin to the reaction flask, and stir at 280 rpm for 3 min to form a mixture.

[0066] Then, 31 parts of hydroxypropyl cellulose and 27 parts of polyoxyethylene were added to the well-stirred mixture. The mixture was stirred at 300 rpm at 35°C to obtain a uniform and continuous film solution.

[0067] When the viscosity of the membrane solution system is controlled at 38.7 Pa·s, it is transferred to a vacuum degassing machine for degassing. The vacuum degree is -0.095 MPa, the exhaust speed is 75 ml / min, and after degassing for 1 hour, it is transferred to a plastic film by scraping. After air drying for 30 minutes, it is peeled off from the plastic film and cut into rectangular blocks of 2.0 cm × 3.0 cm to obtain the guarana oral film agent.

[0068] Example 3

[0069] All raw materials are calculated in 100 parts by weight. Add 8 parts guarana powder, 7 parts taurine, 7 parts sodium sulfobutyl-β-cyclodextrin, 2 parts acesulfame potassium, 1.0 part cooling agent WS-23, 2 parts sodium chloride, 10 parts liquid strawberry flavoring, and 5 parts glycerin to the reaction flask. Stir at 280 rpm for 3 minutes to form a mixture.

[0070] Then, 31 parts of hydroxypropyl cellulose and 27 parts of polyoxyethylene were added to the well-stirred mixture. The mixture was stirred at 300 rpm at 35°C to obtain a uniform and continuous film solution.

[0071] When the viscosity of the membrane solution system is controlled at 38.7 Ps.S, it is transferred to a vacuum degassing machine for degassing. The vacuum degree is -0.095 MPa, the exhaust speed is 75 ml / min, and after degassing for 1 hour, it is transferred to a plastic film by scraping. After air drying for 30 minutes, it is peeled off from the plastic film and cut into rectangular blocks of 2.0 cm × 3.0 cm to obtain the guarana oral film agent.

[0072] Example 4

[0073] All raw materials are calculated in units of 100 parts. Add 10 parts guarana powder, 7 parts taurine, 7 parts sodium sulfobutyl-β-cyclodextrin, 3 parts xylitol, 0.5 parts cooling agent WS-23, 3 parts sodium chloride, 10 parts liquid citrus flavoring, and 7 parts glycerin to the reaction flask. Stir at 280 rpm for 3 minutes to form a mixture.

[0074] Then, 22 parts of hydroxypropyl cellulose and 30.5 parts of polyoxyethylene were added to the well-stirred mixture. The mixture was stirred at 290 rpm at 35°C to obtain a uniform and continuous film solution.

[0075] When the viscosity of the membrane solution system is controlled at 37.6 Pa·s, it is transferred to a vacuum degassing machine for degassing. The vacuum degree is -0.095 MPa, the exhaust speed is 70 ml / min, and after degassing for 1 hour, it is transferred to a plastic film by scraping. After air drying for 30 minutes, it is peeled off from the plastic film and cut into rectangular blocks of 2.0 cm × 3.0 cm to obtain the guarana oral film agent.

[0076] Example 5

[0077] All raw materials are calculated in units of 100 parts by weight. Add 12 parts guarana powder, 9 parts taurine, 8 parts sodium sulfobutyl-β-cyclodextrin, 3 parts xylitol, 0.5 parts cooling agent WS-23, 3 parts sodium chloride, 10 parts liquid passion fruit flavoring, and 7 parts glycerin to the reaction flask. Stir at 280 rpm for 3 minutes to form a mixture.

[0078] Then, 23.5 parts of hydroxypropyl cellulose and 25 parts of polyoxyethylene were added to the well-stirred mixture. The mixture was stirred at 290 rpm at 35°C to obtain a uniform and continuous film solution.

[0079] When the viscosity of the membrane solution system is controlled at 37.9 Pa·s, it is transferred to a vacuum degassing machine for degassing. The vacuum degree is -0.095 MPa, the exhaust speed is 70 ml / min, and after degassing for 1 hour, it is transferred to a plastic film by scraping. After air drying for 30 minutes, it is peeled off from the plastic film and cut into rectangular blocks of 2.0 cm × 3.0 cm to obtain the guarana oral film agent.

[0080] Comparative Example 1

[0081] All raw materials are calculated in units of 100 parts. Add 0 parts guarana powder, 8 parts taurine, 8.5 parts sodium sulfobutyl-β-cyclodextrin, 2 parts xylitol, 0.5 parts cooling agent WS-23, 2 parts sodium chloride, 9 parts liquid wintergreen flavoring, and 5 parts glycerin to the reaction flask. Stir at 300 rpm for 3 minutes to form a mixture.

[0082] Then, 37 parts of hydroxypropyl cellulose and 28 parts of polyoxyethylene were added to the well-stirred mixture. The mixture was stirred at 300 rpm at 35°C to obtain a uniform and continuous film solution.

[0083] When the viscosity of the film solution system is controlled at 40.3 Pa·s, it is transferred to a vacuum degassing machine for degassing. The vacuum degree is -0.095 MPa, the exhaust speed is 75 ml / min, and after degassing for 1 hour, it is transferred to a plastic film by scraping. After air drying for 30 minutes, it is peeled off from the plastic film and cut into rectangular blocks of 2.0 cm × 3.0 cm to obtain the oral film agent.

[0084] Comparative Example 2

[0085] All raw materials are calculated in units of 100 parts. Add 5 parts guarana powder, 8 parts taurine, 0 parts sodium sulfobutyl-β-cyclodextrin, 2 parts xylitol, 0.5 parts cooling agent WS-23, 2 parts sodium chloride, 9 parts liquid wintergreen flavoring, and 5 parts glycerin to the reaction flask. Stir at 300 rpm for 3 minutes to form a mixture.

[0086] Then, 37 parts of hydroxypropyl cellulose and 31.5 parts of polyoxyethylene were added to the well-stirred mixture. The mixture was stirred at 300 rpm at 35°C to obtain a uniform and continuous film solution.

[0087] When the viscosity of the film solution system is controlled at 40.3 Pa·s, it is transferred to a vacuum degassing machine for degassing. The vacuum degree is -0.095 MPa, the exhaust speed is 75 ml / min, and after degassing for 1 hour, it is transferred to a plastic film by scraping. After air drying for 30 minutes, it is peeled off from the plastic film and cut into rectangular blocks of 2.0 cm × 3.0 cm to obtain the oral film agent.

[0088] The raw materials of the orally dissolving film agents in Comparative Example 1 and Examples 1-5 are listed in the table below (wt%).

[0089]

[0090] Example 1: Product Mechanical Strength Test

[0091] 1. Test subjects: Guarana oral film formulations in comparative examples and Examples 1-5.

[0092] 2. Testing Method:

[0093] Refer to GB / T 1040.1-2018 "Determination of Tensile Properties"

[0094] (2) Performance indicators: tensile strength TS>18.0MPa, elongation at break EB>20.0%.

[0095] 3. Test Results: See the table below.

[0096] Example Tensile strength TS (MPa) Elongation at break (EB) (%) Comparative Example 1 25.41±0.70 27.49±0.60 Comparative Example 2 16.27±0.60 17.92±0.60 Example 1 24.75±0.60 26.69±0.55 Example 2 24.37±0.50 26.02±0.60 Example 3 24.63±0.65 26.38±0.60 Example 4 23.35±0.60 25.53±0.60 Example 5 23.42±0.60 25.61±0.60

[0097] Example 2: Results of the Human Character Test

[0098] 1. Test subjects: oral films in comparative examples and Examples 1-5 (the products are dissolved and absorbed by the oral cavity within 3 minutes).

[0099] 2. Test results: as shown in the table below.

[0100]

[0101]

[0102] Material specifications.

[0103]

Claims

1. A guarana oral soluble membrane, characterized in that, It comprises the following parts by weight: 3-20 parts guarana powder, 1-10 parts sodium sulfobutyl ether-β-cyclodextrin, 30-80 parts other film-forming materials, and 2-20 parts plasticizer.

2. The guarana oral soluble membrane as described in claim 1, characterized in that, It meets one or more of the following conditions: (1) The mass fraction of the guarana powder is 5-12 parts, for example, 5 parts, 8 parts, 10 parts, or 12 parts; (2) The other film-forming materials are one or more of hydroxypropyl cellulose and polyethylene oxide; (3) The other film-forming materials are in the form of 48.5-60 parts by weight, for example 48.5 parts, 52.5 parts, 58 parts, and 60 parts; (4) The plasticizer is glycerin; (5) The plasticizer is 5-7 parts by weight, for example, 5 parts or 7 parts; (6) The sodium sulfonyl ether-β-cyclodextrin has a mass fraction of 7-8.5 parts, for example, 7 parts, 8 parts, or 8.5 parts. (7) The guarana oral dissolving film further includes 5.2-37 parts by weight of a flavoring agent; the flavoring agent is preferably one or more of a sweetener, a salty agent, a flavoring agent and a cooling agent; the flavoring agent is preferably 13.5-16.5 parts by weight, for example 13.5 parts, 15 parts, 16.5 parts, or 15.5 parts; (8) The guarana oral soluble film also includes 3-20 parts by weight of an energy substance; the energy substance is preferably taurine; the energy substance is preferably 7-9 parts by weight, for example 7 parts, 8 parts, or 9 parts; (9) The average molecular weight of the sodium sulfobutyl-β-cyclodextrin is 2150-2200; (10) The guarana oral dissolving membrane is used as an anti-fatigue or anti-depressant oral dissolving membrane.

3. The guarana oral soluble membrane as described in claim 2, characterized in that, It is composed of the following parts by weight: 3-20 parts guarana powder, 1-10 parts sodium sulfobutyl ether-β-cyclodextrin, 30-80 parts other film-forming materials, 2-20 parts plasticizer, 5.2-37 parts flavoring agent, and 3-20 parts energy substance.

4. The guarana oral soluble membrane as described in claim 2, characterized in that, It meets one or more of the following conditions: (1) The other film-forming materials are hydroxypropyl cellulose and polyoxyethylene; the preferred mass ratio of hydroxypropyl cellulose to polyoxyethylene is (22-32):(25-30.5) parts, for example 32:28 parts, 31:27 parts, 22:30.5 parts, 23.5:25 parts; (2) The sweetener is xylitol, acesulfame potassium, or sucralose; (3) The salting agent is sodium chloride; (4) The mass ratio of the sweetener to the salty agent is (2-3):(2-3), for example 2:2 or 3:3; (5) The flavoring is wintergreen flavoring, pepper flavoring, strawberry flavoring, citrus flavoring or passion fruit flavoring; (6) The mass ratio of the sweetener to the flavoring is (2-3):(9-10), for example 2:9, 2:10, 3:10, 3:9; (7) The cooling agent is WS-23; (8) The mass ratio of the sweetener to the cooling agent is (2-3):(0.5-1), for example 2:0.5, 2:1, 3:0.5; (9) The guarana powder was produced by Hebei Danming Biotechnology Co., Ltd., with batch number 245080; (10) The hydroxypropyl cellulose was produced by Wuhan Xinweiye Chemical Co., Ltd., with batch number W462407023; (11) The polyoxyethylene was produced by Sichuan Laitejuxin Pharmaceutical Excipients Co., Ltd., with batch number LT256543161.

5. The guarana oral soluble film according to any one of claims 1-4, characterized in that, It satisfies at least one of the following conditions: (1) The guarana oral soluble film is composed of the following parts by weight: 5 parts guarana powder, 32 parts hydroxypropyl cellulose, 28 parts polyoxyethylene, 8.5 parts sodium sulfonyl-β-cyclodextrin, 8 parts taurine, 2 parts xylitol, 2 parts sodium chloride, 9 parts wintergreen flavor, 0.5 parts WS-23, and 5 parts glycerin. (2) The guarana oral soluble film is composed of the following parts by weight: 8 parts guarana powder, 31 parts hydroxypropyl cellulose, 27 parts polyoxyethylene, 7 parts sodium sulfonyl-β-cyclodextrin, 7 parts taurine, 2 parts acesulfame potassium, 2 parts sodium chloride, 10 parts peppermint flavoring, 1 part WS-23, and 5 parts glycerin. (3) The guarana oral soluble film is composed of the following parts by weight: 8 parts guarana powder, 31 parts hydroxypropyl cellulose, 27 parts polyoxyethylene, 7 parts sodium sulfonyl-β-cyclodextrin, 7 parts taurine, 2 parts acesulfame potassium, 2 parts sodium chloride, 10 parts strawberry flavoring, 1 part WS-23, and 5 parts glycerin. (4) The guarana oral soluble film is composed of the following parts by weight: 10 parts guarana powder, 22 parts hydroxypropyl cellulose, 30.5 parts polyoxyethylene, 7 parts sodium sulfonyl-β-cyclodextrin, 7 parts taurine, 3 parts xylitol, 3 parts sodium chloride, 10 parts citrus flavoring, 0.5 parts WS-23, and 7 parts glycerin. (5) The guarana oral soluble film is composed of the following parts by weight: 12 parts guarana powder, 23.5 parts hydroxypropyl cellulose, 25 parts polyoxyethylene, 8 parts sodium sulfobutyl-β-cyclodextrin, 9 parts taurine, 3 parts xylitol, 3 parts sodium chloride, 9 parts passion fruit flavor, 0.5 parts WS-23, and 7 parts glycerin.

6. A method for preparing a guarana oral slurry membrane, characterized in that, It includes the following steps: The membrane solution is defoamed and formed into a film; the membrane solution includes the following parts by weight: 3-20 parts of guarana powder, 1-10 parts of sodium sulfobutyl ether-β-cyclodextrin, 30-80 parts of other film-forming materials, and 2-20 parts of plasticizer.

7. The method for preparing a guarana oral slurry film as described in claim 6, characterized in that, It satisfies at least one of the following conditions: (1) The viscosity of the membrane solution is 37.6-39.5 Pa·s, for example 37.6 Pa·s, 37.9 Pa·s, 38.7 Pa·s, 39.5 Pa·s; (2) The vacuum degree of the defoaming process is -0.095 to -0.1 MPa; (3) The degassing rate is 70-75 mL / min, for example, 70 mL / min or 75 mL / min; (4) The means of forming the film is scraping; (5) After the film is formed, it is transferred to a film, preferably a plastic film; after the film is transferred to the film, it is air-dried for 20-40 minutes, preferably 30 minutes; after air-drying, it is peeled off from the plastic film and cut to obtain the guarana oral solution film. (6) The guarana powder is as defined in any one of claims 1-5; (7) The sodium sulfonyl-β-cyclodextrin is as defined in any one of claims 1-5; (8) The plasticizer is as defined in any one of claims 1-5; (9) The other film-forming materials are as defined in any one of claims 1-5; (10) The membrane liquid further includes a flavoring agent; the flavoring agent is preferably defined as in any one of claims 2-5; (11) The membrane fluid further includes an energy substance; the energy substance is preferably defined as in any one of claims 2-5.

8. The method for preparing a guarana oral slurry film as described in claim 7, characterized in that, The method for preparing the membrane solution includes the following steps: The guarana powder, the sodium sulfobutyl ether-β-cyclodextrin, the flavoring agent, the energy substance, and the plasticizer are mixed and then mixed evenly with the other film-forming materials to obtain the film solution. The mixing speed is preferably 280 rpm to 300 rpm, for example, 280 rpm or 300 rpm; the secondary mixing speed is preferably 290 rpm to 300 rpm, for example, 290 rpm or 300 rpm; and the secondary mixing temperature is preferably 30-40℃, for example, 35℃.

9. A guarana oral soluble membrane, characterized in that, It is prepared by the method of any one of claims 6-8, and the guarana oral dissolving membrane can be used as an anti-fatigue or anti-depressant oral dissolving membrane.

10. The use of a guarana oral soluble film as described in any one of claims 1-9 in the preparation of anti-fatigue foods or antidepressant drugs.

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